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Clinical Advances in Obstructive Sleep Apnea
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Clinical Advances in Obstructive Sleep Apnea

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 619

Special Issue Editor

Prof. Dr. Akiko Noda

E-Mail Website
Guest Editor
Department of Biomedical Sciences, Chubu University Graduate School of Life and Health Sciences, Aichi, Japan
Interests: cardiovascular disease (heart failure, cardiac function), cognitive function (brain function), sleep disorder; exercise; hypertension; sleep apnea; insomnia; dementia; autonomic activity; drowsy driving
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sleep-disordered breathing (SDB), insomnia, and cognitive decline increase with aging. Repeated episodes of end-apneic arousal or hypoxia and consequent sleep fragmentation are associated with increased nocturnal blood pressure, possibly leading to sustained hypertension and atherosclerosis. The relationship between blood pressure levels and cognitive function differs across the lifespan. Hypertension and SDB may negatively affect cognitive function. The proper management of hypertension and SDB is important in mid- and late-life.

Prof. Dr. Akiko Noda
Guest Editor

Manuscript Submission Information

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Keywords

  • sleep apnea
  • hypertension
  • cardiovascular disease
  • dementia
  • endothelial dysfunction
  • atherosclerosis
  • heart failure

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Published Papers (1 paper)

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Research

13 pages, 814 KiB  
Article
Demographic and Sleep Study Factors Influencing Short-Term Adherence to Positive Airway Pressure Therapy in Obstructive Sleep Apnea
by Ji Ho Choi, Yeji Lee, Sungkyoung Shin, Tae Kyoung Ha and Sooyeon Suh
J. Clin. Med. 2025, 14(11), 3988; https://doi.org/10.3390/jcm14113988 - 5 Jun 2025
Viewed by 333
Abstract
Objective: Positive airway pressure (PAP) therapy effectively treats obstructive sleep apnea (OSA), yet adherence to the therapy presents significant challenges. This study identifies demographic and sleep study factors that influence short-term adherence to PAP therapy among patients with OSA by comparing data from [...] Read more.
Objective: Positive airway pressure (PAP) therapy effectively treats obstructive sleep apnea (OSA), yet adherence to the therapy presents significant challenges. This study identifies demographic and sleep study factors that influence short-term adherence to PAP therapy among patients with OSA by comparing data from adherent and non-adherent groups. Methods: Patients diagnosed with OSA via polysomnography who commenced PAP therapy after titration were divided into adherent and non-adherent groups. We employed propensity score matching in a 1:1 ratio based on age, gender, and body mass index (BMI), including a total of 150 patients in the analysis. Logistic regression analyses were conducted on all pertinent variables, excluding those with high multicollinearity. Non-significant variables were omitted from the final model, whose performance was evaluated using a receiver operating characteristic (ROC) curve, calculating the area under the curve (AUC). Results: Data from 150 participants (mean age 49.56 ± 14.31 years, 79% males, mean BMI 28.96 ± 5.11) were analyzed. Significant predictors of adherence included smoking status (odds ratio [OR] 0.267; 95% confidence interval [CI], 0.116–0.580; p = 0.001), Epworth sleepiness scale (OR 1.080; 95% CI, 1.004–1.166; p = 0.042), oxygen desaturation index (ODI) during titration (OR 0.906; 95% CI, 0.829–0.975, p = 0.015), and optimal PAP levels (OR 1.240; 95% CI, 1.007–1.119; p = 0.029). The ROC curve analysis indicated an AUC of 0.765, confirming the model’s effectiveness in distinguishing between adherent and non-adherent patients. Conclusions: Adherence is negatively affected by smoking, whereas higher daytime sleepiness, optimal PAP levels, and a lower ODI during titration are associated with better adherence, underscoring the importance of personalized treatment approaches. Full article
(This article belongs to the Special Issue Clinical Advances in Obstructive Sleep Apnea)
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