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Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition
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Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2024

Special Issue Editor

Dr. Valentina Elisabetta Bounous

E-Mail Website
Guest Editor
1. Division of Obstetrics and Gynecology, Mauriziano Umberto 1st Hospital, Torino, Italy
2. School of Medicine, University of Torino, Torino, Italy
Interests: breast cancer surgery and treatment; menopause; menopause after cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a paper for the Special Issue “Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition”. The first Edition can be found at: https://www.mdpi.com/journal/jcm/special_issues/1F94118XMZ. Works focusing on the treatment of endometrial, cervical, ovarian, vulvar, and vaginal and breast cancers and also on survivorship after them are welcome.

The Special Issue will focus on the new findings in this area of expertise and will cover all the aspects of the path that women have to face. As regards treatment, the Special Issue will accept original articles or reviews on surgical treatment, radiotherapy, and systemic treatment for primary or recurrent disease.

Thanks to the progress in treatment for many gynecological cancers in the last few years, the quality of life of patients has become an important issue for clinicians. In particular, papers focusing on the side effects of treatment, such as lymphedema, on menopausal symptom treatment in this subset of patients, or on the important topic of fertility preservation for gynecological oncological patients are also invited.

Furthermore, we strongly believe that a 360° consideration of patients may lead to an improvement in the adherence to therapy and that the future of gynecological oncology might also look in this direction. We look forward to your contribution.

Dr. Valentina Elisabetta Bounous
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological cancers
  • endometrial cancer
  • ovarian cancer
  • cervical cancer
  • vulvar cancer
  • vaginal cancer
  • breast cancer
  • surgery
  • radiotherapy
  • systemic treatment
  • quality of life

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Related Special Issue

Published Papers (3 papers)

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Research

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30 pages, 829 KiB  
Article
Comprehensive Analysis of Predictors and Outcomes in Breast Cancer Screening in Romania: Insights from Demographic, Clinical, and Lifestyle Factors
by Oana Maria Burciu, Ioan Sas, Adrian-Grigore Merce, Simona Cerbu, Aurica Elisabeta Moatar, Adrian-Petru Merce and Ionut Marcel Cobec
J. Clin. Med. 2025, 14(5), 1415; https://doi.org/10.3390/jcm14051415 - 20 Feb 2025
Viewed by 488
Abstract
Background/Objectives: The primary purpose of this study is to provide a more in-depth insight into various demographic, clinical, and lifestyle factors in relation to breast cancer and to predict the extent to which certain variables described as “predictors” might lead to further investigation. [...] Read more.
Background/Objectives: The primary purpose of this study is to provide a more in-depth insight into various demographic, clinical, and lifestyle factors in relation to breast cancer and to predict the extent to which certain variables described as “predictors” might lead to further investigation. By analyzing a large cohort, we are able to provide valuable and up-to-date information on breast cancer screening, support breast specialists, and further enhance international screening guidelines. Methods: We screened for breast cancer in a population of women aged 50 to 69 years by using the standardized breast cancer imaging screening method (breast mammography) and ultrasonography as a complementary imagistic tool, and we compared the results with the gold standard, breast biopsy. For this, 58,760 women with no known history of breast cancer coming from 4 major regions of Romania (North-East, North-West, South-East, and West) were first evaluated through mammography. Out of these, 3197 women with positive mammograms subsequently underwent a breast ultrasound examination. The remaining 688 patients with positive breast ultrasound were further referred for a breast biopsy. Results: The statistical analysis revealed several predictors such as the body mass index (BMI), positive family medical history of breast cancer, age at first birth, and age at menopause that influenced the progression from mammography (first stage of the screening program) towards echography (additional imaging modality). Furthermore, we established that age, age at first birth, and BMI are significant predictors of progression from echography towards biopsy (the last stage of the screening program). Furthermore, by analyzing the number of positive biopsies (688) out of the total number of patients in the study (58,760), we calculated a total breast cancer detection rate of 8 per 1000 patients. Lastly, by studying the patient demographics in the context of breast cancer (BC) screening, we observed that participants coming from an urban environment presented a higher rate of positive mammographic results as compared to ones of rural provenience. Conclusions: Our study analyzed a large cohort of patients and offers real world data which shows that multiple factors were positively associated with an increased risk of BC. Older age, older age at first birth, and an older menopausal age are all estrogen-dependent risk factors that were linked with an increased breast cancer risk in our study. Furthermore, our findings concerning the rural/urban disparities and regional differences highlight the need for region-specific interventions to address lifestyle risk factors, improve healthcare access, and enhance breast cancer screening and follow-up protocols, particularly in underserved areas like the North-East and South-East regions. Full article
(This article belongs to the Special Issue Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition)
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9 pages, 218 KiB  
Article
Comparative Study of Mastectomy Surgical Techniques Followed by Reconstruction: Hydrodissection and Electrical Plasma Surgery
by Silvia Actis, Giulia Lavalle, Stefania Agus, Elena Paradiso, Francesca Accomasso, Carola Minella, Luca Giuseppe Sgro, Mario Boltri, Paolo Balocco, Annamaria Ferrero and Valentina Elisabetta Bounous
J. Clin. Med. 2025, 14(4), 1338; https://doi.org/10.3390/jcm14041338 - 18 Feb 2025
Viewed by 426
Abstract
Background/Objectives: Mastectomy is a surgical option for breast cancer when conservative treatment is unsuitable, and it is also performed prophylactically in high-risk women. Various surgical techniques can be used for mastectomy, including electrosurgery, which can cause thermal damage to tissues, reducing surgical [...] Read more.
Background/Objectives: Mastectomy is a surgical option for breast cancer when conservative treatment is unsuitable, and it is also performed prophylactically in high-risk women. Various surgical techniques can be used for mastectomy, including electrosurgery, which can cause thermal damage to tissues, reducing surgical precision and delaying wound healing. This study aims to compare electrical plasma surgery and hydrodissection, which appear to be the least traumatic methods, to determine the better option for performing mastectomy with immediate reconstruction. Methods: Conducted at the “Breast Unit” of AO “OrdineMauriziano Umberto I”, this study analyzed 56 patients undergoing 65 mastectomies (9 bilateral, 47 unilateral). A total of 16 were prophylactic, and 49 were oncologic. All patients received immediate subpectoral reconstruction. Data collected included preoperative medical history, pain, drain flow, blood transfusions, hemoglobin levels, and hospital stay duration. Complications were graded using the Clavien-Dindo classification. Results: Both groups were similar in age, body mass index (BMI), smoking habits, and comorbidities. Patients who underwent hydrodissection reported more pain on the first and second postoperative day and had longer hospital stays. The drop in hemoglobin from pre- to postoperative and the volume of surgical drains on the day of surgery and the first and second postoperative days were comparable between groups. Early complications and reintervention rates (Clavien-Dindo grade 3) were similar between techniques. Conclusions: Electrical plasma surgery offers better early postoperative outcomes in terms of pain and hospital stay, although overall complication and reintervention rates are unaffected by the technique used. Larger randomized studies are needed to confirm these findings and optimize patient management. Full article
(This article belongs to the Special Issue Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition)

Other

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9 pages, 7320 KiB  
Case Report
A Case Report of an Adenomatoid Tumor of the Fallopian Tube: The Histopathologic Challenges and a Review of the Literature
by Marcin Jozwik, Katarzyna Bednarczuk, Zofia Osierda, Joanna Wojtkiewicz, Janusz Kocik and Maciej Jozwik
J. Clin. Med. 2025, 14(3), 813; https://doi.org/10.3390/jcm14030813 - 26 Jan 2025
Viewed by 808
Abstract
Background: Adenomatoid tumor (AT) is a rare benign neoplasm of mesothelial origin, which mainly occurs in the male and female genital tracts. The most common site for AT occurrence in women is the uterus, which makes the presentation in the fallopian tube(s) [...] Read more.
Background: Adenomatoid tumor (AT) is a rare benign neoplasm of mesothelial origin, which mainly occurs in the male and female genital tracts. The most common site for AT occurrence in women is the uterus, which makes the presentation in the fallopian tube(s) a rarity with an incidence of approximately 0.5%. The reported extragenital sites include serosal surfaces, adrenal glands, and visceral organs, are even less common. Macroscopically, ATs present as white-grayish or yellowish irregular yet circumscribed firm nodules, often containing cystic components. Owing to a vast array of histomorphological growth patterns, ATs tend to mimic malignancy and trigger overresection. Such clinical situations have been described by several studies for the ovaries, uterus, and fallopian tubes, underlining the importance of differential diagnosis in order to avoid superfluous treatment. Methods: Herein, we report a presentation of an AT at the oviductal lumen, detected incidentally during prophylactic bilateral salpingo-oophorectomy in a 67-year-old patient with a BRCA1 mutation. Results: Immunohistochemical staining revealed a positive expression for calretinin, WT1, and cytokeratin 7, and negative expression for both PAX8 and CD34, thus confirming the diagnosis of AT and excluding tubal malignancy. Conclusions: This report, with a concise review of the global literature on tubal AT, brings attention to the solitary and asymptomatic nature of the tumor. With a clear diagnosis, no surgical radicality is necessary. Full article
(This article belongs to the Special Issue Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition)
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