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Journal of Clinical Medicine, Volume 14, Issue 11

2025 June-1 - 396 articles

Cover Story: Inflammatory arthritides (IAs) are systemic inflammatory syndromes affecting various organs. Although brain involvement has already been reported, it is considered a rare complication. In this study, we investigated the relationship between cardiac and subclinical brain involvement in patients with IAs. We consecutively evaluated 25 patients with IAs and 31 disease controls with non-autoimmune cardiovascular diseases (CVDs) reporting cardiac symptoms and 25 consecutive asymptomatic healthy controls without CVDs using combined brain/heart magnetic resonance imaging (MRI). Amongst patients with IA, increased cardiac T2 ratio, T2 mapping, and ECV were associated with an increased probability of WMH occurrence. In IA patients with cardiac symptoms, myocardial edema was associated with a greater WMH burden, potentially suggesting shared pathophysiologic substrates. View this paper
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Articles (396)

  • Article
  • Open Access
1 Citations
3,435 Views
14 Pages

The Hungry Heart: Managing Cardiogenic Shock in Patients with Severe Anorexia Nervosa—A Case Report Series

  • Manuela Thienel,
  • Rainer Kaiser,
  • Jonas Gmeiner,
  • Martin Orban and ,
  • Stefan Kääb,
  • Tobias Petzold,
  • Steffen Massberg and
  • Clemens Scherer
  • + 3 authors+ 0 author

5 June 2025

Background: Cardiogenic shock is a life-threatening condition characterized by the failure of the heart to maintain adequate circulation, leading to multi-organ dysfunction. While it is most commonly associated with acute myocardial infarction or car...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
3 Citations
3,767 Views
10 Pages

5 June 2025

Background/Objectives: This study assessed the reliability of the Barrett True-K formula in patients who had undergone laser-based corneal refractive surgery by comparing outcomes using measured vs. predicted posterior corneal astigmatism (PCA) withi...

(This article belongs to the Section Ophthalmology)
  • Review
  • Open Access
14 Citations
2,620 Views
14 Pages

5 June 2025

Postoperative pain management after hospital discharge remains one of the main clinical challenges. The use of digital and telemedicine tools offers new opportunities for the continuous monitoring of, and timely intervention in, patients discharged a...

(This article belongs to the Section Anesthesiology)
  • Case Report
  • Open Access
1,917 Views
8 Pages

5 June 2025

Background/Objectives: Horseshoe kidney is a congenital anomaly characterized by the fusion of the kidneys at the lower pole. Polycystic kidney disease with horseshoe kidney is called polycystic horseshoe kidney. Genetic testing is essential for the...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
6 Citations
2,416 Views
16 Pages

Oxidative Stress and Risk Factors in Adult Patients with Bronchial Asthma: A Clinical Analysis of Representative Biomarkers

  • Oana-Elena Melinte,
  • Emanuel Ioan Stavarache,
  • Mona Elisabeta Dobrin,
  • Andrei Tudor Cernomaz and ,
  • Ionel-Bogdan Cioroiu,
  • Daniela Robu Popa,
  • Ionela-Alina Grosu-Creanga,
  • Andreea Zabara Antal and
  • Antigona Carmen Trofor
  • + 4 authors+ 0 author

5 June 2025

Background: Asthma is a chronic inflammatory airway disease in which oxidative stress and antioxidant imbalance play a critical role in disease progression and therapeutic response. This study aimed to evaluate oxidative stress and antioxidant status...

(This article belongs to the Special Issue Advances in Asthma: 2nd Edition)
  • Article
  • Open Access
1 Citations
2,089 Views
15 Pages

Heart Failure, Kidney Function, and Elderly Age, Rather than Levofloxacin Therapy, Are Associated with QTc Prolongation in COVID-19 Patients

  • Katarzyna Wilk-Śledziewska,
  • Rafał Śledziewski,
  • Małgorzata Gryciuk,
  • Piotr Jan Sielatycki and ,
  • Aleksandra Zbroch,
  • Franciszek Kukliński and
  • Edyta Zbroch
  • + 2 authors+ 0 author

5 June 2025

Background: Prolongation of the QT interval is directly related to the risk of ventricular arrhythmias and sudden cardiac death. Age, comorbidities, and treatment schemes have been shown to influence its prolongation and may also significantly affect...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
5 Citations
2,117 Views
12 Pages

Diagnostic Utility of Intratumoral Susceptibility Signals in Adult Diffuse Gliomas: Tumor Grade Prediction and Correlation with Molecular Markers Within the WHO CNS5 (2021) Classification

  • José Ignacio Tudela Martínez,
  • Victoria Vázquez Sáez,
  • Guillermo Carbonell,
  • Héctor Rodrigo Lara and ,
  • Florentina Guzmán-Aroca and
  • Juan de Dios Berna Mestre
  • + 1 author+ 0 author

5 June 2025

Background/Objectives: This study evaluates intratumoral susceptibility signals (ITSS) as imaging markers for glioma grade prediction and their association with molecular and histopathologic features, in the context of the fifth edition of the World...

(This article belongs to the Section Nuclear Medicine & Radiology)
  • Systematic Review
  • Open Access
5 Citations
3,826 Views
47 Pages

5 June 2025

Introduction: Infrazygomatic crest (IZC) miniscrews are widely used for skeletal anchorage in orthodontics. Despite their growing popularity, the optimal insertion parameters—such as height, angulation, and anatomical position—remain cont...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Systematic Review
  • Open Access
8 Citations
4,712 Views
15 Pages

Adjuvant Radiotherapy for Intermediate-Risk Early-Stage Cervical Cancer Post Radical Hysterectomy: A Systematic Review and Meta-Analysis

  • Pedro Henrique Costa Matos da Silva,
  • Gabriela Oliveira Gonçalves Molino,
  • Maírla Marina Ferreira Dias,
  • Ana Gabriela Alves Pereira and ,
  • Nicole dos Santos Pimenta,
  • Deivyd Vieira Silva Cavalcante,
  • Ana Clara Felix de Farias Santos,
  • Sarah Hasimyan Ferreira,
  • Rodrigo da Silva Santos and
  • Angela Adamski da Silva Reis
  • + 5 authors+ 0 author

5 June 2025

Background: The risk of recurrence of early-stage cervical cancer (CC) is associated with prognostic factors such as tumor size, lymphovascular space invasion (LVSI), and deep stromal invasion (DSI). However, the adjuvant pelvic radiotherapy (RT) fol...

(This article belongs to the Special Issue Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition)
  • Article
  • Open Access
3 Citations
2,798 Views
13 Pages

Temporal Patterns of Air Leak Resolution in Secondary Spontaneous Pneumothorax: A Hazard Function Analysis for Optimal Intervention Timing

  • Ryo Takeyama,
  • Yoshikane Yamauchi,
  • Shinya Kohmaru,
  • Shizuka Morita and ,
  • Hikaru Takahashi,
  • Tomoki Nishida,
  • Yuichi Saito and
  • Yukinori Sakao
  • + 3 authors+ 0 author

5 June 2025

Objectives: This study was aimed to identify risk factors for persistent air leak after chest tube placement for secondary spontaneous pneumothorax and to determine the optimal timing of treatment. Methods: We retrospectively analyzed 221 cases of se...

(This article belongs to the Section General Surgery)
  • Systematic Review
  • Open Access
7 Citations
16,079 Views
38 Pages

Children and Adolescents with Co-Occurring Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review of Multimodal Interventions

  • Carmela De Domenico,
  • Angelo Alito,
  • Giulia Leonardi,
  • Erica Pironti and ,
  • Marcella Di Cara,
  • Adriana Piccolo,
  • Carmela Settimo,
  • Angelo Quartarone,
  • Antonella Gagliano and
  • Francesca Cucinotta
  • + 5 authors+ 0 author

5 June 2025

Background/Objectives: The co-occurrence of Attention-deficit/hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) is very common and worsens adaptive functioning. This systematic review evaluates both pharmacological and non-pharmacologi...

(This article belongs to the Section Mental Health)
  • Review
  • Open Access
1,944 Views
22 Pages

Intraoperative Hemostatic Agents in Thoracic Aortic Surgery—A Scoping Review

  • Maite M. T. van Haeren,
  • Caitlin Bozic,
  • Jennifer S. Breel,
  • Susanne Eberl and ,
  • Faridi S. Jamaludin,
  • Denise P. Veelo,
  • Marcella C. A. Müller,
  • Alexander P. J. Vlaar and
  • Henning Hermanns
  • + 4 authors+ 0 author

5 June 2025

Background/Objectives: Patients undergoing open thoracic aortic surgery have the highest bleeding complication rates within cardiac–vascular surgery, but research on coagulation management mostly targets general cardiac surgery. This scoping re...

(This article belongs to the Section Anesthesiology)
  • Communication
  • Open Access
3,127 Views
15 Pages

High-Complexity Questions and Their Answers for Everyday Heart Failure

  • Amelia Campos-Saénz de Santamaría,
  • Javier Pérez-Santana,
  • François Croset,
  • Laura Karla Esterellas-Sánchez and ,
  • Victoria Lobo-Antuña,
  • Miriam Ripoll-Martínez,
  • Sofia Russo-Botero,
  • Henar Gómez-Sacristán,
  • José Pérez-Silvestre and
  • Jorge Rubio-Gracia
  • + 8 authors+ 3 authors

5 June 2025

As part of the “2nd Training Conference on Heart Failure and Atrial Fibrillation for Residents”, held in Madrid in November 2024, a collaborative initiative was launched to address the most common practical challenges in the management of...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
1,086 Views
10 Pages

5 June 2025

Background/Objectives: Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is characterized by cycles of inflammation and tissue remodeling that can culminate in fibrosis. Differentiating between early inflamm...

(This article belongs to the Special Issue Novel Insights into the Diagnosis and Management of Inflammatory Bowel Disease (IBD))
  • Article
  • Open Access
1 Citations
1,150 Views
10 Pages

Results of Cochlear Implantation in Patients with Congenital Rubell—Retrospective Study

  • Aleksandra Kolodziejak,
  • Natalia Czajka,
  • Rita Zdanowicz,
  • Henryk Skarżyński and
  • Piotr Henryk Skarżyński

5 June 2025

Background/Objectives: Congenital rubella syndrome (CRS) is an infection caused by rubella virus transmitted to the fetus during pregnancy, which can cause congenital hearing loss. Cochlear implant can be an effective therapy in patients with severe...

(This article belongs to the Special Issue Current Challenges and Opportunities in Oto-Rhino-Laryngological Surgery)
  • Article
  • Open Access
3 Citations
1,815 Views
20 Pages

5 June 2025

Background/Objectives: The aim of this study was to investigate the effects of periodontal blood flow on the periapical region during various endodontic disinfection procedures. The hypothesis that periodontal blood flow reduces the increase in root...

(This article belongs to the Special Issue Current Advances in Endodontics and Dental Traumatology)
  • Study Protocol
  • Open Access
2,929 Views
16 Pages

Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Adult Patients with Crohn’s Disease: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial

  • Rosario Paloma Cano-Mármol,
  • Virginia Esperanza Fernández-Ruiz,
  • Cristina Martínez-Pascual,
  • Inmaculada Ros-Madrid and ,
  • Gala Martín-Pozuelo,
  • Alba Oliva-Bolarín,
  • María Antonia Martínez-Sánchez,
  • Juan Egea-Valenzuela,
  • María Ángeles Núñez-Sánchez and
  • Mercedes Ferrer-Gómez
  • + 7 authors+ 2 authors

5 June 2025

Background: Crohn’s disease (CD) is an inflammatory bowel disease in which there is an alteration in the homeostasis and functionality of the intestinal mucosa accompanied by a dysbiosis of the commensal microbiota. The analysis of different di...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
2 Citations
1,815 Views
12 Pages

Comparative Assessment of Halitosis and Oral Health-Related Quality of Life Among Children and Young Adults with Clear Aligners, Those with Lingual Orthodontics, and Non-Orthodontic Controls: A Cross-Sectional Study with Dietary Subgroup Analyses

  • Hamsah Musa,
  • Dana-Cristina Bratu,
  • Ioana Georgiana Pașca,
  • Malina Popa and ,
  • Magda Mihaela Luca,
  • Octavia Balean,
  • Ramona Dumitrescu,
  • Ruxadra Sava Rosianu,
  • Atena Galuscan and
  • Roxana Oancea
  • + 5 authors+ 0 author

5 June 2025

Background and Objectives: Halitosis poses a clinical and psychosocial burden, particularly in orthodontic contexts where plaque retention can exacerbate odor production. This cross-sectional study aimed to compare halitosis and oral health-related q...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Article
  • Open Access
1,197 Views
12 Pages

Validation of the Italian Version of the Visual Function and Corneal Health Status (V-FUCHS) Questionnaire: A Patient-Reported Visual Disability Instrument for Fuchs’ Endothelial Corneal Dystrophy

  • Matilde Buzzi,
  • Alberto Carnicci,
  • Martina Maccari,
  • Silvia Magherini and ,
  • Sanjay V. Patel,
  • Gianni Virgili,
  • Fabrizio Giansanti and
  • Rita Mencucci
  • + 3 authors+ 0 author

5 June 2025

Background/Objectives: The Visual Function and Corneal Health Status (V-FUCHS) questionnaire assesses vision-related quality of life in patients affected by Fuchs endothelial corneal dystrophy (FECD) through 15 items, which are divided into the &ldqu...

(This article belongs to the Special Issue Advancements in Cornea Transplantation)
  • Systematic Review
  • Open Access
3 Citations
6,707 Views
14 Pages

Vitamin C as an Adjuvant Analgesic Therapy in Postoperative Pain Management

  • Wioletta Mędrzycka-Dąbrowska,
  • Sandra Lange,
  • Sebastian Dąbrowski,
  • Klaudia Długoborska and
  • Renata Piotrkowska

5 June 2025

Background/Objectives: Postoperative pain occurs in approximately 80% of patients undergoing surgery. Although opioids remain the mainstay of postoperative pain management, their side effects have led to the development of multimodal analgesia strate...

(This article belongs to the Section Anesthesiology)
  • Review
  • Open Access
3 Citations
3,872 Views
17 Pages

Morphological Variability and Clinical Significance of the Fibularis Tertius Muscle: An Extensive Literature Review

  • Marta Pośnik,
  • Andrzej Węgiel,
  • Nicol Zielinska,
  • Kacper Ruzik and ,
  • Łukasz Olewnik,
  • George Triantafyllou,
  • Maria Piagkou and
  • Michał Podgórski
  • + 3 authors+ 0 author

5 June 2025

Background: The muscles and their tendons exhibit considerable morphological variations. While the anterior leg compartment may seem uniform, several well-documented variants of the tibialis anterior, extensor hallucis longus (EHL) and extensor digit...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
1 Citations
3,630 Views
14 Pages

The Role of VibraPlus on Fatigue in Multiple Sclerosis Patients: A Randomized Controlled Trial

  • Caterina Formica,
  • Desirée Latella,
  • Lilla Bonanno,
  • Antonino Lombardo Facciale and ,
  • Giuseppe Paladina,
  • Antonino Leo,
  • Luca Pergolizzi,
  • Bartolo Fonti,
  • Angelo Quartarone and
  • Rocco Salvatore Calabrò
  • + 6 authors+ 1 author

5 June 2025

Background and Objective: Fatigue represents a hallmark symptom in Multiple Sclerosis (MS), but its diagnosis and clinical evaluation is difficult because it is described as a subjective feeling of exhausted physical and mental sensation. Studies hav...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
6 Citations
1,989 Views
13 Pages

5 June 2025

Objective: Positive airway pressure (PAP) therapy effectively treats obstructive sleep apnea (OSA), yet adherence to the therapy presents significant challenges. This study identifies demographic and sleep study factors that influence short-term adhe...

(This article belongs to the Section Respiratory Medicine)
  • Review
  • Open Access
6 Citations
9,781 Views
14 Pages

Treatment of Benign Pigmented Lesions Using Lasers: A Scoping Review

  • Aurore D. Zhang,
  • Janelle Clovie,
  • Michelle Lazar and
  • Neelam A. Vashi

5 June 2025

Lasers are widely employed in the treatment of melanocytic lesions. This scoping review evaluates 77 studies on the efficacy and safety of laser treatments for café-au-lait macules (CALMs), nevus of Ota (NOA), Becker’s nevus (BN), lichen...

(This article belongs to the Special Issue Facial Plastic and Cosmetic Medicine)
  • Review
  • Open Access
43 Citations
10,190 Views
17 Pages

Advances in 3D Printing Applications for Personalized Orthopedic Surgery: From Anatomical Modeling to Patient-Specific Implants

  • Marcin Prządka,
  • Weronika Pająk,
  • Jakub Kleinrok,
  • Joanna Pec and ,
  • Karolina Michno,
  • Robert Karpiński and
  • Jacek Baj
  • + 2 authors+ 0 author

5 June 2025

Three-dimensional (3D) printing has gained substantial interest among scientists and surgeons over the past decade due to its broad potential in medical applications. Its clinical utility has been increasingly recognized, demonstrating promising outc...

(This article belongs to the Special Issue Advances in Trauma and Orthopedic Surgery: 2nd Edition)
  • Review
  • Open Access
29 Citations
15,378 Views
23 Pages

Endometriosis and Nutrition: Therapeutic Perspectives

  • Francesco Giuseppe Martire,
  • Eugenia Costantini,
  • Claudia d’Abate,
  • Giovanni Capria and ,
  • Emilio Piccione and
  • Angela Andreoli
  • + 1 author+ 0 author

5 June 2025

Endometriosis is a chronic, hormone-dependent disorder characterized by an inflammatory response. The disease affects approximately 10% of the general female population, with prevalence rates reaching 30–40% in women with dysmenorrhea and 50&nd...

(This article belongs to the Section Obstetrics & Gynecology)
  • Review
  • Open Access
10 Citations
13,484 Views
14 Pages

Congenital Rubella Syndrome in the Post-Elimination Era: Why Vigilance Remains Essential

  • Livian Cássia De Melo,
  • Marina Macruz Rugna,
  • Talita Almeida Durães,
  • Stefany Silva Pereira and ,
  • Gustavo Yano Callado,
  • Pedro Pires,
  • Evelyn Traina,
  • Edward Araujo Júnior and
  • Roberta Granese
  • + 4 authors+ 0 author

5 June 2025

Congenital Rubella Syndrome (CRS) results from maternal infection with the rubella virus during pregnancy, particularly in the first trimester, when the risk of vertical transmission and severe fetal damage is highest. CRS is characterized by a broad...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
4 Citations
3,032 Views
13 Pages

Antiplatelet Treatment Strategy in MINOCA Patients: Predictors of Decision Making in Clinical Practice and Prognostic Implications

  • Emmanouil Mantzouranis,
  • Ioannis Leontsinis,
  • Panayotis K. Vlachakis,
  • Constantinos Mihas and ,
  • Panagiotis Iliakis,
  • Eirini Dri,
  • Athanasios Sakalidis,
  • Stergios Soulaidopoulos,
  • Christos Fragoulis and
  • Konstantinos Tsioufis
  • + 9 authors+ 4 authors

5 June 2025

Background/Objectives: Large clinical trials have established the optimal antiplatelet strategy in the wide spectrum of coronary artery disease. However, data are scarce regarding MINOCA and the aim of our study is to present data from the current cl...

(This article belongs to the Special Issue Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease)
  • Review
  • Open Access
41 Citations
21,856 Views
32 Pages

5 June 2025

Background: Platelet-rich plasma (PRP) is increasingly utilized for managing knee osteoarthritis (KOA), yet its clinical value remains debated due to the variability in preparation protocols and outcome measures. Methods: This narrative review synthe...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
1 Citations
2,135 Views
11 Pages

Clinically Important Decrease in Liver Stiffness Following Treatment for Hepatitis C: Outcome of the TraP HepC Nationwide Elimination Program

  • Smári Freyr Kristjánsson,
  • Sigurdur Olafsson,
  • Magnús Gottfredsson,
  • Thorvardur Jon Love and
  • Einar Stefán Björnsson

5 June 2025

Background/Objectives: Direct-acting antiviral (DAA) therapy has been highly successful in treating chronic hepatitis C (CHC). The nationwide Treatment as Prevention of Hepatitis C (TraP HepC) initiative that was launched in Iceland in 2016 utilized...

(This article belongs to the Special Issue Cirrhosis and Its Complications: Prognosis and Clinical Management)
  • Article
  • Open Access
3 Citations
1,834 Views
8 Pages

BRIGHT-HD—A Brazilian Research Investigation on Public Health Gains Comparing Survival Rates Between Hemodialysis and Hemodiafiltration: An Observational Study

  • Eduardo P. Luciano,
  • João Chang,
  • Elaine C. S. Arantes,
  • Aline Cordeiro and ,
  • Sandra F. S. Reis,
  • Douglas V. Andrade,
  • Whelington F. Rocha,
  • Andrea O. Magalhães,
  • Cynthia M. Borges and
  • Rosilene M. Elias
  • + 5 authors+ 0 author

5 June 2025

Background/Objectives: High-flux online hemodiafiltration (OL-HDF) appears to be associated with better survival than hemodialysis (HD). In Brazil, OL-HDF is only affordable for patients with private health insurance. Although observational studies h...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
1 Citations
1,473 Views
9 Pages

Usefulness of the Phase Angle in Evaluating Locomotive Syndrome in Cancer Patients

  • Ryoga Kashima,
  • Ryo Yoshikawa,
  • Wataru Saho,
  • Yasumitsu Fujii and ,
  • Risa Harada,
  • Daisuke Makiura,
  • Daisuke Tatebayashi,
  • Katsuya Fujiwara,
  • Mayu Mizuta and
  • Yoshitada Sakai
  • + 6 authors+ 1 author

5 June 2025

Background: Locomotive syndrome (LS), a condition characterized by impaired mobility due to locomotive organ dysfunction, is highly prevalent among patients with cancer. The phase angle (PhA), measured via bioelectrical impedance analysis (BIA), refl...

(This article belongs to the Special Issue Recent Progress in Rehabilitation Medicine—3rd Edition)
  • Case Report
  • Open Access
2,373 Views
12 Pages

Porto-Sinusoidal Vascular Disorder: An Under-Recognized Liver Manifestation in Turner Syndrome

  • Sofia M. Siasiakou,
  • Eleni Stoupi,
  • Afroditi Roumpou,
  • Amalia Papanikolopoulou and ,
  • Nikolaos Syrigos,
  • Dina Tiniakos and
  • Melpomeni Peppa
  • + 2 authors+ 0 author

5 June 2025

Background/Objectives: Turner syndrome (TS) is a genetic chromosomal disorder including various manifestations depending on the karyotype; endocrine, gastrointestinal, respiratory, neurological, urogenital, musculoskeletal, and cardiovascular disorde...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Review
  • Open Access
18 Citations
6,331 Views
20 Pages

5 June 2025

Fibrosis transmembrane conductance regulator (CFTR) modulators (CFTRms) have significantly improved outcomes in people with cystic fibrosis (CF). Real-world evidence, particularly from national and international CF registries, is essential to assess...

(This article belongs to the Special Issue Cystic Fibrosis: Diagnosis and Treatment)
  • Systematic Review
  • Open Access
12 Citations
8,810 Views
18 Pages

5 June 2025

Background: Effective labor analgesia is a cornerstone of obstetric care, influencing maternal satisfaction and birth outcomes. This systematic review evaluates both conventional and emerging analgesia techniques for natural vaginal delivery, emphasi...

(This article belongs to the Section Anesthesiology)
  • Article
  • Open Access
2 Citations
1,823 Views
9 Pages

The Overlooked Threat of Malnutrition: A Point Prevalence Study Based on NRS-2002 Screening in a Tertiary Care Hospital

  • Ekmel Burak Özşenel,
  • Güldan Kahveci,
  • Yıldız Pekcioğlu,
  • Beytullah Güner and
  • Sema Basat

5 June 2025

Background: Malnutrition is increasingly prevalent due to rising life expectancy, oncological cases, and chronic diseases. Early detection is crucial for rehabilitation, complication prevention, and cost reduction. However, nutritional support is oft...

(This article belongs to the Section Clinical Nutrition & Dietetics)
  • Review
  • Open Access
4 Citations
11,791 Views
17 Pages

Oxygen Saturation Targeting in the Neonatal Intensive Care Unit

  • Faeq Almudares,
  • Bheru Gandhi,
  • Jonathan Davies,
  • Xanthi Couroucli and ,
  • Natalie Villafranco,
  • Nidhy Paulose Varghese,
  • Milenka Cuevas Guaman,
  • Charleta Guillory and
  • Binoy Shivanna
  • + 4 authors+ 0 author

4 June 2025

Oxygen (O2) is vital for cellular development, function, proliferation, and repair, underscoring its critical role in organogenesis. Both hypoxia (reduced tissue O2) and hyperoxia (excess tissue O2), when prolonged, can trigger inflammation and oxida...

(This article belongs to the Special Issue Clinical Diagnosis and Management of Neonatal Diseases)
  • Case Report
  • Open Access
5 Citations
3,057 Views
10 Pages

Second Trimester Ultrasound Diagnosis of External Hydrocephalus in Two Fetuses with Noonan Syndrome—Case Report Series

  • Tibor Elekes,
  • Aniko Ladanyi,
  • Eva Pap,
  • Janos Szabo and ,
  • Anett Illes,
  • Nora Gullai and
  • Szabolcs Varbiro
  • + 2 authors+ 0 author

4 June 2025

Background: Noonan syndrome (NS) is a relatively common RASopathy that can be associated with a variety of phenotypic and genotypic variations and potential long-term health consequences. Its most described prenatal ultrasound features in the first t...

(This article belongs to the Special Issue New Advances in Prenatal Diagnosis and Newborn Screening)
  • Article
  • Open Access
3 Citations
2,164 Views
13 Pages

Clinical Characteristics of Patients with Intra-Abdominal Infection Caused by Stenotrophomonas maltophilia

  • Chien-Liang Chen,
  • Chun-Chou Tsai,
  • Wei-Ping Chen,
  • Feng-Yee Chang and ,
  • Ching-Mei Yu,
  • Hung-Sheng Shang,
  • Leung-Kei Siu,
  • Ya-Sung Yang,
  • Jung-Chung Lin and
  • Ching-Hsun Wang
  • + 5 authors+ 0 author

4 June 2025

Background: Intra-abdominal infections (IAIs) caused by Stenotrophomonas maltophilia have rarely been reported. This study aimed to describe the clinical characteristics and risk factors for mortality among patients with S. maltophilia IAIs. Methods:...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
3 Citations
1,920 Views
15 Pages

4 June 2025

Study Design: Pilot randomized clinical trial. Objective: To examine the effect of electrically evoked muscle hypertrophy on indices of spasticity, as measured by Biodex after spinal cord injury (SCI). Setting: Medical research center. Methods: Thirt...

(This article belongs to the Section Clinical Rehabilitation)
  • Systematic Review
  • Open Access
5 Citations
6,422 Views
16 Pages

Diagnostic Challenges and Management Strategies of Pelvic Inflammatory Disease in Sexually Inactive Pediatric and Adolescent Patients: A Systematic Review of Case Reports

  • Adrian Surd,
  • Rodica Mureșan,
  • Andreea Oprea,
  • Kriszta Snakovszki and ,
  • Lucia Maria Sur,
  • Lia-Oxana Usatiuc,
  • Carmen-Iulia Ciongradi and
  • Ioan Sârbu
  • + 3 authors+ 0 author

4 June 2025

Background and objectives: Pelvic inflammatory disease (PID), primarily associated with sexually transmitted infections (STIs), represents a diagnostic challenge in virgin pediatric patients due to the often vague, non-specific symptomatology, which...

(This article belongs to the Special Issue Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition))
  • Article
  • Open Access
3,042 Views
6 Pages

4 June 2025

Background/Objectives: To compare the results of oral chemolysis of non-opaque and semi-opaque kidney stones using potassium citrate (PS) and allopurinol + potassium citrate (ALPS) prospectively without advanced metabolic analysis. Methods: Between 2...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
1,425 Views
12 Pages

Clinicopathologic Features of Isolated AFOP Nodules Radiologically Mimicking Malignancy in Post COVID-19 Patients: A Case Series Study

  • Massimiliano Mancini,
  • Lavinia Bargiacchi,
  • Gisella Guido,
  • Fabiana Messa and ,
  • Beatrice Trabalza Marinucci,
  • Erino Angelo Rendina,
  • Mohsen Ibrahim and
  • Andrea Vecchione
  • + 3 authors+ 0 author

4 June 2025

Background/Objectives: Acute Fibrinous and Organizing Pneumonia (AFOP) is a rare pulmonary condition histologically characterized by intra-alveolar fibrin deposition and organizing pneumonia without hyaline membranes. This study aims to describe the...

(This article belongs to the Section Respiratory Medicine)
  • Review
  • Open Access
4 Citations
3,631 Views
14 Pages

4 June 2025

Background/Objectives: Previous research has established that beta-blockers significantly reduce all-cause mortality, cardiovascular mortality, and recurrent acute myocardial infarction (AMI) in patients with left ventricular dysfunction following AM...

(This article belongs to the Special Issue Acute Myocardial Infarction: Clinical Advances in Prognostic Stratification, Diagnosis, and Treatment)
  • Review
  • Open Access
3 Citations
3,551 Views
25 Pages

Deciphering the Complex Relationships Between the Hemostasis System and Infective Endocarditis

  • Muhammad Aamir Wahab,
  • Atta Ullah Khan,
  • Silvia Mercadante,
  • Iolanda Cafarella and ,
  • Lorenzo Bertolino and
  • Emanuele Durante-Mangoni
  • + 1 author+ 0 author

4 June 2025

Infective endocarditis (IE) arises from complex interactions between microbial pathogens and host hemostasis systems, where dysregulated coagulation mediates microbial persistence and systemic thromboembolic complications. Alterations in primary, sec...

(This article belongs to the Special Issue Diagnostic and Therapeutic Challenges in Infective Endocarditis)
  • Article
  • Open Access
4 Citations
1,530 Views
16 Pages

Validation of the Comprehensive Augmented Reality Testing Platform to Quantify Parkinson’s Disease Fine Motor Performance

  • Andrew Bazyk,
  • Ryan D. Kaya,
  • Colin Waltz,
  • Eric Zimmerman and ,
  • Joshua D. Johnston,
  • Kathryn Scelina,
  • Benjamin L. Walter,
  • Junaid Siddiqui,
  • Anson B. Rosenfeldt and
  • Jay L. Alberts
  • + 6 authors+ 1 author

4 June 2025

Background/Objectives: Technological approaches for the objective, quantitative assessment of motor functions have the potential to improve the medical management of people with Parkinson’s disease (PwPD), offering more precise, data-driven ins...

(This article belongs to the Special Issue Digital Health Technologies in Parkinson’s Disease and Related Disorders)
  • Systematic Review
  • Open Access
7 Citations
7,525 Views
20 Pages

Conservative Treatment with Teriparatide Versus Vertebroplasty for Acute Osteoporotic Vertebral Compression Fractures: A Meta-Analysis

  • Subum Lee,
  • Junseok W. Hur,
  • Younggyu Oh,
  • Sungjae An and ,
  • Yeongu Chung,
  • Danbi Park and
  • Jin Hoon Park
  • + 2 authors+ 0 author

4 June 2025

Background/Objectives: The debate continues, despite numerous studies, on whether vertebroplasty (VP) or conservative treatment is more suitable for osteoporotic vertebral compression fractures (OVCFs). Meanwhile, teriparatide (TP) has shown promise...

(This article belongs to the Special Issue Recent Advances in the Management of Fractures)
  • Article
  • Open Access
4 Citations
2,827 Views
14 Pages

Sutureless Scleral-Fixated Soleko Fil Carlevale Intraocular Lens and Associated Pars Plana Vitrectomy in Aphakia Management: A National Multicenter Audit

  • Lorena Ferrer-Alapont,
  • Carolina Bernal-Morales,
  • Manuel J. Navarro,
  • Diego Ruiz-Casas and ,
  • Claudia García-Arumí,
  • Juan Manuel Cubero-Parra,
  • Jose Vicente Dabad-Moreno,
  • Daniel Velázquez-Villoria,
  • Joaquín Marticorena and
  • Javier Zarranz-Ventura
  • + 13 authors+ 8 authors

4 June 2025

Objective: The aim of this study was to evaluate the clinical outcomes of sutureless scleral-fixated (SSF) Soleko Fil Carlevale intraocular lens (SC-IOL) implants associated with pars plana vitrectomy (PPV) in patients with aphakia secondary to compl...

(This article belongs to the Section Ophthalmology)
  • Case Report
  • Open Access
1 Citations
3,988 Views
14 Pages

4 June 2025

Objectives: This study evaluated peripheral nerve stimulation (PNS) as a treatment for vertebra plana fractures, focusing on its impact on pain intensity, physical function, anxiety, depression, fatigue, social role participation, and pain interferen...

(This article belongs to the Special Issue Clinical Advances in Pain Management)
  • Article
  • Open Access
2 Citations
2,755 Views
12 Pages

Incidence, Impact, and Complications of Short Cephalomedullary Nail Toggling in Patients with Wide Femoral Medullary Canal

  • Ahmed Nageeb Mahmoud,
  • Maria F. Echeverry-Martinez,
  • Catherine Mary Doyle,
  • Juan David Bernate and ,
  • Michael Suk and
  • Daniel Scott Horwitz
  • + 1 author+ 0 author

4 June 2025

Background: Toggling of the short cephalomedullary nail is an understudied phenomenon characterized by a change in the longitudinal axis of the nail in relation to the longitudinal axis of the femoral medullary canal, with subsequent potential loss o...

(This article belongs to the Section Orthopedics)

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J. Clin. Med. - ISSN 2077-0383