Innovative Models for SARS-CoV-2 Pathogenesis
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 23
Special Issue Editor
Interests: SARS-CoV-2
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is with great pleasure that we invite researchers to contribute to our forthcoming Special Issue titled “Innovative Models for SARS-CoV-2 Pathogenesis”. The aim of this Special Issue is to provide readers with cutting-edge insights into the mechanisms of SARS-CoV-2 infection while highlighting innovative experimental models that advance our understanding of viral pathogenesis.
Since its emergence in late 2019, SARS-CoV-2 has posed unprecedented challenges to global health, reshaping scientific priorities. Despite remarkable progress in vaccine development and therapeutic interventions, the complexity of SARS-CoV-2 pathogenesis continues to demand rigorous investigation. The virus displays unique interactions with the host, evading defense mechanisms and inducing a broad spectrum of clinical manifestations. Understanding these processes requires robust experimental models that can faithfully recapitulate the molecular and cellular events underlying infection.
In this regard, advances in cellular systems, organoids, and engineered tissue models have provided invaluable platforms to study viral entry, replication, and host–pathogen interactions at unprecedented resolution. In parallel, animal models (from murine systems to non-human primates) have shed light on disease dynamics, immune dysregulation, and therapeutic efficacy in vivo. These complementary approaches not only enhance our knowledge of SARS-CoV-2 biology but also lay the foundation for preparedness against future coronavirus outbreaks.
We invite researchers to contribute with their work to this Special Issue in the form of original articles, systematic reviews, and brief communications. Contributions addressing the development and application of cellular systems, organoids, and animal models to study SARS-CoV-2 will be especially welcomed, as they provide crucial insights into the design of diagnostic strategies and therapeutic interventions.
Best regards,
Dr. Virginia Lotti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- SARS-CoV-2
- coronavirus
- virus infection
- pathogenesis
- innovative models
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