Radioactive iodine (RAI) treatment for thyroid disease may be a treatment option for patients with high-risk differentiated thyroid cancer (DTC) or hyperthyroidism caused by Graves’ disease, toxic multinodular goiter, and toxic adenoma. Despite...
Purpose: To study in detail how the various quantities entering the calculation of the air-kerma strength of brachytherapy sources affect the final value of this key quantity. Specifically, this study examines the role of the electrons emitted by the...
Accurate positioning is essential in breast radiotherapy; however, rigid phantoms do not reproduce posture-related anatomical deformation. We developed a breast-mimicking rubber and silicone phantom to evaluate dosimetric effects of arm-position-indu...
Palliative radiotherapy (RT) is frequently delivered in time-sensitive clinical settings and requires rapid, patient-centred decision-making while balancing symptom burden, prognosis, comorbidities, treatment burden, and individual goals of care. Inc...
Objectives: To assess the impact of magnetic resonance imaging (MRI) versus computed tomography (CT) on target delineation and dosimetry in adjuvant vaginal cuff brachytherapy (VBT) for endometrial cancer. Methods: Twenty-five consecutive patients re...
Precision radiotherapy is becoming increasingly complex, requiring integration of multimodal imaging, treatment planning, adaptive radiotherapy, and diverse clinical data. This paper proposes agentic AI as a responsible clinical decision-support fram...
Identification of novel biomarkers in triple-negative breast cancer (TNBC), one of the most aggressive breast cancer subtypes, is of critical clinical importance. Although radiation treatment (RT) is a cornerstone of TNBC treatment, resistance to RT...
Pancreatic neuroendocrine neoplasms (PanNENs) are a heterogeneous group of tumors characterized by variable biological behavior and frequent overexpression of somatostatin receptors, making them ideal candidates for theranostic approaches. Over the p...
Background: Radiotherapy commonly requires a computed tomography (CT) dataset for treatment planning. Artificial intelligence-supported radiotherapy systems now enable online adaptive workflows that reduce uncertainties resulting from the use of diag...
Introduction: The increasing costs of cancer care have raised the need for economic evaluations that integrate treatment efficacy and resource utilization. This study aimed to assess the economic value of Lutetium-177 (177Lu)–prostate-specific...
This study aimed to evaluate the utility of a 3D-printed, weight-bearing auxiliary device designed to improve reproducibility and facilitate detector fixation during axiolateral radiography of hip joints known to be affected by inter-operator variabi...
Symptomatic high-grade carotid stenosis may present with extensive ipsilateral hemispheric hypoperfusion without a large infarct core, a grey-zone phenotype between standard early and truly urgent carotid revascularization. This single-centre retrosp...
Endovascular aneurysm repair (EVAR) has become a widely adopted treatment for abdominal aortic aneurysms, offering lower perioperative morbidity and mortality than open surgical repair. Nevertheless, long-term imaging surveillance remains essential b...
Background: High-dose-rate interventional radiotherapy (HDR IRT) relies on accurate dose calculations to ensure safe and effective treatment. The AAPM TG-43 formalism, based on homogeneous water assumptions, has long been the clinical standard, but t...
The aim of this study was to compare the accuracy of different sub-200 µm voxel reconstruction of CBCT scans in the identification of root canal anatomy. Cadaveric dentate maxillae and mandibles with soft tissues attached (69 teeth comprising 9...
Background: Actinium-225 (225Ac) is receiving major attention as the radionuclide of choice for targeted alpha therapy (TAT) due to its outstanding physical properties such as a long physical half-life of 9.9 days and a short range of alpha (α)...
Osteoradionecrosis of the jaw (ORNJ) remains one of the most severe late complications of head and neck radiotherapy. Current evidence suggests that ORNJ is a progressive and biologically heterogeneous disorder driven by microvascular injury, chronic...
Radiotherapy for glioblastoma remains anchored to postoperative structural MRI and anatomy-based target definitions, despite marked spatial heterogeneity and dynamic biological change during chemoradiotherapy. Advanced MRI, amino-acid PET, radiomics,...
Accurate calculation of gamma dose rates in medical and industrial facilities is a critical component of comprehensive dosimetry assessment. Usually, two complementary approaches are employed to this end: experimental measurements and Monte Carlo (MC...
Radiation therapy is central to the management of gynecological cancers, including endometrial, cervical, ovarian, and vaginal malignancies. Despite advances in photon-based techniques, treatment-related toxicity remains significant owing to the anat...
Background: Pancreatic resection (Pancreatoduodenectomy, PD, distal pancreatectomy, DP, or total pancreatectomy, TP) is the standard of care for resectable pancreatic adenocarcinoma (PDAC). Despite advances in multimodal therapy, recurrence rates rem...
Background: Radiation dermatitis (ARD), particularly its most severe form, moist desquamation (MD), is a frequent and distressing complication of external beam radiotherapy (RT) in head and neck (H&N) cancer patients. Standard management often pr...
Radiation therapy quality assurance (RTQA) is critical to the success of RT and impacts trial outcomes. We aimed to evaluate the existence of standardized quantitative metrics to grade contours as part of RTQA and to identify barriers to standardizat...
Preclinical studies and data from other cancers suggest that inhibition of the Hedgehog (Hh) pathway also has antiproliferative effects on glioma cells. A key component of this pathway is the Smoothened (SMO) protein, which is expressed in high-grade...
This study aims to evaluate the quantitative impact of FDG-PET on detecting extra-pelvic metastases in women with cervical cancer, using population-based data, following its approval by US Medicare/Medicaid in 2005 for staging patients without detect...
Microbeam Radiation Therapy (MRT) is a drastically novel approach of radiosurgery, challenging the understanding of how normal tissues respond to radiation therapy, where X-rays generated by a synchrotron light source are collimated into wafers of hi...
Background: Nasopharyngeal carcinoma (NPC) presents significant diagnostic and therapeutic challenges, often due to late-stage detection and its complex anatomical location. The increasing integration of artificial intelligence (AI) into oncology off...
Introduction: Radiotherapy (RT) plays a crucial role in the management of prostate cancer (PC). Artificial intelligence (AI) is reshaping cancer care by providing innovative tools for diagnosis, treatment optimization, and outcome prediction. This re...
Background. Patients with malignant or benign central nervous system (CNS) tumours are evaluated for suitability of treatment modality based on multiple clinical and tumour-related factors. To obtain multidisciplinary consensus, a patient’s fil...
Background: Cancer patients receiving or having received radiotherapy (RT) represent a clinically vulnerable group during the COVID-19 pandemic. However, systematic data on their clinical course, comorbidities, and vaccination status are limited. The...
Cancer remains a significant global health burden, often requiring conventional treatments characterized by considerable side effects and limited tumor specificity. This review addresses the critical gap in understanding the non-thermal mechanisms by...
Background/Objectives: Hemangioblastomas are rare, benign, highly vascular tumors of the central nervous system, frequently associated with von Hippel–Lindau (vHL) disease. Case Presentation: We report a 16-year-old female with vHL presenting w...
Introduction: Lattice Radiation Therapy (LRT) is an evolving spatially fractionated radiation therapy (SFRT) technique that delivers heterogeneous dose distributions to large and radioresistant tumors. The literature highlights LRT’s potential...
This retrospective study evaluated patient radiation dose during fluoroscopy-guided peripherally inserted central catheter (PICC) placement. A total of 1240 consecutive adult patients who underwent PICC placement between January 2023 and December 202...
Stereotactic body radiation therapy (SBRT) for localized prostate cancer delivers high doses per fraction, making dose constraints for the rectum and other organs at risk critical during treatment planning. This study evaluated the association betwee...
Proton therapy offers superior dose localization, yet the biological effects of low-energy protons relevant to superficial tissues remain underexplored. We report the design and validation of a proton irradiation setup developed at the Tandem Acceler...
Anesthesia is the gold standard for immobilization of tumor-bearing mice before radiotherapy which potentially induces stress and distorts disease progression. Irradiation of preclinical cancer models with clinical MV linear accelerator (LINAC) beams...
Background: One method for the radiation therapy of rectal cancer is to set patients supine and treat them with volumetric modulated arc therapy (VMAT). The posterior skin dose is of concern due to undesirable bolusing from mounting surfaces the pati...
Background: Interpretation of radiographs is prone to diagnostic errors. Artificial intelligence (AI) has shown promising results in fracture detection, although systematic evaluation of software updates remains limited. This study compares the diagn...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Pulmonary function tests (PFTs) and quantitative indices (QIs) of computed tomography (CT) are typically used to diagnose COPD. The purpose of this work was t...
Breast cancer remains a major global health challenge, with treatment access further constrained during the COVID-19 pandemic, particularly in resource-limited settings. This study evaluates the in vitro effects of hypofractionated versus conventiona...
We compared scatter correction (SC) in single-photon emission computed tomography (SPECT) images using effective scatter source estimation (ESSE) and the triple-energy window (TEW) method. We acquired 99mTc and 123I images of brain, myocardial, and p...
Radiopharmaceutical therapy (RPT) offers tumor-selective radiation delivery and represents a promising platform for combination with immune checkpoint inhibitors (ICIs). While prior studies suggest that RPT can stimulate antitumor immunity, synergy w...
Purpose: This study aimed to compare QoL outcomes among patients undergoing active breathing control (ABC), voluntary deep inspiration breath hold (vDIBH), and surface-guided radiation therapy (SGRT). Methods: This was a non-randomized, three-arm cli...
Introduction. This study aims to conduct a cost-effectiveness analysis comparing two primary treatment approaches: radical prostatectomy versus radiotherapy plus androgen deprivation therapy (ADT) in patients with Prostate Imaging Reporting and Data...
Radiation therapy (RT) has been one of the standard treatments for prostate cancer; however, its potential impact on nearby neural structures, such as the lumbosacral plexus (LSP), is often overlooked. The lack of contouring in treatment plans has le...
High doses of ionizing radiation during prenatal development can cause growth restriction, or a decrease in growth of the developing offspring. This outcome of intrauterine growth restriction (IUGR) can predispose the offspring to lifelong health out...
Online adaptive radiotherapy mitigates errors in absorbed dose delivery due to daily anatomical changes during hypofractionated breast treatment, particularly when comprehensive nodal therapy includes the internal mammary chain. To illustrate this, w...
Background: FLASH radiotherapy delivers ultra-high dose rates with normal tissue sparing, but mechanisms remain unclear. We present a streamlined workflow for establishing a LINAC-based electron FLASH (eFLASH) platform in low-resource settings withou...
Fractal dimension (Frac) and lacunarity (Lac) are frequently proposed as biomarkers of multiscale image complexity, but their incremental value over standardized radiomics remains uncertain. We position both measures within the Image Biomarker Standa...
