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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Vitamin D Metabolism and Human Health, 2nd Edition

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 10 Dec 2026 | Viewed by 190 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D re-ceptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

The Molecular Cargo of Extracellular Vesicles: A Key to Understanding Their Biological Role

edited by

Elisabetta Chiaradia

and

Sandra Buratta

submission deadline 11 Dec 2026 | 4 articles | Viewed by 7852 | Submission Open

Keywords: extracellular vesicles (EVs); intercellular communication; molecular cargo; proteins in EVs; lipids in EVs; metabolites in EVs; nucleic acids in EVs; horizontal gene transfer; bioactive molecules in EVs

(This special issue belongs to the Section Cell Metabolism)

Research on Biomarkers for Cardiometabolic Risk in Metabolic Syndrome—2nd Edition

edited by Antoaneta Trifonova Gateva and Yavor Sashov Assyov

submission deadline 15 Dec 2026 | 3 articles | Viewed by 2158 | Submission Open

Keywords: metabolic syndrome; vascular complications; biomarkers; carbohydrate disturbances; diabetes; pre-diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition Intake and Lifestyle Intervention on Human Metabolic Health

edited by

Katarzyna Dereń

Edyta Łuszczki

and

Magdalena Zielińska

submission deadline 15 Dec 2026 | 2 articles | Viewed by 1520 | Submission Open

Keywords: dietary patterns; physical activity; sleep and circadian rhythms; insulin resistance; glycemic variability; cardiometabolic risk; energy expenditure; lipid metabolism; continuous glucose monitoring; wearable devices

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad

edited by Simona Georgiana Popa

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1281 | Submission Open

Keywords: cardiometabolic phenotypes of obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Toxicodynamics and Toxicokinetics of New Psychoactive Substances: From In Vitro Insights to In Vivo Impact

edited by

Lea Wagmann

submission deadline 15 Dec 2026 | 1 articles | Viewed by 981 | Submission Open

Keywords: forensic toxicology; clinical toxicology; absorption; metabolism; distribution; excretion; new psychoactive substances; toxicodynamics; toxicokinetics; metabolomics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Immunometabolic Consequences of Aquatic Stress

edited by

Yanchun Sun

submission deadline 15 Dec 2026 | 1 articles | Viewed by 737 | Submission Open

Keywords: aquatic stress; metabolomics; immunometabolism; environmental immunology

(This special issue belongs to the Section Environmental Metabolomics)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 15 Dec 2026 | Viewed by 293 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Signaling Pathways' Interplay and Crosstalk with Metabolism in Human Disease

edited by

Theodoros Karalis

, Emine Kazanc and

Karsten Hiller

submission deadline 15 Dec 2026 | Viewed by 290 | Submission Open

Keywords: human disease; obesity; diabetes; cancer; signaling; metabolism; metabolic rewiring; omics; precision medicine; bioinformatics

(This special issue belongs to the Section Cell Metabolism)

Beyond the Ordinary: Mass Spectrometry-Based Detection of Unexpected Metabolites

edited by

Beate Fuchs

submission deadline 15 Dec 2026 | Viewed by 270 | Submission Open

Keywords: mass spectrometry; unexpected metabolites; data analysis; metabolomics; biological samples

(This special issue belongs to the Section Metabolomic Profiling Technology)

Influence of Maternal Nutrition on Offspring Metabolic Health

edited by

Yoshinori Kubo

and

Hideoki Fukuoka

submission deadline 15 Dec 2026 | Viewed by 188 | Submission Open

Keywords: preconception care; pregnant women; 5-methyltetrahydrofolate; vitamin A; vitamin D; folic acid; trace elements; choline

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiology to Prevention Strategies

edited by

Seong-Uk Baek

and

Caroline Rhéaume

submission deadline 20 Dec 2026 | 1 articles | Viewed by 606 | Submission Open

Keywords: steatotic liver disease; epidemiology; MASLD; MAFLD; non-alcoholic fatty liver disease (NAFLD); liver metabolism; liver diseases; hepatic steatosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacological Properties of Natural Products and Metabolites

edited by

Vanesa Sánchez-Martín

and

Maria Dolores del Castillo

submission deadline 20 Dec 2026 | Viewed by 149 | Submission Open

Keywords: natural products; bioactive metabolites; digestion; metabolic fate; bioavailability; gut microbiota; biotransformation; metabolomics; drug discovery; safety and toxicity

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Nutrition, Metabolism and Physiology in Aquatic Animals, 2nd Edition

edited by

Renlei Ji

and Xueshan Li

submission deadline 20 Dec 2026 | Viewed by 126 | Submission Open

Keywords: nutrition; metabolism; physiology; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Animal Metabolism)

Nutritional Modulation in Metabolic Health

edited by Qi Zhang

submission deadline 20 Dec 2026 | Viewed by 88 | Submission Open

Keywords: nutrition; nutrigenomics; gut microbiota; dietary pattern; functional foods; metabolic syndrome

(This special issue belongs to the Section Nutrition and Metabolism)

SynBio-Driven Metabolic Engineering: From Novel Tools to Real-World Applications

edited by

Hao Wu

and

Jie Cheng

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1173 | Submission Open

Keywords: synthetic biology; metabolic engineering; microbial cell factories; natural products; sustainable production

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Chemical Composition and Therapeutic Potential Analysis of Plant Extracts

edited by

Aleksandar Ž. Kostić

and

Petar M. Batinić

submission deadline 25 Dec 2026 | Viewed by 162 | Submission Open

Keywords: lamiaceae; apiaceae; green extracts and solvents; residual process water after plant thermal carbonization; alkaloids; sesquiterpene lactones; metabolomics; acetylcholinesterase inhibitors; foodborne pathogens; antidiabetic activity

(This special issue belongs to the Section Plant Metabolism)

Application of Metabolomics in Chemistry and Biochemistry

edited by Nerilson Marques Lima,

Teresinha Andrade

and

Felipe de Almeida La Porta

submission deadline 25 Dec 2026 | Viewed by 116 | Submission Open

Keywords: metabolomics; analytical chemistry; biochemistry; mass spectrometry; nuclear magnetic resonance; chemometrics; metabolite annotation; pathway analysis; multi-omics

(This special issue belongs to the Section Advances in Metabolomics)

Nutritional Regulation of Gut Microbiome in Humans and Livestock

edited by Junquan Tian and

Qian Jiang

submission deadline 25 Dec 2026 | Viewed by 84 | Submission Open

Keywords: microbial metabolites; precision nutrition and synbiotics; multi-omics integration; livestock resilience optimization; dysbiosis-amended interventions

(This special issue belongs to the Section Nutrition and Metabolism)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome: 2nd Edition

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5126 | Submission Open

Keywords: metabolic diseases: obesity, diabetes, NAFLD, MAFLD, NASH, metabolic syndrome, etc.; multi-omics: metabolomics, lipidomics, proteomics, etc.; pathogenesis: genetic predispositions, lifestyle factors, microbiome and environmental exposures, etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment: 2nd Edition

edited by

Susumu Muroya

submission deadline 31 Dec 2026 | 4 articles | Viewed by 4424 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Advances on Metabolomics: Driving Innovation in Bio-Analysis and Natural Products Research

edited by

Natalia Drabińska-Fois

Daria Cicha-Wojciechowicz

Patrycja Mojsak

Eliza Matuszewska-Mach

and Martyna Pajewska-Szmyt

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2340 | Submission Open

Keywords: metabolomics; bioanalysis; biomedical research; biomarkers; foodomics; lipidomics; volatilomics; natural products; clinical diagnosis; biomarker discovery; analytical approaches; method development; mass spectrometry; disease detection; microorganisms

(This special issue belongs to the Section Advances in Metabolomics)

Bioactive Secondary Metabolites from Marine Macro- and Microorganisms

edited by

Xiaowei Luo

and

Yonghong Liu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1583 | Submission Open

Keywords: secondary metabolites; bioactivity; marine natural products; marine microorganisms; marine organisms; drug discovery; lead compounds; pharmacological mechanism; marine drugs

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Research in Dairy Cattle Health

edited by

Wei Yang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 1560 | Submission Open

Keywords: dairy cow; nutrient metabolism; feed ingredients; additives; disease; microbes; metabolite biomarkers

(This special issue belongs to the Section Animal Metabolism)

Biomarkers in Obesity, Metabolic Syndrome, and Weight Loss: Advances in Diagnosis, Risk Stratification, and Personalized Management

edited by

Martina Gažarová

Petra Lenártová

and

Magdalena Górnicka

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1429 | Submission Open

Keywords: obesity biomarkers; metabolic risk stratification; adipose tissue dysfunction; nutritional biomarkers; personalized nutrition; nutrition interventions; weight loss interventions; body composition analysis; emerging anthropometric indices

(This special issue belongs to the Section Nutrition and Metabolism)

Open-Source Software in Metabolomics, 2nd Edition

edited by

Seongho Kim

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1396 | Submission Open

Keywords: GC- MS; LC-MS; mass spectrometry; metabolomics; open-source software

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolic Regulation in Cancer Development and Progression

edited by Ovidiu Nicolae Pop and Carmen Pantiș

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1179 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor progression; glycolysis; lipid metabolism; amino acid metabolism; mitochondrial metabolism; tumor microenvironment; immunometabolism; therapeutic resistance

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioactive Compounds: Plant Stress Responses, Metabolic Regulation, and Therapeutic Insights

edited by

Periyasamy Rathinapriya

and

Theivanayagam Maharajan

submission deadline 31 Dec 2026 | 1 articles | Viewed by 807 | Submission Open

Keywords: abiotic stress adaptation; antioxidant potential; cytotoxic and therapeutic activity; plant-derived elicitors; plant metabolism

(This special issue belongs to the Section Plant Metabolism)

Plant-Derived Bioactive Metabolites and Their Applications

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 31 Dec 2026 | Viewed by 224 | Submission Open

Keywords: plant metabolites; characterization methods; biological activities

(This special issue belongs to the Section Plant Metabolism)

Integrative OMICs Analyses of Cardiometabolic Dysfunction

edited by

Rui Wang-Sattler

and Makoto Harada

submission deadline 31 Dec 2026 | Viewed by 208 | Submission Open

Keywords: cardiometabolic disease; metabolic syndrome; OMICs integration; metabolomics; biomarker discovery; machine learning; explainable AI; metabolic stress; inflammation; fibrosis

(This special issue belongs to the Section Integrative Metabolomics)

Microbial and Nutrition Metabolism in Animals

edited by

Zhiming Xu

and Xiaoge Sun

submission deadline 31 Dec 2026 | Viewed by 168 | Submission Open

Keywords: ruminant nutrition; microbial metabolism; lipid metabolism; rumen microbiota; microbial fermentation; microbiome; microbe–host; microorganisms and the environment

(This special issue belongs to the Section Animal Metabolism)

The Effects of Functional Foods on Human Metabolism

edited by

Boqun Liu

submission deadline 31 Dec 2026 | Viewed by 166 | Submission Open

Keywords: functional foods; human metabolism; metabolic pathways; bioactive components; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Fat and Glucose Metabolism: Mechanisms and Regulation

edited by

Getachew D. Belew

submission deadline 31 Dec 2026 | Viewed by 143 | Submission Open

Keywords: fat metabolism; glucose metabolism; intermediary metabolism; energy homeostasis; cardiometabolic diseases; obesity; MASLD/MASH; type 2 diabetes; metabolic regulation; therapeutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Factors in Neurodegenerative Diseases: Mechanisms, Biomarkers, and Therapy

edited by

Anna Serefko

and

Aleksandra Szopa

submission deadline 31 Dec 2026 | Viewed by 130 | Submission Open

Keywords: neurodegenerative diseases; metabolic dysfunction; insulin resistance; obesity; dyslipidemia; oxida-tive stress; glucose metabolism; lipid metabolism; gut–brain axis; biomarkers; therapeutic strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Biomarkers and Metabolites in Clinical Practice and Research

edited by

Mina Hur

submission deadline 31 Dec 2026 | Viewed by 108 | Submission Open

Keywords: identification of disease and non-disease biomarkers and metabolites; understanding the pathogenesis of the diseases through metabolites; physiological response against environmental stress or stimuli; clinical and translational researches; exposure to toxin or chemical drugs; lifestyle, nutrition, and genetic or epigenetic factors

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Influence of Dietary Lipids on Cancer: Effects on Carcinogen Metabolism and Oxidative Stress

edited by

Noemí Cárdenas-Rodríguez

and Daniel Ortega-Cuellar

submission deadline 31 Dec 2026 | Viewed by 74 | Submission Open

Keywords: dietary lipids; cancer metabolism; carcinogen metabolism; oxidative stress; lipidomics; lipid peroxidation; metabolomics; fatty acids; redox signaling; nutritional oncology; high fat diet; cytochrome P450; reactive oxygen species

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolism of Ectotherms: Insights from Amphibians and Reptiles

edited by

Lana Pađen

and Jasna Aladrović

submission deadline 1 Jan 2027 | 2 articles | Viewed by 1252 | Submission Open

Keywords: ectotherm; metabolic processes; amphibians; reptiles

(This special issue belongs to the Section Animal Metabolism)

Functional Foods and Metabolic Health

edited by

Lucas Fornari Laurindo

submission deadline 10 Jan 2027 | Viewed by 435 | Submission Open

Keywords: metabolomics; metabolic analyses; functional foods; metabolic health; chronic disease prevention; bioactive compounds; antioxidants; soluble fiber; probiotics; omega-3 fatty acids; diabetes; dyslipidemia; gut microbiota; obesity; cardiovascular disease; metabolic syndrome; personalized nutrition; nutritional interventions

(This special issue belongs to the Section Plant Metabolism)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 15 Jan 2027 | 5 articles | Viewed by 6218 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 15 Jan 2027 | 2 articles | Viewed by 4294 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

Nutrition, Metabolism and Clinical Management of Liver Diseases

edited by Miguel Suárez Matías

submission deadline 15 Jan 2027 | Viewed by 62 | Submission Open

Keywords: MASLD; MASH; cirrhosis; sarcopenia; malnutrition; alcohol-associated liver disease; liver trans-plantation; gut–liver axis; hepatocellular carcinoma; artificial intelligence

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mycotoxins and Fungal Secondary Metabolism

edited by

Guohua Yin

and Kayla K. Pennerman

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2429 | Submission Open

Keywords: mycotoxins; aflatoxin; patulin; biocontrol; metabolites; fungi

(This special issue belongs to the Section Plant Metabolism)

Bioactive Compounds in Obesity and Its Metabolic Complications

edited by

Patricia Rios Chavez

and Héctor Eduardo Martínez-Flores

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2205 | Submission Open

Keywords: antioxidant; obesity; inflammation; oxidative stress; metabolic syndrome

(This special issue belongs to the Section Plant Metabolism)

Advancements in Mass Spectrometry Techniques for Metabolomic and Pharmaceutical Analysis

edited by

Xiaowei Song

and Fangling Wu

submission deadline 29 Jan 2027 | 1 articles | Viewed by 1107 | Submission Open

Keywords: ambient ionization; mass spectrometry imaging; sample pretreatment; isomer analysis; marker discovery; ion annotation; structural identification; artificial intelligence; multi-omics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Novel Methods of Mass Spectrometry Imaging Towards Biomedical and Environmental Applications

edited by

Xiaoxiao Ma

Zhaoying Wang

and

Yanhua Chen

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1473 | Submission Open

Keywords: mass spectrometry imaging; molecular mapping; new techniques; biomedicine; materials science; environmental research; pharmaceutics

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics: The Role of Natural Products in Drugs

edited by

Jeysson Sanchez-Suarez

and

Jennyfer Andrea Aldana Mejía

submission deadline 31 Jan 2027 | 1 articles | Viewed by 427 | Submission Open

Keywords: metabolomics; natural products; drug discovery; bioactive compounds; computational metabolism; pharmacology; secondary metabolites; therapeutic development

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Amino Acid Metabolism Affecting Obesity and Energy Balance

edited by Xuchao Lyu and

Teruo Miyazaki

submission deadline 31 Jan 2027 | Viewed by 329 | Submission Open

Keywords: metabolomics; enzymes; obesity; amino acids; non-protein amino acids; biomarkers; cell signals

(This special issue belongs to the Section Cell Metabolism)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity: 2nd Edition

edited by

Joshua De Leon

submission deadline 31 Jan 2027 | Viewed by 121 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Beyond Metabolism: The Expanding Role of GLP-1 Receptor Agonists in Modern Medicine

edited by Alessandro Conforti,

Davide Francomano

and

Marco Marchetti

submission deadline 31 Jan 2027 | Viewed by 57 | Submission Open

Keywords: GLP-1 receptor agonists; type 2 diabetes mellitus; obesity; pleiotropic effects; cardiovascular risk; nephroprotection; central nervous system; satiety; chronic inflammation; bone metabolism; musculoskeletal system; osteoarticular; osteoarthritis; weight loss; innovative therapy; integrated medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipids and Fatty Acid Metabolism in Cardiovascular Diseases

edited by

Jasmina Debeljak Martacic

and Tamara Popović

submission deadline 10 Feb 2027 | 1 articles | Viewed by 1641 | Submission Open

Keywords: lipid metabolism; lipidomics; cardiovascular diseases; prevention strategies

(This special issue belongs to the Section Lipid Metabolism)

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