Recent Trends in Nanoantioxidants—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 August 2025 | Viewed by 647

Special Issue Editors


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Guest Editor
Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy
Interests: cosmetics and cosmeceuticals; phytochemicals delivery; liposomes; phospholipid vesicles; antioxidants; antiaging; regenerative treatments; polyphenols; natural chemicals from agri-food by-products; keratinocytes; fibro-blasts; macrophages; in vitro testing; skin hydration; skin elasticity; in vivo clinical trials
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Guest Editor Assistant
Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Italy
Interests: liposomes; nano drug delivery; antioxidants; cosmeceuticals; nutraceuticals; skin delivery; nano vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that certain lifestyle choices and the intake of unhealthy chemicals contribute to an overproduction of reactive oxygen species (ROS), which play a key role in the development of acute or chronic inflammatory diseases, as well as cancer. Their overproduction can lead to oxidative damage, triggering inflammation, DNA damage and other complications.

Antioxidants have the potential to counteract oxidative damage by scavenging a wide range of reactive oxygen species. However, both natural and synthetic compounds, but especially those of natural origin, face significant stability challenges, including photosensitivity, poor water solubility and low bioavailability, limiting their in vivo efficacy.

To overcome these limitations, recent research aims to develop the most suitable systems to deliver antioxidant compounds to the organism by improving their properties. Among these, nanotechnology has emerged as a promising approach. Nano-drug delivery systems reduce the particle size of the active compounds to the nanometer scale, improving their solubility and facilitating absorption. Further formulation strategies include the development of more complex systems such as liposomes or liposome-like systems, solid lipid nanoparticles (SLNs), nanoemulsions and nanostructured lipid carriers (NLCs), which can circulate in the body, promoting and improving their bioavailability.

This Special Issue, “Recent Trends in Nanoantioxidants—2nd Edition”, aims to provide an overview of the recent advances in nano-drug delivery compounds with antioxidant properties, including, but not necessarily restricted to, natural molecules.

Dr. Maria Letizia Manca
Guest Editor

Dr. Matteo Perra
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • nanocarriers
  • liposomes
  • nanocrystals
  • oxidative stress
  • inflammation
  • antioxidant
  • cosmeceuticals
  • nutraceuticals
  • ROS
  • liposomes
  • nanosystems

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Published Papers (2 papers)

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Research

23 pages, 2149 KiB  
Article
Liposomal Delivery of a Biotechnological Lavandula angustifolia Miller Extract Rich in Rosmarinic Acid for Topical Herpes Simplex Therapy
by Federica Fulgheri, Fabrizio Angius, Matteo Perra, Ilenia Delogu, Silvia Puxeddu, Milen I. Georgiev, Renáta Novotná, Jana Franková, Misia Lobina, Aldo Manzin, Maria Manconi and Maria Letizia Manca
Antioxidants 2025, 14(7), 811; https://doi.org/10.3390/antiox14070811 - 30 Jun 2025
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Abstract
Herpes simplex virus type 1 (HSV-1) is a widespread pathogen responsible for recurrent infections, primarily affecting the skin and mucous membranes. With the aim of targeting both the viral infection and the associated inflammatory response, biotechnologically produced Lavandula angustifolia Miller (L. angustifolia [...] Read more.
Herpes simplex virus type 1 (HSV-1) is a widespread pathogen responsible for recurrent infections, primarily affecting the skin and mucous membranes. With the aim of targeting both the viral infection and the associated inflammatory response, biotechnologically produced Lavandula angustifolia Miller (L. angustifolia) extract, rich in rosmarinic acid, was incorporated into liposomal formulations intended for topical application. Lavender is known for its strong anti-inflammatory, antioxidant, wound-healing, and antiviral properties. However, its low stability under certain conditions limits its therapeutic potential. Four different formulations were developed: conventional liposomes, glycerosomes, hyalurosomes, and glycerohyalurosomes. The vesicles were characterized for size, stability, and entrapment efficiency. Glycerosomes were the smallest (~58 nm), while the other formulations ranged around 77 nm, all maintaining a highly negative surface charge, ensuring stability and reduced aggregation. Glycerol-containing formulations demonstrated superior stability over 12 months, while liposomes and hyalurosomes increased their size after only two months. Entrapment efficiency reached up to 100% for most vesicles, except for glycerohyalurosomes (~54%). In vitro studies on Normal Human Dermal Fibroblasts (NHDFs) demonstrated that all formulations were biocompatible and enhanced cell viability under oxidative stress. Glycerosomes, hyalurosomes, and glycerohyalurosomes exhibited significant anti-inflammatory activity by reducing MMP-1 and IL-6 levels in LPS-stimulated fibroblasts. Furthermore, these preliminary results highlighted promising antiviral activity against HSV-1 of the obtained formulations, particularly when applied during or post-infection. Overall, these phospholipid vesicles offer a dual therapeutic approach, combining antioxidant, anti-inflammatory, and antiviral effects, positioning them as promising candidates for the treatment of HSV-induced skin lesions and related inflammatory conditions. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants—2nd Edition)
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19 pages, 1240 KiB  
Article
Inulin Improves the Redox Response in Rats Fed a Diet Containing Recommended Copper Nanoparticle (CuNPs) Levels, While Pectin or Psyllium in Rats Receive Excessive CuNPs Levels in the Diet
by Aleksandra Marzec, Ewelina Cholewińska, Bartosz Fotschki, Jerzy Juśkiewicz and Katarzyna Ognik
Antioxidants 2025, 14(6), 695; https://doi.org/10.3390/antiox14060695 - 8 Jun 2025
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Abstract
The study aimed to determine the effect of dietary inclusion of the recommended (6.5 mg Cu/kg diet) or double the recommended (13.0 mg Cu/kg diet) levels of copper nanoparticles (CuNPs) in combination with different types of dietary fibre on selected redox status indicators [...] Read more.
The study aimed to determine the effect of dietary inclusion of the recommended (6.5 mg Cu/kg diet) or double the recommended (13.0 mg Cu/kg diet) levels of copper nanoparticles (CuNPs) in combination with different types of dietary fibre on selected redox status indicators in the blood and tissues of male Wistar rats. Control groups were fed diets containing cellulose and a mineral mixture with standard or enhanced content of CuCO3. The experimental groups were fed a diet supplemented with CuNPs (6.5 or 13 mg/kg) and combined with various fibre types—cellulose, pectin, inulin, or psyllium. After the feeding period, rats’ organs were collected to assess selected indicators of redox status. The obtained results suggest that the addition of dietary fibre in the form of inulin may beneficially stimulate the response of the redox system in the conditions of CuNPs nutrition at the recommended dose, pectin, or psyllium in the case of an excessive supply of CuNPs in the diet. Thus, selecting the appropriate type of dietary fibre based on the CuNPs’ level in the diet may effectively protect the organism from the potentially harmful prooxidative effect of CuNPs, ultimately contributing to a favourable regulation of their metabolic impact in the body. Full article
(This article belongs to the Special Issue Recent Trends in Nanoantioxidants—2nd Edition)
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