Oxidative Stress in Diabetic Retinopathy and Other Retinal Diseases
A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 1557
Editor
Interests: diabetic microvascular complications; vascular dysfunction; diabetic retinopathy; age-related macular degeneration
Special Issue Information
Dear Colleagues,
Oxidative stress is a central mechanism underlying the pathogenesis of multiple retinal disorders and contributes significantly to progressive vision loss, including diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and optic neuropathy. The retina is particularly susceptible to oxidative damage because of its high metabolic activity, abundant polyunsaturated fatty acids, and continuous exposure to light. In diabetic retinopathy, which progresses from early non-proliferative to advanced proliferative stages, chronic hyperglycemia triggers excessive production of reactive oxygen species. This overproduction leads to mitochondrial dysfunction, vascular leakage, neuroinflammation, and disruption of the blood–retinal barrier. Similarly, oxidative stress plays a pivotal role in retinal pigment epithelial dysfunction, photoreceptor degeneration, and pathological neovascularization in age-related macular degeneration and other retinal diseases.
This Special Issue aims to highlight recent advances in elucidating the molecular mechanisms linking oxidative stress to retinal neurovascular injury and to explore emerging therapeutic strategies. We welcome original research articles and comprehensive reviews addressing redox signaling, mitochondrial dynamics, vascular and neuronal dysfunction, and innovative therapeutic interventions. Studies employing experimental animal models, translational research approaches, and well-designed clinical investigations are particularly encouraged.
By integrating fundamental mechanistic insights with clinical perspectives, this Special Issue seeks to promote the development of targeted strategies to prevent or slow the progression of retinal diseases and ultimately preserve visual function.
Prof. Dr. Kwon-Soo Ha
Guest Editor
Manuscript Submission Information
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Keywords
- vascular dysfunction
- oxidative stress
- mitochondrial dynamics
- neurovascular dysfunction
- diabetic retinopathy
- age-related macular degeneration
- retinal vein occlusion
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