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Journal of Xenobiotics, Volume 15, Issue 6

2025 December - 38 articles

Cover Story: The increasing production of plastic is leading to its accumulation and fragmentation in the environment, causing harmful effects to the biota. Bioplastics such as PLA are emerging as more environmentally friendly alternatives aimed at reducing the impact of plastics and the dependence on petrol-derived products. However, their environmental safety is still to be proven. This study addresses the potential accumulation and toxicity of PLA nanoplastics to three aquatic species: marine rotifers, brine shrimps and zebrafish embryos. Confocal microscopy demonstrates the accumulation of nanoparticles in the bodies of these organisms, but the biological parameters do not reveal acute toxic impact, indicating that the PLA polymer may be safe. Now, the challenge is to produce additive-containing formulations without increasing environmental risk. View this paper
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Articles (38)

  • Article
  • Open Access
644 Views
17 Pages

15 December 2025

The metallurgical industry generates substantial amounts of heavy metal-containing solid waste, posing significant environmental and health risks. This study systematically evaluates the environmental behavior and ecological risks of heavy metals in...

  • Article
  • Open Access
446 Views
11 Pages

12 December 2025

Silver nanomaterials (Ag NMs) are widely used, including in consumer products, and they inevitably enter the environment, with the soil compartment acting as a major sink. However, most available toxicity data focus on the reference Ag NM300K and rel...

  • Review
  • Open Access
1,796 Views
30 Pages

Sweeteners in E-Cigarettes: A Minireview of Flavoring and Biological Action

  • Volodymyr V. Tkach,
  • Tetiana V. Morozova,
  • Isabel Gaivão,
  • Ana Martins-Bessa,
  • Yana G. Ivanushko,
  • José Inácio Ferrão de Paiva Martins and
  • Ana Novo Barros

11 December 2025

The use of sweeteners in e-cigarette liquids has become increasingly common, aiming to enhance the sensory appeal of vaping products. Compounds like aspartame, saccharin, and sucralose are added to provide a sweet taste without any calories, especial...

  • Systematic Review
  • Open Access
1 Citations
1,021 Views
23 Pages

A Systematic Review on the Toxicology of European Union-Approved Triazole Fungicides in Cell Lines and Mammalian Models

  • Constantina-Bianca Vulpe,
  • Adina-Daniela Iachimov-Datcu,
  • Andrijana Pujicic and
  • Bianca-Vanesa Agachi

5 December 2025

Triazole fungicides are widely used in agriculture but may pose risks to human health through occupational, accidental, or environmental exposure. This systematic review aimed to evaluate the toxicity of ten European Union-approved triazole fungicide...

  • Review
  • Open Access
1 Citations
1,247 Views
29 Pages

Bisphenol A (BPA) Modifies Cancer Signaling Pathways: A Neglected Global Health Threat

  • Minatullah Al-Ani,
  • Yassir Al-Ani,
  • Shahad Sabaawi Ibrahim,
  • Raghad Sabaawi Ibrahim,
  • Peter Kubatka and
  • Dietrich Büsselberg

4 December 2025

Bisphenol A (BPA), a synthetic industrial compound widely found in plastics and other materials, has been linked to cancer development. As human exposure increases, BPA may pose potential carcinogenic concerns. Although BPA binds to estrogen receptor...

  • Review
  • Open Access
1,476 Views
31 Pages

2 December 2025

Pharmacological compounds can disrupt glucose homeostasis, leading to impaired glucose tolerance, hyperglycemia, or newly diagnosed diabetes, as well as worsening glycemic control in patients with pre-existing diabetes. Traditional risk factors alone...

  • Review
  • Open Access
935 Views
31 Pages

2 December 2025

Alternaria mycotoxins represent a significant and emerging concern in the field of food safety due to their widespread occurrence in diverse food and feed commodities, including cereals, tomatoes, oilseeds, and dried fruits. Among these, alternariol...

  • Review
  • Open Access
899 Views
22 Pages

Hazards and Health Risks of the Antibacterial Agent Triclosan to Fish: A Review

  • Jiangang Wang,
  • Nannan Ma,
  • Gancong Mo,
  • Xian Qin,
  • Jin Zhang,
  • Xiangping Yao,
  • Jiahua Guo and
  • Zewei Sun

2 December 2025

Triclosan (TCS) is a widely used antimicrobial agent found in personal care products and household cleaners. While valued since the 1960s for its ability to inhibit bacterial fatty acid synthesis, its environmental persistence, ecotoxicity, and bioac...

  • Article
  • Open Access
559 Views
12 Pages

In Vitro Cytotoxic and Genotoxic Evaluation of Nitazenes, a Potent Class of New Synthetic Opioids

  • Francesca Rombolà,
  • Sara Bartoletti,
  • Sabrine Bilel,
  • Patrizia Hrelia,
  • Matteo Marti and
  • Monia Lenzi

2 December 2025

In recent years, the expansion of the illicit market for Novel Psychoactive Substances (NPS) has resulted in the emergence of numerous synthetic recreational drugs specifically designed to evade legal control and analytical detection. Among these, ni...

  • Article
  • Open Access
998 Views
23 Pages

2 December 2025

Exposure to environmental pollutants, including toxic metals, volatile organic compounds (VOCs), and per- and polyfluoroalkyl substances (PFAS), has been increasingly linked to impaired kidney function. However, the combined effects of these exposure...

  • Perspective
  • Open Access
915 Views
25 Pages

1 December 2025

This paper explores the evolving integration of the One Health framework into the European regulatory landscape for plant protection products, focusing on key scientific and procedural challenges. The analysis addresses three fundamental components o...

  • Article
  • Open Access
838 Views
21 Pages

Metabolic Profiling and In Vitro Assessment of the Immunomodulatory Effects of Hydrodistillation-Derived Extracts from the Fruticose Lichen Pseudevernia furfuracea (L.) Zopf. on Human Lymphocytes

  • Yasser Essadki,
  • Antonio Casas-Rodríguez,
  • Antonio Cascajosa-Lira,
  • Leticia Diez-Quijada,
  • Alexandre Campos,
  • Vitor Vasconcelos,
  • Fatima El Khalloufi,
  • Brahim Oudra,
  • Ana M. Cameán and
  • Angeles Jos

1 December 2025

Lichens are complex symbiotic systems known for synthesizing diverse secondary metabolites with documented antimicrobial, antioxidant, and antiproliferative activities. The present study focused on Pseudevernia furfuracea, a species widely distribute...

  • Article
  • Open Access
759 Views
14 Pages

Environmental Exposure to Cadmium and Lead Exacerbates Kidney Function in People with Diabetes

  • Soisungwan Satarug,
  • David A. Vesey,
  • Tanaporn Khamphaya,
  • Donrawee Waeyeng and
  • Supabhorn Yimthiang

1 December 2025

This study investigates the relationship between kidney function and exposure to low-level cadmium (Cd) and lead (Pb) in individuals with and without diabetes. Specifically, it tests the hypothesis that the nephrotoxicity of Cd and Pb reduces the tub...

  • Article
  • Open Access
1,127 Views
29 Pages

Indoor Airborne VOCs from Water-Based Coatings: Transfer Dynamics and Health Implications

  • Jana Růžičková,
  • Helena Raclavská,
  • Marek Kucbel,
  • Pavel Kantor,
  • Barbora Švédová and
  • Karolina Slamová

1 December 2025

Volatile organic compounds (VOCs) emitted from indoor surface coatings can significantly impact indoor air quality and health. This study compared emissions from water-based polyurethane (PUR) and acrylate–polyurethane (ACR–PUR) coatings,...

  • Article
  • Open Access
570 Views
12 Pages

1 December 2025

There is an urgent need to evaluate the toxicity of xenobiotics and environmental mixtures for preventing loss in water quality for the sustainability of aquatic ecosystems. A simple prebiotic chemical pathway based on malate formation from pyruvate...

  • Article
  • Open Access
1,218 Views
24 Pages

PLA Nanoplastics Accumulate but Do Not Cause Acute Toxicity to Marine Rotifers, Brine Shrimps, and Zebrafish Embryos

  • Doyinsola Suliat Mustapha,
  • Olga Rodríguez-Díaz,
  • Miren P. Cajaraville and
  • Amaia Orbea

12 November 2025

Conventional plastics are widely utilised across industrial sectors and in consumer products. However, the growing use of plastics has led to plastic pollution, including the formation of nanoplastics (NPs), which are harmful to aquatic organisms. Bi...

  • Communication
  • Open Access
1 Citations
621 Views
8 Pages

Polybrominated Diphenyl Ethers (PBDEs) in PM1 of Residential Indoor Air: Levels, Seasonal Variability, and Inhalation Exposure Assessment

  • Darija Klinčić,
  • Karla Jagić Nemčić,
  • Ivana Jakovljević,
  • Marija Jelena Lovrić Štefiček and
  • Marija Dvoršćak

12 November 2025

Indoor exposure to polybrominated diphenyl ethers (PBDEs), particularly those bound to fine particulate matter (PM1, particles < 1 µm), may pose a health concern, especially in light of prolonged indoor occupancy and the capacity of ultrafin...

  • Systematic Review
  • Open Access
1 Citations
2,238 Views
24 Pages

A Systematic Review: Migration of Chemical Compounds from Plastic Material Containers in Food and Pharmaceutical Fields

  • Laura Culleré,
  • Estela Sangüesa,
  • Laura Lomba,
  • María Pilar Ribate,
  • Estefanía Zuriaga and
  • Cristina B. García

11 November 2025

A systematic review was conducted on the migration of compounds from plastic containers in the food and pharmaceutical industries, using Web of Science databases and following PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Me...

  • Article
  • Open Access
1 Citations
1,306 Views
23 Pages

Bioaccumulation and Transfer of Potentially Toxic Elements in the Yam-Soil System and Associated Health Risks in Kampala’s Luzira Industrial Area

  • Gabson Baguma,
  • Gadson Bamanya,
  • Hannington Twinomuhwezi,
  • Allan Gonzaga,
  • Timothy Omara,
  • Patrick Onen,
  • Simon Ocakacon,
  • Christopher Angiro,
  • Wilber Waibale and
  • Ronald Ntuwa

11 November 2025

Rapid industrialization in peri-urban centers has accelerated the accumulation of potentially toxic elements (PTEs) in agricultural soils, with implications for food safety and public health concerns. This study quantified PTEs (Cu, Cd, Cr, Pb, and Z...

  • Article
  • Open Access
1,112 Views
14 Pages

10 November 2025

This study analyzed 5731 Egyptian onion samples collected from 2021 to 2024 to detect 430 pesticide residues and evaluate occurrence patterns, EU Maximum Residue Limits (MRLs) compliance, multiple residue prevalence, and consumer health implications....

  • Article
  • Open Access
513 Views
17 Pages

Sustainable Biochar–Alumina Composites for Electroanalytical Sensing of Herbicide and Antibiotic

  • Nataša Jović-Jovičić,
  • Tatjana Novaković,
  • Tanja Barudžija,
  • Marija Ajduković,
  • Natalia Czerwinska,
  • Chiara Giosuè and
  • Zorica Mojović

10 November 2025

The problem of water pollution by various xenobiotics has gained a lot of interest due to their persistence, bioaccumulation potential, and toxic effects on ecosystems and humans. Electrochemical sensors offer a rapid, sensitive, and cost-effective m...

  • Review
  • Open Access
1,189 Views
25 Pages

A Double Challenge for Fish: The Combined Stress of Warming and Pharmaceuticals in Aquatic Systems

  • Tiago Lourenço,
  • Maria João Rocha,
  • Eduardo Rocha and
  • Tânia Vieira Madureira

8 November 2025

Aquatic ecosystems are increasingly threatened by multiple anthropogenic stressors, notably climate change and pollution by pharmaceuticals. Global warming is predicted to raise water temperatures by 2–5 °C by the end of the century. As ect...

  • Article
  • Open Access
676 Views
26 Pages

Low Concentrations of Sulfoxaflor Do Not Adversely Affect mRNA Levels in Various Testicular Cells When Administered to Either Mature or Immature Mice

  • Hayato Terayama,
  • Kenta Nagahori,
  • Daisuke Kiyoshima,
  • Tsutomu Sato,
  • Yoko Ueda,
  • Masahito Yamamoto,
  • Kaori Suyama,
  • Tomoko Tanaka,
  • Midori Yamamoto and
  • Kou Sakabe
  • + 5 authors

7 November 2025

Sulfoxaflor, an insecticide, acts on nicotinic acetylcholine receptors. It has a functional group similar to that of neonicotinoid insecticides, which are testicular toxicants. Recently, the adverse effects of sulfoxaflor on the testes have been repo...

  • Review
  • Open Access
996 Views
30 Pages

7 November 2025

Cyclic nitramine explosives such as octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) are xenobiotics that are utilized in a v...

  • Review
  • Open Access
3 Citations
3,767 Views
45 Pages

Global Evidence on Monitoring Human Pesticide Exposure

  • Tatiane Renata Fagundes,
  • Carolina Coradi,
  • Beatriz Geovana Leite Vacario,
  • Juliana Maria Bitencourt de Morais Valentim and
  • Carolina Panis

7 November 2025

This study analyzes global data on human exposure to pesticides, focusing on glyphosate, POPs, carbamates, and organophosphates, which are among the most widely used in agricultural and urban environments, providing an overview of global human contam...

  • Review
  • Open Access
1 Citations
1,149 Views
16 Pages

Microplastic Polymer Mass Fractions in Marine Bivalves: From Isolation to Hazard Risk

  • Tanja Bogdanović,
  • Irena Listeš,
  • Jennifer Gjerde,
  • Sandra Petričević,
  • Zvonimir Jažo,
  • Eddy Listeš,
  • Jelka Pleadin,
  • Darja Sokolić,
  • Ivona Jadrešin and
  • Federica di Giacinto

6 November 2025

Microplastics (MPs) are a ubiquitous marine pollutant, and their presence in bivalves is receiving increasing attention due to the associated risks to human health. The steps of pretreatment, detection, and quantification in the analysis of MPs depen...

  • Article
  • Open Access
1 Citations
1,140 Views
22 Pages

Ecological and Human Health Risks from Potentially Toxic Elements in Environmental Matrices of Kiteezi Landfill, Uganda

  • Emmanuel Ebbu,
  • Irene Nalumansi,
  • Ivan Kiganda,
  • Caroline Kiwanuka Nakiguli,
  • Patrick Onen,
  • Simon Ocakacon,
  • Christopher Adaku,
  • Timothy Omara and
  • Emmanuel Ntambi

4 November 2025

By the time of this study, Kiteezi landfill was Uganda’s largest waste disposal site and received substantial volumes of municipal solid waste. In the present study, water (n = 36), leachates (n = 36), superficial sediments (n = 30), and Coloca...

  • Article
  • Open Access
781 Views
23 Pages

Aqueous Extract of Limnospira platensis Provides Protection Against Microcystin-Induced Oxidative Stress in Hydroponic Culture of Radish (Raphanus sativus)

  • Mohammed Haida,
  • Badr Ezzyky,
  • Zineb Hakkoum,
  • Richard Mugani,
  • Yasser Essadki,
  • Fatima El Khalloufi,
  • Abdelmajid Haddioui,
  • Mohamed Loukid,
  • Brahim Oudra and
  • Noureddine Bouaïcha

1 November 2025

The eutrophication of aquatic ecosystems often triggers the excessive growth of cyanobacteria, many of which release toxic metabolites such as microcystins (MCs). When irrigation water is contaminated by these compounds, adverse consequences may aris...

  • Article
  • Open Access
833 Views
15 Pages

Surfactant Protein D Mediates the Association Between Smoking and Type 2 Diabetes Mellitus Incidence in the Spanish Adult Population: Di@bet.es Study

  • Wasima Oualla-Bachiri,
  • Ana Lago-Sampedro,
  • Eva García-Escobar,
  • Cristina Maldonado-Araque,
  • Viyey Doulatram-Gamgaram,
  • Marta García-Vivanco,
  • Fernando Martín-Llorente,
  • Juan Luis Garrido,
  • Elías Delgado and
  • Gemma Rojo-Martínez
  • + 6 authors

1 November 2025

It is well known that environmental factors influence the risk of type 2 diabetes mellitus (T2DM). Several studies have linked the xenobiotics present in tobacco or air pollutants to T2DM development, although the underlying mechanisms remain unclear...

  • Article
  • Open Access
720 Views
16 Pages

Hematological and Biochemical Alterations Induced by Sub-Acute Administration of Permethrin in Rats

  • Liliana Carmona-Aparicio,
  • Elvia Coballase-Urrutia,
  • Marisol Orozco-Ibarra,
  • Norma Serrano-García,
  • Silvia Caballero-Salazar,
  • Maritza Ramírez-Pérez,
  • Liliana Rivera-Espinosa,
  • María E. Hernández,
  • Hortencia Montesinos-Correa and
  • Daniel Diaz
  • + 1 author

1 November 2025

Permethrin (PERM) is a synthetic pyrethroid insecticide initially regarded as low risk. However, evidence now indicates that misuse and prolonged exposure can damage multiple physiological systems by disrupting enzymatic functions in subcellular stru...

  • Article
  • Open Access
1 Citations
878 Views
17 Pages

Combined Climate and Chemical Stressors: How Spatial Variability Shapes the Response of Ficopomatus enigmaticus (Fauvel, 1923) to Dimethyl Sulfoxide (DMSO) and Heatwaves, and What It Means for Ecotoxicology

  • Verdiana Vellani,
  • Manuela Piccardo,
  • Francesca Provenza,
  • Serena Anselmi,
  • Valentina Pitacco,
  • Lovrenc Lipej,
  • Stanislao Bevilacqua and
  • Monia Renzi

1 November 2025

Ficopomatus enigmaticus, a reef-forming serpulid, has emerged as a promising candidate for biomonitoring and ecotoxicology studies. Recent research has focused on adult stress responses, highlighting the need to understand population-specific respons...

  • Article
  • Open Access
956 Views
11 Pages

Bisphenol A Levels in Pasteurized Milk Marketed in Plastic Packaging and Associated Health Risk Assessment: A Pilot Study

  • El Amine Cheroual,
  • Khatima Mezhoud,
  • Ilaria Neri,
  • Ouahiba Hadjoudj and
  • Lucia Grumetto

1 November 2025

Bisphenol A (BPA) is a synthetic estrogen widely used in the manufacture of food packaging materials, raising concerns due to its potential migration into food products. This study aims to determine BPA levels in pasteurized milk marketed in Algeria,...

  • Systematic Review
  • Open Access
995 Views
24 Pages

1 November 2025

Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants produced by the incomplete combustion of fuels and biomass. They are highly persistent and can accumulate in the food chain. Honey, a natural product susceptible to atmospheric deposition,...

  • Article
  • Open Access
1 Citations
1,316 Views
27 Pages

1 November 2025

People are exposed to mixtures of metals, per- and polyfluoroalkyl substances (PFAS), phthalates, and polycyclic aromatic hydrocarbons (PAH) rather than single chemicals, yet mixture inference is hampered by high dimensionality, correlation, missingn...

  • Article
  • Open Access
1 Citations
455 Views
14 Pages

1 November 2025

Recently developed quantitative structure–activity relationship (QSAR) prediction uses machine learning techniques with analytical signals from the full scan of mass spectra as input, and does not need exhaustive structural determination to ass...

  • Article
  • Open Access
849 Views
15 Pages

Influence of Pristine and Photoaging Polystyrene Microspheres on Sperm Quality and DNA Integrity of the Sand Dollars Scaphechinus mirabilis

  • Andrey Alexandrovich Mazur,
  • Sergey Petrovich Kukla,
  • Victor Pavlovich Chelomin,
  • Valentina Vladimirovna Slobodskova and
  • Nadezhda Vladimirovna Dovzhenko

23 October 2025

Plastic pollution represents a significant emerging environmental problem. Micro-sized particles of synthetic polymers—microplastics (MPs)—have been identified in all parts of marine ecosystems. In the marine environment, organisms are ex...

  • Article
  • Open Access
752 Views
15 Pages

Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds

  • Yosita Kasemnitichok,
  • Sion Lee,
  • Oh Bin Kwon,
  • Tullayakorn Plengsuriyakarn and
  • Kesara Na-Bangchang

22 October 2025

Curcumin (CUR), atractylodin (ATD), α-mangostin (αMG), ethyl-p-methoxycinnamate (EPMC), ligustilide (LIG), and β-eudesmol (BEU) are commonly used in Thai traditional medicine formulations. This study evaluated the cytotoxic effects o...

  • Article
  • Open Access
1 Citations
835 Views
17 Pages

22 October 2025

This study investigated water quality, metal ion concentrations, and antibiotic residues specifically enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP), across six American shad (Alosa sapidissima) aquaculture sites over a one-year period. Wa...

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J. Xenobiot. - ISSN 2039-4713