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Antibiotics, Volume 12, Issue 7

July 2023 - 148 articles

Cover Story: OP-145 and SAAP-148, two 24-mer antimicrobial peptides derived from human cathelicidin LL-37, exhibit killing efficacy against E. coli at comparable peptide concentrations; however, the extent of membrane permeabilization does not align with the observed bactericidal activity in both living bacteria and mimics for the cytoplasmic membrane (CM). A combination of microbiological and biophysical techniques revealed distinct binding patterns of the peptides to the bacterial surface and differential permeabilization of the E. coli CM depending on the lipopolysaccharide phenotype, while the antimicrobial activity and membrane depolarization were not significantly affected. Furthermore, our findings demonstrated that the depolarization of the CM, resulting from the perturbation of the lipid packing, is crucial for their bactericidal activity. View this paper
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Articles (148)

  • Article
  • Open Access
8 Citations
2,807 Views
21 Pages

Synthesis of Novel Quinazolinone Analogues for Quorum Sensing Inhibition

  • Sahil Shandil,
  • Tsz Tin Yu,
  • Shekh Sabir,
  • David StC. Black and
  • Naresh Kumar

As bacteria continue to develop resistance mechanisms against antimicrobials, an alternative method to tackle this global concern must be developed. As the pqs system is the most well-known and responsible for biofilm and pyocyanin production, quinaz...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,646 Views
11 Pages

Pseudomonas aeruginosa has assumed an increasingly prominent role as the aetiological agent in serious hard-to-treat infections in animals and humans. In this study, 271 P. aeruginosa strains collected from dogs and cats were investigated. The aim of...

  • Article
  • Open Access
17 Citations
3,187 Views
13 Pages

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective—Sample Characteristics and Isolates’ Sources

  • Francesca Zaghen,
  • Valerio Massimo Sora,
  • Gabriele Meroni,
  • Giulia Laterza,
  • Piera Anna Martino,
  • Alessio Soggiu,
  • Luigi Bonizzi and
  • Alfonso Zecconi

Staphylococcus aureus is considered one of the most widespread bacterial pathogens for both animals and humans, being the causative agent of various diseases like food poisoning, respiratory tract infections, nosocomial bacteremia, and surgical site...

  • Feature Paper
  • Article
  • Open Access
6 Citations
2,846 Views
9 Pages

Similarity Analysis of Klebsiella pneumoniae Producing Carbapenemases Isolated from UTI and Other Infections

  • Agata Pruss,
  • Paweł Kwiatkowski,
  • Monika Sienkiewicz,
  • Helena Masiuk,
  • Agnieszka Łapińska,
  • Barbara Kot,
  • Zuzanna Kilczewska,
  • Stefania Giedrys-Kalemba and
  • Barbara Dołęgowska

Klebsiella pneumoniae is an important opportunistic pathogen responsible for severe infections, mainly urinary tract infections (UTIs) and pneumonia. Hospital epidemic infections caused by multiresistant strains of carbapenemase-producing K. pneumoni...

  • Systematic Review
  • Open Access
11 Citations
4,220 Views
19 Pages

A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis

  • María Baus-Domínguez,
  • Sara Bakkali,
  • Paula Hermida-Cabrera,
  • María-Angeles Serrera-Figallo,
  • José-Luis Gutiérrez-Pérez and
  • Daniel Torres-Lagares

(1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-impla...

  • Systematic Review
  • Open Access
11 Citations
16,332 Views
14 Pages

Streptococcus mitis as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review

  • Claudia Colomba,
  • Valeria Garbo,
  • Giovanni Boncori,
  • Chiara Albano,
  • Sara Bagarello,
  • Anna Condemi,
  • Salvatore Giordano,
  • Laura A. Canduscio,
  • Cristina Gallo and
  • Gaspare Parrinello
  • + 1 author

Streptococcus mitis, a normal inhabitant of the oral cavity, is a member of Viridans Group Streptococci (VGS). Generally recognized as a causative agent of invasive diseases in immunocompromised patients, S. mitis is considered to have low pathogenic...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,096 Views
20 Pages

The Prevalence of the Virulence Genes of Staphylococcus aureus in Sickle Cell Disease Patients at KSUMC, Riyadh, Saudi Arabia

  • Adel A. Abdulmanea,
  • Naiyf S. Alharbi,
  • Ali M. Somily,
  • Jamal M. Khaled and
  • Farjah H. Algahtani

Staphylococcus aureus in the blood of sickle cell disease (SCD) patients may result in a significant increase in morbidity and mortality. S. aureus strains contain various virulence characteristics, including the ability to create a variety of toxins...

  • Review
  • Open Access
67 Citations
13,819 Views
39 Pages

Bacterial infections have attracted the attention of researchers in recent decades, especially due to the special problems they have faced, such as their increasing diversity and resistance to antibiotic treatment. The emergence and development of th...

  • Article
  • Open Access
1,925 Views
9 Pages

Do or Don’t: Results of a Multinational Survey on Antibiotic Prophylaxis in Urodynamics

  • Fabian P. Stangl,
  • Laila Schneidewind,
  • Florian M. Wagenlehner,
  • Daniela Schultz-Lampel,
  • Kaven Baeßler,
  • Gert Naumann,
  • Sandra Schönburg,
  • Petra Anheuser,
  • Susanne Winkelhog-Gran and
  • Matthias Saar
  • + 2 authors

Antibiotic prophylaxis contributes substantially to the increase in antibiotic resistance rates worldwide. This investigation aims to assess the current standard of practice in using antibiotic prophylaxis for urodynamics (UDS) and identify barriers...

  • Article
  • Open Access
12 Citations
2,568 Views
16 Pages

Cefto Real-Life Study: Real-World Data on the Use of Ceftobiprole in a Multicenter Spanish Cohort

  • Carmen Hidalgo-Tenorio,
  • Inés Pitto-Robles,
  • Daniel Arnés García,
  • F. Javier Membrillo de Novales,
  • Laura Morata,
  • Raul Mendez,
  • Olga Bravo de Pablo,
  • Vicente Abril López de Medrano,
  • Miguel Salavert Lleti and
  • Pilar Vizcarra
  • + 6 authors

Background: Ceftobiprole is a fifth-generation cephalosporin that has been approved in Europe solely for the treatment of community-acquired and nosocomial pneumonia. The objective was to analyze the use of ceftobiprole medocaril (Cefto-M) in Spanish...

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Antibiotics - ISSN 2079-6382