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Journal of Clinical Medicine, Volume 14, Issue 10

2025 May-2 - 351 articles

Cover Story: Recently, there has been tremendous interest in the use of large language models (LLMs) in radiology. LLMs have been employed for various applications in cancer imaging, including improving reporting speeds and accuracy via the generation of standardized reports, automating the classification and staging of abnormal findings, incorporating appropriate guidelines, and calculating individualized risk scores. LLMs can also improve patients’ comprehension of imaging reports and translate them into multiple languages. Other future applications of LLMs include aiding patient management and preventing and predicting adverse events. However, limitations such as hallucinations and variable performances could present obstacles to their widespread clinical implementation. This review discusses the applications and limitations of LLMs in cancer imaging. View this paper
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Articles (351)

  • Article
  • Open Access
1 Citations
2,384 Views
10 Pages

Electric Scooter Trauma in Rome: A Three-Year Analysis from a Tertiary Care Hospital

  • Bruno Cirillo,
  • Mariarita Tarallo,
  • Giulia Duranti,
  • Paolo Sapienza,
  • Pierfranco Maria Cicerchia,
  • Luigi Simonelli,
  • Roberto Cirocchi,
  • Matteo Matteucci,
  • Andrea Mingoli and
  • Gioia Brachini

21 May 2025

Background: Electric motorized rental scooters (ES) were introduced in Italy in 2019 as an alternative form of urban transportation, aiming to reduce traffic congestion and air pollution. As their popularity has grown, a parallel increase in ES-relat...

  • Article
  • Open Access
1 Citations
840 Views
9 Pages

21 May 2025

Background: Little is known about the impact of pre-injury OAC/APT on severely injured trauma patients admitted to a level I trauma center. Our study focused on impact of pre-injury OAC/APT on the outcomes of this specific cohort of patients. Methods...

  • Article
  • Open Access
1,065 Views
16 Pages

Clinical Value of Bioactive Adrenomedullin and Proenkephalin A in Patients with Left Ventricular Assist Devices: An Observational Study

  • Leyla Dogan,
  • Ahmad Abugameh,
  • Alish Kolashov,
  • Ajay Moza,
  • Andreas Goetzenich,
  • Christian Stoppe,
  • Mohammed Shoaib,
  • Deborah Bergmann,
  • Jan Spillner and
  • Rashad Zayat
  • + 1 author

21 May 2025

Background/Objectives: In the context of acute heart failure, proenkephalin A (penKid) has emerged as a prognostic marker for acute kidney injury (AKI), whereas bioactive adrenomedullin (bio-ADM) has been identified as a significant biomarker linked...

  • Article
  • Open Access
2 Citations
1,254 Views
7 Pages

21 May 2025

Background/Objectives: Primary Ciliary Dyskinesia (PCD) is a rare genetic condition characterized by compromised mucociliary clearance and chronic respiratory manifestations. Anosmia, or the loss of smell, is a lesser-known but clinically relevant sy...

  • Article
  • Open Access
2 Citations
3,601 Views
19 Pages

The Feasibility of a Guideline-Directed Medical Therapy Rapid Up-Titration Programme Among Real-World Heart Failure Patients: A Multicentre Observational Study

  • Fanni Bánfi-Bacsárdi,
  • Arnold Péter Ráduly,
  • Attila Borbély,
  • Noémi Nyolczas,
  • Attila Szilágyi,
  • Tamás G. Gergely,
  • Zsolt Forrai,
  • Judit Papp,
  • Orsolya Rátosi and
  • Balázs Muk
  • + 7 authors

21 May 2025

Background: The 2023 ESC Heart Failure (HF) Guidelines recommend the rapid up-titration of guideline-directed medical therapy (GDMT) for all patients after HF hospitalisation. Real-world data on the implementation of a rapid up-titration programme (R...

  • Review
  • Open Access
2 Citations
3,112 Views
20 Pages

21 May 2025

Background/Objectives: Laparoscopic surgery plays a central role in the management of abdominal trauma, particularly in patients with hemodynamic stability. Recently, single-port laparoscopic surgery (SPLS) has emerged as a technique that further red...

  • Review
  • Open Access
1 Citations
7,546 Views
20 Pages

Efficacy and Safety of Transcranial Magnetic Stimulation for Treating Late-Life Depression: A Scoping Review

  • Ciprian-Ionuț Băcilă,
  • Monica Cornea,
  • Andrei Lomnasan,
  • Claudia Elena Anghel,
  • Andreea Maria Grama,
  • Cristina Elena Dobre,
  • Silvia Rusu and
  • Bogdan Ioan Vintilă

21 May 2025

Background/Objectives: Transcranial magnetic stimulation (TMS) is a non-invasive and well-tolerated treatment, offering an effective alternative for elderly patients with depression, especially when side effects or comorbidities limit medication. Met...

  • Review
  • Open Access
2 Citations
1,899 Views
20 Pages

Drug-Coated Balloons in All-Comer Population—Are We There Yet?

  • Florin-Leontin Lazar,
  • Horea Laurentiu Onea,
  • Calin Homorodean,
  • Ioan Cornel Bitea,
  • Diana Raluca Lazar,
  • Mihai Claudiu Ober,
  • Dan Tataru,
  • Maria Olinic,
  • Mihail Spinu and
  • Dan-Mircea Olinic
  • + 1 author

21 May 2025

With the advancement of interventional coronary procedures, drug-coated balloons have become an increasingly common alternative to drug-eluting stents in the treatment of various lesions. This paradigm shift stems from several advantages that DCBs en...

  • Review
  • Open Access
1 Citations
3,668 Views
17 Pages

Optimizing Imaging Techniques for Left Atrial Appendage Closure: Insights and Emerging Directions

  • Valentina Barletta,
  • Mattia Alberti,
  • Riccardo Agostini,
  • Fausto Pizzino,
  • Giancarlo Trimarchi,
  • Maria Grazia D’Alfonso,
  • Marco Solari,
  • Giulio Zucchelli and
  • Alberto Cresti

21 May 2025

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults and is associated with significant morbidity and mortality, including an increased risk of stroke, heart failure, dementia, and recurrent hospitalizations. As life exp...

  • Article
  • Open Access
3,785 Views
15 Pages

21 May 2025

Objective: to assess the association between attention-deficit/hyperactivity disorder (ADHD), type 1 diabetes mellitus (T1D), and cardiovascular comorbidities in adults. Methods: The Adult Self-Report Scale V1.1 (ASRS) for ADHD symptoms was electroni...

  • Review
  • Open Access
5 Citations
7,893 Views
14 Pages

21 May 2025

Aging is the primary risk factor for chronic diseases such as cardiovascular disease, cancer, and dementia. However, chronological age alone fails to capture individual variability in aging trajectories and disease susceptibility. Recent advances in...

  • Article
  • Open Access
3 Citations
1,522 Views
29 Pages

21 May 2025

Background: The aim of this study was to evaluate corneal endothelial changes following phacoemulsification cataract surgery with intraocular lens implantation in patients with type 2 diabetes (study group) and without diabetes (control group). The s...

  • Case Report
  • Open Access
2 Citations
2,133 Views
11 Pages

21 May 2025

Background: The combination of two or more different types of traumatic dental injuries occurring concurrently to the same tooth presents a significant clinical challenge. By focusing on a rare combination of injuries, this case study explores the is...

  • Article
  • Open Access
7 Citations
5,120 Views
18 Pages

Complications Associated with Immunosuppressive Agents in Solid Organ Transplant Recipients: A Nationwide Analysis

  • Ah Young Lee,
  • Jonghyun Jeong,
  • Kyu-Nam Heo,
  • Soyoung Park,
  • Young-Mi Ah,
  • Ji Min Han,
  • Ju-Yeun Lee and
  • Sang Il Min

21 May 2025

Background: Immunosuppressive therapies are vital for solid organ transplant (SOT) recipients to ensure graft survival, but long-term use can lead to complications. This study aimed to comprehensively evaluate the complications associated with immuno...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,268 Views
25 Pages

Mental Health and Metabolic Outcomes in Early Postpartum in Women with Prediabetes After Gestational Diabetes: A Secondary Analysis of the MELINDA Trial

  • Yana Vanlaer,
  • Caro Minschart,
  • Karolijn Van den Keybus,
  • Nele Myngheer,
  • Toon Maes,
  • Christophe De Block,
  • Niels Bochanen,
  • Inge Van Pottelbergh,
  • Pascale Abrams and
  • Katrien Benhalima
  • + 8 authors

21 May 2025

Aims: To examine the association between depressive symptoms and metabolic profile in women with prior gestational diabetes mellitus (GDM) and early postpartum prediabetes, and to explore whether a mobile-based lifestyle intervention affected mental...

  • Article
  • Open Access
1,409 Views
10 Pages

Evaluation of Etiologies in Evisceration as Rare Cases: A 10-Year Single-Center Experience in the East Mediterranean Region of Türkiye

  • Burak Ulaş,
  • Altan Atakan Ozcan,
  • Burak Mete,
  • Hakan Demirhindi,
  • Merve Ademoğlu Gök and
  • Hülya Binokay

21 May 2025

Objectives: Evisceration is a rarely performed surgical procedure, and literature information regarding the characteristics of patients undergoing this surgery is limited. This study aims to evaluate the demographic features and etiological factors o...

  • Article
  • Open Access
3 Citations
2,256 Views
14 Pages

A Nationwide Epidemiological Study of Chronic Kidney Disease Prevalence in a High-Risk Patient Population Without Prior Diagnosis in Primary Health Care in Poland

  • Alicja Jazienicka,
  • Mateusz Babicki,
  • Magdalena Krajewska,
  • Andrzej Oko,
  • Karolina Kłoda,
  • Aleksander Biesiada and
  • Agnieszka Mastalerz-Migas

21 May 2025

Background/Objectives: Chronic kidney disease (CKD) affects 10 to 15% of the world population. Currently, there are no reliable epidemiological data on the prevalence of CKD in Poland. The aim of this study was to determine the prevalence of CKD in t...

  • Article
  • Open Access
2 Citations
1,779 Views
17 Pages

Clinical Manifestations of Temporomandibular Disorders and Their Relationship with Sleep Disturbances and Emotional Disorders in a Spanish Pediatric Population: A Cross-Sectional Study

  • Fanny Esther Tapia-Sierra,
  • Jesús Miguel Ticona-Flores,
  • Guillermo Reichard-Monefeldt,
  • Naomi Elvira-Tapia,
  • Nuria Esther Gallardo-López and
  • Montserrat Diéguez-Pérez

21 May 2025

The etiology of temporomandibular disorders (TMDs) has been linked to various factors, including functional and psychological factors, which makes it difficult to identify associations between a single etiological factor and the signs and symptoms of...

  • Systematic Review
  • Open Access
2 Citations
2,295 Views
15 Pages

Mineralocorticoid Receptor Antagonists in Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

  • Mithila Zaheen,
  • Fardin Ferdous,
  • Anjalee T. Amarasekera,
  • Johannes Petutschnigg,
  • Frank Edelmann and
  • Timothy C. Tan

21 May 2025

Background/Objectives: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome with limited therapeutic options. Mineralocorticoid receptor antagonists (MRAs) have been shown to improve clinical outcomes in patients with...

  • Systematic Review
  • Open Access
5 Citations
5,346 Views
13 Pages

Consensus-Based Recommendations for Assessing Post-Intensive Care Syndrome: A Systematic Review

  • Helmar Bornemann-Cimenti,
  • Johanna Lang,
  • Sascha Hammer,
  • Kordula Lang-Illievich,
  • Sebastian Labenbacher,
  • Stefan Neuwersch-Sommeregger and
  • Christoph Klivinyi

21 May 2025

Background: Post-intensive care syndrome encompasses physical, cognitive, and psychological impairments that persist in patients after discharge from an intensive care unit. There is considerable variation in the tools used for assessment. This syste...

  • Article
  • Open Access
8,020 Views
11 Pages

Incidence and Risk Factors for Incisional Hernia Following Ileostomy Takedown: A Retrospective Cohort Study

  • Tamás Talpai,
  • Flaviu-Ionuţ Faur,
  • Cătălin-Alexandru Pîrvu,
  • Daniela Marinescu,
  • Cristi Tarta,
  • Dragos Nicolae Margaritescu,
  • Stelian Pantea,
  • Cristian Nica,
  • Rãzvan-Sorin Albu and
  • Valeriu Șurlin
  • + 3 authors

21 May 2025

Background: Incisional hernias are a frequent complication following ileostomy closure, with rates reaching 24%. Protective ileostomies are commonly performed in colorectal surgery, but their closure presents a significant risk for abdominal wall def...

  • Article
  • Open Access
1 Citations
1,000 Views
11 Pages

21 May 2025

Background: We investigated the possibility of predicting tumor burden with salivary extracellular RNA (exRNA) biomarkers in gastric cancer patients. Methods: Saliva samples were prospectively collected from 50 gastric cancer patients who underwent g...

  • Review
  • Open Access
1 Citations
2,136 Views
16 Pages

Limus Devices for the Treatment of SFA: Latest Outcomes and Future Perspectives

  • Genti Xhepa,
  • Agostino Inzerillo,
  • Ilinca Constantinescu,
  • Pierre Faerber,
  • Adrien Gleyzolle,
  • Pierpaolo Biondetti,
  • Filippo Del Grande,
  • Edon Xhepa,
  • Simone Mortellaro and
  • Alexis Ricoeur
  • + 2 authors

21 May 2025

Globally, cardiovascular disease is a leading cause of disability and early death, affecting 422.7 million people and causing 17.9 million deaths (31% of global deaths) in 2015. Peripheral arterial disease, previously overlooked compared to coronary...

  • Article
  • Open Access
1 Citations
2,463 Views
12 Pages

21 May 2025

Background/Objectives: This retrospective study aimed to evaluate whether PRP infiltrations improve quadriceps muscle strength recovery following anterior cruciate ligament reconstruction (ACLR), while minimizing the recovery time required to resume...

  • Article
  • Open Access
1,518 Views
11 Pages

Pulmonary Function and Nocturnal Hypoxemia Patterns in Patients with Obstructive Sleep Apnea

  • Claudia Lucia Toma,
  • Filip Radu,
  • Dragos-Cosmin Zaharia,
  • Ionela Belaconi and
  • Stefan Dumitrache-Rujinski

21 May 2025

Background/Objective: Obesity is a documented risk factor for impaired pulmonary function and abnormal oxyhaemoglobin levels during sleep. This functional impairment becomes more significant when there are additional respiratory pathologies, such as...

  • Article
  • Open Access
3 Citations
3,367 Views
10 Pages

Accuracy of Red Blood Cell Parameters in Predicting α0-Thalassemia Trait Among Non-Anemic Males

  • Benchaya Phanthong,
  • Pimlak Charoenkwan,
  • Threebhorn Kamlungkuea,
  • Suchaya Luewan and
  • Theera Tongsong

21 May 2025

Background/Objectives: Red blood cell (RBC) parameters are routinely used to screen for α- and β-thalassemia traits as part of prenatal diagnosis for severe fetal thalassemia in countries with a high prevalence of the disease. In clinical practice, t...

  • Feature Paper
  • Article
  • Open Access
1 Citations
2,139 Views
12 Pages

Virtual Reality as an Adjuvant Treatment for Acute Pain During an Interventional Process with Capsaicin: A Feasibility Study

  • Anna Server,
  • Maria Sonsoles Cepeda Diez,
  • Carlos Suso-Ribera,
  • Sara Guila Fidel Kinori,
  • Diana Castilla,
  • Francisco Javier Medel and
  • Azucena García-Palacios

21 May 2025

Background/Objectives: This feasibility study explores the use of virtual reality (VR) as an adjunct therapy during capsaicin administration for individuals with chronic neuropathic pain. Chronic neuropathic pain poses significant management challeng...

  • Systematic Review
  • Open Access
2 Citations
3,455 Views
22 Pages

Cluster Analysis in Diabetes Research: A Systematic Review Enhanced by a Cross-Sectional Study

  • Binura Taurbekova,
  • Radmir Sarsenov,
  • Muhammad M. Yaqoob,
  • Kuralay Atageldiyeva,
  • Yuliya Semenova,
  • Siamac Fazli,
  • Andrey Starodubov,
  • Akmaral Angalieva and
  • Antonio Sarria-Santamera

21 May 2025

Background: Diabetes mellitus is a heterogeneous metabolic disorder that poses substantial challenges in the management of patients with diabetes. Emerging research underscores the potential of unsupervised cluster analysis as a promising methodologi...

  • Article
  • Open Access
2,047 Views
10 Pages

Post-Esophagectomy Dumping Syndrome: Assessing Quality of Life of Long-Term Survivors

  • Dionysios Dellaportas,
  • Ioannis Margaris,
  • Eleftherios Tsalavoutas,
  • Zoi Gkiafi,
  • Anastasia Pikouli,
  • Despoina Myoteri,
  • Nikolaos Pararas,
  • Panagis M Lykoudis,
  • Constantinos Nastos and
  • Emmanuel Pikoulis

21 May 2025

Background/Objectives: Survival rates for esophageal cancer patients have markedly improved. Inevitably, attention has been drawn to functional and quality-of-life problems. The aim of the current study was to investigate the prevalence of dumping sy...

  • Opinion
  • Open Access
2 Citations
4,343 Views
14 Pages

Open Mouth Posture Syndrome (OMPS): Classification

  • Can-Florian Keleş,
  • David Morais,
  • Anand Marya,
  • Omar Fawzi Chawshli,
  • Adith Venugopal and
  • Ute Ulrike Botzenhart

21 May 2025

Objectives: This narrative review aims to redefine Open Mouth Posture Syndrome (OMPS) as a multifactorial condition with overlapping symptoms and a cyclical pathophysiology. A novel classification system for OMPS subtypes is proposed to standardize r...

  • Article
  • Open Access
1,762 Views
13 Pages

Evidence for the Necessity of Objective Hearing Tests in Cochlear Implantation Assessment: Excluding Functional Hearing Loss Cases

  • Anita Gáborján,
  • Márton Kondé,
  • Marianna Küstel,
  • Nóra Kecskeméti,
  • László Tamás,
  • Ildikó Baranyi,
  • Gábor Polony and
  • Judit F. Szigeti

20 May 2025

Background/Objectives: Cochlear implantation is a crucial intervention for individuals with severe hearing loss, aiming to restore auditory function and improve quality of life. The decision to recommend cochlear implantation critically depends on ac...

  • Article
  • Open Access
1 Citations
874 Views
13 Pages

Crystal Ball in a Blood’s Drop: Unlocking Hidden Prognostic Power in the Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) for Elderly Hip Fracture Patients

  • Andrea Perna,
  • Giuseppe Rovere,
  • Marco Passiatore,
  • Andrea Franchini,
  • Luca Macchiarola,
  • Francesco Maruccia,
  • Raffaele Vitiello and
  • Franco Lucio Gorgoglione

20 May 2025

Background/Objectives: Hip fractures in elderly patients are associated with high morbidity and mortality, requiring early risk stratification to optimize management. Systemic inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and...

  • Article
  • Open Access
1 Citations
1,047 Views
9 Pages

Cognitive Impairment in ANCA-Associated Vasculitis: A Cross-Sectional Pilot Study

  • Marion Camard,
  • Ana Moises,
  • Katia Bourdic,
  • Laura Venditti,
  • Christian Denier,
  • Julien Henry,
  • Raluca Sterpu,
  • Perla David,
  • Mathilde De Menthon and
  • Fanny Urbain
  • + 4 authors

20 May 2025

Objectives: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises rare systemic vasculitides that can present with cognitive dysfunction. However, data on the screening and characterization of cognitive dysfunction in AAV r...

  • Review
  • Open Access
4 Citations
8,121 Views
18 Pages

Perspective on Perinatal Birth Canal Injuries: An Analysis of Risk Factors, Injury Mechanisms, Treatment Methods, and Patients’ Quality of Life: A Literature Review

  • Patrycja Głoćko,
  • Sylwia Janczak,
  • Agnieszka Nowosielska-Ogórek,
  • Wiktoria Patora,
  • Olga Wielgoszewska,
  • Mateusz Kozłowski and
  • Aneta Cymbaluk-Płoska

20 May 2025

Perineal injuries are a common complication of vaginal delivery, affecting 75–85% of women. This review examines current knowledge on risk factors, classification, treatment, and quality of life impacts. Risk factors are divided into maternal,...

  • Article
  • Open Access
2,445 Views
16 Pages

20 May 2025

Background/Objectives: The nephrotoxicity of immune checkpoint inhibitors (ICIs) combined with proton pump inhibitors (PPIs) has been recognized but lacks a comprehensive analysis. We conducted an in-depth investigation of renal adverse events (rAEs)...

  • Article
  • Open Access
1 Citations
904 Views
10 Pages

Socioeconomic Disadvantage, Residential Remoteness and Access to Specialised Interventions in Cerebral Palsy: A Cross-Sectional Study

  • Simon P. Paget,
  • Kirsty Stewart,
  • Lisa Copeland,
  • Emma Waight,
  • Nadine Smith,
  • Felicity Baker,
  • Jennifer Lewis and
  • on behalf of the Australian Selective Dorsal Rhizotomy Research Group and Australian Paediatric Intrathecal Baclo-fen Research Group

20 May 2025

Aim: Socioeconomic factors are known to influence access to health services, including for children with cerebral palsy (CP). This study aims to determine whether socioeconomic disadvantage and/or geographical remoteness influence access to specialis...

  • Review
  • Open Access
5 Citations
2,591 Views
11 Pages

PSMA PET as a Tool for Active Surveillance of Prostate Cancer—Where Are We at?

  • Jonathon Carll,
  • Jacinta Bonaddio and
  • Nathan Lawrentschuk

20 May 2025

Active surveillance remains the preferred treatment for men with low-risk prostate cancer and select men with favourable intermediate-risk prostate cancer. It involves the close observation of clinicopathological parameters to assess for disease prog...

  • Article
  • Open Access
1 Citations
1,931 Views
15 Pages

20 May 2025

Background: The effectiveness of treatment depends on recognizing the needs and limitations of patients. Hope is a personal resource that facilitates the treatment and recovery process. Dispositional hope encompasses goal-directed action, whereas per...

  • Article
  • Open Access
3 Citations
2,387 Views
14 Pages

Comparative Outcomes of Amblyopia Treatment in High Astigmatism: Stability and Sustained Improvements

  • Chia-Chen Hsu,
  • Lung-Chi Lee,
  • Hsu-Chieh Chang,
  • Chun-Hao Huang and
  • Ke-Hung Chien

20 May 2025

Background/Objectives: Astigmatism is a major risk factor for amblyopia. While optical correction improves visual acuity (VA), the long-term treatment outcomes, particularly in children with high astigmatism, remain understudied. This study aimed to...

  • Review
  • Open Access
2 Citations
5,415 Views
35 Pages

20 May 2025

Cardiovascular magnetic resonance imaging (MRI) is an advanced cardiac imaging modality that is often required when evaluating athletic individuals. Unrestricted imaging planes, excellent spatial resolution, and a lack of ionising radiation are some...

  • Article
  • Open Access
1 Citations
6,258 Views
11 Pages

Heart Rate Variability Prediction of Stimulant-Induced Creativity Gains in Attention-Deficit/Hyperactivity Disorder

  • Carrina Appling,
  • Nanan Nuraini,
  • Eric Hart,
  • David Wang,
  • Aneesh Tosh,
  • David Beversdorf and
  • Bradley Ferguson

20 May 2025

Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent condition etiologically related to suboptimal levels of dopamine (DA) and norepinephrine (NE) that is typically treated with psychostimulant medication. In i...

  • Article
  • Open Access
1 Citations
2,216 Views
10 Pages

Real-Time Measurement of Intrarenal Pressure Using LithoVue™ Elite: Focus on Small Ureteral Access Sheaths and Appropriate Irrigation Settings

  • Naoto Tanaka,
  • Jose Carlo Elises,
  • Fukashi Yamamichi,
  • Yasuhiro Kaku,
  • Yosuke Fukiishi,
  • Masaichiro Fujita and
  • Takaaki Inoue

20 May 2025

Background/Objectives: Intrarenal pressure (IRP) plays a critical role in ensuring the safety of retrograde intrarenal surgery (RIRS), as elevated IRP is associated with complications such as pyelovenous backflow, infection, and renal injury. LithoVu...

  • Review
  • Open Access
32 Citations
7,878 Views
40 Pages

20 May 2025

Background: Digital twin (DT) technology, integrated with artificial intelligence (AI) and machine learning (ML), holds significant potential to transform oncology care. By creating dynamic virtual replicas of patients, DTs allow clinicians to simula...

  • Article
  • Open Access
1 Citations
1,262 Views
8 Pages

20 May 2025

Background: Mixed urinary incontinence (MUI), particularly the urge-predominant subtype, involves both stress urinary incontinence (SUI) and urge urinary incontinence (UUI), posing a therapeutic challenge. Duloxetine, a serotonin–norepinephrine...

  • Article
  • Open Access
2 Citations
1,477 Views
9 Pages

20 May 2025

Objectives: To assess the long-term safety and efficacy of the Serasis® inside-out transobturator midurethral sling (MUS), a partially absorbable soft tape for stress urinary incontinence (SUI). Methods: A cohort study of 146 consecutive women wh...

  • Article
  • Open Access
1 Citations
1,622 Views
13 Pages

Glycocalyx Disintegration Is Associated with Mortality in Chronic Heart Failure

  • Patricia P. Wadowski,
  • Martin Hülsmann,
  • Irene M. Lang,
  • Christian Schörgenhofer,
  • Joseph Pultar,
  • Constantin Weikert,
  • Thomas Gremmel,
  • Sabine Steiner,
  • Renate Koppensteiner and
  • Bernd Jilma
  • + 1 author

20 May 2025

Background: Glycocalyx disintegration is associated with adverse outcomes in patients with trauma or sepsis. As microvascular dysfunction has an impact on disease progression in chronic heart failure (CHF) patients, we hypothesized that changes in mi...

  • Article
  • Open Access
1 Citations
1,631 Views
10 Pages

Postoperative Refractory Diarrhea After Margin Accentuation of the Superior Mesenteric Artery with Irreversible Electroporation in Pancreaticoduodenectomy

  • Eline-Alice Brys,
  • Filip Gryspeerdt,
  • Nikdokht Rashidian,
  • An Verena Lerut,
  • Pieter Dries,
  • Luís Abreu de Carvalho and
  • Frederik Berrevoet

20 May 2025

Background: Pancreatic ductal adenocarcinoma (PDAC) presents a challenge due to its poor prognosis. Irreversible electroporation (IRE) shows promise in improving margin clearance and increasing R0 and R1 indirect resection rates. Although IRE is beli...

  • Review
  • Open Access
2 Citations
29,586 Views
15 Pages

20 May 2025

Over the past two decades, cardiovascular disease (CVD) prevention guidelines have progressively lowered LDL-C targets to <70 mg/dL for high-risk individuals based on the assumption of a linear relationship between LDL-C levels and CVD risk. Howev...

  • Article
  • Open Access
2 Citations
1,026 Views
14 Pages

20 May 2025

Background/Objectives: Posterior pelvic ring fractures are severe injuries requiring surgical stabilization, often through sacroiliac (SI) screw fixation. However, improper screw placement poses risks of neurovascular injury and implant failure. Defi...

  • Article
  • Open Access
6,162 Views
11 Pages

The Effect of Eight Weeks of Passive Heat Therapy on Mental Health, Sleep, and Chronic Pain in Persons with Spinal Cord Injury: A Pilot Study

  • Hannah Uhlig-Reche,
  • Sven Hoekstra,
  • Yubo Wu,
  • Dean Lundt Kellogg,
  • Terry Romo,
  • Christof A. Leicht and
  • Michelle B. Trbovich

20 May 2025

Background/Objectives: Rates of depression, anxiety, sleep disturbances, and chronic pain are higher in people with spinal cord injury (SCI) compared with able-bodied individuals. Passive heat therapy (PHT), which raises core body temperature, may be...

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J. Clin. Med. - ISSN 2077-0383