Oxidative Stress and Biomarkers in Veterinary Medicine

Dear Colleagues,

Oxidative stress represents a key pathophysiological mechanism in numerous veterinary diseases, influencing cellular function, immune responses, metabolic balance, and overall animal health. The imbalance between pro-oxidant processes and antioxidant defenses contributes to tissue damage, inflammation, and dysregulated cellular signaling, ultimately impacting disease onset, progression, and clinical outcomes in both companion and livestock species, as well as wildlife.

This Special Issue, “Oxidative Stress and Biomarkers in Veterinary Medicine”, aims to provide a platform for research focused on redox biology, oxidative damage, and antioxidant systems across veterinary species. Particular emphasis will be placed on the identification, validation, and clinical application of oxidative stress biomarkers relevant for diagnosis, prognosis, monitoring, and therapeutic decision-making.

A special focus of this issue will address the role of oxidative stress and redox imbalance in veterinary oncology, highlighting how oxidative processes contribute to carcinogenesis and tumor progression, as well as the role of oxidative stress biomarkers in the diagnostic investigation of neoplasia. Studies exploring biomarkers of oxidative stress in neoplastic diseases, redox-based interventions, and translational insights bridging veterinary and comparative oncology are especially encouraged.

We invite original research articles, reviews, short communications, and clinical reports addressing—though not limited to—the following topics:

• Mechanisms of oxidative stress and antioxidant defense in veterinary species;
• Biomarkers of oxidative stress: discovery, validation, and clinical utility;
• Oxidative stress in infectious, metabolic, inflammatory, cardiovascular, neurological, and degenerative diseases;
• Oxidative stress and neoplasms: molecular pathways, biomarkers, treatment monitoring, and prognostic value;
• Interactions between oxidative stress, immune function, and inflammation;
• Nutritional, pharmacological, and management strategies targeting oxidative balance;
• Comparative and translational redox research between veterinary and human medicine;
• Methodological advances in oxidative stress assessment in animals.

By integrating multidisciplinary perspectives—from basic science to clinical application—this Special Issue seeks to deepen our understanding of oxidative biology in veterinary medicine and to foster innovative approaches for improving animal health and welfare.

Prof. Dr. Zoe S. Polizopoulou
Dr. Serafeim Chaintoutis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative damage
• redox homeostasis
• reactive oxygen species
• antioxidant systems
• oxidative stress biomarkers