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Journal of Cardiovascular Development and Disease, Volume 12, Issue 8

August 2025 - 42 articles

Cover Story: Epicardial radiofrequency ablation is often required when ventricular tachyarrhythmias originate from epicardial or subepicardial substrates that cannot be effectively ablated endocardially. Irrigated-tip catheters are commonly used for such procedures. Unlike endocardial ablation, where the irrigation fluid is mixed with and drained by the bloodstream, the irrigation fluid used in epicardial procedures accumulates within the pericardial space, which causes the sac to expand, requiring manual drainage multiple times throughout the procedure. Our computer simulations show that the accumulation of intrapericardial fluid plays a critical role: While it may offer some thermal protection to adjacent structures, it substantially reduces energy transmission to the myocardium, compromising lesion formation. View this paper
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Articles (42)

  • Review
  • Open Access
1,755 Views
17 Pages

Multimodality Imaging in Eosinophilic Myocarditis: A Rare Cause of Heart Failure

  • Vincenzo Viccaro,
  • Amabile Valotta,
  • Elena Checcoli,
  • Susanna Landi,
  • Fabio Cattaneo,
  • Andrea Milzi,
  • Mattia Duchini,
  • Giacomo Maria Viani,
  • Alessandro Caretta and
  • Susanne Schlossbauer
  • + 6 authors

Eosinophilic myocarditis (EM) is a rare and potentially fatal form of acute myocarditis. Currently, no validated diagnostic criteria exist, and definitive diagnosis relies on endomyocardial biopsy (EMB) not devoid of periprocedural complications. Thi...

  • Review
  • Open Access
1 Citations
2,480 Views
33 Pages

When Functional Assessment Meets Intravascular Imaging in Patients with Coronary Artery Disease

  • Grigorios Tsigkas,
  • Kassiani-Maria Nastouli,
  • Anastasios Apostolos,
  • Panagiota Spyropoulou,
  • Maria Bozika,
  • Michail I. Papafaklis,
  • Stella Rouzi,
  • Effrosyni Tsimara,
  • Antonios Karanasos and
  • Virginia Mplani
  • + 1 author

Percutaneous Coronary Intervention (PCI) has advanced significantly with the incorporation of imaging and physiology assessment techniques. Fractional Flow Reserve (FFR) and Non-Hyperemic Pressure indices (NHPIs) provide information regarding the fun...

  • Article
  • Open Access
914 Views
15 Pages

Dysfunctional Electron Transport Chain Assembly in COXPD8

  • Gisela Beutner,
  • Heidie L. Huyck,
  • Gail Deutsch,
  • Gloria S. Pryhuber and
  • George A. Porter Jr.

Combined oxidative phosphorylation deficiency type 8 (COXPD8) is an autosomal recessive mitochondrial disorder caused by a mutation of the nuclear encoded mitochondrial alanyl-tRNA synthetase gene (AARS2). Clinical manifestations of COXPD8 include le...

  • Review
  • Open Access
2,774 Views
12 Pages

Blood Pressure Variability in Hypertension: A Rehabilitation Perspective

  • Manikandan Raju,
  • Marco Alfonso Perrone,
  • Anas R. Alashram and
  • Ferdinando Iellamo

The role of blood pressure variability (BPV) as an important marker of cardiovascular (CV) health, specifically its relationship with arterial stiffness and left ventricular remodeling in patients with hypertension, was investigated. This review aime...

  • Article
  • Open Access
829 Views
19 Pages

Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia

  • Kel Vin Woo,
  • Philip T. Levy,
  • Carla J. Weinheimer,
  • Amanda L. Hauck,
  • Aaron Hamvas,
  • David M. Ornitz,
  • Attila Kovacs and
  • Gautam K. Singh

Background: Right heart catheterization (RHC) is the gold-standard for diagnosis of pulmonary hypertension (PH) but is a terminal procedure in neonatal mice. The objective was to validate echocardiographic measures of PH to establish the diagnostic c...

  • Article
  • Open Access
783 Views
14 Pages

Markers in Acute Coronary Syndrome: Distal Coronary Embolism at Percutaneous Coronary Intervention

  • Niya Emilova Semerdzhieva,
  • Simeon Dimitrov,
  • Adelina Tsakova,
  • Mariana Gospodinova,
  • Petar Atanasov and
  • Vesela Lozanova

(1) Introduction: Distal coronary emboli occur in up to 15–30.5% of patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) and are associated with poor myocardial reperfusion in the territory of the i...

  • Review
  • Open Access
1 Citations
1,932 Views
28 Pages

Artificial Intelligence-Guided Neuromodulation in Heart Failure with Preserved and Reduced Ejection Fraction: Mechanisms, Evidence, and Future Directions

  • Rabiah Aslam Ansari,
  • Sidhartha Gautam Senapati,
  • Vibhor Ahluwalia,
  • Gianeshwaree Alias Rachna Panjwani,
  • Anmolpreet Kaur,
  • Gayathri Yerrapragada,
  • Jayavinamika Jayapradhaban Kala,
  • Poonguzhali Elangovan,
  • Shiva Sankari Karuppiah and
  • Naghmeh Asadimanesh
  • + 2 authors

Heart failure, a significant global health burden, is divided into heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF), characterized by systolic dysfunction and diastolic stiffness, respectively. While HFrEF...

  • Review
  • Open Access
703 Views
12 Pages

Hybrid Ablation in Atrial Fibrillation: Bridging Mechanistic Understanding and Clinical Practice

  • Flavia Ravelli,
  • Stefano Branzoli,
  • Alessandro Cristoforetti,
  • Silvia Quintarelli,
  • Alessio Coser,
  • Paolo Moggio,
  • Mark La Meir,
  • Carlo de Asmundis,
  • Luigi Pannone and
  • Francesco Onorati
  • + 2 authors

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, poses a significant burden on global morbidity and healthcare expenditure. Although endocardial catheter ablation and surgical ablation are established therapeutic strategies,...

  • Article
  • Open Access
1,349 Views
14 Pages

Late Gadolinium Enhancement Variation in Asymptomatic Individuals: Comparison with Dilated Cardiomyopathy

  • Seoyeon Park,
  • Soo Jin Cho,
  • Sung Mok Kim,
  • Moon Young Kim and
  • Yeon Hyeon Choe

Late gadolinium enhancements (LGEs) appear in asymptomatic individuals as septal stripes, which mimic abnormal LGEs in patients with dilated cardiomyopathy (DCM). We aimed to evaluate the frequency and extent of LGE variation in asymptomatic individu...

  • Review
  • Open Access
2 Citations
1,816 Views
14 Pages

Mitral Annular Disjunction: Epidemiology, Diagnostic Methods, Prognosis, and Novel Implications

  • Vasileios Tsimpiris,
  • Georgia Kousourna,
  • Aristi Boulmpou,
  • Magdalini Petridou,
  • Chalil Tsavousoglou,
  • Dimitrios Kotzadamis,
  • Christodoulos Papadopoulos,
  • Dimitrios Ntelios,
  • Theodoros Moysiadis and
  • Vassilios Vassilikos
  • + 1 author

Mitral annular disjunction (MAD) is an increasingly recognized structural abnormality of the mitral valve apparatus, often associated with mitral valve prolapse and a heightened risk of ventricular arrhythmias and sudden cardiac death. It is defined...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425