Table of Contents
Toxins, Volume 11, Issue 5 (May 2019)
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Cover Story (view full-size image) The cover depicts the mode of interaction (highlighted in red color) of ricin A chain (RTA) (green [...] Read more. The cover depicts the mode of interaction (highlighted in red color) of ricin A chain (RTA) (green color) with eukaryotic large ribosomal subunit (cryo-EM structure, blue color) to access the conserved sarcin/ricin loop (SRL) and remove a single adenine base, which blocks GTP hydrolysis and impedes the function of the translational machinery. This model demonstrates the evolutionary success of the plant toxin in winning the battle to access the GTPase-associated center—the energetic heart of the ribosome—and hijacking the ribosome P-stalk, which is regarded as a landing platform for translational GTPases. View this paper.