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Antioxidants
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Selected Papers from the 2nd International Electronic Conference on Antioxidants...
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Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025)

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 July 2026 | Viewed by 21471

Special Issue Editors

Prof. Dr. Alessandra Napolitano

E-Mail Website
Guest Editor
Department of Chemical Sciences, University of Naples “Federico II”, Via Cintia 4, I-80126 Naples, Italy
Interests: polyphenol antioxidants of dietary origin; conjugates of polyphenols with sulphydryl compounds of biological relevance; antioxidants from marine sources; valorization of agri food wastes; synthesis and exploitation of biopolymers from natural polyphenols; chemistry and structural investigation of natural polymers from catechols including human epidermal pigments melanins; oxidation chemistry of catecholamines in relation to neurodegenerative disorders; design and preparation of polydopamine related biomaterials with peculiar adhesive properties
Special Issues, Collections and Topics in MDPI journals
Dr. Mario Allegra

E-Mail Website
Guest Editor
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università degli Studi di Palermo, 90123 Palermo, Italy
Interests: eryptosis; antioxidants; oxidative stress; signaling patterns; inflammation; brain metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are thrilled to welcome you to the upcoming 2nd International Electronic Conference on Antioxidants (IECAN 2025), proudly sponsored by the MDPI open access journal Antioxidants.

At present, antioxidants encompass a significant area of investigation for researchers from many disciplines, and their importance in a variety of fields, from health and food to innovative materials, is increasingly appreciated. This event will offer researchers working in the field of antioxidants the opportunity to present and discuss their latest research findings.

We welcome submissions from conference participants of the conference, with the aim being to publish selected extended versions of the papers presented in this Special Issue of Antioxidants.

The topics analyzed will be as follows:

  • Oxidative stress in obesity;
  • Oxidative stress and inflammation in cardiovascular diseases;
  • Antioxidants in chronic disease, from dietary prevention to therapeutic intervention;
  • Antioxidants intake and gut microbiome;
  • Natural and synthetic antioxidants and antioxidant enzyme systems;
  • Antioxidant extraction, assays, and industrial applications.

We look forward to having fruitful discussions and exchanging ideas during this conference, and we eagerly await to receive your contribution, research article or comprehensive review.

Prof. Dr. Alessandra Napolitano
Dr. Mario Allegra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • cardiovascular diseases
  • chronic disease
  • dietary prevention
  • antioxidants intake
  • gut microbiome
  • natural and synthetic antioxidants
  • antioxidant enzyme systems
  • antioxidant extraction

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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19 pages, 1461 KB  
Article
Structural Descriptors and Antioxidant Activity Markers of 4-[4-(2-Aminoethoxy)benzyl]aniline
by Dmitry A. Filimonov, Alexander B. Eresko, Nadezhda N. Trubnikova, Irina A. Kisilenko, Margarita A. Belotserkovskaya, Elena V. Raksha, Roman V. Ishchenko and Dorota M. Chudoba
Antioxidants 2026, 15(2), 256; https://doi.org/10.3390/antiox15020256 - 17 Feb 2026
Viewed by 1403
Abstract
The release of reactive oxygen species accompanying oxidative stress is one of the most significant damaging mechanisms during brain ischemia. Some aspects of the neuroprotective activity of the thyronamine T0AM synthetic analogue, 4-[4-(2-aminoethoxy)benzyl]aniline (ABA), were studied and discussed in two independent experiments using [...] Read more.
The release of reactive oxygen species accompanying oxidative stress is one of the most significant damaging mechanisms during brain ischemia. Some aspects of the neuroprotective activity of the thyronamine T0AM synthetic analogue, 4-[4-(2-aminoethoxy)benzyl]aniline (ABA), were studied and discussed in two independent experiments using a model of acute cerebral ischemia. Antioxidant effects were evaluated in adult male and female Wistar rats (Rattus norvegicus), while neurological outcomes were assessed in adult male outbred white rats. Administration of the ABA in a rat brain hemisphere ischemia model was associated with significant changes in redox markers: malondialdehyde, glutathione peroxidase and superoxide dismutase levels in the ischemic hemisphere. Also, the introduction of ABA into the model of acute cerebral ischemia contributed to a reduction in neurological deficit compared to untreated controls. It was revealed that the considered thyronamine T0AM analogue could control redox status in acute brain ischemia. Mono protonated form of ABA (ABA-H+) is considered to be the main species at pH 6.9–7.2. Structural models of the neutral (ABA), protonated (ABA-H+) thyronamine and its solvate (DMSO…ABA-H+) were used in DFT calculations, followed by estimation of molecular and supramolecular level descriptors. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025))
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17 pages, 1082 KB  
Article
Tris[N-(prop-2-en-1-yl)hydrazinecarbothioamide]-Cobalt(III) Chloride as a Stimulator of the Total Antioxidant Status of Apis mellifera with Acaricidal Activity
by Olga Garbuz, Valeriu Fala, Gheorghe Bordeniuc, Vasilii Graur, Jenny Roy, Nadejda Railean, Victor Tsapkov, Veronica Sardari, Ion Toderas and Aurelian Gulea
Antioxidants 2026, 15(1), 18; https://doi.org/10.3390/antiox15010018 - 22 Dec 2025
Viewed by 694
Abstract
This study investigates the synthesis and potential applications of the coordination compound cobalt(III) complex tris[N-(prop-2-en-1-yl)hydrazinecarbothioamide]-cobalt(III) chloride ([Co(Tsc)3]Cl3). The complex has been synthesized via the reaction of cobalt(II) chloride hexahydrate with N-(prop-2-en-1-yl)hydrazinecarbothioamide in ethanol. Its antioxidant [...] Read more.
This study investigates the synthesis and potential applications of the coordination compound cobalt(III) complex tris[N-(prop-2-en-1-yl)hydrazinecarbothioamide]-cobalt(III) chloride ([Co(Tsc)3]Cl3). The complex has been synthesized via the reaction of cobalt(II) chloride hexahydrate with N-(prop-2-en-1-yl)hydrazinecarbothioamide in ethanol. Its antioxidant activity has been evaluated using 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assay, demonstrating a significant effect with an IC50 of 7.3 µmol/L. Toxicity evaluations using Daphnia magna showed a low half maximal inhibitory concentration (LC50) of 56.3 µmol/L. Experimental results have showed that [Co(Tsc)3]Cl3 significantly elevated the total antioxidant status (TAS) of the hemolymph of honeybees and larvae, increasing it by 5 and 8 times, respectively. The IC50 values for antioxidant activity were 2.5 mg/mL in bee hemolymph and 1.3 mg/mL in larval hemolymph, notably lower than control values of 13.6 mg/mL and 10.0 mg/mL. The stimulatory effect of the coordination compound [Co(Tsc)3]Cl3 on TAS was five times higher than that of vitamin C. Additionally, [Co(Tsc)3]Cl3 exhibited acaricidal properties, effectively inhibiting Varroa destructor with an lethal concentration (LC50) of 0.2 µmol/L. These findings indicate that this cobalt complex could serve both a natural antioxidant and an effective acaricide, offering a promising approach to improv bee health and sustainability in apiculture. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025))
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22 pages, 1263 KB  
Systematic Review
Curcumin in the Treatment of Kidney Disease: A Systematic Review with a Focus on Drug Interactions
by Ebenezer Ofori-Attah, Abigail Aning and Layla Simón
Antioxidants 2025, 14(11), 1369; https://doi.org/10.3390/antiox14111369 - 18 Nov 2025
Cited by 7 | Viewed by 10187
Abstract
Kidney disease (KD) is a major health challenge, affecting millions of people worldwide, highlighting the need for improved prevention and management strategies. The pathophysiological mechanisms converged on a common pathway characterized by inflammation, oxidative stress, fibrosis, nephron loss and failure. Curcumin, the active [...] Read more.
Kidney disease (KD) is a major health challenge, affecting millions of people worldwide, highlighting the need for improved prevention and management strategies. The pathophysiological mechanisms converged on a common pathway characterized by inflammation, oxidative stress, fibrosis, nephron loss and failure. Curcumin, the active compound derived from turmeric (Curcuma longa), attracts considerable interest as a potential therapy for KD due to its anti-inflammatory, antioxidant and anti-fibrotic properties. Despite the benefits of curcumin, co-administration with kidney medications may cause drug interactions. Here, we systematically reviewed the efficacy of curcumin in alleviating KD and its safety when used with conventional treatments. Search terms included: curcumin AND (“diabetic nephropathy” OR “renal disease” OR “kidney disease”). Data on mechanisms of action, redox status, clinical benefits, side effects, and drug interactions were extracted and analyzed. Curcumin reduces oxidative stress, inflammation, apoptosis, fibrosis, ER stress, and lipid and glucose metabolism. Curcumin has multifaceted nephroprotective effects, while it is safe and well-tolerated. The curcumin–drug interactions reviewed were: -piperine, -epigallocatechin gallate, -losartan, -ginkgolide B, -rosuvastatin, -insulin, -cilostazol, and -ginger. These interactions improve curcumin bioavailability, and synergistic anti-inflammatory/antioxidant/antifibrotic and renoprotective effects. Future research should prioritize large-scale clinical trials to evaluate the efficacy and safety of curcumin in diverse KD populations. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025))
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14 pages, 1371 KB  
Systematic Review
The Potential Benefits of Curcumin-Enriched Diets for Adults with Colorectal Cancer: A Systematic Review
by María Neira, Constanza Mena, Keila Torres and Layla Simón
Antioxidants 2025, 14(4), 388; https://doi.org/10.3390/antiox14040388 - 26 Mar 2025
Cited by 6 | Viewed by 7566
Abstract
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Conventional treatments such as chemotherapy and radiotherapy are often associated with severe side effects and limited effectiveness. Curcumin, a polyphenol derived from Curcuma longa, has demonstrated anti-inflammatory and anticancer properties. [...] Read more.
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Conventional treatments such as chemotherapy and radiotherapy are often associated with severe side effects and limited effectiveness. Curcumin, a polyphenol derived from Curcuma longa, has demonstrated anti-inflammatory and anticancer properties. A systematic review of the recent scientific literature followed PRISMA guidelines to evaluate the benefits of a curcumin-enriched diet for adults with colorectal cancer. Articles published between 2018 and 2024 were retrieved from PubMed, SciELO, Google Scholar, and Scopus. Studies meeting the inclusion criteria focused on curcumin, adults, and colorectal cancer outcomes. The administration of curcumin-containing products was associated with improved survival rates, enhanced quality of life, tumor reduction, and anti-inflammatory effects. A curcumin-enriched diet shows potential as an effective adjunct therapy for CRC patients, though its limited bioavailability and potential side effects, such as gastrointestinal discomfort, pose challenges. Addressing these limitations through larger cohorts, extended study durations, and improved formulations to enhance bioavailability is essential. Such efforts could enable the development of personalized dietary recommendations for CRC management. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025))
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