1 November 2026
Cellular responses to silver nanoparticles (AgNPs) may differ across cytogenetic, proliferative, cell-death, and molecular endpoints, making their joint interpretation relevant for integrated response profiling. This descriptive two-donor pilot study...
1 November 2026
Fosfomycin is an antibiotic of growing interest for the treatment of infections caused by multidrug-resistant bacteria. Its marked pharmacokinetic variability, especially in critically ill patients, makes therapeutic drug monitoring (TDM) useful to e...
1 November 2026
Cell identity within the human urogenital tract is strongly influenced by hormonal signaling, yet increasing evidence suggests that epithelial differentiation may also be shaped by microenvironmental cues. In this study, we investigated how hormonal...
1 November 2026
Paternal preconception health is increasingly recognized as an important determinant of reproductive success and offspring development. Plastic-associated contaminants, including endocrine-disrupting chemicals, microplastics, and nanoplastics, have b...
31 October 2026
Underground vegetables are important sources of nutrients, but may accumulate potentially toxic elements (PTEs) from contaminated soils. This study determined twelve PTEs (Hg, Pb, Mn, Cr, Ni, Cu, Zn, Co, Fe, Al, Cd, and As) by ICP-MS in 32 composite...
Background: In 2023, community-initiated biomonitoring was conducted among residents near the Daikin Industries Yodogawa Plant (DIYP), where PFOA contamination had previously been identified. Methods: Serum PFOA and questionnaire data were analyzed i...
The objective of this study was to examine the interactions between 16 polycyclic aromatic hydrocarbons (PAHs) and six metals, namely the xenobiotic metals cadmium (Cd), lead (Pb), and arsenic (As) and the essential metals copper (Cu), zinc (Zn), and...
Dissociative substances are xenobiotics that can cause clinically meaningful disruption to the integration of perception, cognition, bodily awareness, and environmental awareness. This narrative review evaluates eight primary substances grouped acros...
Background: Silymarin is widely used as a hepatoprotective and nephroprotective agent. However, its potential to interact with renal organic anion transporters (OATs) remains poorly understood. This study investigated the effects of silymarin and its...
Ethylene glycol (EG) poisoning is a potentially life-threatening intoxication that can cause neurological toxicity, metabolic acidosis, acute kidney injury, and multiorgan failure. Although serum EG concentrations are useful for guiding treatment, ti...
Anticoagulant rodenticide (AR) poisoning may cause prolonged and potentially life-threatening coagulopathy, while confirmation of exposure can be challenging when the exposure history is unclear. We developed and validated a simplified liquid chromat...
Medicinal and edible plants are valuable sources of biologically active compounds whose composition may vary with botanical identity, geographical origin, environmental conditions, and post-harvest processing. In addition to essential mineral constit...
Clams represent an important part of the marine benthic community and are food sources for invertebrates (worms, amphipods), fish, and mammals. The purpose of this study was to examine the contamination and health status of feral Mya arenaria clam po...
Background/Objectives: Rabeprazole differs from other proton pump inhibitors (PPIs) in its activation and lower dependence on CYP2C19. We compared its System Organ Class (SOC)-level reporting profile with those of esomeprazole, pantoprazole, omeprazo...
Background: Rhabdomyolysis (RM)-induced acute kidney injury (RIAKI) is a common clinical complication with an increasing incidence. Despite optimal care, the mortality rate is almost 15% due to limited pharmacological interventions. Dipyridamole (DPM...
Periploca chevalieri (Apocynaceae Juss.) is an endemic medicinal plant from Cabo Verde that has long been used in traditional medicine, particularly for the management of diabetes and cough. However, to date, no studies focusing on potential adverse...
Cadmium is a widespread environmental toxicant associated particularly with renal tubular injury and skeletal disease. Human evidence regarding chelation-enhanced cadmium elimination is limited. This retrospective paired analysis evaluated changes in...
Tacrolimus (TAC) therapeutic drug monitoring (TDM) routinely monitors whole-blood TAC concentrations; however, these measurements may not accurately reflect renal TAC exposure. We investigated the relationship between whole-blood and kidney tissue TA...
With rapid technological advancement and accelerating industrialization, legacy chemicals and emerging contaminants have caused increasingly severe adverse impacts on ecological environments and human health due to their persistence, bioaccumulation,...
Mining environments are extreme subsurface ecosystems characterized by elevated concentrations of metals and minerals, limited light, and high particulate loads. Occupational health research in mining has traditionally emphasized physical and chemica...
Opioid neurotoxicity is increasingly associated with oxidative stress, mitochondrial dysfunction, and DNA damage; however, direct mechanistic comparisons among structurally diverse opioids remain scarce. We comparatively evaluated morphine, codeine,...
Breast cancer is a heterogeneous disease driven by complex interactions between genetic, hormonal, metabolic, lifestyle, and environmental factors. Among environmental exposures, agricultural pesticides represent potential contributors to breast carc...
Background: Ambient air pollution is a pervasive exposure during pregnancy and childhood, when the central nervous system undergoes rapid development. Objective: To critically examine selected cohort evidence on prenatal and early-childhood exposure...
Zinc oxide nanoparticles (ZnO NPs) rank among the highest-volume engineered nanomaterials, and their partial dissolution generates a composite particle and ion exposure that converges on three measurable molecular layers. This review consolidates qua...
Hydroxylated polychlorinated biphenyls (OH-PCBs) are biologically active metabolites that may contribute to adverse respiratory outcomes, yet their effects on the developing lung remain poorly characterized. This study investigated the impact of 2,2&...
Lithium (Li) mining is one of the most critical strategic resources for sustainable development in the world. However, sources of heavy metals in Li mining have received limited attention. To explore the features and origins of heavy metals in Li min...
Soil contamination by potentially toxic elements (PTEs) remains a major global challenge due to their persistence, toxicity, and bioaccumulation capacity. Despite being widely used for the ex situ remediation of soils polluted by organic contaminants...
The development of an accurate method to extract polycyclic aromatic hydrocarbon (PAH) from water samples is crucial for assessing environmental contamination and protecting public health. Solid-phase extraction (SPE) remains the selected technique f...
Air pollution is a major public health problem worldwide, causing millions of premature deaths every year due to its association with diseases of the respiratory, cardiovascular, neurological, metabolic and carcinogenic systems. A major mechanism of...
Accumulating epidemiological evidence links ambient PM2.5 exposure to elevated Parkinson’s disease (PD) risk, yet the neurotoxicity triggered by PM2.5 multi-pollutant mixtures under real co-exposure scenarios remains insufficiently elucidated....
Polylactic acid (PLA) is among the most widely used biodegradable, biobased polymers, yet it can persist in soils and waters, where accumulation may affect plants and agroecosystems. This narrative, mechanistic review asks why PLA behaves differently...
Organophosphate (OP) pesticide exposure occurs as complex mixtures, yet joint associations with DNA methylation-derived aging measures remain poorly characterized. We examined six urinary dialkylphosphate (DAP) metabolites in relation to epigenetic a...
Environmental lead (Pb) exposure has been proposed as a contributor to glucose dysregulation and type 2 diabetes mellitus (T2DM), but epidemiological consistency, causal interpretation, and human relevance of experimental models remain uncertain. Her...
The impact of bisphenols on the metabolism and kidney function of pregnant women, and consequently on the health of the child, is not yet well known. This study investigated urinary concentrations of bisphenols (BPA, BPF, and BPS) and their associati...
Isometamidium chloride (ISM) is a widely used trypanocidal drug for treating animal trypanosomiasis, despite concerns about toxicity, and emerging drug resistance. A comprehensive in silico evaluation integrating molecular interaction analysis, pharm...
The market for traditional non-selective herbicides has undergone dramatic changes over the past decade. As an emerging herbicide, glufosinate-ammonium’s market share has been steadily increasing. However, with its widespread use, glufosinate-a...
Tyre granule-based artificial turf surfaces are currently a matter of debate. Most of the Agencies involved in environmental and health protection have stated a negligible/virtually negligible risk to health and have issued a general call for caution...
In the context of the global transition towards a more sustainable economy, the use of bioplastics (BPs) is rapidly increasing across several sectors, including industry, medicine and cosmetics. Among BPs, polylactic acid (PLA) is the “polymer...
Metal–organic frameworks (MOFs) possess remarkable physicochemical properties, making them highly attractive candidates for advanced drug delivery, catalysis, water purification, gas separation, and biomedical application. Thus, it is important...
Heavy metals and metalloids are persistent environmental contaminants that accumulate in the central nervous system and interact with endogenous essential metals, yet most neurotoxicological research continues to treat metals as independent agents ra...
Obesity is a disease characterized by excessive accumulation of adipose tissue. It is a multifactorial condition arising from complex interactions among genetic background, lifestyle-related factors (such as physical inactivity, socioeconomic and cul...
Air pollution and temperature are important environmental risk factors for mortality, but variation in risks across causes of death, population groups, and co-exposure conditions remains incompletely characterised. This study used nationwide monthly...
Ultrashort-chain (USC) per- and polyfluoroalkyl substances (PFAS) are increasingly detected in environmental and drinking water systems, yet information regarding their occurrence in alcoholic beverages remains limited. The analysis of USC PFAS in wi...
Cyclo(Pro-Tyr), a marine-derived cyclic dipeptide, has demonstrated anticancer activity, but its toxicological profile remains insufficiently characterized. The present study evaluated the preliminary toxicological effects of Cyclo(Pro-Tyr) using com...
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by chronic inflammation, insulin resistance, and reproductive dysfunction. Although empagliflozin, a sodium-glucose cotransporter-2 inhibitor, has demonstrated anti...
Pesticide contamination of food and environmental matrices represents a potential risk to human health. This study investigated the toxicological effects of commercial glyphosate and dicamba-based herbicide formulations, individually and in combinati...
Atmospheric particulate matter (PM) is a heterogeneous carrier of toxic metals whose environmental fate and biological effects depend on particle size, source-related composition, chemical form, solubility, and bioaccessibility. Lead (Pb), cadmium (C...
Pesticides represent a significant threat to aquatic ecosystems due to their persistence and widespread use in agricultural areas, altering environments and exerting adverse effects on non-target organisms. Tebuthiuron is a phenylurea herbicide exten...
Eastern Croatia includes settlements with historically elevated arsenic (As) concentrations in drinking water. Of 488 recruited adults, nine were excluded solely because no questionnaire was available; the exclusion was independent of measured arseni...
Background: Thyroid hormone synthesis, deiodination, and redox regulation depend on iodine availability and selenium-dependent proteins. Therefore, these nutrients may alter sensitivity to thyroid disturbance brought on by metals and metalloids; neve...
