The Role of Oxidative Stress in Age-Related and Degenerative Eye Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 67
Special Issue Editor
Interests: retinal diseases; age-related macular degeneration (AMD); Müller glia; oxidative stress; mitochondrial dysfunction; macular vulnerability; retinal metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress plays a central role in the development and progression of many eye diseases, especially those associated with aging and neurodegeneration. As reactive oxygen species build up and redox balance is lost, the resulting damage to retinal structures contributes to vision decline in individuals with conditions such as age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, and cataracts.
This Special Issue of Antioxidants brings together current insights into how oxidative stress drives pathology in the aging eye. We are particularly interested in how redox imbalance disrupts key cell types, like the cells of the retinal pigment epithelium, photoreceptors, and ganglion cells, and how these changes intersect with inflammation, mitochondrial dysfunction, protein misfolding, and impaired autophagy.
We invite contributions of original research papers and reviews that explore these mechanisms at any scale, from molecular to systemic. We especially welcome studies on antioxidant therapies, redox-sensitive pathways, gene–environment interactions, emerging biomarkers, and models that advance translational potential.
In addition, we strongly encourage contributions that highlight the application of new technologies in vision science research. This includes the use of artificial intelligence (AI) and machine learning to analyze high-dimensional omics data, predict disease progression, identify novel therapeutic targets, and uncover hidden patterns in redox-related cellular responses. Studies integrating AI with imaging, bioinformatics, or experimental models to address oxidative stress in ocular diseases are particularly welcome.
By drawing attention to this common pathological phenomenon and embracing cutting-edge analytical tools, we hope to deepen understanding of this issue and accelerate progress toward therapies that can meaningfully alter the course of age-related eye disease.
Dr. Ting Zhang
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- age-related macular degeneration
- retinal degeneration
- reactive oxygen species
- redox signaling
- mitochondrial dysfunction
- antioxidant therapy
- artificial intelligence
- multi-omics
- biomarkers
- vision science
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