Oxidative Stress and Biomarkers in Veterinary Medicine

A Special Issue of Antioxidants (ISSN 2076-3921) belonging to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 1 February 2027 | Viewed by 995

Editors


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Guest Editor
Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece
Interests: clinical biochemistry; diagnostic assays; biomarkers; neurological disorders

E-Mail Website
Guest Editor
Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece
Interests: diagnostic assays; biomarkers; immune responses; infections; pathogenesis
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Special Issue Information

Dear Colleagues,

Oxidative stress represents a key pathophysiological mechanism in numerous veterinary diseases, influencing cellular function, immune responses, metabolic balance, and overall animal health. The imbalance between pro-oxidant processes and antioxidant defenses contributes to tissue damage, inflammation, and dysregulated cellular signaling, ultimately impacting disease onset, progression, and clinical outcomes in both companion and livestock species, as well as wildlife.

This Special Issue, “Oxidative Stress and Biomarkers in Veterinary Medicine”, aims to provide a platform for research focused on redox biology, oxidative damage, and antioxidant systems across veterinary species. Particular emphasis will be placed on the identification, validation, and clinical application of oxidative stress biomarkers relevant for diagnosis, prognosis, monitoring, and therapeutic decision-making.

A special focus of this issue will address the role of oxidative stress and redox imbalance in veterinary oncology, highlighting how oxidative processes contribute to carcinogenesis and tumor progression, as well as the role of oxidative stress biomarkers in the diagnostic investigation of neoplasia. Studies exploring biomarkers of oxidative stress in neoplastic diseases, redox-based interventions, and translational insights bridging veterinary and comparative oncology are especially encouraged.

We invite original research articles, reviews, short communications, and clinical reports addressing—though not limited to—the following topics:

  • Mechanisms of oxidative stress and antioxidant defense in veterinary species;
  • Biomarkers of oxidative stress: discovery, validation, and clinical utility;
  • Oxidative stress in infectious, metabolic, inflammatory, cardiovascular, neurological, and degenerative diseases;
  • Oxidative stress and neoplasms: molecular pathways, biomarkers, treatment monitoring, and prognostic value;
  • Interactions between oxidative stress, immune function, and inflammation;
  • Nutritional, pharmacological, and management strategies targeting oxidative balance;
  • Comparative and translational redox research between veterinary and human medicine;
  • Methodological advances in oxidative stress assessment in animals.

By integrating multidisciplinary perspectives—from basic science to clinical application—this Special Issue seeks to deepen our understanding of oxidative biology in veterinary medicine and to foster innovative approaches for improving animal health and welfare.

Prof. Dr. Zoe S. Polizopoulou
Dr. Serafeim Chaintoutis
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • oxidative damage
  • redox homeostasis
  • reactive oxygen species
  • antioxidant systems
  • oxidative stress biomarkers

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Published Papers (1 paper)

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Research

21 pages, 3834 KB  
Article
Comparative Evaluation of Oxidative Stress, Cortisol, Inflammatory Response, and Systemic CO2 Dynamics in Dogs Undergoing Laparoscopic and Open Ovariectomy
by Sandra Čechovičienė, Ieva Šidlauskaitė, Birutė Karvelienė, Ieva Sarapinienė, Ieva Čiapienė, Vita Riškevičienė and Dalia Juodžentė
Antioxidants 2026, 15(7), 886; https://doi.org/10.3390/antiox15070886 - 17 Jul 2026
Viewed by 443
Abstract
A key distinction between open and laparoscopic surgery is the use of CO2 insufflation to create pneumoperitoneum and establish the operative field. This study compared the effects of laparoscopic and open ovariectomy (OVE) on plasma cortisol, oxidative stress (OS), systemic inflammation, and [...] Read more.
A key distinction between open and laparoscopic surgery is the use of CO2 insufflation to create pneumoperitoneum and establish the operative field. This study compared the effects of laparoscopic and open ovariectomy (OVE) on plasma cortisol, oxidative stress (OS), systemic inflammation, and systemic CO2 dynamics in healthy dogs anesthetized under a standardized protocol. Thirty-eight healthy female dogs were enrolled in the study and allocated to the laparotomy (LPTOVE, n = 19) or laparoscopic (LAPOVE, n = 19) OVE group. OS was assessed using total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Systemic inflammation was evaluated by TNF-α and IL-6 concentrations, whereas systemic CO2 dynamics were assessed using plasma total CO2 (TCO2) and end-tidal CO2 (EtCO2). Blood samples were collected prior to sedation (T0), prior to surgical incision (T1), prior to surgical closure in the LPTOVE group or CO2 desufflation in the LAPOVE group (T2), and 2 h postoperatively (T3). Cortisol concentrations at T2 and T3 were significantly higher in the LPTOVE group than in the LAPOVE group. No significant intergroup differences were observed in TOS, TAS, OSI, or TCO2. In the LPTOVE group, TOS significantly decreased at T3, whereas in the LAPOVE group, TOS mildly increased at T1 and OSI significantly decreased at T2. No measurable TNF-α or IL-6 concentrations were detected at the evaluated time points. EtCO2 levels were higher in the LAPOVE group at the end of surgery. These findings suggest that laparoscopic OVE was associated with lower perioperative cortisol concentrations, while systemic redox status, TNF-α and IL-6 concentrations, and carbon dioxide-related parameters remained largely comparable between surgical approaches. Full article
(This article belongs to the Special Issue Oxidative Stress and Biomarkers in Veterinary Medicine)
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