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  • Review
  • Open Access
101 Citations
56,643 Views
30 Pages

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

  • Mariana Chelu,
  • Adina Magdalena Musuc,
  • Monica Popa and
  • Jose Calderon Moreno

3 July 2023

Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent a...

  • Review
  • Open Access
543 Citations
41,350 Views
38 Pages

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

  • Nguyen Hoc Thang,
  • Truong Bach Chien and
  • Dang Xuan Cuong

27 June 2023

Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physic...

  • Review
  • Open Access
197 Citations
37,938 Views
28 Pages

Pectin Hydrogels: Gel-Forming Behaviors, Mechanisms, and Food Applications

  • Nurul Saadah Said,
  • Ibukunoluwa Fola Olawuyi and
  • Won Young Lee

9 September 2023

Pectin hydrogels have garnered significant attention in the food industry due to their remarkable versatility and promising properties. As a naturally occurring polysaccharide, pectin forms three-dimensional (3D) hydrophilic polymer networks, endowin...

  • Review
  • Open Access
37 Citations
29,267 Views
35 Pages

9 April 2025

Hyaluronic acid (HA) is a linear, unbranched polysaccharide classified as a glycosaminoglycan. While HA is found in various tissues throughout the body, over half of its total proportion is found in the skin. The role of HA in the skin is complex and...

  • Article
  • Open Access
14 Citations
26,949 Views
15 Pages

16 April 2023

In this study, poly (ethylene glycol) diacrylate/poly (ethylene oxide) (PEG-DA/PEO) interpenetrating polymer network hydrogels (IPNH) were extruded into 1D filaments and 2D grids. The suitability of this system for enzyme immobilization and CO2 captu...

  • Review
  • Open Access
93 Citations
25,811 Views
38 Pages

Gel Polymer Electrolytes: Advancing Solid-State Batteries for High-Performance Applications

  • Kanakaraj Aruchamy,
  • Subramaniyan Ramasundaram,
  • Sivasubramani Divya,
  • Murugesan Chandran,
  • Kyusik Yun and
  • Tae Hwan Oh

21 July 2023

Gel polymer electrolytes (GPEs) hold tremendous potential for advancing high-energy-density and safe rechargeable solid-state batteries, making them a transformative technology for advancing electric vehicles. GPEs offer high ionic conductivity and m...

  • Review
  • Open Access
113 Citations
23,714 Views
24 Pages

Application of Collagen-Based Hydrogel in Skin Wound Healing

  • Yuan Zhang,
  • Yong Wang,
  • Ying Li,
  • Yunpeng Yang,
  • Mingyuan Jin,
  • Xiaoying Lin,
  • Zeming Zhuang,
  • Kai Guo,
  • Tao Zhang and
  • Weiqiang Tan

27 February 2023

The repair of skin injury has always been a concern in the medical field. As a kind of biopolymer material with a special network structure and function, collagen-based hydrogel has been widely used in the field of skin injury repair. In this paper,...

  • Review
  • Open Access
60 Citations
22,578 Views
23 Pages

25 October 2024

Hydrogels are known for their high water retention capacity and biocompatibility and have become essential materials in tissue engineering and drug delivery systems. This review explores recent advancements in hydrogel technology, focusing on innovat...

  • Review
  • Open Access
89 Citations
19,726 Views
29 Pages

Rheology of Gels and Yielding Liquids

  • Alexander Ya. Malkin,
  • Svetlana R. Derkach and
  • Valery G. Kulichikhin

3 September 2023

In this review, today’s state of the art in the rheology of gels and transition through the yield stress of yielding liquids is discussed. Gels are understood as soft viscoelastic multicomponent solids that are in the incomplete phase separatio...

  • Review
  • Open Access
52 Citations
19,654 Views
36 Pages

Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

  • Adina Alberts,
  • Dana-Ionela Tudorache,
  • Adelina-Gabriela Niculescu and
  • Alexandru Mihai Grumezescu

7 February 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic wound management by addressing challenges such as infection control, moisture balance, and enhanced healing. Important progress has been made, especially wi...

  • Review
  • Open Access
137 Citations
18,987 Views
21 Pages

Essential Guide to Hydrogel Rheology in Extrusion 3D Printing: How to Measure It and Why It Matters?

  • Helena Herrada-Manchón,
  • Manuel Alejandro Fernández and
  • Enrique Aguilar

26 June 2023

Rheology plays a crucial role in the field of extrusion-based three-dimensional (3D) printing, particularly in the context of hydrogels. Hydrogels have gained popularity in 3D printing due to their potential applications in tissue engineering, regene...

  • Review
  • Open Access
106 Citations
17,900 Views
33 Pages

Oleogels as a Fat Substitute in Food: A Current Review

  • Roberta Claro da Silva,
  • Md. Jannatul Ferdaus,
  • Aline Foguel and
  • Thais Lomonaco Teodoro da Silva

24 February 2023

Fats and oils in food give them flavor and texture while promoting satiety. Despite the recommendation to consume predominantly unsaturated lipid sources, its liquid behavior at room temperature makes many industrial applications impossible. Oleogel...

  • Review
  • Open Access
65 Citations
17,134 Views
28 Pages

Hydrogels—A Promising Materials for 3D Printing Technology

  • Gobi Saravanan Kaliaraj,
  • Dilip Kumar Shanmugam,
  • Arish Dasan and
  • Kamalan Kirubaharan Amirtharaj Mosas

22 March 2023

Hydrogels are a promising material for a variety of applications after appropriate functional and structural design, which alters the physicochemical properties and cell signaling pathways of the hydrogels. Over the past few decades, considerable sci...

  • Review
  • Open Access
41 Citations
16,847 Views
27 Pages

An Overview of Ingredients Used for Plant-Based Meat Analogue Production and Their Influence on Structural and Textural Properties of the Final Product

  • Maja Benković,
  • Ana Jurinjak Tušek,
  • Tea Sokač Cvetnić,
  • Tamara Jurina,
  • Davor Valinger and
  • Jasenka Gajdoš Kljusurić

22 November 2023

Plant-based meat analogues are food products made from vegetarian or vegan ingredients that are intended to mimic taste, texture and appearance of meat. They are becoming increasingly popular as people look for more sustainable and healthy protein so...

  • Review
  • Open Access
20 Citations
16,534 Views
27 Pages

Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects

  • Shivam U. Desai,
  • Sai Sadhananth Srinivasan,
  • Sangamesh Gurappa Kumbar and
  • Isaac L. Moss

15 January 2024

Millions of people worldwide suffer from low back pain and disability associated with intervertebral disc (IVD) degeneration. IVD degeneration is highly correlated with aging, as the nucleus pulposus (NP) dehydrates and the annulus fibrosus (AF) fiss...

  • Article
  • Open Access
2 Citations
16,177 Views
32 Pages

Gelatin/Cerium-Doped Bioactive Glass Composites for Enhancing Cellular Functions of Human Mesenchymal Stem Cells (hBMSCs)

  • Andrey Iodchik,
  • Gigliola Lusvardi,
  • Alfonso Zambon,
  • Poh Soo Lee,
  • Hans-Peter Wiesmann,
  • Anne Bernhardt and
  • Vera Hintze

1 June 2025

Delayed or non-healing of bone defects in an aging, multi-morbid population is still a medical challenge. Current replacement materials, like autografts, are limited. Thus, artificial substitutes from biodegradable polymers and bioactive glasses (BGs...

  • Review
  • Open Access
79 Citations
16,150 Views
27 Pages

17 February 2023

Polymer gels are a valuable class of polymeric materials that have recently attracted significant interest due to the exceptional properties such as versatility, soft-structure, flexibility and stimuli-responsive, biodegradability, and biocompatibili...

  • Review
  • Open Access
59 Citations
15,995 Views
28 Pages

Food Emulsion Gels from Plant-Based Ingredients: Formulation, Processing, and Potential Applications

  • Canice Chun-Yin Yiu,
  • Sophie Wenfei Liang,
  • Kinza Mukhtar,
  • Woojeong Kim,
  • Yong Wang and
  • Cordelia Selomulya

26 April 2023

Recent advances in the understanding of formulations and processing techniques have allowed for greater freedom in plant-based emulsion gel design to better recreate conventional animal-based foods. The roles of plant-based proteins, polysaccharides,...

  • Review
  • Open Access
91 Citations
15,989 Views
46 Pages

8 March 2024

Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amount...

  • Review
  • Open Access
63 Citations
15,975 Views
36 Pages

Chitosan Hydrogels for Water Purification Applications

  • Mariana Chelu,
  • Adina Magdalena Musuc,
  • Monica Popa and
  • Jose M. Calderon Moreno

17 August 2023

Chitosan-based hydrogels have gained significant attention for their potential applications in water treatment and purification due to their remarkable properties such as bioavailability, biocompatibility, biodegradability, environmental friendliness...

  • Review
  • Open Access
80 Citations
15,733 Views
36 Pages

2 January 2025

This review summarizes the fundamental concepts, recent advancements, and emerging trends in the field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, the field continues to evolve dynamically, and certain research direct...

  • Article
  • Open Access
4 Citations
15,658 Views
20 Pages

27 May 2025

This study investigates the Quality by Design (QbD)-driven development and optimization of a nanoemulgel incorporating Kunzea ericoides oil for transdermal therapy. Nanoemulgels enhance percutaneous drug delivery, sustain release profiles, and improv...

  • Review
  • Open Access
64 Citations
15,584 Views
26 Pages

Progress of Hydrogel Dressings with Wound Monitoring and Treatment Functions

  • Shanshan Jin,
  • Md All Amin Newton,
  • Hongju Cheng,
  • Qinchen Zhang,
  • Weihong Gao,
  • Yuansheng Zheng,
  • Zan Lu,
  • Zijian Dai and
  • Jie Zhu

28 August 2023

Hydrogels are widely used in wound dressings due to their moisturizing properties and biocompatibility. However, traditional hydrogel dressings cannot monitor wounds and provide accurate treatment. Recent advancements focus on hydrogel dressings with...

  • Article
  • Open Access
1 Citations
15,449 Views
14 Pages

Poloxamer-Driven Drug Delivery System for Anti-Inflammatory Drugs Using Small-Angle Neutron Scattering Approach

  • Rodrigo Rhinow,
  • Margareth K. K. D. Franco,
  • Mont Kumpugdee Vollrath,
  • Guinther Kellermann and
  • Fabiano Yokaichiya

30 May 2025

Poloxamer-based drug delivery systems are widely used in the pharmaceutical sector. The structural characterization of these systems is crucial for the development of new drug delivery systems and for the optimization of their properties. In this stu...

  • Article
  • Open Access
22 Citations
15,255 Views
24 Pages

Clinical Perspectives on the Injectability of Cross-Linked Hyaluronic Acid Dermal Fillers: A Standardized Methodology for Commercial Product Benchmarking with Inter-Injector Assessments

  • Patrick Micheels,
  • Alexandre Porcello,
  • Thierry Bezzola,
  • Daniel Perrenoud,
  • Pierre Quinodoz,
  • Yogeshvar Kalia,
  • Eric Allémann,
  • Alexis Laurent and
  • Olivier Jordan

26 January 2024

The injectability of cross-linked hyaluronic acid (HA) dermal fillers is influenced by polymer concentration, polymer cross-linking type and degree, the presence of lidocaine or other functional excipients, types of syringes, and injection techniques...

  • Review
  • Open Access
39 Citations
15,115 Views
38 Pages

A Comprehensive Review of Functional Gel Polymer Electrolytes and Applications in Lithium-Ion Battery

  • Md. Shahriar Ahmed,
  • Mobinul Islam,
  • Bikash Raut,
  • Sua Yun,
  • Hae Yong Kim and
  • Kyung-Wan Nam

29 August 2024

The rapid expansion of flexible and wearable electronics has necessitated a focus on ensuring their safety and operational reliability. Gel polymer electrolytes (GPEs) have become preferred alternatives to traditional liquid electrolytes, offering en...

  • Review
  • Open Access
54 Citations
14,897 Views
36 Pages

Gel Formulations for Topical Treatment of Skin Cancer: A Review

  • Marta Slavkova,
  • Borislav Tzankov,
  • Teodora Popova and
  • Christina Voycheva

22 April 2023

Skin cancer, with all its variations, is the most common type of cancer worldwide. Chemotherapy by topical application is an attractive strategy because of the ease of application and non-invasiveness. At the same time, the delivery of antineoplastic...

  • Review
  • Open Access
125 Citations
14,418 Views
50 Pages

22 March 2024

Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, and structural similarity to the extracellular matri...

  • Review
  • Open Access
61 Citations
14,028 Views
15 Pages

Progress in Research on Metal Ion Crosslinking Alginate-Based Gels

  • Yantao Wang,
  • Zhenpeng Shen,
  • Huili Wang,
  • Zhaoping Song,
  • Dehai Yu,
  • Guodong Li,
  • Xiaona Liu and
  • Wenxia Liu

27 December 2024

Alginate is an important natural biopolymer and metal ion-induced gelation is one of its most significant functional properties. Alginate-based hydrogels crosslinked with metal ions are commonly utilized in the food, biomedical, tissue engineering, a...

  • Review
  • Open Access
90 Citations
13,968 Views
23 Pages

22 October 2023

In recent years, significant advancements in the field of advanced materials and hydrogel engineering have enabled the design and fabrication of smart hydrogels and nanogels that exhibit sensitivity to specific signals or pathological conditions, lea...

  • Review
  • Open Access
80 Citations
13,801 Views
28 Pages

Aerogels for Thermal Protection and Their Application in Aerospace

  • Runze Jin,
  • Zihan Zhou,
  • Jia Liu,
  • Baolu Shi,
  • Ning Zhou,
  • Xinqiao Wang,
  • Xinlei Jia,
  • Donghui Guo and
  • Baosheng Xu

26 July 2023

With the continuous development of the world’s aerospace industry, countries have put forward higher requirements for thermal protection materials for aerospace vehicles. As a nano porous material with ultra-low thermal conductivity, aerogel ha...

  • Review
  • Open Access
63 Citations
13,631 Views
20 Pages

Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity

  • Lívia Budai,
  • Marianna Budai,
  • Zsófia Edit Fülöpné Pápay,
  • Zsófia Vilimi and
  • István Antal

7 June 2023

Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational bu...

  • Review
  • Open Access
13 Citations
13,138 Views
37 Pages

A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications

  • Andik Nisa Zahra Zainuddin,
  • Nurul Nadhirah Mustakim,
  • Farah Alea Rosemanzailani,
  • Nur Izzah Md Fadilah,
  • Manira Maarof and
  • Mh Busra Fauzi

12 March 2025

Honey has long been recognized for its medicinal properties, particularly in wound healing. Recent advancements in material science have led to the development of honey-containing hydrogels, combining the natural healing properties of honey with the...

  • Review
  • Open Access
36 Citations
12,980 Views
35 Pages

7 October 2023

Polymeric hydrogels are a complex class of materials with one common feature—the ability to form three-dimensional networks capable of imbibing large amounts of water or biological fluids without being dissolved, acting as self-sustained contai...

  • Review
  • Open Access
54 Citations
12,951 Views
42 Pages

Food-Grade Oleogels: Trends in Analysis, Characterization, and Applicability

  • Simona Perța-Crișan,
  • Claudiu-Ștefan Ursachi,
  • Bianca-Denisa Chereji,
  • Iolanda Tolan and
  • Florentina-Daniela Munteanu

6 May 2023

Currently, a large number of scientific articles can be found in the research literature in the field focusing on the use of oleogels for food formulation to improve their nutritional properties. The present review focuses on the most representative...

  • Review
  • Open Access
31 Citations
12,928 Views
32 Pages

Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review

  • Popat Mohite,
  • Abhijeet Puri,
  • Shubham Munde,
  • Nitin Ade,
  • Ashwini Kumar,
  • Pensak Jantrawut,
  • Sudarshan Singh and
  • Chuda Chittasupho

7 November 2024

Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) repre...

  • Communication
  • Open Access
16 Citations
12,679 Views
9 Pages

28 July 2023

The aim of the case series was to determine the efficacy of a new medical device developed for adipose tissue restoration in the face. The medical device used the patented NAHYCO® Hybrid Technology to deliver 45 mg of high- (1400 ± 200 kDa...

  • Article
  • Open Access
9 Citations
12,408 Views
22 Pages

Formulation and Evaluation of Turmeric- and Neem-Based Topical Nanoemulgel against Microbial Infection

  • Sumon Giri,
  • Anhic Chakraborty,
  • Chiranjit Mandal,
  • Tushar Kanti Rajwar,
  • Jitu Halder,
  • Zainab Irfan and
  • Mostafa M. Gouda

5 September 2024

The combination of nanoemulgel and phytochemistry has resulted in several recent discoveries in the field of topical delivery systems. The present study aimed to prepare nanoemulgel based on turmeric (Curcuma longa) and neem (Azadirachta indica) agai...

  • Review
  • Open Access
35 Citations
12,256 Views
39 Pages

7 April 2025

Hydrogels have emerged as a transformative technology in agriculture, offering significant potential to enhance crop resilience, improve water use efficiency, and promote sustainable farming practices. These three-dimensional polymeric networks can a...

  • Review
  • Open Access
26 Citations
12,023 Views
15 Pages

A Review of High-Temperature Aerogels: Composition, Mechanisms, and Properties

  • Conghui Wang,
  • Letian Bai,
  • Hongxin Xu,
  • Shengjian Qin,
  • Yanfang Li and
  • Guanglei Zhang

23 April 2024

High-temperature aerogels have garnered significant attention as promising insulation materials in various industries such as aerospace, automotive manufacturing, and beyond, owing to their remarkable thermal insulation properties coupled with low de...

  • Article
  • Open Access
2 Citations
11,937 Views
30 Pages

Clinical Safety and Efficacy of Hyaluronic Acid–Niacinamide–Tranexamic Acid Injectable Hydrogel for Multifactorial Facial Skin Quality Enhancement with Dark Skin Lightening

  • Sarah Hsin,
  • Kelly Lourenço,
  • Alexandre Porcello,
  • Michèle Chemali,
  • Cíntia Marques,
  • Wassim Raffoul,
  • Marco Cerrano,
  • Lee Ann Applegate and
  • Alexis E. Laurent

26 June 2025

Facial aging is a complex process manifesting as skin hyperpigmentation, textural irregularities, and a diminished elasticity, hydration, and evenness of tone. The escalating demand for minimally invasive aesthetic interventions has driven the develo...

  • Review
  • Open Access
30 Citations
11,916 Views
41 Pages

Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications

  • Adina Alberts,
  • Andreea Gabriela Bratu,
  • Adelina-Gabriela Niculescu and
  • Alexandru Mihai Grumezescu

5 April 2025

Collagen-based wound dressings have developed as an essential component of contemporary wound care, utilizing collagen’s inherent properties to promote healing. This review thoroughly analyzes collagen dressing advances, examining different for...

  • Review
  • Open Access
6 Citations
11,884 Views
28 Pages

Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology

  • Trung Quang Nguyen,
  • Thinh Van Pham,
  • Yusuf Andriana and
  • Minh Ngoc Truong

3 January 2025

Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C. militaris-derived bioactive gels for applications in dermatolo...

  • Review
  • Open Access
40 Citations
11,838 Views
24 Pages

6 March 2024

Gellan gum (GG) is a linear, negatively charged exopolysaccharide that is biodegradable and non-toxic. When metallic ions are present, a hard and transparent gel is produced, which remains stable at a low pH. It exhibits high water solubility, can be...

  • Review
  • Open Access
51 Citations
11,614 Views
18 Pages

NaDES Application in Cosmetic and Pharmaceutical Fields: An Overview

  • Carla Villa,
  • Debora Caviglia,
  • Francesco Saverio Robustelli della Cuna,
  • Guendalina Zuccari and
  • Eleonora Russo

28 January 2024

Natural deep eutectic solvents (NaDES) represent a new generation of green, non-flammable solvents, useful as an efficient alternative to the well-known ionic liquids. They can be easily prepared and exhibit unexpected solubilizing power for lipophil...

  • Review
  • Open Access
41 Citations
11,605 Views
28 Pages

Liquid Embolic Agents for Endovascular Embolization: A Review

  • Amrita Pal,
  • Jeffrey Blanzy,
  • Karime Jocelyn Rosas Gómez,
  • Mark C. Preul and
  • Brent L. Vernon

4 May 2023

Endovascular embolization (EE) has been used for the treatment of blood vessel abnormalities, including aneurysms, AVMs, tumors, etc. The aim of this process is to occlude the affected vessel using biocompatible embolic agents. Two types of embolic a...

  • Review
  • Open Access
47 Citations
11,529 Views
31 Pages

Natural Regenerative Hydrogels for Wound Healing

  • Mariana Chelu,
  • Jose M. Calderon Moreno,
  • Adina Magdalena Musuc and
  • Monica Popa

23 August 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability to reassemble the extracellular matrix....

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Gels - ISSN 2310-2861