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Open AccessArticle

Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts

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Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy
2
Laboratory of Chemical, Galenic and Pharmacological Development of Drugs, Faculty of Pharmacy of Monastir, University of Monastir, 5000 Monastir, Tunisia
3
Tree and Timber Institute (IVALSA), National Research Council of Italy (CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy
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Department of Agriculture, Environment, Food and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Firenze, Italy
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Department of Packaging, Experimental Station for the Food Preserving Industry (SSICA), Viale Tanara 31/A, 43121 Parma, Italy
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Center for Molecular and Translational Oncology, Parco Area delle Scienze, 43124 Parma, Italy
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(5), 286; https://doi.org/10.3390/toxins11050286
Received: 15 April 2019 / Revised: 10 May 2019 / Accepted: 17 May 2019 / Published: 22 May 2019
(This article belongs to the Special Issue Biocontrol Agents and Natural Compounds against Mycotoxinogenic Fungi)
Citrullus colocynthis L. Schrader is an annual plant belonging to the Cucurbitaceae family, widely distributed in the desert areas of the Mediterranean basin. Many pharmacological properties (anti-inflammatory, anti-diabetic, analgesic, anti-epileptic) are ascribed to different organs of this plant; extracts and derivatives of C. colocynthis are used in folk Berber medicine for the treatment of numerous diseases—such as rheumatism arthritis, hypertension bronchitis, mastitis, and even cancer. Clinical studies aimed at confirming the chemical and biological bases of pharmacological activity assigned to many plant/herb extracts used in folk medicine often rely on results obtained from laboratory preliminary tests. We investigated the biological activity of some C. colocynthis stem, leaf, and root extracts on the mycotoxigenic and phytopathogenic fungus Aspergillus flavus, testing a possible correlation between the inhibitory effect on aflatoxin biosynthesis, the phytochemical composition of extracts, and their in vitro antioxidant capacities. View Full-Text
Keywords: antimycotoxigenic activity; Citrullus colocynthis; Aspergillus flavus; model system; HPLC-MS/MS antimycotoxigenic activity; Citrullus colocynthis; Aspergillus flavus; model system; HPLC-MS/MS
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MDPI and ACS Style

Degola, F.; Marzouk, B.; Gori, A.; Brunetti, C.; Dramis, L.; Gelati, S.; Buschini, A.; Restivo, F.M. Aspergillus flavus as a Model System to Test the Biological Activity of Botanicals: An Example on Citrullus colocynthis L. Schrad. Organic Extracts. Toxins 2019, 11, 286.

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