You are currently on the new version of our website. Access the old version .

43 Results Found

  • Article
  • Open Access
13 Citations
3,091 Views
10 Pages

The Advantages of Radiofrequency Echographic MultiSpectrometry in the Evaluation of Bone Mineral Density in a Population with Osteoarthritis at the Lumbar Spine

  • Carla Caffarelli,
  • Antonella Al Refaie,
  • Caterina Mondillo,
  • Giuditta Manasse,
  • Alessandro Versienti,
  • Maria Dea Tomai Pitinca,
  • Edoardo Conticini,
  • Bruno Frediani and
  • Stefano Gonnelli

Background: Osteoarthritis (OA) in the lumbar spine can potentially lead to an overestimation of bone mineral density (BMD), and this can be a challenge in accurately diagnosing conditions like osteoporosis, where precise measurement of BMD is crucia...

  • Article
  • Open Access
5 Citations
3,827 Views
12 Pages

21 September 2023

Background: In previous studies, many imaging analyses have been conducted to explore the changes in the intervertebral disc degeneration (DD), facet joint osteoarthritis (FJOA), L4 inclination angle (L4IA), pelvis-related parameters, lumbar lordosis...

  • Article
  • Open Access
2 Citations
4,113 Views
19 Pages

The aim of this study was to determine a cost-effective diagnostic method for lumbar herniated disc with knee osteoarthritis (LHD-KOA) based on aberrant outcome measures, levels of biomarkers, and examination of the lower-extremity. Data were separat...

  • Article
  • Open Access
16 Citations
7,002 Views
10 Pages

Facet joint osteoarthritis is a prominent feature of degenerative spine disorders, highly prevalent in ageing populations, and considered a major cause for chronic lower back pain. Since there is no targeted pharmacological therapy, clinical manageme...

  • Article
  • Open Access
9 Citations
2,725 Views
10 Pages

28 September 2021

Concurrent knee osteoarthritis (KOA) and degenerative lumbar spinal disease (LSD) has increased, but the total knee arthroplasty (TKA) effect on degenerative LSD remains unclear. The aim of this study was to retrospectively analyze to compare radiolo...

  • Article
  • Open Access
11 Citations
4,101 Views
10 Pages

Gait Variability to Phenotype Common Orthopedic Gait Impairments Using Wearable Sensors

  • Junichi Kushioka,
  • Ruopeng Sun,
  • Wei Zhang,
  • Amir Muaremi,
  • Heike Leutheuser,
  • Charles A. Odonkor and
  • Matthew Smuck

29 November 2022

Mobility impairments are a common symptom of age-related degenerative diseases. Gait features can discriminate those with mobility disorders from healthy individuals, yet phenotyping specific pathologies remains challenging. This study aims to identi...

  • Article
  • Open Access
680 Views
14 Pages

17 October 2025

Background/Objectives: Knee osteoarthritis (KOA) is multifactorial, and longitudinal evidence isolating early predictors remains limited. We investigated predictors of incident KOA in community-dwelling older adult Japanese women. Methods: We analyze...

  • Article
  • Open Access
168 Citations
12,538 Views
18 Pages

Osteoarthritis in the Middle-Aged and Elderly in China: Prevalence and Influencing Factors

  • Xueshan Sun,
  • Xuemei Zhen,
  • Xiaoqian Hu,
  • Yuanyuan Li,
  • Shuyan Gu,
  • Yuxuan Gu and
  • Hengjin Dong

Background: Osteoarthritis is a common joint disease, with the acceleration of the aging process in China, it has troubled the middle-aged and elderly. There have been some epidemiological studies of osteoarthritis conducted in one single site, and m...

  • Article
  • Open Access
6 Citations
3,531 Views
12 Pages

24 February 2022

This study aimed to evaluate the effect of dietary protein intake and regular exercise on low back pain (LBP) using data from the Korea National Health and Nutrition Examination Survey. A total of 2367 middle-aged and older adults (≥50 years) who...

  • Review
  • Open Access
4 Citations
3,767 Views
26 Pages

Image-Guided Minimally Invasive Treatment Options for Degenerative Lumbar Spine Disease: A Practical Overview of Current Possibilities

  • Makoto Taninokuchi Tomassoni,
  • Lorenzo Braccischi,
  • Mattia Russo,
  • Francesco Adduci,
  • Davide Calautti,
  • Marco Girolami,
  • Fabio Vita,
  • Alberto Ruffilli,
  • Marco Manzetti and
  • Paolo Spinnato
  • + 5 authors

Lumbar back pain is one of the main causes of disability around the world. Most patients will complain of back pain at least once in their lifetime. The degenerative spine is considered the main cause and is extremely common in the elderly population...

  • Case Report
  • Open Access
3 Citations
10,931 Views
6 Pages

Severe Atrophy of the Ipsilateral Psoas Muscle Associated with Hip Osteoarthritis and Spinal Stenosis—A Case Report

  • Byeongcheol Lee,
  • Sang Eun Lee,
  • Yong Han Kim,
  • Jae Hong Park,
  • Ki Hwa Lee,
  • Eunsu Kang,
  • Sehun Kim,
  • Nakyung Lee and
  • Daeseok Oh

15 January 2021

Pathology of the lumbar spine and hip joint can commonly coexist in the elderly. Anterior and lateral leg pain as symptoms of hip osteoarthritis and spinal stenosis can closely resemble each other, with only subtle differences in both history and phy...

  • Article
  • Open Access
3 Citations
2,437 Views
11 Pages

Sulphurous Crenotherapy Is Effective at Reducing Pain and Disability in Overweight/Obese Patients Affected by Chronic Low Back Pain from Spine Osteoarthritis

  • Maria Costantino,
  • Valeria Conti,
  • Graziamaria Corbi,
  • Irene Ciancarelli,
  • Giovanni Morone and
  • Amelia Filippelli

19 September 2022

Crenotherapy is recognized as being effective in patients with osteoarthritis of the spine, but to date there is no indication if it is effective for patients who are overweight or obese. The aim of this study is to evaluate the efficacy of sulphurou...

  • Article
  • Open Access
6 Citations
3,715 Views
12 Pages

Diagnostic Value of an Additional Sequence (Large-Field Coronal Stir) in a Routine Lumbar Spine MR Imaging Protocol to Investigate Lumbar Radiculopathy

  • Quentin Patriat,
  • François-Victor Prigent,
  • Serge Aho,
  • Marc Lenfant,
  • André Ramon,
  • Romaric Loffroy,
  • Aurelien Lambert and
  • Paul Ornetti

28 September 2023

Objective. Lumbar radiculopathy mainly originates in the spine (lumbar disc herniation or spine osteoarthritis) but can sometimes be explained by extra-spinal nerve compression or confused with referred pain mimicking radiculopathy. Our main objectiv...

  • Article
  • Open Access
3 Citations
1,849 Views
11 Pages

An Analysis of the Preoperative Factors, Spinopelvic Mobility and Sagittal Spinal Alignment in Pre-THA Patients

  • Mariusz Łaziński,
  • Włodzimierz Niemyjski,
  • Michał Niemyjski,
  • Marek Synder,
  • Marek Drobniewski,
  • Łukasz Olewnik and
  • Andrzej Borowski

27 August 2023

Hip arthroplasty is a very effective medical procedure. The optimal positioning of the components and the functioning of the endoprosthesis are influenced, among other things, by the mobility and balance of the spine. The aim of the study was to anal...

  • Article
  • Open Access
20 Citations
4,144 Views
11 Pages

The Impact of Hip Mobility on Lumbar and Pelvic Mobility before and after Total Hip Arthroplasty

  • Youngwoo Kim,
  • Claudio Vergari,
  • Yu Shimizu,
  • Hiroyuki Tokuyasu and
  • Mitsuru Takemoto

31 December 2022

Hip arthrosis and total hip arthroplasty (THA) can alter a patient’s balance and spinopelvic mobility. In this study, we hypothesized that lumbar, pelvic, and hip mobility and their inter-relations are affected by THA and that their study could...

  • Article
  • Open Access
6 Citations
2,454 Views
10 Pages

14 November 2023

Background and Objectives: Lumbar spinal stenosis (LSS) is a degenerative condition posing significant challenges in clinical management. Despite the use of radiological parameters and patient-reported outcome measures like the Oswestry Disability In...

  • Article
  • Open Access
10 Citations
4,588 Views
10 Pages

Unexpected Sex Differences in the Relationship of Sacroiliac Joint and Lumbar Spine Degeneration

  • Maximilian Muellner,
  • Virginie Kreutzinger,
  • Luis Becker,
  • Torsten Diekhoff,
  • Matthias Pumberger,
  • Friederike Schömig,
  • Mark Heyland and
  • Katharina Ziegeler

The relationship between degenerative changes of the sacroiliac joints and the lumbar spine on CT has not been studied yet. The aim of this analysis is to determine the nature of their association as well as the influence of fixed anatomical spinopel...

  • Article
  • Open Access
978 Views
13 Pages

The Effect of Knee Extension Limitation on Lumbar Intervertebral Disc Compression Force During Walking: A 3D Musculoskeletal Analysis

  • Yuhei Kotaki,
  • Daisuke Kudo,
  • Ryota Kimura,
  • Yuji Kasukawa,
  • Hiroaki Kijima,
  • Hidetomo Saito,
  • Michio Hongo,
  • Takehiro Iwami and
  • Naohisa Miyakoshi

27 October 2025

Knee–spine interactions suggest that limited knee extension may elevate spinal loading during ambulation in older adults. This study aimed to estimate lumbar intervertebral disc loads during walking in patients with knee extension limitations u...

  • Article
  • Open Access
1,101 Views
10 Pages

Prevalence of Osteoporosis and Vitamin D Levels in Patients Undergoing Total Hip Arthroplasty: Insights from a Single-Center Experience in Italy

  • Amarildo Smakaj,
  • Riccardo Iundusi,
  • Angela Chiavoghilefu,
  • Tommaso Cardelli,
  • Danilo Rossi,
  • Claudio Raso,
  • Umberto Tarantino and
  • Elena Gasbarra

Background: Patients awaiting total hip arthroplasty (THA), particularly those with hip osteoarthritis (OA), face an elevated risk of osteoporosis due to age and gender-related factors. Osteoporosis, indicated by low bone mineral density (BMD), can a...

  • Article
  • Open Access
5 Citations
3,520 Views
11 Pages

14 January 2022

Background and Objective: This study assessed comorbidities and health-related quality of life (HRQOL) in subjects with lumbar spine osteoarthritis (OA) in the Korean population. Materials and Methods: We analyzed 3256 subjects who were 50 years or o...

  • Article
  • Open Access
8 Citations
3,697 Views
8 Pages

Effect of Spinal Alignment Changes on Lower Back Pain in Patients Treated with Total Hip Arthroplasty for Hip Osteoarthritis

  • Fumiko Saiki,
  • Takeyuki Tanaka,
  • Naohiro Tachibana,
  • Hirofumi Oshima,
  • Taizo Kaneko,
  • Chiaki Horii,
  • Hideki Nakamoto,
  • So Kato,
  • Toru Doi and
  • Yasushi Oshima
  • + 3 authors

9 November 2021

Background and objectives: The influence of changes in spinal alignment after total hip arthroplasty (THA) on improvement in lower back pain (LBP) remains controversial. To evaluate how changes in spinal malalignment correlate with improvement in pre...

  • Review
  • Open Access
56 Citations
13,759 Views
19 Pages

Objective: The purpose of this study was to determine the effects of practicing Taichi on attenuating bone mineral density (BMD) loss. Methods: Both electronic and manual searches were performed for randomized controlled trials (RCTs) examining Taich...

  • Review
  • Open Access
65 Citations
15,020 Views
15 Pages

The Impact of Spinopelvic Mobility on Arthroplasty: Implications for Hip and Spine Surgeons

  • Henryk Haffer,
  • Dominik Adl Amini,
  • Carsten Perka and
  • Matthias Pumberger

8 August 2020

Spinopelvic mobility represents the complex interaction of hip, pelvis, and spine. Understanding this interaction is relevant for both arthroplasty and spine surgeons, as a predicted increasing number of patients will suffer from hip and spinal patho...

  • Article
  • Open Access
741 Views
13 Pages

Background/Objectives: Rapidly progressive osteoarthritis of the hip (RPOH) has unique diagnostic and surgical challenges due to rapid joint degeneration and acetabular structural alterations. This study aimed to investigate correlations between preo...

  • Article
  • Open Access
36 Citations
8,361 Views
27 Pages

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

  • Ping Li,
  • Lutz Fleischhauer,
  • Claudia Nicolae,
  • Carina Prein,
  • Zsuzsanna Farkas,
  • Maximilian Michael Saller,
  • Wolf Christian Prall,
  • Raimund Wagener,
  • Juliane Heilig and
  • Attila Aszodi
  • + 3 authors

Matrilins (MATN1, MATN2, MATN3 and MATN4) are adaptor proteins of the cartilage extracellular matrix (ECM), which bridge the collagen II and proteoglycan networks. In humans, dominant-negative mutations in MATN3 lead to various forms of mild chondrod...

  • Article
  • Open Access
19 Citations
4,308 Views
19 Pages

Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model

  • Marta Bryk,
  • Jakub Chwastek,
  • Magdalena Kostrzewa,
  • Jakub Mlost,
  • Aleksandra Pędracka and
  • Katarzyna Starowicz

6 October 2020

Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid and TRPV1 receptors. The purpose of our study was to examine alterations in...

  • Review
  • Open Access
2 Citations
2,852 Views
11 Pages

Challenges in Total Hip Arthroplasty with Prior Spinal Arthrodesis: A Comprehensive Review of Biomechanics, Complications, and Surgical Strategies

  • Riccardo Giai Via,
  • Francesco Onorato,
  • Michele Reboli,
  • Stefano Artiaco,
  • Matteo Giachino,
  • Francesco Bosco and
  • Alessandro Massè

28 May 2024

Total hip arthroplasty (THA) has revolutionized patients’ lives with hip osteoarthritis. However, the increasing prevalence of THA in individuals with prior lumbar arthrodesis (LA) poses unique challenges. This review delves into the biomechani...

  • Article
  • Open Access
13 Citations
4,803 Views
15 Pages

Causal Link between Gut Microbiota, Neurophysiological States, and Bone Diseases: A Comprehensive Mendelian Randomization Study

  • Shaoting Luo,
  • Zhiyang Chen,
  • Linfang Deng,
  • Yufan Chen,
  • Weizheng Zhou,
  • Federico Canavese and
  • Lianyong Li

11 September 2023

Increasing evidence highlights a robust correlation between the gut microbiota and bone diseases; however, the existence of a causal relationship between them remains unclear. In this study, we thoroughly examined the correlation between gut microbio...

  • Review
  • Open Access
32 Citations
24,083 Views
17 Pages

Extracorporeal Shock Wave Therapy for the Treatment of Musculoskeletal Pain: A Narrative Review

  • Hortensia De la Corte-Rodríguez,
  • Juan M. Román-Belmonte,
  • Beatriz A. Rodríguez-Damiani,
  • Aránzazu Vázquez-Sasot and
  • Emérito Carlos Rodríguez-Merchán

26 October 2023

Extracorporeal shock waves are high-intensity mechanical waves (500–1000 bar) of a microsecond duration with a morphology characterized by a rapid positive phase followed by a negative phase. Background: Extracorporeal shock waves have been use...

  • Article
  • Open Access
5 Citations
2,439 Views
14 Pages

Correlation between Adrenoceptor Expression and Clinical Parameters in Degenerated Lumbar Intervertebral Discs

  • Marco Brenneis,
  • Zsuzsa Jenei-Lanzl,
  • Johannes Kupka,
  • Sebastian Braun,
  • Marius Junker,
  • Frank Zaucke,
  • Marcus Rickert and
  • Andrea Meurer

5 December 2022

Despite advanced knowledge of the cellular and biomechanical processes of intervertebral disc degeneration (IVDD), the trigger and underlying mechanisms remain unclear. Since the sympathetic nervous system (SNS) has been shown to exhibit catabolic ef...

  • Article
  • Open Access
4 Citations
2,507 Views
11 Pages

Background: Evidence on the close association between osteoarthritis (OA) and lung diseases is supported by the shared pathogenesis of the two diseases. We assessed the association between knee and spine OA and chronic obstructive pulmonary disease (...

  • Review
  • Open Access
1 Citations
2,325 Views
14 Pages

Focused Ultrasounds in the Rehabilitation Setting: A Narrative Review

  • Carmelo Pirri,
  • Nicola Manocchio,
  • Daniele Polisano,
  • Andrea Sorbino and
  • Calogero Foti

24 April 2025

Focused ultrasound (FUS) is an emerging noninvasive technology with significant therapeutic potential across various clinical domains. FUS enables precise targeting of tissues using mechanisms like thermoablation, mechanical disruption, and neuromodu...

  • Article
  • Open Access
29 Citations
8,415 Views
15 Pages

Osteoarthritis (OA) is a joint disease in which cartilage degenerates as a result of mechanical and biochemical changes. The main OA symptom is chronic pain involving both peripheral and central mechanisms of nociceptive processing. Our previous stud...

  • Systematic Review
  • Open Access
43 Citations
31,592 Views
18 Pages

Work-Related Musculoskeletal Disorders: A Systematic Review and Meta-Analysis

  • Chiara Greggi,
  • Virginia Veronica Visconti,
  • Marco Albanese,
  • Beatrice Gasperini,
  • Angela Chiavoghilefu,
  • Caterina Prezioso,
  • Benedetta Persechino,
  • Sergio Iavicoli,
  • Elena Gasbarra and
  • Umberto Tarantino
  • + 1 author

6 July 2024

Background: Musculoskeletal disorders (MSDs) involve muscles, nerves, tendons, joints, cartilage, and spinal discs. These conditions can be triggered by both the work environment and the type of work performed, factors that, in some cases, can also e...

  • Article
  • Open Access
26 Citations
4,916 Views
9 Pages

Effects of Chronic Comorbidities on the Health-Related Quality of Life among Older Patients after Falls in Vietnamese Hospitals

  • Hai Minh Vu,
  • Long Hoang Nguyen,
  • Tung Hoang Tran,
  • Kiet Tuan Huy Pham,
  • Hai Thanh Phan,
  • Hieu Ngoc Nguyen,
  • Bach Xuan Tran,
  • Carl A. Latkin,
  • Cyrus S.H. Ho and
  • Roger C.M. Ho

Although comorbidities are prevalent in older people experiencing falls, there is a lack of studies examining their influence on health-related quality of life (HRQOL) in this population. This study examines the prevalence of comorbidities and associ...

  • Systematic Review
  • Open Access
4,429 Views
33 Pages

Prolotherapy as a Regenerative Treatment in the Management of Chronic Low Back Pain: A Systematic Review

  • Stelian-Ilie Mociu,
  • Andreea-Dalila Nedelcu,
  • Andreea-Alexandra Lupu,
  • Andreea-Bianca Uzun,
  • Dan-Marcel Iliescu,
  • Elena-Valentina Ionescu and
  • Madalina-Gabriela Iliescu

2 September 2025

Background: Chronic low back pain markedly impairs quality of life and imposes a significant economic burden on public health. The complex pathophysiology of chronic low back pain arises from the complex anatomical configuration of the lumbar region,...

  • Article
  • Open Access
3 Citations
1,483 Views
15 Pages

Systemic Inflammation in Hip Fracture and Osteoarthritis: Insights into Pathways of Immunoporosis

  • Bernardo Abel Cedeno-Veloz,
  • Alba María Rodriguez-Garcia,
  • Fabricio Zambom-Ferraresi,
  • Soledad Domínguez-Mendoza,
  • Irene Guruceaga-Eguillor,
  • Virginia Ruiz-Izquieta,
  • Juan Jose Lasarte and
  • Nicolás Martinez-Velilla

19 September 2025

Inflammaging has been implicated in age-related bone loss and fragility fractures through immune-mediated effects on bone turnover. We aimed to explore the relationship between systemic inflammatory markers and bone health in older adults, focusing o...

  • Systematic Review
  • Open Access
10 Citations
7,927 Views
26 Pages

30 March 2024

The global aging population faces significant health challenges, including an increasing vulnerability to disability due to natural aging processes. Wearable lower limb exoskeletons (LLEs) have emerged as a promising solution to enhance physical func...

  • Systematic Review
  • Open Access
8 Citations
2,716 Views
31 Pages

Radiofrequency Echographic Multi Spectrometry—A Novel Tool in the Diagnosis of Osteoporosis and Prediction of Fragility Fractures: A Systematic Review

  • Elena Icătoiu,
  • Andreea-Iulia Vlădulescu-Trandafir,
  • Laura-Maria Groșeanu,
  • Florian Berghea,
  • Claudia-Oana Cobilinschi,
  • Claudia-Gabriela Potcovaru,
  • Andra-Rodica Bălănescu and
  • Violeta-Claudia Bojincă

25 February 2025

Background/Objectives: Given the significant economic and social burden of osteoporosis, there is growing interest in developing an efficient alternative to the traditional dual-energy X-ray absorptiometry (DXA). Radiofrequency Echographic Multi Spec...

  • Article
  • Open Access
7 Citations
3,208 Views
14 Pages

The Change of Lumbar Spinal Stenosis Symptoms over a Six-Year Period in Community-Dwelling People

  • Koji Otani,
  • Shin-ichi Kikuchi,
  • Shoji Yabuki,
  • Takuya Nikaido,
  • Kazuyuki Watanabe,
  • Kinshi Kato,
  • Hiroshi Kobayashi and
  • Shin-ichi Konno

16 October 2021

Background and Objectives: The high prevalence of lumbar spinal stenosis (LSS) and its negative impact on quality of life in the elderly is well known. However, the longitudinal time course of LSS symptoms remains unclear. The purpose of this study w...

  • Article
  • Open Access
5 Citations
4,744 Views
12 Pages

Spine, Pelvis and Hip Kinematics—Characterizing the Axial Plane in Healthy and Osteoarthritic Hips

  • Danilo S. Catelli,
  • Brendan Cotter,
  • Mario Lamontagne and
  • George Grammatopoulos

23 October 2021

Abnormal spinopelvic movements are associated with inferior outcomes following total hip arthroplasty (THA). This study aims to (1) characterize the agreement between dynamic motion and radiographic sagittal assessments of the spine, pelvis, and hip;...

  • Article
  • Open Access
2 Citations
2,925 Views
21 Pages

2 February 2023

Changes in clinical presentation, radiographic progression (RP), bone mineral density (BMD), bone turnover (BT), and cartilage turnover (CT) markers were compared in two groups of patients with hip osteoarthritis (HOA) over a period of 7 years. Each...

  • Article
  • Open Access
3,101 Views
10 Pages

Radiographic and Tomographic Study of the Cranial Bones in Children with the Idiopathic Type of West Syndrome

  • Ali Al Kaissi,
  • Sergey Ryabykh,
  • Farid Ben Chehida,
  • Hamza Al Kaissi,
  • Vasileios Dougales,
  • Vladimir M. Kenis and
  • Franz Grill

Background: Neither radiological phenotypic characteristics nor reconstruction CT scan has been used to study the early anatomical disruption of the cranial bone in children with the so-called idiopathic type of West syndrome. Material and Methods: T...