Molecular Mechanisms of Cellular Senescence and Aging

Dear Colleagues,

Cellular senescence is a fundamental hallmark of aging characterized by irreversible cell cycle arrest. Mounting evidence indicates that cellular senescence is a fundamental driver of aging and a wide range of age-associated pathologies. Senescence can be triggered by diverse stresses: DNA damage, telomere attrition, oncogene activation, epigenetic alterations, mitochondrial dysfunction, proteotoxic stress, and metabolic perturbations. A defining feature of senescence is the senescence-associated secretory phenotype (SASP), a complex secretome that impacts tissue homeostasis and inflammatory responses. The other defining feature is increased resistance to apoptosis. Numerous studies revealed substantial heterogeneity among senescent cells with respect to their initiating stimuli, biomarkers, secretory profiles, biological functions and molecular mechanisms governing the initiation, maintenance and propagation of senescence.

This Special Issue welcomes original research and reviews that advance our understanding of the diverse molecular mechanisms underlying cellular senescence, aging, and age-related diseases and explore potential therapeutic strategies targeting senescence and senescence-associated pathways.

Dr. Yang Yang
Guest Editor

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