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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Risk Prediction and Novel Biomarker Discovery of Chronic Diseases by Advanced Methodologies in Lipidomics and Metabolomics

edited by

Ying Zhang

, Kang Chen and Jun Ding

submission deadline 15 May 2025 | 2 articles | Viewed by 4116 | Submission Open

Keywords: chronic diseases; lipidomics; metabolomics; risk prediction; biomarker discovery

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Gut Microbiome Metabolomics

edited by

Ulrike E. Rolle-Kampczyk

Beatrice Engelmann

and

Sven-Bastiaan Haange

submission deadline 15 May 2025 | 1 articles | Viewed by 1201 | Submission Open

Keywords: gut microbiome– host interaction; cross talk; metabolomics; omics- technologies; microbiome signatures; new diagnostic tools; novel therapeutic strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Vitamin D and Its Crucial Role in Pregnancy: From Deficiency to Optimal Health for Both Mother, Fetus and Child in Later Life

edited by

Pinar Bor

and

Agnete Larsen

submission deadline 15 May 2025 | Viewed by 253 | Submission Open

Keywords: epigenetics; fetal development; inflammation; metabolic disorders; metabolomics; microbiota; nutrition; offspring; placenta; pregnancy; pregnancy complications; vitamin D; vitamin D receptor; vitamin D deficiency; disease

(This special issue belongs to the Section Nutrition and Metabolism)

Flavonoids: Novel Therapeutic Potential for Chronic Diseases

edited by Aleksandra Kozłowska and Shawn R. Campagna

submission deadline 15 May 2025 | Viewed by 175 | Submission Open

Keywords: flavonoids; chronic diseases; inflammation; diabetes; anthocyanins; cardiovascular diseases; neurodegenerative disorders; quercetin

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Impact of Macronutrients on Metabolism

edited by Janine Wirth

submission deadline 20 May 2025 | 7 articles | Viewed by 69541 | Submission Open

Keywords: carbohydrate intake; dietary protein; chronic metabolic response

(This special issue belongs to the Section Nutrition and Metabolism)

Towards Clinical Interpretation of Metabolomic Data

edited by Tomáš Adam

submission deadline 20 May 2025 | 2 articles | Viewed by 2168 | Submission Open

Keywords: biochemistry; data mining; metabolism; biochemical interpretation; plasma; serum; urine; cerebrispinal fluid; biofluids; human; biochemistry; metabolomic; metabolic diseases; clinical diagnosis

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Physiology Under Environmental Coercion

edited by

Yanchun Sun

, Zhijun Tan and

Shuqun Xue

submission deadline 20 May 2025 | 2 articles | Viewed by 1839 | Submission Open

Keywords: metabolic physiology; metabolomics; environmental toxicology

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Responses to Ruminant Nutrition and Production Practices

edited by

Nara Regina Brandão Cônsolo

Germán Darío Ramírez-Zamudio

and

Romana Turk

submission deadline 25 May 2025 | Viewed by 249 | Submission Open

Keywords: ruminant metabolism; metabolomics; omics; biomarkers; nutrition strategies; production management

(This special issue belongs to the Section Animal Metabolism)

Metabolomic Fingerprinting: Challenges and Opportunities

edited by Christina Virgiliou and

Olga-Angeliki Begou

submission deadline 30 May 2025 | 2 articles | Viewed by 2949 | Submission Open

Keywords: metabolomics/metabonomics; mass spectrometry; metabolome; HRMS; hyphenated techniques

(This special issue belongs to the Section Integrative Metabolomics)

Metabolomic Approaches to Flavonoid Profiling and Metabolism

edited by

Gabin Thierry Mbahbou Bitchagno

submission deadline 30 May 2025 | Viewed by 152 | Submission Open

Keywords: flavonoid profiling; metabolomics; high-throughput platforms; biosynthetic pathways; health benefits; plant breeding; biotechnology; polyphenols; antioxidant activity; metabolic regulation

(This special issue belongs to the Section Plant Metabolism)

Glucose Metabolism in Pregnancy

edited by Moen Gunn-Helen

submission deadline 31 May 2025 | 5 articles | Viewed by 9473 | Submission Open

Keywords: glucose metabolism; gestational diabetes; pregnancy; diabetes; glucose

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics-Based Biomarkers for Nutrition and Health

edited by Cheng Zheng and

Daniel Raftery

submission deadline 31 May 2025 | 3 articles | Viewed by 5694 | Submission Open

Keywords: biomarker; metabolomics; nutritional epidemiology; disease diagnostics and prevention; risk prediction

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics of the Eye and Adnexa

edited by

Seher Yuksel

and

Igor A. Butovich

submission deadline 31 May 2025 | 2 articles | Viewed by 2443 | Submission Open

Keywords: metabolomics; metabolites; ocular disease; Meibomian gland dysfunction; age-related macular de-generation; glaucoma; diabetic retinopathy; keratoconus; gas chromatography/liquid chromatog-raphy-mass spectrometry; nuclear magnetic resonance spectroscopy

(This special issue belongs to the Section Advances in Metabolomics)

Nuclear Magnetic Resonance-Powered Metabolomics: Progress and Future Prospects

edited by Abhinav Dubey

submission deadline 31 May 2025 | 2 articles | Viewed by 2233 | Submission Open

Keywords: solution-state NMR; metabolism; clinical studies; biomarker discovery; high-throughput data analysis

(This special issue belongs to the Section Advances in Metabolomics)

Harnessing the Power of NMR Metabolomics in Unraveling Metabolic Diseases

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 31 May 2025 | 1 articles | Viewed by 1837 | Submission Open

Keywords: metabolomics; NMR; precision medicine; translational medicine; metabolic disease

(This special issue belongs to the Section Integrative Metabolomics)

The Comorbidity of Neurodegenerative and Metabolic Diseases

edited by

Anna Serefko

and

Aleksandra Szopa

submission deadline 31 May 2025 | 2 articles | Viewed by 1814 | Submission Open

Keywords: neurodegenerative diseases; metabolic diseases; depression; dementia; Parkinson’ s disease; Alzheimer’ s disease; Huntington’ s disease; obesity; diabetes

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Multimodal Approaches to Diagnosing Metabolic Bone Diseases

edited by Simona D’Amore,

Antonio G. Solimando

and Uma Ramaswami

submission deadline 31 May 2025 | 1 articles | Viewed by 1758 | Submission Open

Keywords: bone disease; bone involvement in congenital and acquired conditions; artificial intelligence; bi-omarker discovery; clinical algorithm; integrated imaging approaches; omics-based approaches

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics Studies in Ruminant Models: Unraveling Nutritional Physiology and Health

edited by

Jože Starič

and

Marko R. Cincovic

submission deadline 31 May 2025 | 1 articles | Viewed by 1696 | Submission Open

Keywords: feed supplements; metabolic profiles; metabolic biomarkers; metabolic stress; metabolomics

(This special issue belongs to the Section Advances in Metabolomics)

Comprehensive Insights into Metabolic Pathways: Genome-Scale Modeling Techniques

edited by

Priyanka Baloni

submission deadline 31 May 2025 | 2 articles | Viewed by 1620 | Submission Open

Keywords: metabolism; systems biology; genome-scale metabolic modeling; multi-omics data; data integration; data analysis; metabolic regulation; biomarker; drug targets

(This special issue belongs to the Section Advances in Metabolomics)

Fat and Glucose Metabolism

edited by

Getachew D. Belew

and John Griffith Jones

submission deadline 31 May 2025 | 1 articles | Viewed by 1236 | Submission Open

Keywords: nutrient metabolism; energy homeostasis; insulin resistance; diabetes; obesity; MAFLD; metabolic disorders; therapeutic agents

(This special issue belongs to the Section Cell Metabolism)

Multiomics and Metabolism in Infectious Diseases and Cancer: Unveiling Novel Mechanisms and Biomarkers

edited by Menghuan Zhang

submission deadline 31 May 2025 | 1 articles | Viewed by 1084 | Submission Open

Keywords: multiomics; machine learning; metabolic modeling; cancer metabolism; metabolic pathways; thera-peutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Synthetic Biology Approaches for Expanding the Metabolic Capabilities of E. coli

edited by

Angelo Bañares

and Kei Anne Baritugo

submission deadline 31 May 2025 | Viewed by 258 | Submission Open

Keywords: synthetic biology; Escherichia coli (E. coli); metabolic engineering; genome editing (crispr-cas9); novel metabolic pathways; high-value chemicals; biofuels; bioremediation; environmental sensing; microbial cell factory

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Research of Inborn Errors of Metabolism

edited by

Vincenza Gragnaniello

and

Maria Fuller

submission deadline 31 May 2025 | Viewed by 248 | Submission Open

Keywords: inborn errors of metabolism; pathogenic mechanisms; bio-chemical pathway; inherited diseases; diagnosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advancing Metabolite Biomarkers in Neurodegenerative Disease: Discovery, Integration, and Therapeutic Potential

edited by Robert Logan

submission deadline 31 May 2025 | Viewed by 138 | Submission Open

Keywords: biomarkers; neurodegeneration; metabolites; metabolic pathways; metabolomic; Alzheimer’ s disease; Parkinson’ s disease

(This special issue belongs to the Section Cell Metabolism)

Functional Foods and Natural Bioactive Compounds: Strategies to Face Metabolic Syndrome and Related Non-Communicable Diseases

edited by

Paola Gauffin-Cano

, Sebastián Torres and

Roxana Medina

submission deadline 2 Jun 2025 | 3 articles | Viewed by 5837 | Submission Open

Keywords: functional foods; bioactive compounds; fermented foods; fermented beverages; fermented vegetable foods; probiotics; prebiotics; synbiotics; postbiotics; metabolic syndrome; non-communicable diseases

(This special issue belongs to the Section Nutrition and Metabolism)

Stress and Inflammation: Drivers, Biomarkers and Physiological Effects

edited by Eric Trexler

submission deadline 9 Jun 2025 | Viewed by 292 | Submission Open

Keywords: physical activity; nutrition; health behavior; obesity; stress; inflammation; biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Role of Metabolites in Gut-Brain Axis

edited by Abhijit Maji

submission deadline 10 Jun 2025 | Viewed by 151 | Submission Open

Keywords: gut microbiota; gut– brain axis; neurological disorder; metabolomics; behavior

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomic Advances in Promoting Exercise-Induced Metabolic Changes

edited by

Alex Castro

and Mara Patrıcia Traina Chacon-Mikahi

submission deadline 15 Jun 2025 | 7 articles | Viewed by 15816 | Submission Open

Keywords: metabolome; metabolites; exercise; physical activity; metabolic signatures

(This special issue belongs to the Section Advances in Metabolomics)

Clinical Nutrition and Metabolic Diseases

edited by

Desirée Victoria-Montesinos

Ana María García-Muñoz

and

José Francisco López-Gil

submission deadline 15 Jun 2025 | 2 articles | Viewed by 2467 | Submission Open

Keywords: clinical nutrition; metabolic disorders; nutritional intervention; metabolic health; disease prevention; biomarkers; nutritional therapy

(This special issue belongs to the Section Nutrition and Metabolism)

Childhood Obesity and Its Associated Metabolic Complications

edited by Marina Ybarra and Tiago Jeronimo dos Santos

submission deadline 15 Jun 2025 | Viewed by 144 | Submission Open

Keywords: pediatrics; obesity; diabetes; metabolic syndrome; childhood obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Genome-Scale Metabolic Networks in Plants

edited by

Akhilesh Yadav

and Dawei Yan

submission deadline 15 Jun 2025 | Viewed by 128 | Submission Open

Keywords: metabolites; genomics; transcriptomics; omics; pathway; network

(This special issue belongs to the Section Plant Metabolism)

Interactions between Exercise Physiology and Metabolism

edited by

Lijing Gong

and Enming Zhang

submission deadline 20 Jun 2025 | 5 articles | Viewed by 5858 | Submission Open

Keywords: exercise; metabolism; physical activity; chronic disease prevention; exerkines

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Secondary Metabolites: Phytochemical Analysis and Bioactivity Assays

edited by

Chiara Toniolo

and

Luca Santi

submission deadline 23 Jun 2025 | 9 articles | Viewed by 6878 | Submission Open

Keywords: secondary metabolites; phytochemical analysis; biological activity; plant extracts; bioactive compounds; medicinal plants; food plants

(This special issue belongs to the Section Plant Metabolism)

Plants and Plant-Based Foods for Metabolic Disease Prevention

edited by

Sandra Barbalho

, Rosa Direito,

Adriano Araujo

and

Élen Landgraf Guiguer

submission deadline 30 Jun 2025 | 7 articles | Viewed by 14145 | Submission Open

Keywords: plants; plant foods; plant-based diet; medicinal plants; inflammation; oxidative stress; inflammatory diseases; metabolic diseases; neurodegenerative diseases

(This special issue belongs to the Section Nutrition and Metabolism)

Meeting the Challenge of Metabolomics Analysis by Using Multidimensional Gas Chromatography with Mass Spectrometry

edited by

Yong Foo Wong

and

Philip J. Marriott

submission deadline 30 Jun 2025 | 6 articles | Viewed by 13782 | Submission Open

Keywords: GC× GC; MDGC; metabolites; high-resolution mass spectrometry; metabolite profiling; metabolite fingerprinting; biomarker; plant secondary compounds; disease diagnosis

(This special issue belongs to the Section Metabolomic Profiling Technology)

Exploring Uric Acid and Beyond

edited by

Pietro Cirillo

and

Claudio Borghi

submission deadline 30 Jun 2025 | 4 articles | Viewed by 11875 | Submission Open

Keywords: uric acid; cardiovascular risk; kidney disease; obesity; diabetes; lipid metabolism; immune programming

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Technology in Quality and Safety of Agricultural Products and Foods

edited by

Yasuhiro Date

submission deadline 30 Jun 2025 | 6 articles | Viewed by 9129 | Submission Open

Keywords: metabolomics; metabolic profiling; metabolic fingerprinting; foodomics; nuclear magnetic resonance spectroscopy; mass spectrometry; multivariate analysis; machine learning

(This special issue belongs to the Section Food Metabolomics)

Metabolomics in Human Diseases and Health

edited by Dimitris Kounatidis and

Iordanis Mourouzis

submission deadline 30 Jun 2025 | 6 articles | Viewed by 7863 | Submission Open

Keywords: metabolomics; NAFLD; biomarkers; obesity; mass spectrometry; NMR spectroscopy; diabetes mellitus; cancer; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Advances in Metabolomics)

Animal Nutritional Metabolism and Toxicosis Disease

edited by

Meng-yao Guo

submission deadline 30 Jun 2025 | 6 articles | Viewed by 7581 | Submission Open

Keywords: high-fat food; mammals; fish; metabolic blocks; toxosis; treatment of disease

(This special issue belongs to the Section Animal Metabolism)

Advanced Metabolic Profiling via Gas Chromatography–Mass Spectrometry and Liquid Chromatography–Mass Spectrometry

edited by

Ana Margarida Araújo

submission deadline 30 Jun 2025 | 6 articles | Viewed by 6223 | Submission Open

Keywords: chromatographic methods; mass spectrometry techniques; metabolic profiling; methodological advancements; biomarker discovery; environmental monitoring; food safety and quality; clinical diagnosis; drug development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Chemical Profiling of Metabolites from Honey Bee Products

edited by

and

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2964 | Submission Open

Keywords: honey bee products; chemical profiles; biomarkers; authenticity assessment; bioactive compounds; bioactive potential; metabolic perturbations

(This special issue belongs to the Section Food Metabolomics)

Novel Approaches for Metabolomics in Drugs and Biomarkers Discovery: 2nd Edition

edited by

Cecília R.C. Calado

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1966 | Submission Open

Keywords: metabolomics; drugs discovery; biomarkers discovery; diagnostic; prognosis

(This special issue belongs to the Section Advances in Metabolomics)

Insights into Tumor Cell Metabolism and Epigenetics

edited by

Sara Granja

, Vera Miranda-Gonçalves and Filipa Vieira

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1520 | Submission Open

Keywords: Warburg effect; epigenetic alterations; metabolic reprogramming; epigenome; transcriptional regula-tion; fatty acid metabolism

(This special issue belongs to the Section Cell Metabolism)

Vitamin D Metabolism and Human Health

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1404 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D receptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Dysregulation in Fatty Liver Disease

edited by Ambrin Farizah Babu and

Youfei Guan

submission deadline 30 Jun 2025 | 1 articles | Viewed by 982 | Submission Open

Keywords: metabolic dysregulation; metabolic homeostasis; insulin resistance; oxidative stress; lipid metabolism; glucose metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Diet on Metabolic Health of Obese People

edited by

Magdalena Górnicka

Marta Jeruszka-Bielak

and Irena Keser

submission deadline 30 Jun 2025 | 1 articles | Viewed by 837 | Submission Open

Keywords: diet; dietary pattern; bioactive food compounds; body composition; nutrition-related biomarkers; metabolites; metabolic disorders; obesity

(This special issue belongs to the Section Nutrition and Metabolism)

Liver Injury and Regeneration—Metabolic Research

edited by Miguel Suárez Matías

submission deadline 30 Jun 2025 | 1 articles | Viewed by 670 | Submission Open

Keywords: metabolism-associated steatotic liver disease; metabolic syndrome; chronic liver disease; liver fibrosis; hepatocellular carcinoma; metabolomic; endoscopy; non-invasive liver disease assessment; artificial intelligence; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis and Its Trends

edited by

Mohammad Mehdi Banoei

and

Mehdi Mirsaeidi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 566 | Submission Open

Keywords: mass spectrometry-based metabolomics; targeted metabolomics; health and disease; precision medi-cine; biomarker discovery; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity

edited by

Pengcheng Wang

submission deadline 30 Jun 2025 | Viewed by 533 | Submission Open

Keywords: metabolomics; drug/xenobiotic metabolism; drug– drug interactions; drug toxicity; ADME; new modalities peptides; antibody-drug conjugates; protein therapeutics; oligonucleotide therapeutics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases

edited by Mark G. Filipovic, Corina Manuela Bello and Markus M. Luedi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 479 | Submission Open

Keywords: cardiovascular; biomarkers; risk factors; outcome; prognostication; metabolism; metabolomics; risk markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

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