You are currently on the new version of our website. Access the old version .

45 Results Found

  • Review
  • Open Access
4 Citations
2,858 Views
11 Pages

The Pediatric Trochlear Migraine: Diagnostic and Therapeutic Implications

  • Vincenzo Raieli,
  • Federica Reina,
  • Daniela D’Agnano,
  • Giovanna Martina Nocera,
  • Mariarita Capizzi,
  • Francesca Marchese and
  • Vittorio Sciruicchio

17 May 2022

Trochlear Migraine has been recently described as the concurrence of strictly unilateral migraine and ipsilateral trochleodynia with relief of migraine after successful treatment of trochleodynia. This disorder has been interpreted as “cluster-...

  • Review
  • Open Access
13 Citations
10,326 Views
15 Pages

Acute Confusional Migraine: Distinct Clinical Entity or Spectrum of Migraine Biology?

  • Ashar M. Farooqi,
  • Jennifer M. Padilla and
  • Teshamae S. Monteith

7 February 2018

The goal of this review is to explore the literature reports of acute confusional migraine (ACM) including patient characteristics, migraine symptomatology, and proposed diagnostic criteria. A literature review was conducted using PubMed, Scopus and...

  • Case Report
  • Open Access
3 Citations
3,497 Views
10 Pages

Migrainous infarction (MI) is a rare disorder. The precise diagnostic criteria for this diagnosis have been available in the International Classification of Headache Disorders (ICHD) since 1988, but many cases do not fulfil these criteria. This paper...

  • Review
  • Open Access
13 Citations
7,172 Views
22 Pages

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

  • Federica Canfora,
  • Giulia Ottaviani,
  • Elena Calabria,
  • Giuseppe Pecoraro,
  • Stefania Leuci,
  • Noemi Coppola,
  • Mattia Sansone,
  • Katia Rupel,
  • Matteo Biasotto and
  • Daniela Adamo
  • + 2 authors

In exploring chronic orofacial pain (COFP), this review highlights its global impact on life quality and critiques current diagnostic systems, including the ICD-11, ICOP, and ICHD-3, for their limitations in addressing COFP’s complexity. Firstly, thi...

  • Article
  • Open Access
3 Citations
4,879 Views
11 Pages

Orthostatic Headache in Children Including Postural Tachycardia Syndrome and Orthostatic Hypotension: A Near-Infrared Spectroscopy Study

  • Soken Go,
  • Gaku Yamanaka,
  • Akiko Kasuga,
  • Kanako Kanou,
  • Tomoko Takamatsu,
  • Mika Takeshita,
  • Natsumi Morishita,
  • Shinichiro Morichi,
  • Yu Ishida and
  • Hisashi Kawashima
  • + 4 authors

21 December 2020

Background and aim: Although head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term’s relevance and aimed to elucidate the a...

  • Article
  • Open Access
1 Citations
1,462 Views
9 Pages

Cardiovascular Risk Factors and Family History of Major Thrombotic Events in Children with Migraine: A 12-Year Retrospective Single-Centre Study

  • Roberta Rossi,
  • Stefania Benetti,
  • Barbara Lauria,
  • Giulia Grasso,
  • Emanuele Castagno,
  • Fulvio Ricceri,
  • Claudia Bondone and
  • Antonia Versace

29 March 2023

Background: Migraine is one of the most frequent primary headaches in childhood. The role of thrombotic predisposition in its pathogenesis is debated. Our aim was to analyse the cardiovascular risk factors and family history of major thrombotic event...

  • Article
  • Open Access
1,220 Views
12 Pages

Will I Have a Hangover Headache Tomorrow? A Prospective Cohort Study of the Predictors of Delayed Alcohol-Induced Headache

  • David García-Azorín,
  • Lucinia Colilla-Cantalejo,
  • Álvaro Sierra Mencía,
  • Yésica González Osorio,
  • Andrea Recio García,
  • Ana Echavarría-Íñiguez and
  • Ángel L. Guerrero

7 November 2025

Introduction: Alcohol-induced headaches are one of the most prevalent types of headaches. The International Classification of Headache Disorders defined them as throbbing and bilateral, and their phenotype combines characteristics of migraines and he...

  • Review
  • Open Access
17 Citations
4,613 Views
11 Pages

27 January 2023

The purpose of the present study is to examine possible differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache are comparable to primary headache disorders; but occurring in the...

  • Brief Report
  • Open Access
20 Citations
835 Views
2 Pages

Migraine Headache in Patients with Idiopathic Intracranial Hypertension

  • Farzad Sina,
  • Saeed Razmeh,
  • Neda Habibzadeh,
  • Arefeh Zavari and
  • Mona Nabovvati

2 October 2017

Migraine is a neurological disorder that afflicts many people in the world and can cause severe disability during the attacks. The pathophysiology of migraine is complex and not fully understood. It seems that migraine is common in idiopathic intracr...

  • Article
  • Open Access
4 Citations
2,967 Views
11 Pages

This study aimed to investigate the relationship between rosacea and headaches, focusing on different subtypes, as well as the associated clinical features and triggering factors. In this prospective study, 300 patients diagnosed with rosacea and 320...

  • Article
  • Open Access
22 Citations
3,875 Views
19 Pages

Questionnaire-Based Survey during COVID-19 Vaccination on the Prevalence of Elderly’s Migraine, Chronic Daily Headache, and Medication-Overuse Headache in One Japanese City—Itoigawa Hisui Study

  • Masahito Katsuki,
  • Junko Kawahara,
  • Yasuhiko Matsumori,
  • Chinami Yamagishi,
  • Akihito Koh,
  • Shin Kawamura,
  • Kenta Kashiwagi,
  • Tomohiro Kito,
  • Akio Entani and
  • Fuminori Yamagishi
  • + 3 authors

11 August 2022

Background: The prevalence of headache disorders, migraine, chronic daily headache (CDH), and medication-overuse headache (MOH) among the elderly in Japan has not been sufficiently investigated. We performed a questionnaire-based survey and revealed...

  • Review
  • Open Access
4 Citations
3,367 Views
14 Pages

4 October 2020

Headaches are common complaints in children. The International Classification of Headache Disorders, 3rd edition (beta version), defines more than 280 types of headaches. Primary headaches refer to independent conditions that cause pain and include m...

  • Article
  • Open Access
2 Citations
3,165 Views
13 Pages

ComPAIN—Communication of Pain in Patients with Headache

  • Emma Eicher,
  • Sabina Räz,
  • Pascale Stucki,
  • Cinzia Röthlin,
  • Miranda Stattmann,
  • Bettina Grossenbacher,
  • Eileen Neumann,
  • Heiko Pohl,
  • Yvonne Ilg and
  • Susanne Wegener
  • + 1 author

Primary headaches are a common debilitating health condition. Proper diagnosis and treatment depend on patients’ communication. We wanted to explore differences in pain communication with a special interest in potential sex differences. Patient...

  • Article
  • Open Access
21 Citations
7,501 Views
13 Pages

24 October 2020

Both tinnitus and headache are very prevalent conditions in the general population, with bidirectional co-occurrence of them. A number of studies revealed a high prevalence of headache in tinnitus patients; however, most of them used self-reported sy...

  • Article
  • Open Access
2,707 Views
19 Pages

Tracking Migraine Symptoms: A Longitudinal Comparison of Smartphone-Based Headache Diaries and Clinical Interviews

  • Nicolas Vandenbussche,
  • Jonas Van Der Donckt,
  • Mathias De Brouwer,
  • Bram Steenwinckel,
  • Marija Stojchevska,
  • Femke Ongenae,
  • Sofie Van Hoecke and
  • Koen Paemeleire

Background/Objectives: By leveraging the capabilities of a smartphone-based headache diary, the objective of this study was to determine the amount of agreement between migraine-associated symptomatology during headache events and the symptoms docume...

  • Article
  • Open Access
7 Citations
2,849 Views
14 Pages

Profiling the Spectrum of Headache Disorders on 440 Breast Cancer Patients: Highlights on Clinical and Pathological Mechanisms

  • Mariya Boyanova Ilieva,
  • Paola Tiberio,
  • Rosalba Torrisi,
  • Jacopo Lanzone,
  • Vittorio Di Piero,
  • Armando Santoro,
  • Alessandro Viganò and
  • Rita De Sanctis

Although widely studied, the association between migraines (M) and breast cancer (BC) risk remains evasive. In this prospective single-center study, 440 early or locally advanced BC patients were enrolled at IRCCS Humanitas Research Hospital. Clinica...

  • Review
  • Open Access
26 Citations
7,062 Views
22 Pages

Mapping Assessments Instruments for Headache Disorders against the ICF Biopsychosocial Model of Health and Disability

  • Domenico D'Amico,
  • Stewart J. Tepper,
  • Erika Guastafierro,
  • Claudia Toppo,
  • Matilde Leonardi,
  • Licia Grazzi,
  • Paolo Martelletti and
  • Alberto Raggi

Headache disorders have a strong impact on sufferers’ lives. However, the “content” of assessment instruments addressing concepts, such as disability and quality of life (QoL), has not comprehensively been addressed. We searched SCOPUS for research p...

  • Case Report
  • Open Access
2,881 Views
6 Pages

The syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a rare, self-limiting condition with severe headaches combined with neurological symptoms. However, evidence-based recommendations on diagnos...

  • Review
  • Open Access
3 Citations
2,342 Views
11 Pages

Orofacial Migraine—A Narrative Review

  • Rafael Benoliel and
  • Arne May

26 September 2024

The diagnosis of migraine is based on clear criteria outlined in the International Classification of Headache Disorders version 3 (ICHD-3). Notably, the criteria in ICHD-3 omit the location of the migraine. There are increasing reports of migraine in...

  • Article
  • Open Access
3 Citations
2,893 Views
15 Pages

The Role of Pain Inflexibility and Acceptance among Headache and Temporomandibular Disorders Patients

  • Vanessa Marcelino,
  • Maria Paço,
  • Andreia Dias,
  • Vera Almeida,
  • José Carlos Rocha,
  • Rui Azevedo,
  • Miguel Alves-Ferreira,
  • Carolina Lemos and
  • Teresa Pinho

Temporomandibular disorders (TMD) and headache are complex. This study aims to assess the association between TMD, headache, and psychological dimensions such as psychological inflexibility and pain acceptance. The sample consisted of 120 participant...

  • Article
  • Open Access
16 Citations
4,280 Views
13 Pages

Headache in Post-COVID-19 Patients: Its Characteristics and Relationship with the Quality of Life

  • Endang Mutiawati,
  • Hendrix Indra Kusuma,
  • Marhami Fahriani,
  • Harapan Harapan,
  • Syahrul Syahrul and
  • Nasrul Musadir

21 October 2022

Little is known on the characteristics of headaches associated with coronavirus disease 2019 (COVID-19) in Indonesia. The objective of this study was to describe the characteristics of headache in post-COVID-19 patients, and its impact on the patient...

  • Article
  • Open Access
12 Citations
2,899 Views
14 Pages

Clinical Characteristics of Headache in Multiple Sclerosis Patients: A Cross-Sectional Study

  • Iwona Rościszewska-Żukowska,
  • Sabina Galiniak and
  • Halina Bartosik-Psujek

17 May 2023

Primary headaches are known to be associated with multiple sclerosis (MS), but previous studies concerning this relationship are not conclusive. Nowadays, there are no studies assessing the prevalence of headaches in Polish MS patients. The aim of th...

  • Review
  • Open Access
5 Citations
4,606 Views
12 Pages

SUNCT/SUNA in Pediatric Age: A Review of Pathophysiology and Therapeutic Options

  • Carlo Alberto Cesaroni,
  • Jacopo Pruccoli,
  • Luca Bergonzini,
  • Giuseppe Quatrosi,
  • Luigi Vetri,
  • Michele Roccella and
  • Antonia Parmeggiani

21 September 2021

The International Classification of Headache Disorders, 3rd edition (ICHD3) defines Short-lasting Unilateral Neuralgiform Headache Attacks (SUNHA) as attacks of moderate or severe, strictly unilateral head pain lasting from seconds to minutes, occurr...

  • Article
  • Open Access
3 Citations
1,610 Views
13 Pages

Migraine and Tension-Type Headache Are Associated with Multiple Sclerosis: A Case–Control Study

  • Panagiotis Gklinos,
  • Maria-Eleftheria Evangelopoulos,
  • Georgios Velonakis and
  • Dimos Dimitrios Mitsikostas

17 April 2025

Background/Objectives: Over the past few decades, there has been increased scientific interest in the prevalence of headache disorders among people with MS (pwMS). Although the latest data suggest an association between migraine and multiple sclerosi...

  • Review
  • Open Access
13 Citations
12,201 Views
7 Pages

Current Perspective on Retinal Migraine

  • Yu Jeat Chong,
  • Susan P. Mollan,
  • Abison Logeswaran,
  • Alexandra B. Sinclair and
  • Benjamin R. Wakerley

23 August 2021

Retinal migraine was first formally described in 1882. Various terms such as “ocular migraine” and “ophthalmic migraine” have since been used interchangeably in the literature. The lack of a consistent consensus-based definition has led to controvers...

  • Review
  • Open Access
25 Citations
6,005 Views
11 Pages

Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons

  • Matilde Capi,
  • Leda Marina Pomes,
  • Giulia Andolina,
  • Martina Curto,
  • Paolo Martelletti and
  • Luana Lionetto

Background: Oftentimes, persistent post traumatic headache (PPTH) and migraine are phenotypically similar and the only clinical feature that differentiate them is the presence of a mild or moderate traumatic brain injury (mTBI). The aim of this study...

  • Article
  • Open Access
1 Citations
2,442 Views
11 Pages

Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up

  • Maria Laura Manzo,
  • Federica Reina,
  • Edvige Correnti,
  • Francesca D’Aiuto,
  • Daniela D’Agnano,
  • Andrea Santangelo,
  • Luigi Vetri,
  • Giuseppe Santangelo,
  • Laura Maniscalco and
  • Vincenzo Raieli
  • + 2 authors

24 March 2023

Background: Despite its high prevalence, the clinical course of pediatric migraine has not been fully understood, and previous studies present conflicting results. We present here the findings of a 10-year follow-up study involving children with seve...

  • Article
  • Open Access
2 Citations
5,311 Views
13 Pages

Quantitative Cluster Headache Analysis for Neurological Diagnosis Support Using Statistical Classification

  • Mohammed El-Yaagoubi,
  • Inmaculada Mora-Jiménez,
  • Younes Jabrane,
  • Sergio Muñoz-Romero,
  • José Luis Rojo-Álvarez and
  • Juan Antonio Pareja-Grande

10 August 2020

Cluster headache (CH) belongs to the group III of The International Classification of Headaches. It is characterized by attacks of severe pain in the ocular/periocular area accompanied by cranial autonomic signs, including parasympathetic activation...

  • Article
  • Open Access
6 Citations
2,715 Views
12 Pages

New Genetic Biomarkers of the Overlap Syndrome Tension-Type Headache and Arterial Hypertension

  • Polina V. Alyabyeva,
  • Olga V. Chastina,
  • Marina M. Petrova,
  • Natalia V. Lareva,
  • Natalia P. Garganeeva,
  • Galina A. Chumakova,
  • Marina S. Cherniaeva and
  • Natalia A. Shnayder

9 October 2022

Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an important molecule involved in regulation of cerebral and extra cerebra...

  • Review
  • Open Access
2,632 Views
28 Pages

Children’s Headache Through Drawings: A Narrative Review and a Portrait Gallery

  • Floriana Ferro,
  • Caterina Gaspari,
  • Giulia Manfrè,
  • Federica Cernigliaro,
  • Daniela D’Agnano,
  • Ruben Panzica,
  • Edvige Correnti,
  • Maria Rosita Ruta,
  • Francesca Marchese and
  • Vincenzo Raieli
  • + 5 authors

23 June 2025

Headache represents one of the most prevalent and disabling conditions in the pediatric population, with significant repercussions on mental and psychological well-being, as well as on academic achievement and social functioning, ultimately leading t...

  • Article
  • Open Access
6 Citations
5,800 Views
12 Pages

Idiopathic Non-Dental Facial Pain Syndromes in Italian Children: A Clinical Case Series

  • Edvige Correnti,
  • Salvatore Lo Cascio,
  • Federica Cernigliaro,
  • Roberta Rossi,
  • Daniela D’Agnano,
  • Giulia Grasso,
  • Annamaria Pellegrino,
  • Barbara Lauria,
  • Andrea Santangelo and
  • Vincenzo Raieli
  • + 4 authors

23 March 2023

Background. The orofacial pain syndromes (OFPs) are a heterogeneous group of syndromes characterized by painful attacks involving the orofacial structures. They may be summarily subdivided into two great categories: (1) orofacial pain mainly attribut...

  • Article
  • Open Access
4 Citations
3,103 Views
13 Pages

Sleep Bruxism and Obstructive Sleep Apnea Are Not Risk Factors for Tension-Type Headache (TTH): A Polysomnographic Study

  • Bartłomiej Błaszczyk,
  • Helena Martynowicz,
  • Piotr Niemiec,
  • Jakub Przegrałek,
  • Martyna Staszkiewicz,
  • Anna Wojakowska,
  • Sławomir Budrewicz and
  • Marta Waliszewska-Prosół

29 June 2024

Background: Tension-type headache (TTH) is the most common primary headache. Obstructive sleep apnea (OSA) and sleep bruxism (SB) are two of the most common sleep disorders; however, the relationship between TTH, OSA, and SB has not been conclusively...

  • Article
  • Open Access
611 Views
12 Pages

Associations Between Chronotype and Pain, Sleep Quality, Depression, and Quality of Life in Patients with Tension-Type Headache

  • Emine Kılıçparlar Cengiz,
  • Yasemin Ekmekyapar Fırat,
  • Barış Yılbaş and
  • Süleyman Dönmezler

14 November 2025

Background: Chronotype refers to an individual’s preferred timing of activity and rest within a 24-h period, reflecting behavioral manifestations of the endogenous circadian rhythm. Variations in circadian timing may contribute to the temporal...

  • Case Report
  • Open Access
10 Citations
6,015 Views
15 Pages

Diffuse Leptomeningeal Glioneuronal Tumour with 9-Year Follow-Up: Case Report and Review of the Literature

  • Milda Sarkinaite,
  • Indre Devyziene,
  • Jurgita Makstiene,
  • Algimantas Matukevicius and
  • Rymante Gleizniene

In 2016, the World Health Organisation Classification (WHO) of Tumours was updated with diffuse leptomeningeal glioneuronal tumour (DLGNT) as a provisional unit of mixed neuronal and glial tumours. Here, we report a DLGNT that has been re-diagnosed w...

  • Article
  • Open Access
3 Citations
1,940 Views
17 Pages

23 December 2024

Sandflies, small insects primarily from the Psychodidae family, are commonly found in sandy, tropical, and subtropical regions. Most active during dawn and dusk, female sandflies feed on blood to facilitate egg production. In doing so, they can trans...

  • Review
  • Open Access
3 Citations
3,100 Views
11 Pages

Benign Paroxysmal Torticollis

  • Elisabetta Tozzi,
  • Luca Olivieri and
  • Pamela Silva

31 May 2024

Background: The purpose of this review is to clarify the natural course of benign paroxysmal torticollis (BPT) and update the information on the relationship of this disorder with migraine. BPT belongs to a group of “episodic syndromes that may...

  • Article
  • Open Access
420 Views
11 Pages

Psychometric Validation of the Arabic Version of the WPAI:Migraine Questionnaire in Patients with Migraine

  • Abdulrazaq Albilali,
  • Rema A. Almutawa,
  • Elaf A. Almusahel,
  • Renad A. Almutawa,
  • Nasser A. Almutawa,
  • Faisal M. Almutawa,
  • Shiekha AlAujan and
  • Haya M. AlMalag

12 December 2025

Background: Migraine is a highly prevalent neurological disorder and a leading cause of disability, particularly among working-age adults. Although the Work Productivity and Activity Impairment (WPAI) questionnaire is widely used to assess the functi...

  • Viewpoint
  • Open Access
10 Citations
4,381 Views
8 Pages

Neuroangiostrongyliasis: Updated Provisional Guidelines for Diagnosis and Case Definitions

  • Carlos Graeff-Teixeira,
  • Kittisak Sawanyawisuth,
  • Shan Lv,
  • William Sears,
  • Zhaily González Rodríguez,
  • Hilda Hernández Álvarez,
  • Pedro Casanova Arias,
  • Leticia Karolini Walger Schultz,
  • Alicia Rojas and
  • Kenton Kramer
  • + 2 authors

Angiostrongylus cantonensis is the main causative agent for eosinophilic meningoencephalitis in humans. Larvae are rarely found in the cerebral spinal fluid (CSF). Consequently, serology and DNA detection represent important diagnostic tools. However...

  • Article
  • Open Access
3,065 Views
11 Pages

17 July 2023

An estimated 4–8% of all women, and 16–25% of women with migraine, have menstrual migraine (MM), which causes considerable disability, but is underdiagnosed and undertreated. We investigated the burden of disease, health-care seeking beha...

  • Review
  • Open Access
5 Citations
8,725 Views
10 Pages

28 February 2024

Visual snow syndrome (VSS) is a rarely diagnosed neurological phenomenon. It is a visual disorder characterised by the presence of numerous white, black, or translucent dots in the visual field, resembling the ‘snow’ of an analogue TV set...

  • Article
  • Open Access
5 Citations
3,228 Views
14 Pages

Orofacial Migraine and Other Idiopathic Non-Dental Facial Pain Syndromes: A Clinical Survey of a Social Orofacial Patient Group

  • Federica Reina,
  • Giuseppe Salemi,
  • Mariarita Capizzi,
  • Salvatore Lo Cascio,
  • Antonio Marino,
  • Giuseppe Santangelo,
  • Andrea Santangelo,
  • Mirko Mineri,
  • Filippo Brighina and
  • Carmelo Attilio Costa
  • + 1 author

Background: Orofacial pain syndromes (OFPs) are a heterogeneous group of syndromes mainly characterized by painful attacks localized in facial and oral structures. According to the International Classification of Orofacial Pain (ICOP), the last three...

  • Protocol
  • Open Access
998 Views
15 Pages

Background: Temporomandibular disorders (TMDs) are the most common source of non-dental orofacial pain, with peak prevalence during adolescence and young adulthood—the same age group when orthodontic treatment is typically initiated. Although o...

  • Article
  • Open Access
491 Views
10 Pages

28 November 2025

Background/Objectives: Migraine affects approximately 10% of school-aged children, and frequently co-occurs with orthostatic intolerance (OI). However, although low serum zinc levels have been linked to migraine in adults, yet evidence in pediatric p...

  • Systematic Review
  • Open Access
732 Views
7 Pages

This literature review deals with the question whether neck pain (NP) constitutes a symptom or a trigger of migraine. Firstly, a short survey about some techniques for measuring NP in association and relation with migraine is presented. Secondly, the...

  • Article
  • Open Access
3 Citations
1,814 Views
16 Pages

An Integrative Migraine Polygenic Risk Score Is Associated with Age at Onset But Not Chronification

  • Bruce A. Chase,
  • Roberta Frigerio,
  • Susan Rubin,
  • Tiffani Franada,
  • Irene Semenov,
  • Steven Meyers,
  • Stuart Bergman-Bock,
  • Angela Mark,
  • Thomas Freedom and
  • Katerina Markopoulou
  • + 10 authors

29 October 2024

Background/Objective: Genome-wide association studies (GWASs) demonstrate a complex genetic landscape for migraine risk. Migraine polygenic risk scores (PRSs) developed from GWAS data may have utility for predicting disease course. We analyzed the st...