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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolomics and Plant Defence, 2nd Edition

edited by

Shitou Xia

and

Junxing Lu

submission deadline 5 Aug 2026 | 12 articles | Viewed by 10386 | Submission Open

Keywords: metabolomics; plant defence; biotic and abiotic stress; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Host Cell Metabolism in Bacterial Infection: From Molecular Mechanisms to Therapeutic Targets

edited by Marcia Berrêdo-Pinho and

Roberta Olmo Pinheiro

submission deadline 10 Aug 2026 | 1 articles | Viewed by 1606 | Submission Open

Keywords: host–pathogen interactions; metabolic reprogramming; immunometabolism; lipid metabolism; purinergic signaling; host-directed therapy; multi-omics approaches

(This special issue belongs to the Section Cell Metabolism)

Metabolic Profiling During Horticultural Fruit Development

edited by

Haipeng Zhang

and Shuai Zhang

submission deadline 10 Aug 2026 | Viewed by 365 | Submission Open

Keywords: metabolomics; omics; horticultural plants

(This special issue belongs to the Section Plant Metabolism)

Metabolite Profiles in Inflammatory Diseases

edited by Rodica Pădureanu and

Ionut Donoiu

submission deadline 15 Aug 2026 | 6 articles | Viewed by 7313 | Submission Open

Keywords: gut; inflammation; markers; metabolomics; multiple sclerosis; rheumatoid arthritis; lung disease; osteoarthritis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Current Research in Metabolic Syndrome and Cardiometabolic Disorders

edited by

Ciprian Ilie Rosca

and

Yunping Qiu

submission deadline 15 Aug 2026 | 5 articles | Viewed by 6850 | Submission Open

Keywords: metabolic syndrome; obesity; dyslipidemias; hyperuricemia; diabetes mellitus; cardiovascular diseases; heart failure; arrythmias; acute or chronic coronary syndromes; SGLT2-inhibitors; metabolic liver diseases; COVID-19 infection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Changes During Pre- and Post-Harvest Fruit and Vegetable Decay, Ripening and Senescence—2nd Edition

edited by

Analía Concellón

and

María José Zaro

submission deadline 15 Aug 2026 | 4 articles | Viewed by 5004 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Role of Lipid Metabolism in Cardiovascular Health

edited by Irma Magaly Rivas Serna and

Timothy O'Toole

submission deadline 15 Aug 2026 | 3 articles | Viewed by 4636 | Submission Open

Keywords: metabolism of lipids; lipid classes; lipid species; cardiovascular health; lipidomics; cardiometabolic disease; cardiovascular disease; atherosclerosis; dyslipidemia; phospholipids; glyceride lipids; non-glyceride lipids; sphingolipids; ceramides; cardiac biomarkers; mechanism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Drug Metabolism, Interactions and Toxicity: Advances in Metabolomics Approaches

edited by

Pengcheng Wang

and Rheem A. Totah

submission deadline 15 Aug 2026 | 3 articles | Viewed by 2995 | Submission Open

Keywords: metabolomics; drug/xenobiotic metabolism; drug–drug interactions; drug–endobiotic interactions; drug toxicity; biomarkers; ADME; 3D in vitro model

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Connections Between Nutrition, Epidemiology, and Metabolism

edited by

Kijoon Kim

submission deadline 15 Aug 2026 | 2 articles | Viewed by 2796 | Submission Open

Keywords: nutritional epidemiology; metabolism; antioxidants; medicinal herbs; functional ingredients; chronic disease; public health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Responses to Feed and Nutrition in Livestock

edited by

Arda Yıldırım

and

Baichuan Deng

submission deadline 15 Aug 2026 | 4 articles | Viewed by 1948 | Submission Open

Keywords: animal nutrition; feed metabolomics; livestock metabolism; feed ingredients; biochemical characterization of feeds; functional feed additives; metabolic profiling; gut microbiota–host metabolism; precision nutrition

(This special issue belongs to the Section Animal Metabolism)

Metabolomics Biomarker Discovery in Respiratory, Cardiovascular and Metabolic Disorders

edited by

Joaquim Gea

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1929 | Submission Open

Keywords: metabolomics; small molecules; mass spectrometry; NMR; personalized medicine; biomarkers; cardiovascular disorders; respiratory diseases; endocrine metabolic abnormalities

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Effects of Trace Elements and Endocrine-Disrupting Compounds on Metabolic Health

edited by

Kamila Pokorska-Niewiada

and

Agata Witczak

submission deadline 15 Aug 2026 | 1 articles | Viewed by 692 | Submission Open

Keywords: the role of trace elements and/or EDCs in the development of metabolic syndrome; trace elements and endocrine-active substances in biological samples, their potential use as biomarkers of metabolic disorders; progress in research on multifactorial relationships determining metabolic health/development of metabolic diseases; progress in clinical research on the importance of elements and EDCs in metabolic pathways; the impact of genetic and environmental disorders on metabolite levels and fluxes

(This special issue belongs to the Section Environmental Metabolomics)

Zebrafish Models in the Study of Diabetes and Metabolic Dysfunction

edited by

Liqing Zang

submission deadline 15 Aug 2026 | Viewed by 425 | Submission Open

Keywords: zebrafish; diabetes; obesity; metabolic dysfunction; insulin resistance; hyperglycemia; lipid metabolism; drug screening; nutraceuticals; gene editing; high-fat diet; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Emerging Inflammatory and Metabolic Biomarkers in Hayfever

edited by

Moneisha Gokhale

Serap Azizoǧlu

and

Elena Planells

submission deadline 15 Aug 2026 | Viewed by 388 | Submission Open

Keywords: IgE sensitisation; allergic rhinitis; allergenic capacity; thunderstorm asthma; asthma; immunotherapy; indoor air quality; questionnaire survey; quality of life; lived experience; hayfever; allergic rhinitis; ocular allergy

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Foodomics: Advanced Molecular Profiling for Future Nutrition and Sustainable Food Systems

edited by

Sung-Tong Chin

and

Suwimol Chockchaisawasdee

submission deadline 15 Aug 2026 | Viewed by 275 | Submission Open

Keywords: food system sustainability; molecular fingerprinting of food; untargeted high-resolution metabolomics; food peptidomics; nutriomics bioinformatics

(This special issue belongs to the Section Food Metabolomics)

Metabolomics Applications in Agriculture, Health and the Environment

edited by

Priyanka Reddy

submission deadline 15 Aug 2026 | Viewed by 211 | Submission Open

Keywords: metabolomics; environmental exposure; agricultural systems; biomarker discovery; chemical pheno-typing; systems biology; translational omics; functional metabolomics

(This special issue belongs to the Section Advances in Metabolomics)

Metabolic Responses to Exercise and Nutrition: From Molecular Mechanisms to Functional Performance

edited by Do-Houn Kim and

Chang Liu

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3272 | Submission Open

Keywords: metabolomics; exercise metabolism; nutritional metabolites; biomarkers; functional performance; physical activity; metabolic adaptation; movement capacity; exercise–nutrition interactions; personalized nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

Recent Advances in Drug Metabolism and Transport

edited by Deepak Ahire and Shyam Kamble

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1290 | Submission Open

Keywords: ADME; drug metabolism and transport; pharmacokinetics; PBPK modeling; PK/PD; proteomics; personalized medicine

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolomic Signatures in Cancer

edited by Michael Daniel and

Peter Oefner

submission deadline 20 Aug 2026 | Viewed by 384 | Submission Open

Keywords: cancer metabolomics; metabolic reprogramming; biomarker discovery; tumor microenvironment; metabolic signatures; therapeutic response; early detection; mass spectrometry; NMR spectroscopy; multi-omics integration

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mechanisms and Prevention in Steatotic Liver Disease

edited by

Nobuyuki Toshikuni

submission deadline 20 Aug 2026 | Viewed by 205 | Submission Open

Keywords: steatotic liver disease; hepatocyte inflammation; liver fibrogenesis; gut-liver axis metabolites; lipotoxicity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

edited by

Mircea-Catalin Fortofoiu

submission deadline 21 Aug 2026 | Viewed by 277 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); diagnostic biomarkers; non-invasive diagnosis; therapeutic strategies; translational research; clinical translation; metabolic disorders; dyslipidemia

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Disorders and Inflammatory Bowel Diseases

edited by Fotios S. Fousekis

submission deadline 25 Aug 2026 | 5 articles | Viewed by 5304 | Submission Open

Keywords: inflammatory bowel disease; ulcerative colitis; crohn’s disease; adipose tissue; obesity; metabolic disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Influencing Factors of Nutrients and Metabolites in Plants

edited by

Lahcen Hssaini

and

Eimad Dine Tariq Bouhlali

submission deadline 25 Aug 2026 | 2 articles | Viewed by 2003 | Submission Open

Keywords: metabolic reprogramming; nutrient homeostasis; metabolic flux analysis; plant-environment interactions; chemometric analysis; metabolic phenotyping; stress metabolomics; metabolic engineering; precision phenotyping

(This special issue belongs to the Section Plant Metabolism)

Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions

edited by

Samuel Treviño

submission deadline 31 Aug 2026 | 4 articles | Viewed by 7812 | Submission Open

Keywords: murine models; metabolic diseases; molecular mechanisms; biochemical pathways; pharmacological strategies; interactome; comorbidities; metabolic phenotypes; novel techniques

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Studies in Ruminant Models: Unraveling Nutritional Physiology and Health

edited by

Jože Starič

and

Marko R. Cincovic

submission deadline 31 Aug 2026 | 3 articles | Viewed by 6468 | Submission Open

Keywords: feed supplements; metabolic profiles; metabolic biomarkers; metabolic stress; metabolomics

(This special issue belongs to the Section Advances in Metabolomics)

Metabolism of Bioactives and Natural Products: 2nd Edition

edited by Kamila Misiakiewicz-Has, Barbara Wiszniewska and

Sylwia Rzeszotek

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2834 | Submission Open

Keywords: natural products; bioactive; medicinal plants; phytochemicals; isoflavones; triterpenes; coumarins; alkaloids; prebiotics; carotenoids; polyphenols; organosulfur compounds

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Metabolome and Metabolomics

edited by

Subhash Minocha

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1591 | Submission Open

Keywords: metabolomics; LC/MS-based metabolomics; plant science; metabolic pathways; biotechnology applications; sustainable agriculture

Metabolomic Strategies for Deep Systems Profiling Towards Biomarker Discovery and Precision Medicine

edited by

Silvia Valentinuzzi

and

Troy D. Wood

submission deadline 31 Aug 2026 | 1 articles | Viewed by 988 | Submission Open

Keywords: metabolomics; biomarker discovery; mass spectrometry; omics integration; molecular signatures; precision medicine

(This special issue belongs to the Section Integrative Metabolomics)

Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications

edited by

Raja Gopal Reddy Mooli

Hang Cheng

and

Nathan Lanning

submission deadline 31 Aug 2026 | Viewed by 427 | Submission Open

Keywords: oxygen; hypoxia; metabolism; Hypoxia Inducible Factors (HIFs); prolyl hydroxylase domain-containing enzymes (PHDs); metabolic regulation; glucose metabolism; fatty acid metabolism; TCA cycle; metabolites

(This special issue belongs to the Section Cell Metabolism)

Metabolomics Approaches in Chemical Ecology: Decoding Interspecies Interactions Through Metabolic Profiling

edited by

Remington X. Poulin

and

C. Benjamin Naman

submission deadline 31 Aug 2026 | Viewed by 415 | Submission Open

Keywords: metabolomics; chemically mediated interactions; analytical chemistry; ecology; natural products; signaling molecules

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolic Characteristics of Microbial Cells and Enzymes

edited by

Hao Wu

and

Wei Zeng

submission deadline 31 Aug 2026 | Viewed by 303 | Submission Open

Keywords: microbial cell; enzyme; metabolic property; metabolites; metabolic engineering; enzyme engineering; synthetic biology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Integrative Metabolomics: Pathway Dynamics, Exposure Analysis and Precision Health

edited by Soundara Viveka Thangaraj and

Wei Sha

submission deadline 31 Aug 2026 | Viewed by 284 | Submission Open

Keywords: metabolomics; toxicology; biomarkers; pathway modeling; personalized medicine

(This special issue belongs to the Section Integrative Metabolomics)

Advances in Cancer Metabolism

edited by Haowen Jiang,

Man Zhao

and

Duo Zhang

submission deadline 5 Sep 2026 | 1 articles | Viewed by 2448 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; immunometabolism; mitochondrial metabolism; oncometabolites; metabolic–epigenetic crosstalk; single-cell metabolomics; spatial metabolomics; metabolic flux analysis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle

edited by Paulo Cezar de Freitas Mathias, Lucas Paulo Jacinto Saavedra and

Rodrigo Mello Gomes

submission deadline 15 Sep 2026 | 5 articles | Viewed by 17858 | Submission Open

Keywords: obesity; diabetes; DOHaD; metabolic programming; treatment; intervention; cardiovascular disease; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Changes in Body Composition (Bone, Muscle, Adipose Tissue) with Age and Accompanying Biomarkers for Each Tissue

edited by

Jasminka Ilich

submission deadline 15 Sep 2026 | 2 articles | Viewed by 2611 | Submission Open

Keywords: bone; muscle; adipose tissue; osteosarcopenic adiposity; nutrition, physical activity, and lifestyle habits influencing body composition; inflammatory markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Biomarkers in Cardiometabolic Disease: Early Detection, Risk Assessment, and Guiding Treatment

edited by

Grzegorz K. Jakubiak

submission deadline 15 Sep 2026 | 2 articles | Viewed by 2495 | Submission Open

Keywords: atherosclerosis; biomarkers; endothelial dysfunction; oxidative stress; inflammation; dyslipidemia; hyperglycemia; visceral adipose tissue; myocardial ischemia

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Technology in Quality and Safety of Agricultural Products and Foods, 2nd Edition

edited by

Yasuhiro Date

submission deadline 15 Sep 2026 | 2 articles | Viewed by 1925 | Submission Open

Keywords: metabolomics; metabolic profiling; metabolic fingerprinting; foodomics; nuclear magnetic resonance spectroscopy; mass spectrometry; multivariate analysis; machine learning

(This special issue belongs to the Section Food Metabolomics)

Metabolic Dysfunction in Diabetic Neuropathy

edited by

Tatsuya Fukuda

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1455 | Submission Open

Keywords: diabetic neuropathy; metabolic dysfunction; type 2 diabetes; peripheral nerve complications; insulin resistance; sarcopenia; metabolic biomarkers; real-world clinical data

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

New Findings on Microbial Metabolism and Its Effects on Human Health

edited by

Ulrike E. Rolle-Kampczyk

Beatrice Engelmann

and

Sven-Bastiaan Haange

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1173 | Submission Open

Keywords: metabolomics; microbial metabolism; microbial crosstalk; cross-feeding; xenobiotic and microbial metabolism; multi-omics integration; system biology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolomics in Infectious Diseases

edited by

María Ángeles Jiménez Sousa

and

Rubén Martín-Escolano

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1150 | Submission Open

Keywords: metabolomics; infectious diseases; pathogenesis; prognosis; biomarkers; host–pathogen interaction; therapeutic targets; diagnosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Medicinal Plants in the Management of Type 2 Diabetes and Insulin Resistance

edited by

Fernanda Artemisa Espinoza-Hernández

, Gerardo Mata Torres Valle and

Xin Fang

submission deadline 15 Sep 2026 | Viewed by 529 | Submission Open

Keywords: type 2 diabetes; insulin resistance; medicinal plants; natural products; action mechanisms; pharmacology

(This special issue belongs to the Section Plant Metabolism)

Probiotics and Dietary Supplements for Metabolic Health

edited by

Katarzyna Skrypnik

submission deadline 15 Sep 2026 | Viewed by 377 | Submission Open

Keywords: probiotics; prebiotics; synbiotics; dietary supplements; gut microbiota; metabolomics; metabolic syndrome; obesity; insulin resistance; lipid metabolism

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Ambrin Farizah Babu and

Ze Xiang

submission deadline 15 Sep 2026 | Viewed by 284 | Submission Open

Keywords: MASLD; biomarkers; diet and lifestyle; molecular mechanisms; drug development

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Influencing Factors of Metabolic Changes in Polycystic Ovary Syndrome

edited by

Iwona Szydłowska

and

Jolanta Nawrocka-Rutkowska

submission deadline 20 Sep 2026 | 1 articles | Viewed by 898 | Submission Open

Keywords: PCOS; metabolic changes; hormones; lifestyle; gut microbiota

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Immunometabolic Role of the Erythrocyte

edited by

Charalampos Papadopoulos

and

Vassilis L. Tzounakas

submission deadline 20 Sep 2026 | Viewed by 359 | Submission Open

Keywords: erythrocyte; immunometabolism; TLR9; glycerophospholipids; sphingolipids; purines; sugars; amino acids; eryptosis; CD47

(This special issue belongs to the Section Cell Metabolism)

Redox Signaling and Metabolic Changes in Liver Diseases

edited by

Kamalakannan Radhakrishnan

submission deadline 20 Sep 2026 | Viewed by 270 | Submission Open

Keywords: redox signaling; metabolic disease; oxidative stress; mitochondrial function; antioxidant defense; energy metabolism; therapeutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacodynamics and Innovative Therapeutic Strategies for Metabolic Disorders

edited by

Josué V. Espinosa-Juárez

Osmar Antonio Jaramillo-Morales

and

Victor Gault

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1480 | Submission Open

Keywords: pharmacology; experimental therapeutics; metabolic diseases; drug development; therapeutic innovations; metabolic pathways; pharmacodynamics; disease management

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Obesity and Metabolic Health, 2nd Edition

edited by

Natalia Ferreira Mendes

and

Eliana Pereira De Araújo

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1402 | Submission Open

Keywords: glial cells; blood–brain barrier; gut microbiota; immune surveillance; glucose metabolism; energy metabolism; food intake

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Signaling, Therapeutics and Controlled Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 30 Sep 2026 | 2 articles | Viewed by 6301 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics Insights into Environmental Pollution: Unraveling Metabolic Responses to Contaminants

edited by

Dechun Chen

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5366 | Submission Open

Keywords: metabolomics; environmental contaminants; biomarkers; toxicity mechanisms; metabolic alterations; ecological health; human health; cellular metabolism; organismal metabolism; pollution mitigation strategies

(This special issue belongs to the Section Environmental Metabolomics)

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