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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Immunometabolic Role of the Erythrocyte

edited by

Charalampos Papadopoulos

and

Vassilis L. Tzounakas

submission deadline 20 Sep 2026 | Viewed by 317 | Submission Open

Keywords: erythrocyte; immunometabolism; TLR9; glycerophospholipids; sphingolipids; purines; sugars; amino acids; eryptosis; CD47

(This special issue belongs to the Section Cell Metabolism)

Redox Signaling and Metabolic Changes in Liver Diseases

edited by

Kamalakannan Radhakrishnan

submission deadline 20 Sep 2026 | Viewed by 240 | Submission Open

Keywords: redox signaling; metabolic disease; oxidative stress; mitochondrial function; antioxidant defense; energy metabolism; therapeutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacodynamics and Innovative Therapeutic Strategies for Metabolic Disorders

edited by

Josué V. Espinosa-Juárez

Osmar Antonio Jaramillo-Morales

and

Victor Gault

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1227 | Submission Open

Keywords: pharmacology; experimental therapeutics; metabolic diseases; drug development; therapeutic innovations; metabolic pathways; pharmacodynamics; disease management

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Obesity and Metabolic Health, 2nd Edition

edited by

Natalia Ferreira Mendes

and

Eliana Pereira De Araújo

submission deadline 25 Sep 2026 | 1 articles | Viewed by 749 | Submission Open

Keywords: glial cells; blood–brain barrier; gut microbiota; immune surveillance; glucose metabolism; energy metabolism; food intake

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Signaling, Therapeutics and Controlled Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 30 Sep 2026 | 2 articles | Viewed by 6060 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics Insights into Environmental Pollution: Unraveling Metabolic Responses to Contaminants

edited by

Dechun Chen

submission deadline 30 Sep 2026 | 4 articles | Viewed by 4996 | Submission Open

Keywords: metabolomics; environmental contaminants; biomarkers; toxicity mechanisms; metabolic alterations; ecological health; human health; cellular metabolism; organismal metabolism; pollution mitigation strategies

(This special issue belongs to the Section Environmental Metabolomics)

LC-MS/MS Analysis for Plant Secondary Metabolites, 2nd Edition

edited by Tiantian Ye

submission deadline 30 Sep 2026 | 5 articles | Viewed by 4514 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

The Impact of Environmental Contaminants on Neurodevelopment and Human Metabolism

edited by

Cláudia Sirlene Oliveira

and

Izonete Cristina Guiloski

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4414 | Submission Open

Keywords: pesticides; metals; mercury; methylmercury; developing organism; oxidative stress

(This special issue belongs to the Section Environmental Metabolomics)

Metabolomics in Human Diseases and Health: 2nd Edition

edited by

Dimitris Kounatidis

and

Iordanis Mourouzis

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4298 | Submission Open

Keywords: metabolomics; NAFLD; biomarkers; obesity; mass spectrometry; NMR spectroscopy; diabetes mellitus; cancer; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Advances in Metabolomics)

Metabolic Research in Animal Nutrition and Production, 2nd Edition

edited by Tietao Zhang and Qingkui Jiang

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1117 | Submission Open

Keywords: special economic animals; companion animals; nutrition; metabolomics; microbiome; metabolites; animal nutrition; animal production; animal health and disease; metabolic phenotypes

(This special issue belongs to the Section Animal Metabolism)

The Role of Metabolites and the Gut Microbiota in Development, Homeostasis, and Diseases

edited by Miriam Di Mattia and

Valentina Petito

submission deadline 30 Sep 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: microbiota; metabolites; gut homeostasis; intestinal barrier; host interactions; inflammation; gut–organ axis

(This special issue belongs to the Section Cell Metabolism)

Metabolism in Lung Development and Injury/Repair Throughout Human Lifetime

edited by

Evgenia Dobrinskikh

submission deadline 30 Sep 2026 | Viewed by 264 | Submission Open

Keywords: lung development; injury and repair; metabolomics; transcriptomics; lipidomics; surfactant metabolism; redox biology; spatial metabolomics; imaging; single cell; FGR; CDH; preterm birth; fibrosis; environmental exposure; aging

(This special issue belongs to the Section Cell Metabolism)

Metabolic Pathways in Cardiovascular and Cerebrovascular Conditions

edited by

Angom Ramcharan Singh

submission deadline 30 Sep 2026 | Viewed by 150 | Submission Open

Keywords: cardiovascular metabolism; cerebrovascular disease; metabolic reprogramming; mitochondrial dysfunction; endothelial metabolism; neurovascular unit; oxidative stress and redox signaling; lipid and glucose metabolism; hypoxia and ischemia; metabolic inflammation; heart–brain axis; therapeutic metabolic targeting

(This special issue belongs to the Section Cell Metabolism)

Management of Diabetes and Its Metabolic Complications

edited by

Aldo Ferreira-Hermosillo

submission deadline 12 Oct 2026 | Viewed by 405 | Submission Open

Keywords: diabetes complications; physiopathology; therapeutics; diet therapy; cardiovascular disease; metabolic dysfunction-associated steatotic liver disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Lipidomics in MASLD and Related Liver Disorders

edited by Aleksandra Bołdys and Michał Nicze

submission deadline 15 Oct 2026 | 2 articles | Viewed by 3158 | Submission Open

Keywords: MASLD; metabolomics; lipidomics; liver disease; biomarkers; metabolic profiling; nonalcoholic fatty liver disease; oxidative stress; mitochondrial dysfunction; systems biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Early-Stage Biomarkers: Metabolomics in Preclinical and Prodromal Disease Detection

edited by

Sonali Mishra

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1174 | Submission Open

Keywords: early-stage biomarkers; metabolomics; biomarker validation; untargeted and targeted approaches; cohort studies; multi-omics integration; machine learning / AI; translational research; early disease detection; cancer, neurodegenerative, cerebrovascular, autoimmune, infectious, and psychiatric disorders

(This special issue belongs to the Section Advances in Metabolomics)

Biological Activity and Chemical Biodiversity of Plant Secondary Metabolites

edited by

Catherine Cook

submission deadline 15 Oct 2026 | Viewed by 282 | Submission Open

Keywords: secondary metabolites; chemical diversity; biological activities; plant defense; environmental interactions; nutritional and medicinal applications

(This special issue belongs to the Section Plant Metabolism)

Metabolic Responses to Exercise Training

edited by

Hee-Tae Roh

submission deadline 15 Oct 2026 | Viewed by 273 | Submission Open

Keywords: exercise metabolism; exercise training; physical activity; acute exercise responses; environmental exercise physiology; metabolomics; metabolic pathways; myokines and adipokines; metabolic flexibility; chronic disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Plant–Microbe Interactions: Advances and Applications

edited by

Nabil Radouane

and Salima Boutahiri

submission deadline 15 Oct 2026 | Viewed by 242 | Submission Open

Keywords: metabolomics; plant–microbe interactions; sustainable agriculture; biocontrol; disease resistance; LC-MS; GC-MS; metagenomics

(This special issue belongs to the Section Plant Metabolism)

Metabolic Control of Inflammatory Responses

edited by

Xin Li

submission deadline 15 Oct 2026 | Viewed by 224 | Submission Open

Keywords: immunometabolism; inflammation; metabolic reprogramming; macrophages; metabolites; immune signaling; metabolomics; metabolic pathways; tissue microenvironment; chronic inflammation

(This special issue belongs to the Section Cell Metabolism)

Microbiome in Diabetes Progression and Insulin Resistance

edited by Dragan M. Nikolic and

Snežana B. Pajović

submission deadline 15 Oct 2026 | Viewed by 203 | Submission Open

Keywords: microbiome; insulin secretion; insulin resistance; obesity; diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Agriculture and Food: Advanced Detection, Risk Assessment, and Management of Plant Diseases, Pest Damage, and Toxins in the Agri-Food Chain

edited by

Yasuhiro Date

submission deadline 15 Oct 2026 | Viewed by 181 | Submission Open

Keywords: metabolomics; metabolic profiling; agri-food chain; plant diseases; pest damage; toxins; nuclear magnetic resonance spectroscopy; mass spectrometry

(This special issue belongs to the Section Food Metabolomics)

Advances in Bioactive Compounds and Functional Foods

edited by

Aurelia Scarano

and

Teodoro Semeraro

submission deadline 16 Oct 2026 | 1 articles | Viewed by 230 | Submission Open

Keywords: bioactive compounds; secondary metabolites; metabolic processes; functional foods; biodiversity; nutritional applications; biological activities

(This special issue belongs to the Section Plant Metabolism)

From Feed to Function: Metabolic Insights into Animal Nutrition

edited by

Kinga Szczepanik

and

Mengyao Guo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 403 | Submission Open

Keywords: metabolism; nutrition; metabolic pathways; animal physiology

(This special issue belongs to the Section Animal Metabolism)

Nutritional and Metabolic Regulation of Animal Reproduction

edited by

Gabriele Brecchia

and

Olimpia Barbato

submission deadline 23 Oct 2026 | Viewed by 164 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient metabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

Gene-Regulated Metabolic Networks

edited by Babak Nami

submission deadline 25 Oct 2026 | Viewed by 162 | Submission Open

Keywords: genetics; metabolism; metabolic networks; mitochondrial biogenesis; epigenetics; nutrient sensing; metabolomics; metabolic signaling; cellular homeostasis

(This special issue belongs to the Section Cell Metabolism)

Research on Metabolic Biomarkers in Different Diseases

edited by Xiaohui Liu

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1774 | Submission Open

Keywords: metabolomics; biomarkers; diseases; methodology; bioinformatics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Metabolomics and Multi-Omics Approaches to Study Metabolite-Host Interactions

edited by

Paulo Wender Portal Gomes

and

Olimpio Montero

submission deadline 30 Oct 2026 | Viewed by 193 | Submission Open

Keywords: metabolite–host interactions; mass spectrometry; multi-omics integration; untargeted metabolomics; systems biology; biomarkers; environmental metabolomics; computational metabolomics

(This special issue belongs to the Section Integrative Metabolomics)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 7181 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 3707 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

Machine Learning Applications in Metabolomics Analysis: 2nd Edition

edited by

Leonardo Franco

and

Martin Grootveld

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3307 | Submission Open

Keywords: metabolites; biofluids; artificial intelligence; metabolomics; machine learning

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Advances in Secondary Metabolites: Phytochemical Profiling and Bioactivity Evaluation

edited by

Raquel Cariño-Cortés

and

Mario Ortiz

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2695 | Submission Open

Keywords: secondary metabolites; pain; inflammation; chronic-degenerative diseases; chemoprevention; metabolic syndrome; plants

(This special issue belongs to the Section Plant Metabolism)

Metabolomics in Clinical Research: Advancing Precision Medicine Through the Analysis of Biological Samples

edited by

Joana Pinto

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2617 | Submission Open

Keywords: metabolomics; precision medicine; biomarker discovery; clinical research; disease mechanisms; metabolic profiling; multi-omics integration; biological samples; diagnostic biomarkers; therapeutic monitoring

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1427 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Lipid Metabolism in Age-Related Diseases: 2nd Edition

edited by

Simona Fenizia

Elettra Barberis

and

Marcello Manfredi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1337 | Submission Open

Keywords: lipid metabolism; metabolic diseases; high-throughput mass spectrometry-based lipidomics; aging; lipid biomarkers; precision medicine

(This special issue belongs to the Section Lipid Metabolism)

Human Nutrition and Metabolic Health

edited by

Beata Stasiewicz

Justyna Borawska-Dziadkiewicz

and

Paweł Glibowski

submission deadline 31 Oct 2026 | 2 articles | Viewed by 1044 | Submission Open

Keywords: diet; human nutrition; metabolism; health; diet-related diseases; biomarkers; metabolites; food-derived bioactive compounds; peptides

(This special issue belongs to the Section Nutrition and Metabolism)

Women’s Special Issue Series: Metabolomic Profiling Technology

edited by

Thusitha W. Rupasinghe

and

RuAngelie Edrada-Ebel

submission deadline 31 Oct 2026 | Viewed by 588 | Submission Open

Keywords: metabolomics; metabolomic profiling technology; metabolism; analytical chemistry; NMR; mass spectrometry

(This special issue belongs to the Section Metabolomic Profiling Technology)

Advanced Metabolic Profiling via Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry: 2nd Edition

edited by

Ana Margarida Araújo

submission deadline 31 Oct 2026 | Viewed by 382 | Submission Open

Keywords: chromatographic methods; mass spectrometry techniques; metabolic profiling; methodological ad-vancements; biomarker discovery; environmental monitoring; food safety and quality; clinical diagnosis; drug development

(This special issue belongs to the Section Advances in Metabolomics)

The Aging Blueprint: Decoding Biomarkers of Bone and Muscle Health

edited by

Sagar Vyavahare

submission deadline 31 Oct 2026 | Viewed by 366 | Submission Open

Keywords: metabolomics; bone; muscle; aging; biomarker

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of VOCs in Communication Between Plants and Microorganisms on Metabolomics

edited by

Valentina Lazazzara

submission deadline 31 Oct 2026 | Viewed by 346 | Submission Open

Keywords: volatile organic compounds (VOCs); plant-microbe interaction; sustainable agriculture; plant signaling; plant–pathogen interactions; plant growth promotion; microbial volatiles; plant defense mechanisms; biocontrol

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Pharmacometabolomics in Drug Mechanism, Efficacy and Toxicity

edited by Christian Giommi and Camilla Morresi

submission deadline 31 Oct 2026 | Viewed by 335 | Submission Open

Keywords: pharmacometabolomics; drug mechanisms; metabolic biomarkers; drug efficacy; drug toxicity; metabolic flux analysis; lipidomics and metabolomics profiling; computational metabolomics; systems pharmacology; precision medicine

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Muscle Wasting in Metabolic Dysfunction: Mechanisms and Therapeutic Innovations

edited by

Chia Chi Chuang Key

submission deadline 31 Oct 2026 | 1 articles | Viewed by 317 | Submission Open

Keywords: muscle wasting; obesity; diabetes; critical illness; adipose–muscle crosstalk; inflammation; metabolic dysfunction

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Spatial Metabolome Revealed: AI and Deep Learning in Tissue-Level Molecular Mapping

edited by Mario Flores and Yufang Jin

submission deadline 31 Oct 2026 | Viewed by 251 | Submission Open

Keywords: artificial intelligence; deep learning; spatial transcriptomics; spatial metabolomics; computational biology; biomarker discovery; metabolic pathways; precision medicine; multi-omics integration; disease modeling

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Insights into Perioperative Cardiovascular Risk and Outcomes

edited by Mark G. Filipovic and Markus M. Luedi

submission deadline 31 Oct 2026 | Viewed by 189 | Submission Open

Keywords: cardiovascular risk; perioperative risk; metabolomics; ischemia; outcome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Regulation of Stem Cell Aging by Metabolism and Epigenetics

edited by

Maurice B. Fluitt

and Katherine Carvalho

submission deadline 31 Oct 2026 | Viewed by 170 | Submission Open

Keywords: stem cell aging; metabolic reprogramming; epigenetic regulation; non‑coding RNAs (miRNAs, lncRNAs, circRNAs); mitochondrial dysfunction; apoptosis and autophagy; chromatin remodeling; cellular senescence; regenerative decline; age‑related diseases and disorders

(This special issue belongs to the Section Cell Metabolism)

Analytical Techniques Applied in Metabolomics

edited by

María García Nicolás

and Anil Meher

submission deadline 31 Oct 2026 | Viewed by 168 | Submission Open

Keywords: metabolomics; analytical techniques; mass spectrometry; chromatography; ion mobility spectrometry; nuclear magnetic resonance (NMR); targeted and untargeted metabolomics; sample preparation; metabolite identification; data processing and analysis

(This special issue belongs to the Section Advances in Metabolomics)

Driving Drug Discovery and Toxicology Forward with Multiomics

edited by

Ala F. Nassar

submission deadline 31 Oct 2026 | Viewed by 122 | Submission Open

Keywords: omics; ADMETox; drug discovery; LC-MS/MS; AI

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Functional Foods and Natural Bioactive Compounds: Strategies to Face Metabolic Syndrome and Related Non-Communicable Diseases—2nd Edition

edited by

Paola Gauffin-Cano

, Sebastián Torres and

Roxana Medina

submission deadline 2 Nov 2026 | 2 articles | Viewed by 2220 | Submission Open

Keywords: functional foods; bioactive compounds; fermented foods; fermented beverages; fermented vegetable foods; probiotics; prebiotics; synbiotics; postbiotics; metabolic syndrome; non-communicable diseases

Advances in NMR- and MS-Based Metabolomics and Its Applications

edited by

Anna Maria D’Ursi

and Carmen Marino

submission deadline 4 Nov 2026 | 3 articles | Viewed by 3853 | Submission Open

Keywords: NMR; MS; biofluids; machine learning; tissue; cells cultures; nutraceuticals

(This special issue belongs to the Section Advances in Metabolomics)

Gut Microbiota-Host Metabolic Axis: From Diet to Systemic Health

edited by Ran An and Jing Zhang

submission deadline 10 Nov 2026 | 3 articles | Viewed by 1221 | Submission Open

Keywords: microbiota; prebiotic; probiotic; diet; systemic health; intervention

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

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