Table of Contents
Microorganisms, Volume 8, Issue 5 (May 2020) – 171 articles
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Cover Story (view full-size image) Filamentous bacteriophages are promising immunogenic carriers for antigen delivery. Their use is [...] Read more. Filamentous bacteriophages are promising immunogenic carriers for antigen delivery. Their use is based on the modification of phage display technology; in particular, multiple copies of exogenous peptides (or polypeptides) can be covalently linked to viral capsid proteins and expressed on the phage coat. This study, for the first time, proposes the use of polymeric poly (lactic-co-glycolic acid) (PLGA) microparticles (MPs), to encapsulate fd bacteriophage displaying antigenic peptides and to demonstrate the immunogenicity of the encapsulated bacteriophages after their release by MPs. Our results show that PLGA MPs-encapsulated bacteriophages are stable and retain their immunogenic properties, demonstrating that microparticles can represent an important tool for the development of bacteriophage-based immunotherapeutic platforms. View this paper