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Open AccessArticle

Fusaoctaxin A, an Example of a Two-Step Mechanism for Non-Ribosomal Peptide Assembly and Maturation in Fungi

1
Department of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark
2
Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad-Lorenz-Straße 24, Tulln an der Donau 3430, Austria
3
Division of Biotechnology and Plant Health, Norwegian Institute of Bioeconomy Research, 1433 Ås, Norway
4
Department of Chemistry and Bioscience, Aalborg University, Niels Bohrs Vej 8, 6700 Esbjerg, Denmark
*
Author to whom correspondence should be addressed.
Toxins 2019, 11(5), 277; https://doi.org/10.3390/toxins11050277
Received: 5 March 2019 / Revised: 13 May 2019 / Accepted: 14 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Recent Advances in Fusarium Research)
Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS. However, a recent study showed that the octapeptide fusaoctaxin A is tandemly synthesized by two NRPSs in Fusarium graminearum. Here, we illuminate parts of the biosynthetic route of fusaoctaxin A, which is cleaved into the tripeptide fusatrixin A and the pentapeptide fusapentaxin A during transport by a cluster-specific ABC transporter with peptidase activity. Further, we deleted the histone H3K27 methyltransferase kmt6, which induced the production of fusaoctaxin A. View Full-Text
Keywords: Fusarium; NRPS; secondary metabolites; Mycotoxins; ABC-transporter; peptidase Fusarium; NRPS; secondary metabolites; Mycotoxins; ABC-transporter; peptidase
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Westphal, K.R.; Nielsen, K.A.H.; Wollenberg, R.D.; Møllehøj, M.B.; Bachleitner, S.; Studt, L.; Lysøe, E.; Giese, H.; Wimmer, R.; Sørensen, J.L.; Sondergaard, T.E. Fusaoctaxin A, an Example of a Two-Step Mechanism for Non-Ribosomal Peptide Assembly and Maturation in Fungi. Toxins 2019, 11, 277.

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