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8,119 Results Found

  • Article
  • Open Access
32 Citations
7,107 Views
16 Pages

Enhanced Intestinal Absorption of Insulin by Capryol 90, a Novel Absorption Enhancer in Rats: Implications in Oral Insulin Delivery

  • Hiroki Ukai,
  • Kazuki Iwasa,
  • Takamasa Deguchi,
  • Masaki Morishita,
  • Hidemasa Katsumi and
  • Akira Yamamoto

Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration. However, the effects of f...

  • Article
  • Open Access
6 Citations
2,227 Views
11 Pages

26 October 2021

A special phenomenon of resonance mode separation is observed during the study of a high sensitivity folded-cavity enhanced absorption spectroscopy for the measurement of trace gases. The phenomenon affects the measurement of gas absorption spectrum...

  • Article
  • Open Access
1 Citations
1,651 Views
11 Pages

Plasmonic-Enhanced Infrared Absorption Platform for Broadband and Multiple Molecular Fingerprint Retrieval

  • Yulong Hu,
  • Zexing Zheng,
  • Huishan Ma,
  • Shuguang Zhu,
  • Yiming Yu,
  • Jie Hong,
  • Weiwei Tang,
  • Jiale He,
  • Libo Zhang and
  • Xiaoshuang Chen
  • + 2 authors

13 February 2025

The mid-infrared (mid-IR) region, often referred to as the molecular fingerprint region, encompasses the distinctive absorption spectra characteristic of numerous important molecules. However, the intrinsically small molecular absorption cross-sectio...

  • Article
  • Open Access
2,960 Views
18 Pages

12 March 2023

NO3 radicals are one of the very important trace gases in the atmosphere. Accurate measurements of NO3 can provide data support for atmospheric chemistry research. Due to the extremely low content of NO3 radicals in the atmosphere, it is a challenge...

  • Article
  • Open Access
8 Citations
2,414 Views
11 Pages

21 June 2022

Graphene is well-known for its extraordinary physical properties such as broadband optical absorption, high electron mobility, and electrical conductivity. All of these make it an excellent candidate for several infrared applications such as photodet...

  • Article
  • Open Access
2,670 Views
10 Pages

6 October 2022

To further improve the performance of cavity-enhanced spectroscopy systems, a high-quality U-cavity system was established. In the process of the experiment, an asymmetric ripple effect, which is different from the previous etalon effect, was found,...

  • Article
  • Open Access
10 Citations
6,546 Views
12 Pages

Repetitively Mode-Locked Cavity-Enhanced Absorption Spectroscopy (RML-CEAS) for Near-Infrared Gas Sensing

  • Qixin He,
  • Minhan Lou,
  • Chuantao Zheng,
  • Weilin Ye,
  • Yiding Wang and
  • Frank K. Tittel

2 December 2017

A Pound-Drever-Hall (PDH)-based mode-locked cavity-enhanced sensor system was developed using a distributed feedback diode laser centered at 1.53 µm as the laser source. Laser temperature scanning, bias control of the piezoelectric ceramic transducer...

  • Article
  • Open Access
9 Citations
3,720 Views
11 Pages

1 February 2023

Among the transitional metal dichalcogenides (TMDCs), molybdenum disulfide (MoS2) is considered an outstanding candidate for biosensing applications due to its high absorptivity and amenability to ionic current measurements. Dielectric metasurfaces h...

  • Article
  • Open Access
12 Citations
4,273 Views
14 Pages

Probing Denaturation of Protein A via Surface-Enhanced Infrared Absorption Spectroscopy

  • Valentina Di Meo,
  • Massimo Moccia,
  • Gennaro Sanità,
  • Alessio Crescitelli,
  • Annalisa Lamberti,
  • Vincenzo Galdi,
  • Ivo Rendina and
  • Emanuela Esposito

15 July 2022

We apply surface-enhanced infrared absorption (SEIRA) spectroscopy to monitor the denaturation process of a surface-bound protein A monolayer. Our proposed platform relies on a plasmonic metasurface comprising different spatial subregions (“pix...

  • Review
  • Open Access
40 Citations
7,667 Views
25 Pages

Review of Incoherent Broadband Cavity-Enhanced Absorption Spectroscopy (IBBCEAS) for Gas Sensing

  • Kaiyuan Zheng,
  • Chuantao Zheng,
  • Yu Zhang,
  • Yiding Wang and
  • Frank K. Tittel

27 October 2018

Incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS) is of importance for gas detection in environmental monitoring. This review summarizes the unique properties, development and recent progress of the IBBCEAS technique. Principle o...

  • Article
  • Open Access
16 Citations
3,207 Views
10 Pages

Absorption-Enhanced Ultra-Thin Solar Cells Based on Horizontally Aligned p–i–n Nanowire Arrays

  • Xueguang Yuan,
  • Xiaoyu Chen,
  • Xin Yan,
  • Wei Wei,
  • Yangan Zhang and
  • Xia Zhang

A horizontally aligned GaAs p–i–n nanowire array solar cell is proposed and studied via coupled three-dimensional optoelectronic simulations. Benefiting from light-concentrating and light-trapping properties, the horizontal nanowire array...

  • Review
  • Open Access
38 Citations
8,649 Views
38 Pages

19 August 2023

Infrared absorption spectroscopy is an effective tool for the detection and identification of molecules. However, its application is limited by the low infrared absorption cross-section of the molecule, resulting in low sensitivity and a poor signal-...

  • Article
  • Open Access
6 Citations
4,437 Views
16 Pages

18 October 2023

Methanol is a prospective hydrogen storage medium that holds the potential to address the challenges of hydrogen storage and transportation. However, hydrogen production via methanol steam reforming faces several key obstacles, including high reactio...

  • Article
  • Open Access
54 Citations
7,157 Views
18 Pages

Mechanical Metamaterials Foams with Tunable Negative Poisson’s Ratio for Enhanced Energy Absorption and Damage Resistance

  • Shaohua Cui,
  • Baoming Gong,
  • Qian Ding,
  • Yongtao Sun,
  • Fuguang Ren,
  • Xiuguo Liu,
  • Qun Yan,
  • Hai Yang,
  • Xin Wang and
  • Bowen Song

1 October 2018

Systematic and deep understanding of mechanical properties of the negative Poisson’s ratio convex-concave foams plays a very important role for their practical engineering applications. However, in the open literature, only a negative Poisson&r...

  • Article
  • Open Access
5 Citations
2,984 Views
12 Pages

4 December 2021

In the field of modern optical communication systems and photoelectric detection, new components with complex functions and excellent performance are urgently needed. In this paper, a graphene-based parity–time (PT) symmetry structure is propos...

  • Article
  • Open Access
39 Citations
8,517 Views
14 Pages

17 June 2015

The paper presents one of the laser absorption spectroscopy techniques as an effective tool for sensitive analysis of trace gas species in human breath. Characterization of nitric oxide, carbonyl sulphide and ethane, and the selection of their absorp...

  • Article
  • Open Access
12 Citations
3,242 Views
19 Pages

19 May 2021

Surface Enhanced on Infrared Absorption (SEIRAS) and Raman Spectroscopy (SERS) are nondestructive analytic techniques used to detect low concentrations and recognize the fingerprints of molecules. The recognition of the absorption from samples by con...

  • Article
  • Open Access
25 Citations
5,785 Views
11 Pages

25 August 2019

The qualitative and quantitative analysis to trace gas in exhaled human breath has become a promising technique in biomedical applications such as disease diagnosis and health status monitoring. This paper describes an application of a high spectral...

  • Article
  • Open Access
7 Citations
2,860 Views
13 Pages

28 December 2023

Glyoxal (CHOCHO) is a trace gas in the atmosphere, often used as an indicator of biogenic emissions. It is frequently compared to formaldehyde concentrations, which serve as indicators of anthropogenic emissions, to gain insights into the characteris...

  • Review
  • Open Access
176 Citations
19,705 Views
24 Pages

Intestinal Absorption Study: Challenges and Absorption Enhancement Strategies in Improving Oral Drug Delivery

  • Maisarah Azman,
  • Akmal H. Sabri,
  • Qonita Kurnia Anjani,
  • Mohd Faiz Mustaffa and
  • Khuriah Abdul Hamid

8 August 2022

The oral route is the most common and practical means of drug administration, particularly from a patient’s perspective. However, the pharmacokinetic profile of oral drugs depends on the rate of drug absorption through the intestinal wall befor...

  • Article
  • Open Access
9 Citations
4,507 Views
16 Pages

Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats

  • Tammam Alama,
  • Kosuke Kusamori,
  • Masaki Morishita,
  • Hidemasa Katsumi,
  • Toshiyasu Sakane and
  • Akira Yamamoto

Generally, the use of absorption enhancers might be the most effective approaches to ameliorate the enteric absorption of poorly absorbed substances. Among numerous absorption enhancers, we already reported that a gemini surfactant, sodium dilauramid...

  • Review
  • Open Access
228 Citations
21,591 Views
23 Pages

Absorption-Enhancing Effects of Bile Salts

  • Eskandar Moghimipour,
  • Abdulghani Ameri and
  • Somayeh Handali

10 August 2015

Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been e...

  • Article
  • Open Access
15 Citations
4,249 Views
16 Pages

The Effect of Absorption-Enhancement and the Mechanism of the PAMAM Dendrimer on Poorly Absorbable Drugs

  • Juan Lu,
  • Nannan Li,
  • Yaochun Gao,
  • Nan Li,
  • Yifei Guo,
  • Haitao Liu,
  • Xi Chen,
  • Chunyan Zhu,
  • Zhengqi Dong and
  • Akira Yamamoto

10 August 2018

The polyamidoamine (PAMAM) dendrimer is a highly efficient absorption promoter. In the present study, we studied the absorption-enhancing effects and the mechanism of PAMAM dendrimers with generation 0 to generation 3 (G0–G3) and concentrations...

  • Article
  • Open Access
11 Citations
3,140 Views
9 Pages

Dual-Band Light Absorption Enhancement in Hyperbolic Rectangular Array

  • Honglong Qi,
  • Tian Sang,
  • La Wang,
  • Xin Yin,
  • Jicheng Wang and
  • Yueke Wang

16 May 2019

The effect of dual-band light absorption enhancement in a hyperbolic rectangular array (HRA) is presented. The enhanced light absorption of the HRA results from the propagating surface plasmon (PSP) resonance, and a dual-band absorption with low and...

  • Editorial
  • Open Access
32 Citations
8,557 Views
10 Pages

Transmucosal Absorption Enhancers in the Drug Delivery Field

  • Sam Maher,
  • Luca Casettari and
  • Lisbeth Illum

Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely...

  • Article
  • Open Access
41 Citations
5,561 Views
16 Pages

6 January 2022

A composite structure composed of a porous-material layer mosaicked with a perforated resonator is proposed to improve the low-frequency sound absorption of the porous layer. This structure is investigated in the form of a porous-material matrix (PM)...

  • Article
  • Open Access
50 Citations
6,094 Views
8 Pages

Plasmonic Absorption Enhancement in Elliptical Graphene Arrays

  • Jiajia Chen,
  • Yu Zeng,
  • Xibin Xu,
  • Xifang Chen,
  • Zigang Zhou,
  • Pengcheng Shi,
  • Zao Yi,
  • Xin Ye,
  • Shuyuan Xiao and
  • Yougen Yi

19 March 2018

In this paper, we come up with a wavelength tunable absorber which is made up of periodically elliptical graphene arrays in the far-infrared and terahertz regions. Through simulation, we find that we can increase the length of long axis of the ellips...

  • Review
  • Open Access
254 Citations
16,348 Views
20 Pages

Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes

  • Maliheh Ghadiri,
  • Paul M. Young and
  • Daniela Traini

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are being developed every year, making it vital to find a non-invasive route such as nasal or pulmonary for their administration. However, a major concern for some of th...

  • Review
  • Open Access
6 Citations
4,447 Views
14 Pages

Nano-grating Assisted Light Absorption Enhancement for MSM-PDs Performance Improvement: An Updated Review

  • Narottam Das,
  • Mohammad Nur-E-Alam,
  • Alif Islam and
  • Ain Zulaikha Maslihan Ain

28 November 2021

The primary focus of this review article mainly emphasizes the light absorption enhancement for various nanostructured gratings assisted metal-semiconductor-metal photodetectors (MSM-PDs) that are so far proposed and developed for the improvement of...

  • Article
  • Open Access
6 Citations
2,863 Views
13 Pages

28 October 2021

Black carbon (BC), particularly internally mixed and aged BC, exerts a significant influence on the environment and climate. Black carbon coated by non-absorbing materials shows an enhancement of BC absorption, whereas absorptive coatings on BC can r...

  • Article
  • Open Access
16 Citations
11,562 Views
13 Pages

Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization

  • Rebecca Nofsinger,
  • Sophie-Dorothee Clas,
  • Rosa I. Sanchez,
  • Abbas Walji,
  • Kimberly Manser,
  • Becky Nissley,
  • Jaume Balsells,
  • Amrithraj Nair,
  • Qun Dang and
  • Yunhui Wu
  • + 8 authors

24 February 2014

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or en...

  • Article
  • Open Access
7 Citations
2,827 Views
9 Pages

Enhancing the Terahertz Absorption Spectrum Based on the Low Refractive Index All-Dielectric Metasurface

  • Pingan Liu,
  • Wenping Li,
  • Naichang Chen,
  • Chan Ma,
  • Xiangjun Li and
  • Dexian Yan

10 November 2022

We presented an angle-multiplexing low refractive index dielectric metasurface for terahertz absorption spectrum enhancement of lactose with high Q resonance properties. The unit cell structure of the acrylonitrile butadiene styrene (ABS) square stru...

  • Article
  • Open Access
12 Citations
5,042 Views
16 Pages

Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine

  • Yusuke Kamiya,
  • Tsutomu Yamaki,
  • Shigehiro Omori,
  • Masaki Uchida,
  • Kazuo Ohtake,
  • Mitsutoshi Kimura,
  • Hiroshi Yamazaki and
  • Hideshi Natsume

25 January 2018

We reported that the introduction of polyethylene glycol (PEG) to poly-l-ornithine (PLO), which is an homopolymeric basic amino acid having absorption-enhancement ability, prolonged retention time in an in vitro inclined plate test, probably due to a...

  • Review
  • Open Access
2 Citations
1,658 Views
23 Pages

17 September 2025

The integration of nanofluids into solar collectors has gained increasing attention due to their potential to enhance heat transfer and support the transition toward low-carbon energy systems. However, a systematic understanding of their photothermal...

  • Article
  • Open Access
13 Citations
4,528 Views
14 Pages

Arrays of Plasmonic Nanostructures for Absorption Enhancement in Perovskite Thin Films

  • Tianyi Shen,
  • Qiwen Tan,
  • Zhenghong Dai,
  • Nitin P. Padture and
  • Domenico Pacifici

We report optical characterization and theoretical simulation of plasmon enhanced methylammonium lead iodide (MAPbI 3 ) thin-film perovskite solar cells. Specifically, various nanohole (NH) and nanodisk (ND) arrays are fabricated on gold/MAPbI...

  • Review
  • Open Access
143 Citations
24,674 Views
28 Pages

12 December 2014

The transdermal application of drugs has attracted increasing interest over the last decade or so, due to the advantages it offers, compared to other delivery methods. The development of an efficient means of transdermal delivery can increase drug co...

  • Article
  • Open Access
25 Citations
8,045 Views
17 Pages

The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the oral bioavailability of these drugs. Absorption-enhancing agents of natural origins have re...

  • Article
  • Open Access
6 Citations
4,596 Views
12 Pages

2 February 2020

Infrared (IR) absorbers based on a metal–insulator–metal (MIM) have been widely investigated due to their high absorption performance and simple structure. However, MIM absorbers based on ultrathin spacers suffer from low field enhancemen...

  • Article
  • Open Access
15 Citations
6,090 Views
8 Pages

23 August 2016

In this paper, anisotropic graphene plasmonic structures are explored for light trapping and absorption enhancement in surrounding media. It is shown that electrically tunable and versatile spectral and polarization selectivity can be realized. Parti...

  • Article
  • Open Access
1,434 Views
19 Pages

Enhancing Oral Absorption of an Ester Prodrug by Coating Drug Crystals with Binary Lipid Systems and Evaluating the Influence of Compositions

  • Xiaowei Dong,
  • Tao Zhang,
  • Hellen L. Moreno Sanchez,
  • Jaylen C. Mans,
  • Sung Hun Bae and
  • Liangqiao Bian

Background/Objectives: Prodrug strategies are a vital aspect of drug development, with ester prodrugs particularly notable for modifying parent drug properties through ester functional groups to enhance oral absorption. However, ester prodrugs are pr...

  • Article
  • Open Access
7 Citations
4,153 Views
15 Pages

Off-Axis Cavity-Enhanced Absorption Spectroscopy of 14NH3 in Air Using a Gain-Switched Frequency Comb at 1.514 μm

  • Satheesh Chandran,
  • Albert A. Ruth,
  • Eamonn P. Martin,
  • Justin K. Alexander,
  • Frank H. Peters and
  • Prince M. Anandarajah

28 November 2019

A custom-designed gain-switched frequency comb (GSFC) source was passively coupled to a medium finesse (F ≈ 522) cavity in off-axis configuration for the detection of ammonia (14NH3) in static dry air. The absorption of ammonia was detected in...

  • Article
  • Open Access
2 Citations
4,272 Views
10 Pages

Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine

  • Hisanao Kishimoto,
  • Kaori Miyazaki,
  • Hiroshi Tedzuka,
  • Ryosuke Ozawa,
  • Hanai Kobayashi,
  • Yoshiyuki Shirasaka and
  • Katsuhisa Inoue

22 October 2021

As advanced synthetic technology has enabled drug candidate development with complex structure, resulting in low solubility and membrane permeability, the strategies to improve poorly absorbed drug bioavailability have attracted the attention of phar...

  • Article
  • Open Access
25 Citations
2,016 Views
12 Pages

In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox

  • Catharina BENEKE,
  • Alvaro VILJOEN and
  • Josias HAMMAN

1 April 2012

The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance (TEER) as well as transport of...

  • Article
  • Open Access
7 Citations
4,025 Views
13 Pages

Surface-Enhanced Absorption Spectroscopy for Optical Fiber Sensing

  • Silje S. Fuglerud,
  • Karolina Milenko,
  • Astrid Aksnes and
  • Dag R. Hjelme

19 December 2019

Visible and near-infrared spectroscopy are widely used for sensing applications but suffer from poor signal-to-noise ratios for the detection of compounds with low concentrations. Enhancement by surface plasmon resonance is a popular technique that c...

  • Article
  • Open Access
1,258 Views
23 Pages

Anemoside B4 Rectal Thermosensitive In Situ Gel to Treat Ulcerative Colitis by Overcoming Oral Bioavailability Barriers with Absorption Enhancer-Assisted Delivery

  • Xiaomeng Lei,
  • Canjian Wang,
  • Mingyan Xia,
  • Guansheng Zhang,
  • Tangxun Wang,
  • Yang Chen,
  • Yufang Huang,
  • Tiantian Wang,
  • Dongxun Li and
  • Guosong Zhang
  • + 1 author

Background: Anemoside B4 (AB4), the major bioactive saponin from Pulsatilla chinensis, exhibits anti-inflammatory, anti-tumor, anti-apoptotic, and analgesic properties. However, its clinical translation for ulcerative colitis (UC) is constrained by p...

  • Article
  • Open Access
12 Citations
6,965 Views
8 Pages

All-Semiconductor Plasmonic Resonator for Surface-Enhanced Infrared Absorption Spectroscopy

  • Wei Wei,
  • Jinpeng Nong,
  • Xiao Jiang,
  • Na Chen,
  • Suqin Luo and
  • Linlong Tang

19 January 2017

Infrared absorption spectroscopy remains a challenge due to the weak light-matter interaction between micron-wavelengthed infrared light and nano-sized molecules. A highly doped semiconductor supports intrinsic plasmon modes at infrared frequencies,...

  • Article
  • Open Access
24 Citations
5,296 Views
13 Pages

17 September 2021

Hierarchical lattices are structures composed of self-similar or dissimilar architected metamaterials that span multiple length scales. Hierarchical lattices have superior and tunable properties when compared to conventional lattices, and thus, open...

  • Article
  • Open Access
7 Citations
8,798 Views
13 Pages

Fano Resonance Enhanced Nonreciprocal Absorption and Scattering of Light

  • Ben Hopkins,
  • Andrey E. Miroshnichenko,
  • Alexander N. Poddubny and
  • Yuri S. Kivshar

22 June 2015

We reveal that asymmetric plasmonic nanostructures can exhibit significantly different absorption and scattering properties for light that propagates in opposite directions, despite the conservation of total extinction. We analytically demonstrate th...

  • Article
  • Open Access
30 Citations
7,533 Views
18 Pages

Pharmaceutical Cocrystal Development of TAK-020 with Enhanced Oral Absorption

  • Kouya Kimoto,
  • Mitsuo Yamamoto,
  • Masatoshi Karashima,
  • Miyuki Hohokabe,
  • Junpei Takeda,
  • Katsuhiko Yamamoto and
  • Yukihiro Ikeda

18 March 2020

The objective of this study was to improve the solubility of poorly water-soluble drugs by pharmaceutical cocrystal engineering techniques and select the best pharmaceutical forms with high solubility and solubilized formulations for progress from th...

  • Article
  • Open Access
8 Citations
3,349 Views
10 Pages

Enhanced SO2 Absorption Capacity of Sodium Citrate Using Sodium Humate

  • Zhiguo Sun,
  • Yue Zhou,
  • Shichao Jia,
  • Yaru Wang,
  • Dazhan Jiang and
  • Li Zhang

20 July 2021

A novel method of improving the SO2 absorption performance of sodium citrate (Ci-Na) using sodium humate (HA–Na) as an additive was put forward. The influence of different Ci-Na concentration, inlet SO2 concentration and gas flow rate on desulfurizat...

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