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24 Results Found

  • Communication
  • Open Access
1,599 Views
11 Pages

XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease

  • Simon Woelfel,
  • Joel Dütschler,
  • Daniel Junker,
  • Marius König,
  • Georg Leinenkugel,
  • Claudia Krieger,
  • Samuel Truniger,
  • Annett Franke,
  • Seraina Koller and
  • Stephan Brand
  • + 10 authors

16 July 2025

Background: Mucosal immunity plays a pivotal role in preventing infections with SARS-CoV-2. While COVID-19 mRNA vaccines induce robust systemic immune responses in patients with inflammatory bowel disease (IBD), little is known about their efficacy i...

  • Brief Report
  • Open Access
1 Citations
2,421 Views
12 Pages

STAR LIGHT Study: XBB.1.5 COVID-19 mRNA Vaccines Boost Systemic but Not Mucosal Immunity Against the SARS-CoV-2 JN.1 Variant in Patients with Chronic Liver Disease

  • Simon Woelfel,
  • Daniel Junker,
  • Irina Bergamin,
  • Pamela Meyer-Herbon,
  • Roman Stillhard,
  • Nicole Graf,
  • Georg Leinenkugel,
  • Joel Dütschler,
  • Marius König and
  • Stephan Brand
  • + 18 authors

31 October 2024

Background: Patients with chronic liver disease (CLD) have impaired vaccine immunogenicity and an excess risk of severe COVID-19. While variant-adapted COVID-19 mRNA vaccines are recommended for vulnerable individuals, their efficacy in patients with...

  • Brief Report
  • Open Access
8 Citations
2,781 Views
12 Pages

Systemic and Mucosal Immunogenicity of Monovalent XBB.1.5-Adapted COVID-19 mRNA Vaccines in Patients with Inflammatory Bowel Disease

  • Simon Woelfel,
  • Joel Dütschler,
  • Daniel Junker,
  • Marius König,
  • Georg Leinenkugel,
  • Nicole Graf,
  • Claudia Krieger,
  • Samuel Truniger,
  • Annett Franke and
  • Stephan Brand
  • + 14 authors

15 July 2024

Recently updated COVID-19 mRNA vaccines encode the spike protein of the omicron subvariant XBB.1.5 and are recommended for patients with inflammatory bowel disease (IBD) on immunosuppressive treatment. Nonetheless, their immunogenicity in patients wi...

  • Article
  • Open Access
1 Citations
2,350 Views
15 Pages

Revealing the Binarity of HD 36030—One of the Hottest Flare Stars

  • Olga Maryeva,
  • Péter Németh and
  • Sergey Karpov

12 April 2023

The Kepler and TESS space missions significantly expanded our knowledge of what types of stars display flaring activity by recording a vast amount of super-flares from solar-like stars, as well as detecting flares from hotter stars of A-F spectral ty...

  • Article
  • Open Access
6 Citations
2,641 Views
23 Pages

Small object detection in traffic sign applications often faces challenges like complex backgrounds, blurry samples, and multi-scale variations. Existing solutions tend to complicate the algorithms. In this study, we designed an efficient and simple...

  • Article
  • Open Access
3 Citations
3,638 Views
22 Pages

Through signs and symbols, maps represent geographic space in a generalized and abstracted way. Cartographic research is, therefore, concerned with establishing a mutually shared set of signs and semiotic rules to communicate geospatial information s...

  • Article
  • Open Access
12 Citations
3,425 Views
15 Pages

11 January 2023

As one of the entropy-based methods, the k-Star algorithm benefits from information theory in computing the distances between data instances during the classification task. k-Star is a machine learning method with a high classification performance an...

  • Communication
  • Open Access
6 Citations
1,590 Views
11 Pages

Femtoscopy has the capacity to probe the space-time geometry of the particle-emitting source in heavy-ion collisions. In particular, femtoscopy of like-sign kaon pairs may shed light on the origin of non-Gaussianity of the spatial emission probabilit...

  • Article
  • Open Access
22 Citations
3,048 Views
21 Pages

1 September 2022

The development of green residences is crucial to reducing energy consumption and carbon emissions of the construction industry. However, the study on the spatial distribution characteristics of green residences and its influencing factors has not at...

  • Article
  • Open Access
2 Citations
1,217 Views
11 Pages

IRAS 17449+2320: A Possible Binary System with the B[e] Phenomenon and a Strong Magnetic Field

  • Sergey Zharikov,
  • Anatoly Miroshnichenko,
  • Inna Reva,
  • Raushan Kokumbaeva,
  • Chingis Omarov,
  • Steve Danford,
  • Alicia Aarnio,
  • Nadine Manset,
  • Ashish Raj and
  • Joseph Daglen
  • + 1 author

31 March 2025

We report the recent results of a long-term spectroscopic and photometric monitoring of IRAS 17449+2320, a member of the least studied group of objects with the B[e] phenomenon called FS CMa-type objects. The main hypothesis for explaining the strong...

  • Article
  • Open Access
1,893 Views
12 Pages

Background/Objectives: Granular cell tumors (GCTs) are rare neurogenic tumors with Schwann cell differentiation. Although most are benign, 1–2% exhibit malignant behavior. The imaging features of GCTs remain poorly characterized due to their ra...

  • Article
  • Open Access
2 Citations
3,010 Views
20 Pages

14 October 2024

Safety culture is a key feature between employees’ job performance and organizational commitment. Hotel businesses are an important component of the service sector, and a customer-oriented approach in these businesses increases organizational p...

  • Review
  • Open Access
522 Views
26 Pages

19 November 2025

We review the recent progress in Monte Carlo simulations of dense two-color QCD (QC2D), focusing on the phase diagram, the equation of state, and the sound velocity in the low-temperature regime. In three-color QCD at finite density, especially at lo...

  • Review
  • Open Access
35 Citations
13,181 Views
20 Pages

1 January 2023

Front-of-Pack Nutrition labels (FOPNLs) aim to improve consumers’ food purchases and prompt product reformulation by the food and beverage industry. Despite their widespread use, the effectiveness of FOPNL in achieving these goals is still a ma...

  • Article
  • Open Access
8 Citations
2,524 Views
24 Pages

Formulation of Polymeric Nanoparticles Loading Baricitinib as a Topical Approach in Ocular Application

  • Negar Beirampour,
  • Paola Bustos-Salgado,
  • Núria Garrós,
  • Roya Mohammadi-Meyabadi,
  • Òscar Domènech,
  • Joaquim Suñer-Carbó,
  • María José Rodríguez-Lagunas,
  • Garyfallia Kapravelou,
  • María Jesús Montes and
  • Mireia Mallandrich
  • + 1 author

Topical ocular drug delivery faces several challenges due to the eye’s unique anatomy and physiology. Physiological barriers, tear turnover, and blinking hinder the penetration of drugs through the ocular mucosa. In this context, nanoparticles...

  • Article
  • Open Access
1,012 Views
17 Pages

Tracing Ice-Age Legacies: Phylogeography and Glacial Refugia of the Endemic Chiton Tonicina zschaui (Polyplacophora: Ischnochitonidae) in the West Antarctic Region

  • M. Cecilia Pardo-Gandarillas,
  • Carolina Márquez-Gajardo,
  • Pamela Morales,
  • Jennifer Catalán,
  • Kristen Poni,
  • Sebastián Rosenfeld,
  • Angie Díaz,
  • Kevin M. Kocot and
  • Christian M. Ibáñez

6 September 2025

Phylogeographic studies in Antarctica allow us to understand the demographic events of populations during glacial periods. In this study, the polyplacophoran Tonicina zschaui was analyzed in several localities on the West Antarctic Coast using the mi...

  • Article
  • Open Access
495 Views
18 Pages

24 November 2025

This study addresses the trade-off between accuracy and efficiency in predicting the aerodynamics and wakes of large wind turbines. We developed a unified immersed boundary–actuator line framework with large-eddy simulation. The actuator line e...

  • Article
  • Open Access
4 Citations
2,916 Views
13 Pages

The Effect of Prolactin on Gene Expression and the Secretion of Reproductive Hormones in Ewes during the Estrus Cycle

  • Sicong Yue,
  • Jiaxin Chen,
  • Chunhui Duan,
  • Xiangyun Li,
  • Ruochen Yang,
  • Meijing Chen,
  • Yu Li,
  • Zhipan Song,
  • Yingjie Zhang and
  • Yueqin Liu

25 June 2024

Prolactin (PRL) plays an important role in animal follicle development and ovulation. However, its regulatory effects on the different stages of the estrus cycle in ewes are unclear. In this study, bromocriptine (BCR, PRL inhibitor) was used to study...

  • Review
  • Open Access
19 Citations
11,572 Views
19 Pages

Cytauxzoon felis: An Overview

  • Yvonne M. Wikander and
  • Kathryn E. Reif

13 January 2023

Cytauxzoon felis is a tick-transmitted, obligate, hemoprotozoal, piroplasmid pathogen of felids and the causative agent of cytauxzoonosis. It has a complex life cycle which includes a tick as its definitive host and a felid as its intermediate host....

  • Review
  • Open Access
21 Citations
7,796 Views
30 Pages

Possibilities for an Aerial Biosphere in Temperate Sub Neptune-Sized Exoplanet Atmospheres

  • Sara Seager,
  • Janusz J. Petkowski,
  • Maximilian N. Günther,
  • William Bains,
  • Thomas Mikal-Evans and
  • Drake Deming

The search for signs of life through the detection of exoplanet atmosphere biosignature gases is gaining momentum. Yet, only a handful of rocky exoplanet atmospheres are suitable for observation with planned next-generation telescopes. To broaden pro...

  • Article
  • Open Access
182 Citations
39,512 Views
23 Pages

Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects

  • Ma’mon M. Hatmal,
  • Mohammad A. I. Al-Hatamleh,
  • Amin N. Olaimat,
  • Malik Hatmal,
  • Dina M. Alhaj-Qasem,
  • Tamadur M. Olaimat and
  • Rohimah Mohamud

Background: Since the coronavirus disease 2019 (COVID-19) was declared a pandemic, there was no doubt that vaccination is the ideal protocol to tackle it. Within a year, a few COVID-19 vaccines have been developed and authorized. This unparalleled in...

  • Article
  • Open Access
11 Citations
3,348 Views
19 Pages

Influence of Estrus on Dairy Cow Milk Exosomal miRNAs and Their Role in Hormone Secretion by Granulosa Cells

  • Wenju Liu,
  • Chao Du,
  • Liangkang Nan,
  • Chunfang Li,
  • Haitong Wang,
  • Yikai Fan,
  • Ao Zhou and
  • Shujun Zhang

Estrus is crucial for cow fertility in modern dairy farms, but almost 50% of cows do not show the behavioral signs of estrus due to silent estrus and lack of suitable and high-accuracy methods to detect estrus. MiRNA and exosomes play essential roles...

  • Article
  • Open Access
12 Citations
3,740 Views
21 Pages

Chick Chorioallantoic Membrane as a Patient-Derived Xenograft Model for Uveal Melanoma: Imaging Modalities for Growth and Vascular Evaluation

  • Theodora Tsimpaki,
  • Nikolaos E. Bechrakis,
  • Berthold Seitz,
  • Miriam M. Kraemer,
  • Hongtao Liu,
  • Sami Dalbah,
  • Ekaterina Sokolenko,
  • Utta Berchner-Pfannschmidt and
  • Miltiadis Fiorentzis

24 February 2023

Background: Patient-derived tumor xenografts (PDXs) have emerged as valuable preclinical in vivo models in oncology as they largely retain the polygenomic architecture of the human tumors from which they originate. Although animal models are accompan...

  • Article
  • Open Access
9 Citations
1,307 Views
13 Pages

Bortezomib in Multiple Myeloma and Lymphoma: A Systematic Review and Clinical Practice Guideline

  • D. Reece,
  • K. Imrie,
  • A. Stevens,
  • C.A. Smith and
  • for the Hematology Disease Site Group of Cancer Care Ontario’s Program in Evidence-Based Care

1 October 2006

Questions: (1) In patients with multiple myeloma, Waldenström macroglobulinemia, or lymphoma, what is the efficacy of bortezomib alone or in combination as measured by survival, quality of life, disease control (for example, time to progression), res...