Next Article in Journal
Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
Previous Article in Journal
Molecular Structures of the Products of a Diphosphonate Ester Building Block with Lewis Bases
Open AccessReview

Absorption-Enhancing Effects of Bile Salts

Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-33184, Iran
Department of Drug and Food Control, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-33184, Iran
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(8), 14451-14473;
Received: 19 June 2015 / Revised: 28 July 2015 / Accepted: 31 July 2015 / Published: 10 August 2015
(This article belongs to the Section Medicinal Chemistry)
Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been extensively studied to enhance transepithelial permeability for different marker molecules and drugs. They readily agglomerate at concentrations above their critical micelle concentration (CMC). The mechanism of absorption enhancement by bile salts appears to be complex. The aim of the present article was to review bile salt structure and their application as absorption enhancers and the probable mechanism for increasing permeation based on previous studies. View Full-Text
Keywords: bile salts; drug delivery; absorption enhancers bile salts; drug delivery; absorption enhancers
Show Figures

Figure 1

MDPI and ACS Style

Moghimipour, E.; Ameri, A.; Handali, S. Absorption-Enhancing Effects of Bile Salts. Molecules 2015, 20, 14451-14473.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop