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Separations, Volume 9, Issue 8

2022 August - 44 articles

Cover Story: Food Contact Materials (FCMs) are an undervalued source of food contamination and a potential route of human exposure to chemicals that are harmful to the endocrine system. Food and water are the main sources of exposure due to their contact with polymeric packaging materials.
European Regulation 10/2011 on plastics in contact with food requires migration tests on FCMs to evaluate the presence of the listed substances and of not intentionally added substances (NIASs) not listed in the regulation and not subjected to restrictions. NIAS are defined as impurities present in the substances used or reaction intermediates formed during the production process, a reaction, or a product’s decomposition. The presence of NIAS in samples tested implies safety risks. The safety risks associated with these compounds must be assessed in line with internationally recognized principles on risk assessment. View this paper
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Articles (44)

  • Article
  • Open Access
7 Citations
3,643 Views
12 Pages

Aerobic granular sludge (AGS) application in treating municipal wastewater has been greatly restricted due to its low stability. It has been found that operation parameters have a great impact on stability. The organic loading rate (OLR) and dissolve...

  • Article
  • Open Access
14 Citations
2,834 Views
10 Pages

Research into Gas Chromatography–Mass Spectrometry (GC-MS) for Ensuring the Effect of 1 MeV-Accelerated Electrons on Volatile Organic Compounds in Turkey Meat

  • Ulyana Bliznyuk,
  • Polina Borshchegovskaya,
  • Timofey Bolotnik,
  • Alexander Chernyaev,
  • Victoria Ipatova,
  • Alexander Nikitchenko,
  • Oleg Shinkarev,
  • Dmitry Yurov,
  • Oleg Khmelevskiy and
  • Igor Rodin

One of the most important tasks in the food industry is the search for alternative biochemical markers of radiation treatment in dietary, chilled meat products such as chicken and turkey. Major organic volatile chemicals found in meat products can be...

  • Article
  • Open Access
5 Citations
2,229 Views
10 Pages

Preparation of Thermodesorption Tube Standards: Comparison of Usual Methods Using Accuracy Profile Evaluation

  • Clément De Saint Jores,
  • Romain Klein,
  • Agathe Legendre,
  • José Dugay,
  • Didier Thiébaut and
  • Jérôme Vial

In order to quantify organic impurities in gas produced from renewable sources, thermal desorption coupled with GC-MS or GC×GC-MS is very useful. However, the preparation of the standard tubes appears not to be trivial. For that, different stra...

  • Article
  • Open Access
2,418 Views
15 Pages

The Quality Control of Midecamycin and the Predictive Demarcation between Its Impurities and Components

  • Mingyan Yu,
  • Weijian Wang,
  • Wenkun Liu,
  • Huiru Yang,
  • Tong Sun,
  • Haiyun Zhao and
  • Dejun Chen

Midecamycin is a 16-membered macrolide antibiotic. It can inhibit the synthesis of bacterial proteins by blocking up the activity of peptidyl transferase in the 50S ribosome. We used high-resolution mass spectrometry to analyze midecamycin, and quant...

  • Review
  • Open Access
30 Citations
14,505 Views
26 Pages

An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices

  • Carmen Tesoro,
  • Filomena Lelario,
  • Rosanna Ciriello,
  • Giuliana Bianco,
  • Angela Di Capua and
  • Maria Assunta Acquavia

L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabacea...

  • Article
  • Open Access
4 Citations
2,665 Views
12 Pages

New Approach for Trace Thallium Removal in High Purity Ammonium Rhenate Solution by P204 Extraction

  • Aifei Yi,
  • Ying Liu,
  • Xingwu Lu,
  • Song Chen,
  • Honglin Jiang,
  • Chuanbing Shao,
  • Xuetao Yuan and
  • Yanxi Yin

Thallium (Tl) is an extremely toxic rare metal to the eco-environment. Trace thallium impurity in ammonium perrhenate is harmful to the high-temperature mechanical properties of rhenium metal used for aeroengine single crystal blade. The di(2-ethylhe...

  • Article
  • Open Access
4 Citations
4,002 Views
10 Pages

Unlocking the Treasure Box: The Role of HEPES Buffer in Disassembling an Uncommon Ferritin Nanoparticle

  • Alessio Incocciati,
  • Lucia Bertuccini,
  • Alberto Boffi,
  • Alberto Macone and
  • Alessandra Bonamore

Ferritins are ideal nanoparticles as drug delivery systems due to their hollow-sphere structure and the ability to target specific receptors on the cell surface. Here, we develop and characterize a new ferritin derived from the chimeric humanized A. ...

  • Article
  • Open Access
2 Citations
2,279 Views
9 Pages

Development and Validation of a Sensitive HPLC Assay for Determination of Sparfloxacin According to the European Medicines Agency Guideline

  • Cristina López,
  • Raquel Díez,
  • José M. Rodríguez,
  • Matilde Sierra,
  • Juan J. García,
  • Nélida Fernández,
  • M. José Diez and
  • Ana M. Sahagún

Sparfloxacin, a synthetic antibiotic belonging to the third-generation fluoroquinolones, has numerous pharmacokinetic and microbiological advantages which can make it an excellent candidate for the treatment of infections in sheep. The objective of t...

  • Article
  • Open Access
11 Citations
3,769 Views
11 Pages

Two New HPLC Methods, Assessed by GAPI, for Simultaneous Determination of Four Antipsychotics in Pharmaceutical Formulations: A Comparative Study

  • Eman A. Abdel Hameed,
  • Zaitona A. Abd El-Naby,
  • Alaa El Gindy,
  • Sawsan A. Zaitone,
  • Reem Alshaman,
  • Roshdy E. Saraya and
  • Gasser M. Khairy

Antipsychotics are widely used to treat various mental disorders. Combination therapies were approved by the FDA to treat manic states. Quetiapine fumarate, aripiprazole, asenapine maleate, and chlorpromazine HCl are frequently used for treatment of...

  • Article
  • Open Access
3 Citations
2,336 Views
11 Pages

The accumulation of rare-earth and heavy metal ions from wastewater is important for industrial technology. However, practical accumulators of metal ions are expensive with respect procurement of raw materials, synthesis, and preparation. Therefore,...

  • Article
  • Open Access
1 Citations
3,596 Views
11 Pages

Artemisinin (ART) is a sesquiterpene lactone and a popular malaria drug used in many parts of the world. Artesunate (ARTS) is a semi-synthetic derivative of ART with improved pharmacokinetic properties. However, the half-life of ARTS is less than an...

  • Article
  • Open Access
2 Citations
3,074 Views
14 Pages

A multicomponent pharmaceutical that contains loratadine, paracetamol, and pseudoephedrine was quantified using HPLC-PDA. The three analytes were well-separated and quantified in the dosage form on a C-18 column using a gradient mobile phase. A quali...

  • Article
  • Open Access
7 Citations
2,918 Views
14 Pages

The dynamic response of particles is closely related to screening efficiency. To study the dynamic response of particles, the dynamic equations of a particle on a screening surface are established based on the elastoplastic contact model of spherical...

  • Article
  • Open Access
11 Citations
3,432 Views
13 Pages

Design of an Experimental Study for the Simultaneous Determination of Cefepime, Piperacillin and Tazobactam Using Micellar Organic Solvent-Free HPLC

  • Hani M. Hafez,
  • Sami El Deeb,
  • Esraa Abd Alkareem Naji,
  • Zahraa Ali Aziz,
  • Amaal Sajid Mahmood,
  • Nooralhuda Ibrahim Khalil and
  • Adel Ehab Ibrahim

Application of Sustainable analytical chemistry concepts has become crucial in order to remove the environmentally harmful impacts originating from the routine use of analytical techniques. Here, a new LC method is developed and its parameters are an...

  • Article
  • Open Access
3 Citations
3,211 Views
11 Pages

Due to a trend to higher sustainability, biodiesel is often mixed into petrodiesel. The analysis of these blends on a molecular level is not trivial, since huge differences in concentrations and polarity of the analytes require a large dynamic range...

  • Article
  • Open Access
3 Citations
2,468 Views
12 Pages

Geumgwesingihwan (GGSGH) is an oriental herbal formula made by adding Achyranthes bidentate Blume and Plantago asiatica L. to Yukmijiwhanghwan. It has been used for the treatment of edema since ancient times. The purpose of this study is to develop a...

  • Article
  • Open Access
1 Citations
3,742 Views
13 Pages

In the present research, we propose the use of a novel hydraulic classifier equipped with a W-shaped reflector to enhance classification performance. The effects of the structural dimensions of a W-shaped reflector on the flow field of a classifier a...

  • Article
  • Open Access
3 Citations
3,512 Views
15 Pages

Laurus azorica: Valorization through Its Phytochemical Study and Biological Activities

  • Mariana M. Viveiros,
  • Maria Carmo Barreto and
  • Ana M. L. Seca

Laurus azorica (Seub.) Franco is an endemic species from the Azores, traditionally used in all the islands as a seasoning in cooking. The studies carried out with this species refer mainly to its essential oils. The study that was developed here allo...

  • Review
  • Open Access
13 Citations
12,967 Views
18 Pages

Identification of Epigallocatechin-3-Gallate (EGCG) from Green Tea Using Mass Spectrometry

  • Iyyakkannu Sivanesan,
  • Manikandan Muthu,
  • Anusha Kannan,
  • Suraj Shiv Charan Pushparaj,
  • Jae-Wook Oh and
  • Judy Gopal

In an era where humanity is reinstating its lost hope and expectation on natural products, green tea occupies quite a position for what it has proven to be, in its endeavors for human welfare and health. Epigallocatechin-3-gallate (EGCG) is the key t...

  • Article
  • Open Access
6 Citations
4,379 Views
17 Pages

Aqueous Extracts of Fish Roe as a Source of Several Bioactive Compounds

  • Marta Guedes,
  • Virgínia M. F. Gonçalves,
  • Maria Elizabeth Tiritan,
  • Rui L. Reis,
  • Helena Ferreira and
  • Nuno M. Neves

Regular consumption of seafood and, in particular, fish has been associated with important health benefits. A fish product that has been increasingly included in the human nutrition is roe. Despite its nutritional value has been established (fatty ac...

  • Review
  • Open Access
14 Citations
4,959 Views
23 Pages

Occurrence, Distribution and Health Risk of Short-Chain Chlorinated Paraffins (SCCPs) in China: A Critical Review

  • Xufeng Zhang,
  • Ru Fan,
  • Yang Xu,
  • Yun-Ze Gao,
  • Aaron Bizimana,
  • Anastacia Rochelle Naidoo,
  • Bao-Cang Han and
  • Xiang-Zhou Meng

With being listed in the Stockholm Convention, the ban on short-chain chlorinated paraffins (SCCPs) has been put on the agenda in China. Based on the literature over the past decade, this study comprehensively analyzed the occurrence, distribution of...

  • Article
  • Open Access
8 Citations
3,987 Views
11 Pages

Extraction and Physicochemical Composition of Irvingiagabonensis Almond Oil: A Potential Healthy Source of Lauric-Myristic Oil

  • Sidrine Kerthy Koumba Ibinga,
  • Muriel Cerny,
  • Eric Lacroux,
  • Jean-François Fabre,
  • Romain Valentin,
  • Othmane Merah,
  • Raphaël Bikanga and
  • Zéphirin Mouloungui

Irvingia gabonensis is a non-timber forest product, whose fruit contains an edible fat-rich kernel. This fat can be used not only in human food but also as a source of raw materials in the cosmetic, pharmaceutical and nutraceutical industries. This w...

  • Article
  • Open Access
7 Citations
2,770 Views
8 Pages

Ecofriendly Validated RP-HPTLC Method for Simultaneous Determination of the Bioactive Sesquiterpene Coumarins Feselol and Samarcandin in Five Ferula Species Using Green Solvents

  • Maged S. Abdel-Kader,
  • Mohammed H. Alqarni,
  • Sura Baykan,
  • Bintug Oztürk,
  • Mohammad Ayman A. Salkini,
  • Hasan S. Yusufoglu,
  • Prawez Alam and
  • Ahmed I. Foudah

An environmentally friendly unreported rapid and simple reverse-phase high-performance thin-layer chromatography (RP-HPTLC) has been designed for the simultaneous determination of bioactive sesquiterpene coumarins feselol and samarcandin in the metha...

  • Article
  • Open Access
5 Citations
3,705 Views
19 Pages

A Multi-Analytical Characterization of Mortars from Kathmandu (Nepal) Historical Monuments

  • Anna Tsoupra,
  • Monalisa Maharjan,
  • Dora Teixeira,
  • Antonio Candeias,
  • Cristina Galacho and
  • Patrícia Moita

The historical monuments of the ‘City of Temples’ (Kathmandu) represent an intrinsic component of Nepal’s cultural heritage. The 2015 devastating Gorkha earthquake, besides human casualties, has led to a widespread demolition or par...

  • Article
  • Open Access
26 Citations
5,792 Views
18 Pages

Metabolomic and Proteomic Profile of Dried Hop Inflorescences (Humulus lupulus L. cv. Chinook and cv. Cascade) by SPME-GC-MS and UPLC-MS-MS

  • Paola Nezi,
  • Vittoria Cicaloni,
  • Laura Tinti,
  • Laura Salvini,
  • Matteo Iannone,
  • Sara Vitalini and
  • Stefania Garzoli

Hop (Humulus lupulus L.) is grown mainly for the production of beer. The flowers of the female plant give it the bitter taste and pungent aroma. There are a large number of hop varieties differing in their α-acid content, essential oil levels a...

  • Article
  • Open Access
3 Citations
3,888 Views
12 Pages

In High-Performance Liquid Chromatography (HPLC), the separation of reducing sugars can typically show three possible typologies of chromatographic profiles (i.e., single peak, two resolved peaks and two peaks interconnected by a plateau) due to the...

  • Article
  • Open Access
10 Citations
3,399 Views
15 Pages

Expanding the Knowledge Related to Flavors and Fragrances by Means of Three-Dimensional Preparative Gas Chromatography and Molecular Spectroscopy

  • Gemma De Grazia,
  • Lorenzo Cucinotta,
  • Archimede Rotondo,
  • Paola Donato,
  • Luigi Mondello and
  • Danilo Sciarrone

As universally known, gas chromatography (GC) coupled with mass spectrometry (MS) allows us to acquire spectra that can be searched in specific databases to attain qualitative information on a peak of interest. When not present in databases, structur...

  • Article
  • Open Access
9 Citations
2,435 Views
15 Pages

We studied the effect of the mixed phase of nickel oxide–gallium oxide–graphene (NiO-Ga2O2/G) heterostructure nanocomposite on the photocatalytic degradation of Congo red dye. The effect was investigated based on NiO-Ga2O2 junction, NiO-g...

  • Article
  • Open Access
8 Citations
5,698 Views
20 Pages

Simultaneous Extraction of Four Antibiotic Compounds from Soil and Water Matrices

  • Alison M. Franklin,
  • Danielle M. Andrews,
  • Clinton F. Williams and
  • John E. Watson

The incidence of antibiotic resistance is on the rise and becoming a major health concern. Analyzing the presence of antibiotic compounds in the environment is critical for determining the potential health effects for humans, animals, and ecosystems....

  • Article
  • Open Access
11 Citations
3,130 Views
14 Pages

Aflatoxin B1 (AFB1) is a common mycotoxin present in agricultural and food products. Therefore, rapid screening methods must be developed for AFB1 detection with high sensitivity and good selectivity. In this study, we developed an analytical method...

  • Article
  • Open Access
9 Citations
5,918 Views
15 Pages

Development and Validation of a Novel HPLC Method for the Determination of Ephedrine Hydrochloride in Nasal Ointment

  • Konstantinos Kallinteris,
  • Kostas Gkountanas,
  • Iοannis Karamitros,
  • Haris Boutsikaris and
  • Yannis Dotsikas

A simple, precise, and cost-effective reverse phase ion pair chromatographic (RP-IP-HPLC) method was developed and validated for the determination of Ephedrine Hydrochloride in a nasal ointment. A simple and fast extraction protocol was developed for...

  • Review
  • Open Access
20 Citations
6,960 Views
41 Pages

Lycium Genus Polysaccharide: An Overview of its Extraction, Structures, Pharmacological Activities and Biological Applications

  • Bo Wang,
  • Lu Han,
  • Jun-Mei Liu,
  • Jin Zhang,
  • Wen Wang,
  • Bing-Ge Li,
  • Cai-Xia Dong and
  • Chang-Cai Bai

Polysaccharide is considered to be the main active ingredient of the genus Lycium L., which is taken from the dried fruit of the famous Chinese herbal medicine and precious tonic known as wolfberry. Traditional uses include nourishing the liver and k...

  • Article
  • Open Access
5 Citations
2,849 Views
19 Pages

The technology of simultaneously recovering V and Ti from vanadium slag via ammonium salt roasting has proven to be an efficient route. However, due to the phase stability and complex chemical composition of vanadium slag, intermediate materials cont...

  • Article
  • Open Access
7 Citations
2,126 Views
18 Pages

Investigation of the Rearrangement of Reactive–Inert Particulate Structures in a Single Channel of a Wall-Flow Filter

  • Julia R. D. Thieringer,
  • Nicolas Hafen,
  • Jörg Meyer,
  • Mathias J. Krause and
  • Achim Dittler

Wall-flow filters are a standard component in exhaust gas aftertreatment and have become indispensable in vehicles. Ash and soot particles generated during engine combustion are deposited in diesel or gasoline particulate filters. During regeneration...

  • Article
  • Open Access
9 Citations
3,396 Views
14 Pages

Mussel Inspired Polydopamine as Silica Fibers Coating for Solid-Phase Microextraction

  • Antonella Aresta,
  • Stefania R. Cicco,
  • Danilo Vona,
  • Gianluca Maria Farinola and
  • Carlo Zambonin

Commercial solid-phase microextraction fibers are available in a limited number of expensive coatings, which often contain environmentally harmful substances. Consequently, several different approaches have been used in the attempt to develop new sor...

  • Article
  • Open Access
10 Citations
3,262 Views
15 Pages

Taxanes are natural compounds with strong antitumor activity. In this study, we first extracted taxanes from the needles of Taxus cuspidata using ultrasonic (US) extraction, and then assessed the effects of different extraction conditions on the yiel...

  • Article
  • Open Access
4 Citations
2,351 Views
15 Pages

Analysis of Oxidized 1-Palmitoyl-2-Arachidonoyl-Sn-Glycero-3 Phosphocholine Products in Uremic Patients by LC-ESI/MS

  • Chiz-Tzung Chang,
  • I-Ting Chang,
  • Min-Hui Hsia,
  • Chun-Cheng Wang,
  • Chao-Jung Chen,
  • Hsin-Bai Zou,
  • Yu-Qing Chen,
  • Wen-Chien Chiu,
  • Zhi-Ru Lin and
  • Mine-Yine Liu

A simple liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI/MS) method has been developed to analyze oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (ox-PAPC) products on the lipoproteins of uremic patients. The n...

  • Article
  • Open Access
8 Citations
2,591 Views
17 Pages

Green Ag/AgCl as an Effective Plasmonic Photocatalyst for Degradation and Mineralization of Methylthioninium Chloride

  • Patchimaporn Udomkun,
  • Thirasant Boonupara,
  • Siwaporn M. Smith and
  • Puangrat Kajitvichyanukul

A green synthesis of Ag/AgCl with an exceptional SPR and photocatalysis property is greatly benefit to the environmental application especially pollutant removal. In this work, a novel green plasmonic photocatalysis of Ag/AgCl nanocatalyst using aque...

  • Article
  • Open Access
22 Citations
5,830 Views
16 Pages

In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents

  • Baraa M. I. S. Jadalla,
  • Justin J. Moser,
  • Rajan Sharma,
  • Ninon G. E. R. Etsassala,
  • Samuel Ayodele Egieyeh,
  • Jelili A. Badmus,
  • Jeanine L. Marnewick,
  • Denzil Beukes,
  • Christopher N. Cupido and
  • Ahmed A. Hussein

Diabetes mellitus (DM) is a group of systemic metabolic disorders with a high rate of morbidity and mortality worldwide. Due to the detrimental side effects of the current treatment, there is a great need to develop more effective antidiabetic drugs...

  • Article
  • Open Access
6 Citations
5,160 Views
12 Pages

The extractive distillation of a methanol and dimethyl carbonate (DMC) azeotrope system was taken as an example, and the simulation and optimization of the conventional extractive process (CEP) and extractive dividing wall column (EDWC) were carried...

  • Article
  • Open Access
9 Citations
4,308 Views
11 Pages

Release of Selected Non-Intentionally Added Substances (NIAS) from PET Food Contact Materials: A New Online SPE-UHPLC-MS/MS Multiresidue Method

  • Riccardo Aigotti,
  • Nicola Giannone,
  • Alberto Asteggiano,
  • Enrica Mecarelli,
  • Federica Dal Bello and
  • Claudio Medana

Food contact materials (FCMs) are an underestimated source of food chemical contaminants and a potentially relevant route of human exposure to chemicals that are harmful to the endocrine system. Foods and water are the main sources of exposure due to...

  • Review
  • Open Access
11 Citations
3,940 Views
17 Pages

Flavor is an important index to evaluate the sensory quality of tobacco. The process of fermentation is a key step in the production of aromatic substances in tobacco leaves and an important factor in improving their quality. Worldwide, reams of rese...

  • Article
  • Open Access
13 Citations
2,482 Views
8 Pages

Polyphenols are present in many plants and herbs, and the scientific community and consumers are aware of their health-promoting effects. Plants of Greek origin were studied for their polyphenol content and their antioxidant and antimicrobial activit...

  • Article
  • Open Access
6 Citations
2,122 Views
13 Pages

In this paper, the photocatalytic effect of zirconia/laser-induced graphene on the degradation of methylene blue was comprehensively studied. The average particle size measured by HRTEM is 6 nm for both ZrO2 and ZrO2/G10 samples, which explains the h...

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Separations - ISSN 2297-8739