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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Translational Perspectives on Cancer Energy Metabolism: From Metabolic Mechanisms to Clinical Applications

edited by

Michael Weichhaus

and Helen Turner

submission deadline 15 Nov 2026 | Viewed by 377 | Submission Open

Keywords: cancer metabolism; Warburg effect; metabolic reprogramming; metabolic flux analysis; biomarkers; targeted therapies; clinical translation; population metabolomics; health disparities

(This special issue belongs to the Section Cell Metabolism)

Harnessing Cancer Metabolism: Unveiling New Therapeutic Approaches and Diagnostic Tools

edited by

Victor H. Villar

, Alejandro Huerta-Uribe and Ruhi Deshmukh

submission deadline 15 Nov 2026 | Viewed by 321 | Submission Open

Keywords: cancer; metabolic pathways; apoptosis; treatment

(This special issue belongs to the Section Cell Metabolism)

Metabolic Regulation for Sustainable Animal Production and Health

edited by

Liuting Wu

and Yan Wang

submission deadline 15 Nov 2026 | Viewed by 257 | Submission Open

Keywords: nutrient utilization; feed efficiency; gut health; animal physiological functions; metabolic homeostasis

(This special issue belongs to the Section Animal Metabolism)

Optical Assessment of Metabolism—2nd Edition

edited by

Wesley Baker

and

Joseph B. Majeski

submission deadline 15 Nov 2026 | Viewed by 239 | Submission Open

Keywords: diffuse optical spectroscopy; metabolomics; oxygen metabolism; mitochondria; fluorescence imaging; Raman spectroscopy; intrinsic optical imaging; clinical applications; speckle-based flow techniques; optical coherence tomography; Fourier transform near-infrared spectroscopy

(This special issue belongs to the Section Metabolomic Profiling Technology)

New Horizons in Metabolomics-Based Chemical Insight

edited by

Gaia Meoni

and

Giovanni Niero

submission deadline 15 Nov 2026 | Viewed by 170 | Submission Open

Keywords: metabolomics; chemical insight; metabolite discovery; mass spectrometry; NMR spectroscopy; structural elucidation; metabolite annotation; chemical diversity; multi-omics integration; computational metabolomics; machine learning; molecular networking; cheminformatics; environmental metabolomics; exposomics; analytical chemistry; metabolic pathways; natural products discovery

(This special issue belongs to the Section Advances in Metabolomics)

Neurometabolics in a Nutshell

edited by

Justyna Paprocka

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2913 | Submission Open

Keywords: neurometabolic disorders; rare diseases; diagnosis; differential diagnosis; treatment options

(This special issue belongs to the Section Cell Metabolism)

The Association Between Metabolic Dysfunction-Related Fatty Liver Disease and Cardiovascular Diseases

edited by

Philipp Kasper

submission deadline 20 Nov 2026 | 1 articles | Viewed by 884 | Submission Open

Keywords: MASLD; MASH; diabetes; arterial hypertension; dyslipidemia; fibrosis; cardiovascular risk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Derivatization Techniques in Mass Spectrometry: Unlocking the Low-Abundance Metabolome

edited by

Yuqi Feng

and Quanfei Zhu

submission deadline 20 Nov 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: chemical derivatization; mass spectrometry probes; low-abundance metabolites

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolic Alterations in Chronic Viral Infections

edited by Monserrat Álvarez-Zavala and Engin Berber

submission deadline 20 Nov 2026 | Viewed by 217 | Submission Open

Keywords: chronic viral infection; metabolism; biomarkers; metabolites; oxidative stress

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Food Metabolomics for Functional Food Development and Analysis, Second Edition

edited by

Amanda J. Lloyd

and

MJ Pilar Martinez-Martin

submission deadline 20 Nov 2026 | Viewed by 151 | Submission Open

Keywords: natural food fortification; functional foods; bioactive compounds; nutraceuticals; food biofortification; food analysis; nutritional enhancement; food testing; metabolomics

(This special issue belongs to the Section Food Metabolomics)

Early Metabolic Dysfunction in Children and Adolescents: The Role of Oxidative Stress and Micronutrients

edited by

Teofana Otilia Bizerea-Moga

and Rade Vukovic

submission deadline 20 Nov 2026 | Viewed by 125 | Submission Open

Keywords: early metabolic dysfunction; oxidative stress; micronutrients; pediatric metabolic syndrome; insulin resistance; obesity in children and adolescents; metabolic risk factors; antioxidant status

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Biomarker Discovery in Critical Care Therapeutics

edited by

Mohammad Mehdi Banoei

and

Brent Warren Winston

submission deadline 20 Nov 2026 | Viewed by 124 | Submission Open

Keywords: metabolomics; biomarker discovery; critical care; precision medicine; therapeutics; multi-omics integration; patient stratification; translational medicine; systems biology

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Clinical Nutrition and Metabolic Diseases, 2nd Edition

edited by

Desirée Victoria-Montesinos

and

Ana María García-Muñoz

submission deadline 25 Nov 2026 | 1 articles | Viewed by 334 | Submission Open

Keywords: clinical nutrition; metabolic disorders; nutritional intervention; metabolic health; disease prevention; biomarkers; nutritional therapy

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications: 2nd Edition

edited by Adam D. Kennedy and Greg Michelotti

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1075 | Submission Open

Keywords: metabolomics; precision medicine; clinical disease; biomarkers; therapeutics; clinical metabolomics; nutrition; functional medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Nutritional and Metabolic Regulation for One Health Across the Lifespan

edited by

Xinhui Wang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 816 | Submission Open

Keywords: nutrition; metabolism; one health; lifespan; artificial intelligence; metabolite; microbiome; precision nutrition; causal inference; multi-omics

(This special issue belongs to the Section Nutrition and Metabolism)

Bile Acid Transport and Metabolic Disorders

edited by

Subha Arthur

submission deadline 30 Nov 2026 | 1 articles | Viewed by 306 | Submission Open

Keywords: bile acid transporters; FXR (Farnesoid X Receptor); TGR5; enterohepatic circulation; metabolic regulation; NAFLD (non-alcoholic fatty liver disease); gut microbiota; insulin resistance; bile acids and cardiovascular diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Unlocking Nature’s Toolbox: Advances in Plant Metabolites Identification: 2nd Edition

edited by

Ramona Paltinean

and

Irina Ielciu

submission deadline 30 Nov 2026 | Viewed by 259 | Submission Open

Keywords: natural compounds; plant metabolites; extraction methods; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Effects of Stress on Animal Metabolism—2nd Edition

edited by

Krystyna Pierzchala-Koziec

and Colin Scanes

submission deadline 30 Nov 2026 | Viewed by 195 | Submission Open

Keywords: stressors; ACTH; glucocorticoids; mineralocorticoids; opioids; glycemia; growth; development; lactation; pregnancy

(This special issue belongs to the Section Animal Metabolism)

Advances in NMR-Based Metabolomics for Biomedical Research

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 1 Dec 2026 | Viewed by 287 | Submission Open

Keywords: metabolomics; NMR; biomedical research

(This special issue belongs to the Section Metabolomic Profiling Technology)

Lipid Metabolism in Chronic Diseases

edited by

Chuanhai Zhang

Jin Zhou

and

Quanwei Wei

submission deadline 2 Dec 2026 | 1 articles | Viewed by 482 | Submission Open

Keywords: lipid metabolism; chronic diseases; lipidomics; metabolic reprogramming; inflammation; cardiometabolic disorders; insulin resistance; lipid signaling; oxidative stress; therapeutic targets

(This special issue belongs to the Section Lipid Metabolism)

Molecular Mechanisms of Metabolic Pathway Regulation by Phytochemicals

edited by

Carlos Lopez-Ortiz

submission deadline 4 Dec 2026 | Viewed by 344 | Submission Open

Keywords: phytochemicals; plant metabolism; secondary metabolites; gene expression regulation; metabolomics

(This special issue belongs to the Section Plant Metabolism)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment, 2nd Edition

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 5 Dec 2026 | 1 articles | Viewed by 1243 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional disorders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Vitamin D Metabolism and Human Health, 2nd Edition

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 10 Dec 2026 | Viewed by 178 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D re-ceptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 11 Dec 2026 | 4 articles | Viewed by 7777 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

Research on Biomarkers for Cardiometabolic Risk in Metabolic Syndrome—2nd Edition

edited by Antoaneta Trifonova Gateva and Yavor Sashov Assyov

submission deadline 15 Dec 2026 | 3 articles | Viewed by 2074 | Submission Open

Keywords: metabolic syndrome; vascular complications; biomarkers; carbohydrate disturbances; diabetes; pre-diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition Intake and Lifestyle Intervention on Human Metabolic Health

edited by

Katarzyna Dereń

Edyta Łuszczki

and

Magdalena Zielińska

submission deadline 15 Dec 2026 | 2 articles | Viewed by 1455 | Submission Open

Keywords: dietary patterns; physical activity; sleep and circadian rhythms; insulin resistance; glycemic variability; cardiometabolic risk; energy expenditure; lipid metabolism; continuous glucose monitoring; wearable devices

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad

edited by Simona Georgiana Popa

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1242 | Submission Open

Keywords: cardiometabolic phenotypes of obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Toxicodynamics and Toxicokinetics of New Psychoactive Substances: From In Vitro Insights to In Vivo Impact

edited by

Lea Wagmann

submission deadline 15 Dec 2026 | 1 articles | Viewed by 936 | Submission Open

Keywords: forensic toxicology; clinical toxicology; absorption; metabolism; distribution; excretion; new psychoactive substances; toxicodynamics; toxicokinetics; metabolomics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Immunometabolic Consequences of Aquatic Stress

edited by

Yanchun Sun

submission deadline 15 Dec 2026 | 1 articles | Viewed by 702 | Submission Open

Keywords: aquatic stress; metabolomics; immunometabolism; environmental immunology

(This special issue belongs to the Section Environmental Metabolomics)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 15 Dec 2026 | Viewed by 289 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Signaling Pathways' Interplay and Crosstalk with Metabolism in Human Disease

edited by

Theodoros Karalis

, Emine Kazanc and

Karsten Hiller

submission deadline 15 Dec 2026 | Viewed by 287 | Submission Open

Keywords: human disease; obesity; diabetes; cancer; signaling; metabolism; metabolic rewiring; omics; precision medicine; bioinformatics

(This special issue belongs to the Section Cell Metabolism)

Beyond the Ordinary: Mass Spectrometry-Based Detection of Unexpected Metabolites

edited by

Beate Fuchs

submission deadline 15 Dec 2026 | Viewed by 263 | Submission Open

Keywords: mass spectrometry; unexpected metabolites; data analysis; metabolomics; biological samples

(This special issue belongs to the Section Metabolomic Profiling Technology)

Influence of Maternal Nutrition on Offspring Metabolic Health

edited by

Yoshinori Kubo

and

Hideoki Fukuoka

submission deadline 15 Dec 2026 | Viewed by 181 | Submission Open

Keywords: preconception care; pregnant women; 5-methyltetrahydrofolate; vitamin A; vitamin D; folic acid; trace elements; choline

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiology to Prevention Strategies

edited by

Seong-Uk Baek

and

Caroline Rhéaume

submission deadline 20 Dec 2026 | 1 articles | Viewed by 514 | Submission Open

Keywords: steatotic liver disease; epidemiology; MASLD; MAFLD; non-alcoholic fatty liver disease (NAFLD); liver metabolism; liver diseases; hepatic steatosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacological Properties of Natural Products and Metabolites

edited by

Vanesa Sánchez-Martín

and

Maria Dolores del Castillo

submission deadline 20 Dec 2026 | Viewed by 143 | Submission Open

Keywords: natural products; bioactive metabolites; digestion; metabolic fate; bioavailability; gut microbiota; biotransformation; metabolomics; drug discovery; safety and toxicity

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nutrition, Metabolism and Physiology in Aquatic Animals, 2nd Edition

edited by

Renlei Ji

and Xueshan Li

submission deadline 20 Dec 2026 | Viewed by 121 | Submission Open

Keywords: nutrition; metabolism; physiology; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Animal Metabolism)

Nutritional Modulation in Metabolic Health

edited by Qi Zhang

submission deadline 20 Dec 2026 | Viewed by 85 | Submission Open

Keywords: nutrition; nutrigenomics; gut microbiota; dietary pattern; functional foods; metabolic syndrome

(This special issue belongs to the Section Nutrition and Metabolism)

SynBio-Driven Metabolic Engineering: From Novel Tools to Real-World Applications

edited by

Hao Wu

and

Jie Cheng

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1147 | Submission Open

Keywords: synthetic biology; metabolic engineering; microbial cell factories; natural products; sustainable production

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Chemical Composition and Therapeutic Potential Analysis of Plant Extracts

edited by

Aleksandar Ž. Kostić

and

Petar M. Batinić

submission deadline 25 Dec 2026 | Viewed by 158 | Submission Open

Keywords: lamiaceae; apiaceae; green extracts and solvents; residual process water after plant thermal carbonization; alkaloids; sesquiterpene lactones; metabolomics; acetylcholinesterase inhibitors; foodborne pathogens; antidiabetic activity

(This special issue belongs to the Section Plant Metabolism)

Application of Metabolomics in Chemistry and Biochemistry

edited by Nerilson Marques Lima,

Teresinha Andrade

and

Felipe de Almeida La Porta

submission deadline 25 Dec 2026 | Viewed by 113 | Submission Open

Keywords: metabolomics; analytical chemistry; biochemistry; mass spectrometry; nuclear magnetic resonance; chemometrics; metabolite annotation; pathway analysis; multi-omics

(This special issue belongs to the Section Advances in Metabolomics)

Nutritional Regulation of Gut Microbiome in Humans and Livestock

edited by Junquan Tian and

Qian Jiang

submission deadline 25 Dec 2026 | Viewed by 82 | Submission Open

Keywords: microbial metabolites; precision nutrition and synbiotics; multi-omics integration; livestock resilience optimization; dysbiosis-amended interventions

(This special issue belongs to the Section Nutrition and Metabolism)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment: 2nd Edition

edited by

Susumu Muroya

submission deadline 31 Dec 2026 | 4 articles | Viewed by 4319 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Advances on Metabolomics: Driving Innovation in Bio-Analysis and Natural Products Research

edited by

Natalia Drabińska-Fois

Daria Cicha-Wojciechowicz

Patrycja Mojsak

Eliza Matuszewska-Mach

and Martyna Pajewska-Szmyt

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2300 | Submission Open

Keywords: metabolomics; bioanalysis; biomedical research; biomarkers; foodomics; lipidomics; volatilomics; natural products; clinical diagnosis; biomarker discovery; analytical approaches; method development; mass spectrometry; disease detection; microorganisms

(This special issue belongs to the Section Advances in Metabolomics)

Bioactive Secondary Metabolites from Marine Macro- and Microorganisms

edited by

Xiaowei Luo

and

Yonghong Liu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1560 | Submission Open

Keywords: secondary metabolites; bioactivity; marine natural products; marine microorganisms; marine organisms; drug discovery; lead compounds; pharmacological mechanism; marine drugs

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Research in Dairy Cattle Health

edited by

Wei Yang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1454 | Submission Open

Keywords: dairy cow; nutrient metabolism; feed ingredients; additives; disease; microbes; metabolite biomarkers

(This special issue belongs to the Section Animal Metabolism)

Biomarkers in Obesity, Metabolic Syndrome, and Weight Loss: Advances in Diagnosis, Risk Stratification, and Personalized Management

edited by

Martina Gažarová

Petra Lenártová

and

Magdalena Górnicka

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1390 | Submission Open

Keywords: obesity biomarkers; metabolic risk stratification; adipose tissue dysfunction; nutritional biomarkers; personalized nutrition; nutrition interventions; weight loss interventions; body composition analysis; emerging anthropometric indices

(This special issue belongs to the Section Nutrition and Metabolism)

Open-Source Software in Metabolomics, 2nd Edition

edited by

Seongho Kim

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1298 | Submission Open

Keywords: GC- MS; LC-MS; mass spectrometry; metabolomics; open-source software

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Regulation in Cancer Development and Progression

edited by Ovidiu Nicolae Pop and Carmen Pantiș

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1158 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor progression; glycolysis; lipid metabolism; amino acid metabolism; mitochondrial metabolism; tumor microenvironment; immunometabolism; therapeutic resistance

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Compounds: Plant Stress Responses, Metabolic Regulation, and Therapeutic Insights

edited by