Next Article in Journal
How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles
Next Article in Special Issue
Inhibitory Effects of Human Primary Intervertebral Disc Cells on Human Primary Osteoblasts in a Co-Culture System
Previous Article in Journal
Sinomenine Hydrochloride Inhibits the Metastasis of Human Glioblastoma Cells by Suppressing the Expression of Matrix Metalloproteinase-2/-9 and Reversing the Endogenous and Exogenous Epithelial-Mesenchymal Transition
Previous Article in Special Issue
Genetic Determinants of Antibody Levels in Cerebrospinal Fluid in Multiple Sclerosis: Possible Links to Endogenous Retroviruses
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle

Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis

1
Department of Spine Surgery, University Hospital of Basel, 4031 Basel, Switzerland
2
Department of Biomedical Engineering, University Hospital of Basel, 4123 Allschwil, Switzerland
3
School of Engineering & Physical Sciences, Mechanical, Process & Energy Engineering, Heriot-Watt University, Edinburgh EH14 4AS, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(3), 845; https://doi.org/10.3390/ijms19030845
Received: 24 January 2018 / Revised: 6 March 2018 / Accepted: 9 March 2018 / Published: 14 March 2018
(This article belongs to the Special Issue Musculoskeletal Diseases Therapy)
  |  
PDF [18444 KB, uploaded 14 March 2018]
  |  

Abstract

Facet joint osteoarthritis is a prominent feature of degenerative spine disorders, highly prevalent in ageing populations, and considered a major cause for chronic lower back pain. Since there is no targeted pharmacological therapy, clinical management of disease includes analgesic or surgical treatment. The specific cellular, molecular, and structural changes underpinning facet joint osteoarthritis remain largely elusive. The aim of this study was to determine osteoarthritis-related structural alterations in cortical and trabecular subchondral bone compartments. To this end, we conducted comparative micro computed tomography analysis in healthy (n = 15) and osteoarthritic (n = 22) lumbar facet joints. In osteoarthritic joints, subchondral cortical plate thickness and porosity were significantly reduced. The trabecular compartment displayed a 42 percent increase in bone volume fraction due to an increase in trabecular number, but not trabecular thickness. Bone structural alterations were associated with radiological osteoarthritis severity, mildly age-dependent but not gender-dependent. There was a lack of association between structural parameters of cortical and trabecular compartments in healthy and osteoarthritic specimens. The specific structural alterations suggest elevated subchondral bone resorption and turnover as a potential treatment target in facet joint osteoarthritis. View Full-Text
Keywords: osteoarthritis; lumbar spine; facet joint; subchondral bone; computed tomography osteoarthritis; lumbar spine; facet joint; subchondral bone; computed tomography
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Netzer, C.; Distel, P.; Wolfram, U.; Deyhle, H.; Jost, G.F.; Schären, S.; Geurts, J. Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis. Int. J. Mol. Sci. 2018, 19, 845.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top