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Bioengineering
Special Issues
Advances and Innovations in Wound Repair and Regeneration
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Advances and Innovations in Wound Repair and Regeneration

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 3051

Special Issue Editors

Dr. Shiva Akbarzadeh

E-Mail Website
Guest Editor
1. Skin Bioengineering Laboratory, Victorian Adult Burns Service, Alfred Health, 89 Commercial Road, Melbourne, VIC, Australia
2. Department of Surgery, Monash University, 99 Commercial Road, Melbourne, VIC 3004, Australia
Interests: skin tissue engineering; skin grafting; wound repair; cell and tissue therapies; adult stem cells
Prof. Dr. Azam Ali

E-Mail Website
Guest Editor
1. Centre for Bioengineering & Nanomedicine (Dunedin), Faculty of Dentistry, Division of Health Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand
2. Sir John Walsh Research Institute (SJWRI), Faculty of Dentistry, Division of Health Sciences, University of Otago, 310 Great King Street North, Dunedin 9016, New Zealand
Interests: biomaterials; 3D biofabrication; tissue engineering & regenerative medicine; wound care; drug-deliver system; medical devices & technology

Special Issue Information

Dear Colleagues,

Despite many years of research, repairing wounds through regeneration without scarring in a timely fashion remains an unmet clinical need. Skin grafting remains the gold standard for closing large wounds but has many inherent limitations. Most importantly, skin grafts lack appendages, including hair follicles, and undergo contracture over time. Even in smaller wounds that heal spontaneously within three weeks, the tissue is replaced with scar tissue, resulting in cosmetic and physiological long-term consequences.

The aim of this Special Issue is to showcase the latest novel approaches in cell therapy, biomaterials, small molecules, nanoparticles, organoids, and animal models for wound regeneration. Multi-disciplinary technological innovations such as 3D printing and automation will also be included. Reviews and clinical studies are also welcome.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Small molecules and nanoparticles for wound repair
  • Anti-fibrotic drugs
  • Engineered skin grafts
  • Dermal substitutes
  • Biological wound dressings
  • Three-dimensional skin printing
  • Animal models

Dr. Shiva Akbarzadeh
Prof. Dr. Azam Ali
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • engineered skin graft
  • three-dimensional skin printing
  • skin grafting in animal models
  • dermal substitutes

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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16 pages, 7618 KiB  
Article
Collagen Remodeling of Strattice™ Firm in a Nonhuman Primate Model of Abdominal Wall Repair
by Kelly Bolden, Jared Lombardi, Nimesh Kabaria, Eric Stec and Maryellen Gardocki-Sandor
Bioengineering 2025, 12(8), 796; https://doi.org/10.3390/bioengineering12080796 - 24 Jul 2025
Viewed by 370
Abstract
This study characterized collagen remodeling in an electron-beam-sterilized porcine acellular dermal matrix (E-PADM) by evaluating host response kinetics during wound healing. E-PADM (n = 6 lots/time point) was implanted in an abdominal wall bridging defect in nonhuman primates (N = 24). [...] Read more.
This study characterized collagen remodeling in an electron-beam-sterilized porcine acellular dermal matrix (E-PADM) by evaluating host response kinetics during wound healing. E-PADM (n = 6 lots/time point) was implanted in an abdominal wall bridging defect in nonhuman primates (N = 24). Histological, immunohistochemical, and biochemical assessments were conducted. Pro-inflammatory tissue cytokines peaked 1 month post-implantation and subsided to baseline by 6 months. E-PADM-specific serum immunoglobulin G antibodies increased by 213-fold from baseline at 1 month, then decreased to <10-fold by 6–9 months. The mean percentage tissue area staining positively for matrix metalloproteinase-1 plateaued at 3 months (40.3 ± 16.9%), then subsided by 6 months (16.3 ± 11.1%); tissue inhibitor matrix metalloproteinase-1 content plateaued at 1 month (39.0 ± 14.3%), then subsided by 9 months (13.0 ± 8.8%). Mean E-PADM thickness (1.7 ± 0.2 mm pre-implant) increased at 3 months (2.9 ± 1.5 mm), then decreased by 9 months (1.9 ± 1.1; equivalent to pre-implant). Histology demonstrated mild inflammation between 1–3 months, then a peak in host tissue deposition, with ≈75%–100% E-PADM collagen turnover, and fibroblast infiltration and neovascularization between 3–6 months. Picrosirius red staining revealed that mature E-PADM collagen was replaced by host-associated neo-collagen by 6 months. E-PADM implantation induced wound healing, which drove dermal E-PADM collagen remodeling to native, functional fascia-like tissue at the implant site. Full article
(This article belongs to the Special Issue Advances and Innovations in Wound Repair and Regeneration)
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11 pages, 2829 KiB  
Article
Biomimetic Full-Thickness Artificial Skin Using Stromal Vascular Fraction Cells and Autologous Keratinocytes in a Single Scaffold for Wound Healing
by Jung Huh, Seong-Ho Jeong, Eun-Sang Dhong, Seung-Kyu Han and Kyung-Chul Moon
Bioengineering 2025, 12(7), 736; https://doi.org/10.3390/bioengineering12070736 - 5 Jul 2025
Viewed by 560
Abstract
We developed biomimetic full-thickness artificial skin using stromal vascular fraction (SVF) cells and autologous keratinocytes for the dermal and epidermal layers of skin, respectively. Full-thickness artificial skin scaffolds were fabricated using 4% porcine collagen and/or elastin in a low-temperature three-dimensional printer. Two types [...] Read more.
We developed biomimetic full-thickness artificial skin using stromal vascular fraction (SVF) cells and autologous keratinocytes for the dermal and epidermal layers of skin, respectively. Full-thickness artificial skin scaffolds were fabricated using 4% porcine collagen and/or elastin in a low-temperature three-dimensional printer. Two types of scaffolds with collagen-to-elastin ratios of 100:0 and 100:4 were printed and compared. The scaffolds were analyzed for collagenase degradation, tensile strength, and structural features using scanning electron microscopy. By 24 h, the collagen-only scaffolds showed gradual degradation, and the collagen-elastin scaffolds retained the highest structural integrity but were not degraded. In the tensile strength tests, the collagen-only scaffolds exhibited a tensile strength of 2.2 N, while the collagen-elastin scaffolds showed a tensile strength of 4.2 N. Cell viability tests for keratinocytes displayed an initial viability of 89.32 ± 3.01% on day 1, which gradually increased to 97.22 ± 4.99% by day 7. Similarly, SVF cells exhibited a viability of 93.68 ± 1.82% on day 1, which slightly improved to 97.12 ± 1.64% on day 7. This study presents a novel strategy for full-thickness artificial skin development, combining SVF and keratinocytes with an optimized single collagen scaffold and a gradient pore-density structure. Full article
(This article belongs to the Special Issue Advances and Innovations in Wound Repair and Regeneration)
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Review

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27 pages, 2110 KiB  
Review
Curcumin-Loaded Drug Delivery Systems for Acute and Chronic Wound Management: A Review
by Xiaoxuan Deng, Jithendra Ratnayake and Azam Ali
Bioengineering 2025, 12(8), 860; https://doi.org/10.3390/bioengineering12080860 - 11 Aug 2025
Viewed by 410
Abstract
Wound healing is a physiological process including haemostasis, inflammation, proliferation, and remodelling. Acute wounds typically follow a predictable healing process, whereas chronic wounds cause prolonged inflammation and infection, failing to progress through typical healing phases and presenting significant clinical challenges. A combination of [...] Read more.
Wound healing is a physiological process including haemostasis, inflammation, proliferation, and remodelling. Acute wounds typically follow a predictable healing process, whereas chronic wounds cause prolonged inflammation and infection, failing to progress through typical healing phases and presenting significant clinical challenges. A combination of wound care techniques and therapeutic agents is required to manage chronic wounds effectively. Curcumin is a bioactive compound derived from Curcuma longa and has gained attention for its potent antioxidant, anti-inflammatory, and antibacterial properties. The first part of this review aims to provide a comprehensive overview of the physiology of wound healing, focusing on the pathophysiology and management of acute and chronic wounds, followed by the biological activity of curcumin in wound healing, emphasising its impact on promoting tissue repair. Finally, this review explores curcumin-loaded dressings, such as hydrogels, nanofibrous membranes, polymeric micelles, and films, offering controlled drug release and targeted curcumin delivery to enhance wound healing. Full article
(This article belongs to the Special Issue Advances and Innovations in Wound Repair and Regeneration)
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14 pages, 672 KiB  
Review
Towards Extracellular Vesicles in the Treatment of Epidermolysis Bullosa
by Aaron Gabriel W. Sandoval and Evangelos V. Badiavas
Bioengineering 2025, 12(6), 574; https://doi.org/10.3390/bioengineering12060574 - 27 May 2025
Viewed by 927
Abstract
Epidermolysis bullosa (EB) is a debilitating genetic skin disorder characterized by extreme fragility, chronic wounds, and severe complications, particularly in its most severe form, recessive dystrophic EB (RDEB). Current treatments focus on symptomatic relief through wound care and pain management, with recent FDA [...] Read more.
Epidermolysis bullosa (EB) is a debilitating genetic skin disorder characterized by extreme fragility, chronic wounds, and severe complications, particularly in its most severe form, recessive dystrophic EB (RDEB). Current treatments focus on symptomatic relief through wound care and pain management, with recent FDA approvals of Vyjuvek and Filsuvez providing new but limited therapeutic options. However, emerging research highlights the potential of extracellular vesicles (EVs) derived from mesenchymal stem cells as a promising approach to address both the symptoms and underlying pathology of EB. EVs function as carriers of bioactive molecules, modulating inflammation, promoting tissue regeneration, and even delivering functional type VII collagen to RDEB patient cells. Unlike whole-cell therapies, EVs are non-immunogenic, have greater stability, and avoid risks such as graft-versus-host disease or tumorigenic transformation. Additionally, EVs offer diverse administration routes, including topical application, local injection, and intravenous delivery, which could extend their therapeutic reach beyond skin lesions to systemic manifestations of EB. However, challenges remain, including standardization of EV production, scalability, and ensuring consistent therapeutic potency. Despite these hurdles, EV-based therapies represent a transformative step toward addressing the complex pathology of EB, with the potential to improve wound healing, reduce fibrosis, and enhance patient quality of life. Full article
(This article belongs to the Special Issue Advances and Innovations in Wound Repair and Regeneration)
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