Aortic stenosis (AS) is associated with the development of replacement myocardial fibrosis/scar. Given the dose-dependent relationship between scar and clinical outcomes after aortic valve replacement (AVR) surgery, scar quantity may serve as an impo...
Background: An important determinant of mortality in AS is the presence and quantity of myocardial scar. Scar quantification using late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging may be a useful risk-stratificatio...
Very few objective scar evaluations have been conducted with burn survivors, which limits our knowledge of the clinical recovery profile of hypertrophic scars (HSc) and donor site scars (D). The purpose of this study was to prospectively quantify the...
Background/Objectives: Cardiac magnetic resonance (CMR) imaging is a key tool for diagnosing cardiovascular disease, but its analysis remains time-consuming and dependent on expert interpretation, which can limit throughput and reproducibility. To ad...
In the past, climate change led the United Nations to define the Sustainable Development Goals Statement “blueprint to achieve a better and more sustainable future” and the European Commission to promote the “bioeconomy” conce...
Background: In arrhythmogenic right ventricular cardiomyopathy (ARVC) non-invasive scar evaluation is not included among the diagnostic criteria or the predictors of ventricular arrhythmias (VA) and sudden death (SD). Computed tomography (CT) has exc...
Late gadolinium enhancement (LGE) MRI is the gold standard technique for myocardial viability assessment. Although the technique accurately reflects the damaged tissue, there is no clinical standard to quantify myocardial infarction (MI). Moreover, c...
Aim: In patients meeting the criteria for LV apical ballooning syndrome, CMR typically identifies myocardial oedema without Late Gadolinium Enhancement (LGE). However, LGE does not exclude LV apical ballooning syndrome and small necrotic areas can be...
Late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) permits non-invasive quantification of myocardial fibrosis; however, automated scar segmentation remains challenging due to limited expert annotations and reduced image quality c...
One of the most prevalent causes of olfactory loss includes traumatic brain injury with subsequent shearing of olfactory axons at the level of the cribriform plate (anterior skull base). Scar tissue at this level may prevent axonal regrowth toward th...
Cardiac magnetic resonance imaging (MRI) is increasingly recognized as a promising tool for tissue characterization in atrial fibrillation (AF), providing detailed insights into anatomy, fibrosis, and scarring. While MRI cannot directly guide ablatio...
Floods represent frequent hazards in both low- and first-order catchments; however, to date, the investigation of peak flow discharges in the latter catchments has been omitted due to the absence of gauging stations. The quantification of flood param...
This study investigates the potential of the ultrasound imaging technique in the assessment of Anterior Cruciate Ligament (ACL) pathologies by standardizing the examination process. We focused on four key ultrasound parameters: the inclination of the...
Left untreated, nonalcoholic fatty liver disease can progress to nonalcoholic steatohepatitis (NASH), fibrosis, and end-stage liver disease. To date, few if any therapies have proven effective against NASH with fibrosis. Quantification and qualificat...
The surface fragmentation of karst landscapes leads to a high degree of coupling between fire scar site boundaries and topographic relief. However, the applicability of spatio-temporal data fusion methods for fire scar extraction in such geomorpholog...
Hypertension is one of the most important cardiovascular risk factors, associated with significant morbidity and mortality. Chronic high blood pressure leads to various structural and functional changes in the myocardium. Different sophisticated imag...
Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of...
Background and Objectives: Wound healing encompasses a multitude of factors and entails the establishment of interactions among components of the basement membrane. The quantification of particle concentrations can serve as valuable biomarkers for as...
Background/Objectives: Autologous cell suspension (ACS)-based therapy is a promising strategy to enhance wound healing, yet limitations in current methodologies hinder clinical efficacy. We have previously developed VeritaCell, a rapid isolation meth...
Fibrosis accompanies various pathologies, and there is thus an unmet medical need for non-invasive, sensitive, and quantitative methods for the assessment of fibrotic processes. Currently, needle biopsy with subsequent histological analysis is routin...
Coronary microvascular dysfunction (CMD) is a major mechanism of myocardial ischemia and adverse cardiovascular outcomes in patients with angina or dyspnea, both in the absence and in the presence of obstructive coronary artery disease. Because the c...
The prevention of sudden cardiac death (SCD) in cardiomyopathies (CM) remains a challenge. The current guidelines still favor the implantation of devices for the primary prevention of SCD only in patients with severely reduced left ventricular ejecti...
Sudden cardiac death due to hypertrophic cardiomyopathy (HCM), is the most common autopsy-proven cause of unexpected medical death in children after infancy. This mode of death is preventable by implantation of an internal cardiac defibrillator (ICD)...
Pulmonary fibrosis is a progressive lung disease characterized by interstitial tissue fibrosis, with idiopathic pulmonary fibrosis being the most common subtype. The disease leads to persistent scarring and fibrotic remodeling of lung tissue followin...
Background/Objectives: To evaluate whether global myocardial glucose metabolism and its regional heterogeneity, quantified using dynamic 18F-fluorodeoxyglucose positron emission tomography (FDG PET), are associated with cardiovascular outcomes in pat...
Cyanoacrylate-based adhesives are commonly used for wound closure due to their short synthesis time, aesthetic outcomes, and minimal discomfort. However, reported adverse effects include the release of cytotoxic metabolites, inflammation, and foreign...
Background and Objectives: To compare the accuracy of multimodality imaging (myocardial perfusion imaging with single-photon emission computed tomography (SPECT MPI), 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET), and cardiovascul...