Oxidative Stress and Therapeutic Approaches in Lung Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 10 August 2026 | Viewed by 1942

Special Issue Editor


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Guest Editor
1. Department of Pediatrics, Medical College of Wisconsin, Suite C410, Children Corporate Center, 999N 92nd Street, Milwaukee, WI 53226, USA
2. Children’s Research Institute, Medical College of Wisconsin, 8701 W Watertown Plank Rd., Wauwatosa, WI 53226, USA
Interests: neonatal-perinatal medicine; prematurity; lung diseases; neonatal disorders; free radicals research
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Special Issue Information

Dear Colleagues,

We are excited to announce a new Special Issue for Antioxidants, ‘Oxidative Stress and Therapeutic Approaches in Lung Diseases’.

Oxidative stress—an imbalance between reactive oxygen species production and antioxidant defenses—plays a central role in the onset, progression, and exacerbation of numerous lung diseases, including COPD (chronic obstructive pulmonary disease), asthma, pulmonary fibrosis, and acute lung injury. Despite increasing evidence supporting the value of antioxidant-based interventions, such therapies have not yet become standard clinical practice, highlighting a persistent gap between experimental research and patient care.

This Special Issue aims to bridge this gap by providing a platform for both scientists and clinicians to present innovative research, mechanistic insights, translational studies, and clinical perspectives. We particularly welcome submissions that address the following:

  • Molecular and cellular mechanisms of oxidative stress in lung pathology;
  • Novel antioxidant compounds, therapeutic targets, and delivery strategies;
  • Preclinical and clinical studies evaluating antioxidant interventions;
  • Biomarkers for oxidative stress-related lung injuries;
  • Interdisciplinary approaches integrating redox biology with therapeutic development.

We anticipate that this Special Issue will foster meaningful dialog and collaboration, ultimately inspiring new therapeutic strategies that will improve outcomes for patients with lung diseases.

Prof. Dr. Ru-Jeng Teng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • antioxidant therapy
  • therapeutic strategies
  • patient care

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Published Papers (1 paper)

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Review

21 pages, 590 KB  
Review
Glutathione-Mediated Redox Regulation of Immune Dysfunction in COVID-19 and Tuberculosis
by John Dawi, Scarlet Affa, Yura Misakyan, Edgar Gonzalez, Stephen Affa and Vishwanath Venketaraman
Antioxidants 2026, 15(2), 214; https://doi.org/10.3390/antiox15020214 - 6 Feb 2026
Viewed by 1635
Abstract
Tuberculosis and coronavirus disease 2019, also known as COVID-19, remain major global health challenges that disproportionately affect individuals with metabolic disorders, chronic inflammation, and limited access to healthcare. Although these diseases are caused by different pathogens, they share important host-related determinants of severity, [...] Read more.
Tuberculosis and coronavirus disease 2019, also known as COVID-19, remain major global health challenges that disproportionately affect individuals with metabolic disorders, chronic inflammation, and limited access to healthcare. Although these diseases are caused by different pathogens, they share important host-related determinants of severity, including immune dysfunction, oxidative stress, endothelial injury, and maladaptive inflammatory responses. Glutathione, the primary intracellular antioxidant and a key regulator of redox balance, has emerged as an important host factor connecting these processes across infectious diseases. This review integrates experimental, translational, and clinical evidence supporting the role of glutathione in regulating immune function, oxidative stress, and tissue damage in tuberculosis and COVID-19. In tuberculosis, glutathione deficiency compromises macrophage antimicrobial activity, disrupts granuloma structure, and alters T helper cell responses, leading to impaired immune containment and disease progression. In COVID-19, reduced glutathione levels are associated with redox imbalance, excessive cytokine signaling, endothelial dysfunction, and thromboinflammatory complications, especially in high-risk populations. In both diseases, glutathione depletion reduces host resilience and increases vulnerability to severe outcomes through shared immune and vascular pathways. By unifying disease-specific findings within a host-directed framework, this review highlights glutathione and redox signaling as common vulnerability pathways that help explain overlapping risk profiles for severe tuberculosis and COVID-19. It also places glutathione biology within the broader context of host-directed immunotherapy, emphasizing its potential role in prevention-focused and resilience-based strategies that complement pathogen-targeted treatments. Although current evidence does not support simple claims of disease prevention, it provides strong mechanistic justification for further investigation of glutathione as a modifiable host factor in high-risk populations. Full article
(This article belongs to the Special Issue Oxidative Stress and Therapeutic Approaches in Lung Diseases)
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