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12.4
6.6
Journals
Antioxidants
Special Issues
Carotenoids in Health and Disease
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Carotenoids in Health and Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2804

Special Issue Editor

Dr. Kazutoshi Shindo

E-Mail Website
Guest Editor
Department of Food and Nutrition, Japan Women’s University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo 112-8681, Japan
Interests: functional carotenoids

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) are molecules containing at least one oxygen atom and one or more unpaired electrons and can exist independently. Additionally, ROS include oxygen-free radicals, such as superoxide anion radicals, hydroxyl radicals, hydroperoxyl radicals, singlet oxygen, and free nitrogen radicals. Under physiological conditions, small quantities of ROS form mainly in hepatocytes and macrophages during normal cell processes, such as aerobic respiration, or inflammatory processes, and damage important biomolecules, such as lipids, proteins, and DNA. Over time, this damage significantly contributes to aging and the development of several conditions, such as autoimmune diseases, neurodegenerative disorders, various types of cancers, diabetes mellitus-related complications, stroke, heart attacks, pain, and inflammation. Considering antioxidant intake may help prevent ROS-mediated cellular damage and diseases, I am conducting research focusing on carotenoids as antioxidants. In this Special Issue, I invite reports on new antioxidant carotenoids or known carotenoids with new antioxidant functions.

Dr. Kazutoshi Shindo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant activities of carotenoids
  • analytical chemistry on carotenoids
  • reactive oxygen species (ROS) and disease
  • production of carotenoids

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Published Papers (2 papers)

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Research

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19 pages, 2797 KiB  
Article
Aster-B Modulates Oxidative Stress Responses and Carotenoid Distribution in ARPE-19 Cells
by Vidya Gopakumar and Johannes von Lintig
Antioxidants 2025, 14(5), 575; https://doi.org/10.3390/antiox14050575 - 10 May 2025
Viewed by 1566
Abstract
Lipid metabolism and oxidative stress are major contributors to ocular diseases, including drusen formation and photoreceptor damage. Aster-B, encoded by GRAMD1B, mediates the non-vesicular transport of cholesterol and carotenoids and is highly expressed in the human eye, though its specific ocular functions [...] Read more.
Lipid metabolism and oxidative stress are major contributors to ocular diseases, including drusen formation and photoreceptor damage. Aster-B, encoded by GRAMD1B, mediates the non-vesicular transport of cholesterol and carotenoids and is highly expressed in the human eye, though its specific ocular functions remain unknown. We investigated Aster-B’s role in ARPE-19 cells, a model of the retinal pigment epithelium (RPE), using CRISPR/dCas9 to generate an Aster-B-expressing cell line. Aster-B expression significantly improved cell survival under oxidative stress induced by hydrogen peroxide (H2O2) and was associated with the activation of the p53 and TGFβ signaling pathways, indicating a role in modulating stress responses. To confirm its lipid transport activity, we treated cholesterol-depleted cells with carotenoids and tracked their localization. In Aster-B-expressing cells, carotenoids accumulated in mitochondria, while in control cells, they remained in other cellular compartments. Under oxidative stress, mitochondrial carotenoid levels declined in Aster-B-expressing cells but not in control cells. Interestingly, carotenoids enhanced survival in control cells exposed to H2O2 but had a detrimental effect in Aster-B-expressing cells, suggesting that carotenoid function is context and location dependent. These findings highlight Aster-B’s role in coordinating lipid transport and stress responses in the RPE, with implications for oxidative stress-related eye diseases. Full article
(This article belongs to the Special Issue Carotenoids in Health and Disease)
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Review

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24 pages, 993 KiB  
Review
Astaxanthin: A Compound in the Prevention of Chronic Diseases and as a Potential Adjuvant Treatment Agent
by Xiao Zhu, Xi Chen, Matthew Wang and Honghua Hu
Antioxidants 2025, 14(6), 715; https://doi.org/10.3390/antiox14060715 - 12 Jun 2025
Cited by 1 | Viewed by 908
Abstract
Astaxanthin (AST) is a fat-soluble carotenoid antioxidant. AST exhibits multiple protective mechanisms, including its antioxidant, anti-inflammatory, immunomodulatory, anti-apoptotic, nervous system-protective, anti-tumor, and anti-fibrotic effects. These effects make it a promising compound for the prevention of chronic diseases. AST can protect the nervous system [...] Read more.
Astaxanthin (AST) is a fat-soluble carotenoid antioxidant. AST exhibits multiple protective mechanisms, including its antioxidant, anti-inflammatory, immunomodulatory, anti-apoptotic, nervous system-protective, anti-tumor, and anti-fibrotic effects. These effects make it a promising compound for the prevention of chronic diseases. AST can protect the nervous system against neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. It also protects the liver and helps reduce the risk of chronic kidney disease. Additionally, it improves cardiovascular health and has anti-diabetic properties. This review aims to provide an updated overview covering the protective effects of AST against various chronic diseases, including its antioxidant, anti-inflammatory, and anti-apoptotic effects. We also discuss the strategies used for improving astaxanthin bioavailability and its potential as an adjuvant therapeutic agent. Full article
(This article belongs to the Special Issue Carotenoids in Health and Disease)
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