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  • Article
  • Open Access
624 Views
9 Pages

Background: Combination therapy for Enterococcus faecalis was established in the 1940s due to high rates of treatment failure, especially for infective endocarditis (IE). However, during this period antimicrobials were limited, optimal dosing was unk...

  • Article
  • Open Access
522 Views
9 Pages

Background/Objectives: Our objective was to describe the safety and efficacy of enteral droxidopa, a norepinephrine prodrug, for intravenous (IV) vasopressor weaning in intensive care unit (ICU) patients. Methods: This was a single-center, retrospect...

  • Article
  • Open Access
485 Views
10 Pages

Using Conjoint Analysis to Elicit Benefit–Risk Preferences for Different Treatment Options Among Psoriasis Patients Receiving Systemic Therapy

  • Antonios Tsartsarakis,
  • Eleftheria Tampouratzi,
  • Christos Moulias,
  • Konstantinos Sfaelos and
  • Vassilis Aletras

Background: Psoriasis has a huge impact on a patient’s life. Treatment dissatisfaction and non-adherence are common among patients with psoriasis, partly due to discordance between individual preferences and recommended treatments. The modern s...

  • Review
  • Open Access
1,798 Views
19 Pages

Advancements in Hematopoietic Stem Cell Therapy: From Biological Pathways to Emerging Therapeutic Strategies

  • Viviana Cortiana,
  • Harshal Chorya,
  • Rabab Hunaid Abbas,
  • Jade Gambill,
  • Adhith Theyver,
  • Chandler H. Park and
  • Yan Leyfman

Hematopoietic stem cell (HSC) therapy remains essential in treating blood disorders, autoimmune diseases, neurodegenerative conditions, and cancers. Despite its potential, challenges arise from the inherent heterogeneity of HSCs and the complexity of...

  • Article
  • Open Access
756 Views
13 Pages

Real-Life Experience with Cytomegalovirus Hyperimmune Globulin in a Lung Transplant Unit: Long-Term Outcomes

  • Raquel Sanabrias Fernández de Sevilla,
  • Sarela García-Masedo Fernández,
  • Rosalía Laporta Hernández,
  • Myriam Aguilar Pérez,
  • Christian García Fadul,
  • María Teresa Lázaro Carrasco de la Fuente,
  • Enrique Rodríguez Rubio,
  • Amelia Sánchez Guerrero,
  • Carlos Almonacid Sánchez and
  • María Piedad Ussetti Gil

Background/Objectives: Cytomegalovirus (CMV) infection is a frequent complication after lung transplantation, especially in high-risk donor-positive/recipient-negative (D+/R−) patients. CMV-specific hyperimmunoglobulin (CMV-HIG), administered e...

  • Review
  • Open Access
3,011 Views
13 Pages

Androgen Deprivation Therapy and Salvage Radiotherapy in Post-Radical Prostatectomy Biochemical Recurrence of Prostate Cancer: Current Evidence

  • Paula Simon-Silva,
  • Rocio del Castillo-Acuña,
  • Jonathan Saavedra-Bejarano,
  • Angeles Sanchez-Galvez,
  • Antonio Lazo-Prados and
  • Manuel Luis Blanco-Villar

Background/Objectives: Biochemical recurrence (BCR) occurs in 15–40% of men within five years of radical prostatectomy (RP), presenting a major challenge for long-term disease control. While salvage radiotherapy (SRT) and androgen deprivation t...

  • Communication
  • Open Access
3,524 Views
13 Pages

Low-Dose Dimethyl Sulfoxide (DMSO) Suppresses Androgen Receptor (AR) and Its Splice Variant AR-V7 in Castration-Resistant Prostate Cancer (CRPC) Cells

  • Namrata Khurana,
  • Hogyoung Kim,
  • Talal Khan,
  • Shohreh Kahhal,
  • Amar Bukvic,
  • Asim B. Abdel-Mageed,
  • Debasis Mondal and
  • Suresh C. Sikka

Background: The outgrowth of castration-resistant prostate cancer (CRPC) dictates patient morbidity and mortality. Recurrence of prostate cancer (PC) following androgen-deprivation therapy (ADT) often occurs due to constitutively active androgen rece...

  • Article
  • Open Access
1,092 Views
10 Pages

The Impact of Prior Substance Use on Postoperative Outcomes Following Gender-Affirming Surgery

  • Chrishaun Alexander,
  • Akeem Henry,
  • Derek Nuamah,
  • Joshua Lewis,
  • Bryce Gantt,
  • Kelsey M Green,
  • Malory Alexis and
  • Oyetokunbo Ibidapo-Obe

Background/Objectives: Gender-affirming surgery (GAS) is associated with improved mental health outcomes in transgender and gender-diverse (TGD) individuals. However, TGD populations experience disproportionately high rates of substance use disorders...

  • Systematic Review
  • Open Access
1,789 Views
18 Pages

Effectiveness of Lifestyle-Based Approaches for Adults with Multiple Chemical Sensitivity: A Systematic Review

  • Isidro Miguel Martín Pérez,
  • David Alejandro Parra Castillo,
  • Carlos Pastor Ruiz de la Fuente and
  • Sebastián Eustaquio Martín Pérez

Background: Multiple Chemical Sensitivity (MCS) is a complex, disabling condition marked by non-specific symptoms in response to low-level chemical exposures. It often leads to substantial impairments in quality of life, psychological health, and dai...

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Therapeutics - ISSN 2813-9909