Recent Trends in Nanoantioxidants—2nd Edition

Dear Colleagues,

It is well known that certain lifestyle choices and the intake of unhealthy chemicals contribute to an overproduction of reactive oxygen species (ROS), which play a key role in the development of acute or chronic inflammatory diseases, as well as cancer. Their overproduction can lead to oxidative damage, triggering inflammation, DNA damage and other complications.

Antioxidants have the potential to counteract oxidative damage by scavenging a wide range of reactive oxygen species. However, both natural and synthetic compounds, but especially those of natural origin, face significant stability challenges, including photosensitivity, poor water solubility and low bioavailability, limiting their in vivo efficacy.

To overcome these limitations, recent research aims to develop the most suitable systems to deliver antioxidant compounds to the organism by improving their properties. Among these, nanotechnology has emerged as a promising approach. Nano-drug delivery systems reduce the particle size of the active compounds to the nanometer scale, improving their solubility and facilitating absorption. Further formulation strategies include the development of more complex systems such as liposomes or liposome-like systems, solid lipid nanoparticles (SLNs), nanoemulsions and nanostructured lipid carriers (NLCs), which can circulate in the body, promoting and improving their bioavailability.

This Special Issue, “Recent Trends in Nanoantioxidants—2nd Edition”, aims to provide an overview of the recent advances in nano-drug delivery compounds with antioxidant properties, including, but not necessarily restricted to, natural molecules.

Dr. Maria Letizia Manca
Guest Editor

Dr. Matteo Perra
Guest Editor Assistant

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