Oxidative Stress and Mitochondrial Dysfunction in Metabolic Disorders
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 28
Special Issue Editors
Interests: energy metabolism; metabolic plasticity; mitochondrial function; obesity related type 2 diabetes; exercise; lifestyle; integrative physiology; systems biology
Special Issues, Collections and Topics in MDPI journals
2. Clinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland
Interests: exercise training; mitochondria; skeletal muscle; humans
Special Issues, Collections and Topics in MDPI journals
Interests: pancreatic islet; islet transplantation; islet revascularization; VEGFA; PTP1B; diabetes; type 1 diabetes; type 2 diabetes; obesity; clock genes; islet metabolism
Special Issue Information
Dear Colleagues,
Metabolic diseases, such as diabetes, obesity, cardiovascular problems, and non-alcoholic fatty liver disease, constitute major global health issues, influenced by intricate interactions among genetic, environmental, and lifestyle factors. Central to their pathogenesis are oxidative stress—arising from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses—and mitochondrial dysfunction. Mitochondria, which are known as the powerhouses of the cell, are important generators of ROS and are also susceptible to oxidative damage. This dual involvement fosters a detrimental cycle that undermines metabolic function and accelerates disease progression.
This Special Issue will investigate the complex relationship among oxidative stress, mitochondrial dysfunctions, and metabolic diseases, including both basic research and clinical applications.
We welcome submissions of original research articles, comprehensive reviews, clinical studies, and short communications, with the aim of showcasing pioneering research and ideas that elucidate fundamental mechanisms and investigate novel therapeutic options.
We invite contributions exploring the intricate interplay among ROS generation, antioxidant defense mechanisms, and biological redox signaling pathways. An emphasis will be placed on research exploring mitochondrial dynamics, biogenesis, and bioenergetics in relation to metabolic balance and metabolic diseases, alongside studies exploring innovative therapeutic approaches aimed at addressing mitochondrial malfunction and oxidative stress. The scope also includes investigations into the genetic and epigenetic determinants of metabolic diseases, the effects of environmental and lifestyle changes on disease progression, and advanced therapeutic strategies, including, but not limited to, antioxidant interventions, mitochondria-targeted therapies, innovative drug delivery systems, and biomarker development. Through this Special Issue, we aim to establish a comprehensive platform for discussing advanced knowledge, current challenges, and future perspectives in the field, with a key focus on emerging technologies and methodologies for investigating oxidative stress and mitochondrial dysfunction.
Through this Special Issue, we aspire to advance our understanding of the pathophysiological mechanisms underlying metabolic disorders and facilitate the development of more effective therapeutic strategies for their prevention and treatment. This Special Issue will serve as a valuable resource for researchers, academics, clinicians, and healthcare professionals working at the intersection of oxidative stress, mitochondrial biology, and metabolic diseases.
Dr. Pablo M. García-Rovés
Dr. Steen Larsen
Guest Editors
Dr. Hugo J Alves-Figueiredo
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic diseases
- oxidative stress
- mitochondrial dysfunction
- antioxidant therapies
- lifestyle interventions
- gene therapies
- mitochondrial transfer therapies
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