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Antioxidants
Special Issues
The Interaction Between Gut Microbiota and Host Oxidative Stress
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The Interaction Between Gut Microbiota and Host Oxidative Stress

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2259

Special Issue Editor

Prof. Dr. Jie Yin

E-Mail Website
Guest Editor
College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
Interests: nutrition and metabolism (amino acids); oxidative stress and redox biology; gut microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our previous edition “Role of Antioxidants Intake on Gut Microbiome” garnered an exceptional response, with a substantial number of high-quality submissions, resulting in a successful compilation of cutting-edge research. Building on this success, I am delighted to announce our a new Special Issue on a similar topic, titled “The Interaction Between Gut Microbiota and Host Oxidative Stress”.

This new special issue in Antioxidants focuses on the role of host oxidative stress in gut microbiota-guided diseases or gut microbial dysbiosis involved in oxidative injury. Several papers in the previous edition identified an antioxidant characteristic of probiotics; thus, this new edition further emphasizes the improvement in gut microbiota compositions by diet or probiotics as promising therapeutic agents, targeting host antioxidant systems to alleviate diseases. We invite contributions that explore the interaction between gut microbiota and host oxidative stress, particularly in designing innovative therapies for diseases.

Prof. Dr. Jie Yin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidants
  • gut microbiome
  • immunity

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Published Papers (2 papers)

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Research

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30 pages, 7021 KiB  
Article
Anti-Inflammatory Effect of Dendrobium officinale Extract on High-Fat Diet-Induced Obesity in Rats: Involvement of Gut Microbiota, Liver Transcriptomics, and NF-κB/IκB Pathway
by Runze Zhou, Yixue Wang, Shiyun Chen, Fanjia Cheng, Yuhang Yi, Chenghao Lv and Si Qin
Antioxidants 2025, 14(4), 432; https://doi.org/10.3390/antiox14040432 - 3 Apr 2025
Viewed by 402
Abstract
The growing prevalence of obesity is being increasingly acknowledged as a major public health issue. This mainly stems from the excessive intake of dietary fats. Dendrobium officinale (DO), recognized as an herb with dual roles of food and medicine, is renowned for its [...] Read more.
The growing prevalence of obesity is being increasingly acknowledged as a major public health issue. This mainly stems from the excessive intake of dietary fats. Dendrobium officinale (DO), recognized as an herb with dual roles of food and medicine, is renowned for its diverse health-promoting effects. Nevertheless, the specifics of its antiobesity and anti-inflammatory properties and the underlying mechanisms are still obscure. The present study shows that treatment with Dendrobium officinale extract (DOE) alleviates obesity, liver steatosis, inflammation, and oxidative stress in rats that are obese due to a high-fat diet (HFD). Firstly, with respect to HFD obese rats, higher doses of DOE significantly reduced TG, TC, LDL-C, blood glucose, and liver AST and ALT, along with lipid droplets. Meanwhile, DOE supplementation significantly reduced oxidative stress induced by ROS and MDA and increased the levels of GSH-Px and SOD in liver tissues. Furthermore, integrated analysis of transcriptomic and microbiomic data revealed that DOE modulated inflammatory responses through the NF-κB/IκB pathway. This regulatory mechanism was evidenced by corresponding changes in the protein expression levels of both NF-κB and IκB. Additionally, DOE was found to modulate gut microbiota composition in obese rats, specifically reducing the relative abundance of Bilophila while increasing beneficial bacterial populations, particularly the genera Akkermansia and Roseburia. These findings suggest that DOE may help retain the homeostasis of the gut microbiota and improve metabolic health by regulating inflammation in the liver and intestine, thereby providing protection against obesity and related metabolic syndromes. Our study demonstrates that DOE, as a natural botanical extract, can effectively facilitate the prevention or treatment of metabolic syndrome through precision dietary interventions. Full article
(This article belongs to the Special Issue The Interaction Between Gut Microbiota and Host Oxidative Stress)
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Review

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38 pages, 2354 KiB  
Review
Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD
by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini and Luca Miele
Antioxidants 2025, 14(1), 56; https://doi.org/10.3390/antiox14010056 - 6 Jan 2025
Cited by 1 | Viewed by 1383
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to a range of pathological outcomes, including metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to a range of pathological outcomes, including metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms driving MASLD initiation and progression remain incompletely understood. Oxidative stress and lipid peroxidation are pivotal in the “multiple parallel hit model”, contributing to hepatic cell death and tissue damage. Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes’ ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. Moreover, various exogenous factors impact gut microbiota and its involvement in MASLD-related oxidative stress, such as air pollution, physical activity, cigarette smoke, alcohol, and dietary patterns. This manuscript aims to provide a state-of-the-art overview focused on the intricate interplay between gut microbiota, lipid peroxidation, and MASLD pathogenesis, offering insights into potential strategies to prevent disease progression and its associated complications. Full article
(This article belongs to the Special Issue The Interaction Between Gut Microbiota and Host Oxidative Stress)
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