Oxidative Stress in Bone Metabolic Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 23
Special Issue Editor
Special Issue Information
Dear Colleagues,
The intricate relationship between oxidative stress and bone metabolic homeostasis is increasingly recognized as a pivotal factor in the pathogenesis and progression of diverse skeletal disorders. This Special Issue of Antioxidants, titled "Oxidative Stress in Bone Metabolic Diseases," aims to collate cutting-edge research and comprehensive reviews exploring the multifaceted role of oxidative damage in disrupting bone metabolism.
We invite original research articles and reviews that investigate the mechanistic links between elevated reactive oxygen species (ROS), impaired antioxidant defenses, and the development or exacerbation of bone metabolic diseases. Key areas of interest include, but are not limited to, the following:
- Pathogenesis: Elucidating how oxidative stress contributes to osteoporosis, bone malnutrition, parathyroid hormone-related bone diseases, osteomalacia, rickets, hereditary metabolic bone diseases (e.g., osteogenesis imperfecta, hypophosphatasia), and tumor-induced bone metabolic abnormalities.
- Intervention Strategies: Evaluating the therapeutic potential, mechanisms of action, and efficacy of antioxidants (endogenous, dietary, pharmacological) in preventing or treating these conditions. Studies on novel delivery systems or combination therapies are welcome.
- Mitochondrial Dysfunction: Highlighting research on mitochondrial ROS generation, bioenergetic failure, and mitochondrial quality control as central mediators of oxidative bone damage and potential targets for functional intervention.
- Molecular Mechanisms: Exploring signaling pathways (e.g., RANKL/RANK/OPG, Wnt/β-catenin), transcription factors (e.g., Nrf2, FOXOs), and cellular processes (osteoblast/osteoclast/osteocyte dysfunction, apoptosis, senescence) modulated by oxidative stress in bone.
This Special Issue seeks to foster a deeper understanding of redox biology in skeletal health and disease. We encourage submissions of high-quality basic, translational, and clinical research to advance knowledge and identify novel therapeutic avenues.
We look forward to your valuable contributions.
Dr. Zhongbo Liu
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- bone metabolic diseases
- osteoporosis
- mitochondrial dysfunction
- antioxidants
- reactive species
- osteoblast/osteoclast/osteocyte
- Nrf2
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