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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunometabolism and Metabolomics in Lung Disease

edited by Claudio Tirelli and Stefano Centanni

submission deadline 20 Feb 2025 | Viewed by 66 | Submission Open

Keywords: metabolomics; lung physiopathology; biomarkers; COPD; ILD; nuclear magnetic resonance spectroscopy; mass spectrometry; exhaled breath condensate; metabolites; immunometabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Cancer Metabolomics 2024

edited by

Bénédicte Elena-Herrmann

submission deadline 25 Feb 2025 | 1 articles | Viewed by 1568 | Submission Open

Keywords: metabolomics approaches and technologies; cancer and chronic diseases; diagnosis or predictive metabolic biomarkers; multi-omics studies; tumor metabolism; molecular epidemiology of cancer

(This special issue belongs to the Section Cell Metabolism)

Unlocking the Mysteries of Muscle Metabolism in the Animal Sciences

edited by

David E. Gerrard

and

Sally E. Johnson

submission deadline 28 Feb 2025 | 6 articles | Viewed by 5922 | Submission Open

Keywords: muscle; amino acid metabolism; energy metabolism; metabolites; protein; growth

(This special issue belongs to the Section Animal Metabolism)

Application of Metabolomics in Clinical Neonatology

edited by

Kosmas Sarafidis

and

Helen G. Gika

submission deadline 28 Feb 2025 | 3 articles | Viewed by 4635 | Submission Open

Keywords: neonate; disease pathophysiology; biomarkers; definition and diagnosis; outcome; omics; neonatal intensive care; neonatology; precision medicine

(This special issue belongs to the Section Advances in Metabolomics)

Impact of Food and Bioactive Compounds on Metabolic Diseases

edited by

Bungo Shirouchi

and

Hayato Maeda

submission deadline 28 Feb 2025 | 3 articles | Viewed by 3690 | Submission Open

Keywords: food factors; bioactive compounds; food function; metabolism; metabolites; gut microbiota (flora); metabolic syndrome; metabolic diseases (disorders)

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics in Disease Mechanisms and Drug Targets

edited by

Kefeng Li

submission deadline 28 Feb 2025 | 2 articles | Viewed by 3250 | Submission Open

Keywords: metabolomics; disease mechanism; drug target; biomarker; disease prediction

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nutrition and Metabolism in Human Diseases 2nd Edition

edited by

Xinhui Wang

submission deadline 28 Feb 2025 | 2 articles | Viewed by 2122 | Submission Open

Keywords: nutrition; metabolism; nutrient; metabolite; disease

(This special issue belongs to the Section Nutrition and Metabolism)

Reactive Oxygen Species and Energy Metabolic Alterations in Health and Disease

edited by

Paola Maycotte

and

Álvaro Marín-Hernández

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1628 | Submission Open

Keywords: cancer; ROS; glycolysis; mitochondria; autophagy; antioxidant system; glutathione; oxidative phosphorylation

(This special issue belongs to the Section Cell Metabolism)

Gut Microbe-Derived Metabolites in the Onset of Chronic Diseases

edited by Jonathan Wei Jie Lee and Adrian Low

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1074 | Submission Open

Keywords: gut microbiome; chronic gut disease; sulfidogenic bacteria; methanogens; secondary bile acids; short-chain fatty acids; tryptophan metabolites

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolites and Thyroid

edited by Carolina Castro Porto Silva Janovsky and Caroline Serrano-Nascimento

submission deadline 28 Feb 2025 | 1 articles | Viewed by 1028 | Submission Open

Keywords: metabolomics; hypothyroidism; hyperthyroidism; thyroid cancer; thyroid function; endocrine disruptors; lipidomics; proteomics

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Mass Spectrometry for Plant Metabolite Analysis: Techniques and Applications

edited by

Mila Radan

and

Prakash Babu Adhikari

submission deadline 28 Feb 2025 | Viewed by 301 | Submission Open

Keywords: mass spectrometry; plant metabolomics; biomarker discovery; metabolic networks: metabolic flux; MS data analysis; metabolic diseases

(This special issue belongs to the Section Plant Metabolism)

Role of Metabolic Factors and Their Interactions on Diabetes and Its Complications

edited by Yun Shen

submission deadline 28 Feb 2025 | Viewed by 172 | Submission Open

Keywords: metabolic risk factors; diabetes comorbidities; bioinformatics; machine learning; multi-omics integration; cardiovascular disease; dyslipidemia; insulin resistance; biomarkers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Environmental Metabolites Insights into Health and Disease

edited by

Yu Sun

submission deadline 28 Feb 2025 | Viewed by 134 | Submission Open

Keywords: environmental metabolites; probiotics; health; disease; toxic metabolites; protective metabolites; metabolomics; environmental exposure; molecular mechanisms; metabolic pathways

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Interaction between Gut Microbiota and Dietary Bioactive Compounds: Lipids, Carbohydrates, and Phytochemicals

edited by

Han Peng

submission deadline 28 Feb 2025 | Viewed by 115 | Submission Open

Keywords: food prebiotics; gut– organ axes; bioactive supplements; lipids; carbohydrates; phytochemicals; purification/processing technology; supplement formulation; alternative proteins/lipids

(This special issue belongs to the Section Nutrition and Metabolism)

Adrenal Neuroendocrine System and Cardiometabolic Health

edited by

Moe Thuzar

submission deadline 28 Feb 2025 | Viewed by 94 | Submission Open

Keywords: adrenal; metabolic syndrome; cardiovascular health; glucocorticoid; mineralocorticoid

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

New Insights into Microalgae Metabolism

edited by Wei Ding and

Yongteng Zhao

submission deadline 28 Feb 2025 | Viewed by 92 | Submission Open

Keywords: microalgae metabolism; carbon fixation; lipids; high-value compounds; synthetic biology; stress responses

(This special issue belongs to the Section Food Metabolomics)

Role of Nutraceuticals in Metabolic Disorders: Mechanisms and Benefits

edited by

Susmita Barman

submission deadline 28 Feb 2025 | Viewed by 83 | Submission Open

Keywords: nutraceuticals; functional foods; metabolic syndrome

Lifestyle Medicine for Chronic Diseases

edited by

Caroline Rhéaume

and

Abu Hena Mostafa Kamal

submission deadline 28 Feb 2025 | Viewed by 66 | Submission Open

Keywords: lifestyle medicine; chronic diseases; metabolomics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development

edited by

Emiliano Lasagna

and

Ishaku L. Haruna

submission deadline 28 Feb 2025 | Viewed by 60 | Submission Open

Keywords: myostatin; MSTN; GDF8; muscle development; muscular hypertrophy; metabolites and metabolism; omics sciences; myostatin pathways

(This special issue belongs to the Section Animal Metabolism)

Adipose Tissue, Reproduction and Metabolic Health in Women

edited by

Aldo Ferreira-Hermosillo

and Renata Saucedo

submission deadline 5 Mar 2025 | 1 articles | Viewed by 1931 | Submission Open

Keywords: adiposity; gestational diabetes; preeclampsia; pregnancy; obesity; polycystic ovarian syndrome; infertility; reproductive health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring and Expanding Horizons in Secondary Metabolites: Biosynthesis, Identification, Regulation and Biological Activity

edited by

Alberto Jorge Oliveira Lopes

Antônio Cantanhede Filho

and Claúdia Quintino Da Rocha

submission deadline 10 Mar 2025 | 1 articles | Viewed by 1856 | Submission Open

Keywords: secondary metabolites; biosynthesis; regulation; identification; plants; microorganisms; marine organisms; animals; bioactivity; drug discovery; natural products

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Expanding Boundaries in Spatial Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 10 Mar 2025 | Viewed by 123 | Submission Open

Keywords: spatial lipidomics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; lipids biochemistry

(This special issue belongs to the Section Lipid Metabolism)

Lifestyle Interventions: A Challenging Therapeutic Strategy for Metabolic Syndrome 2nd Edition

edited by

and

submission deadline 15 Mar 2025 | 1 articles | Viewed by 2279 | Submission Open

Keywords: diabetes; metabolic syndrome; insulin resistance; obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 15 Mar 2025 | 1 articles | Viewed by 874 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 15 Mar 2025 | Viewed by 100 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Carotenoid Metabolism

edited by

Robin Ghosh

submission deadline 15 Mar 2025 | Viewed by 79 | Submission Open

Keywords: carotenoids; metabolism; systems biology; nutrigenomics; apocarotenoids

Metabolic Research in Bladder Cancer

edited by

Dechao Feng

submission deadline 15 Mar 2025 | Viewed by 71 | Submission Open

Keywords: bladder cancer; metabolic biomarkers; metabolic reprogramming; tumor microenvironment; molecular mechanisms

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interactions of Diet, Exercise, and Metabolism

edited by

Raphael Gonçalves de Oliveira

, Dartagnan Pinto Guedes and Laís Campos de Oliveira

submission deadline 19 Mar 2025 | Viewed by 107 | Submission Open

Keywords: physical exercise; physical fitness; physical activity; diet; food; and nutrition; feeding behavior; me-tabolism; metabolic process

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Analysis of Specialized Metabolites in Natural Products

edited by

Aikaterini Koutsaviti

and

Christos Petrou

submission deadline 20 Mar 2025 | Viewed by 108 | Submission Open

Keywords: structure elucidation; isolation; evaluation of activity; plant bioactive secondary metabolites; methodology development

(This special issue belongs to the Section Plant Metabolism)

Lipidomics in Health and Disease

edited by

Paul Wood

submission deadline 30 Mar 2025 | 2 articles | Viewed by 2664 | Submission Open

Keywords: lipidomics; high-resolution mass spectrometry; lipid derivatization; lipid chromatography; diagnostics; therapeutics

(This special issue belongs to the Section Lipid Metabolism)

Exploring Potential Diagnostic and Prognostic Salivary Biomarkers in Cancer—2nd Edition

edited by

Lyudmila Bel'skaya

and

Martin Grootveld

submission deadline 31 Mar 2025 | 2 articles | Viewed by 5618 | Submission Open

Keywords: salivary biomarkers; metabolomics; salivaomics; diagnosis; prognosis; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle

edited by Paulo Cezar de Freitas Mathias, Lucas Paulo Jacinto Saavedra and

Rodrigo Mello Gomes

submission deadline 31 Mar 2025 | 3 articles | Viewed by 4185 | Submission Open

Keywords: obesity; diabetes; DOHaD; metabolic programming; treatment; intervention; cardiovascular disease; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 31 Mar 2025 | 2 articles | Viewed by 1704 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Proteomics and Metabolomics in Veterinary and Animal Health

edited by

Anita Horvatić

and

Andrea Gelemanović

submission deadline 31 Mar 2025 | Viewed by 227 | Submission Open

Keywords: metabolomics; proteomics; bioinformatics; omics data integration; mass spectrometry; veterinary medicine; animal health; biomarker discovery; metabolic pathways; molecular interactions

(This special issue belongs to the Section Integrative Metabolomics)

Lichen Secondary Metabolites in Cancer Research

edited by

Michal Goga

and

Martin Kello

submission deadline 31 Mar 2025 | Viewed by 113 | Submission Open

Keywords: identification of lichen substances; extraction; purification; methodology; anti-cancer effects; epigenetics; apoptosis pathways modulation; resistance mechanisms; tumor microenvironment modulation

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Mar 2025 | Viewed by 101 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 31 Mar 2025 | Viewed by 98 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation

edited by Andrea Castellaneta and

Ilario Losito

submission deadline 31 Mar 2025 | Viewed by 91 | Submission Open

Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Research in Lipid Metabolism in Animals

edited by

Bing Han

Lihong Zhao

and Zhenlong Wang

submission deadline 31 Mar 2025 | Viewed by 80 | Submission Open

Keywords: lipid metabolism; bile acid; gut microbiota; obesity; meat quality

(This special issue belongs to the Section Animal Metabolism)

The Interplay between Inflammation and Metabolism in Disease

edited by

Elena Planells

submission deadline 31 Mar 2025 | Viewed by 80 | Submission Open

Keywords: critically ill patients; micronutrients; vitamins; minerals; nutritional assessment; requirements; biomarkers; antioxidants; oxidative stress; inflammation; infection; supplementation; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Research in Animal Nutrition and Production

edited by Tietao Zhang and Qingkui Jiang

submission deadline 31 Mar 2025 | Viewed by 59 | Submission Open

Keywords: special economic animals; companion animals; nutrition; metabolomics; microbiome; metabolites; animal nutrition; animal production; animal health and disease; metabolic phenotypes

(This special issue belongs to the Section Animal Metabolism)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 31 Mar 2025 | Viewed by 44 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

The Digital Revolution in Livestock Production and Metabolism: Foodomics for a Viable Future and Beyond

edited by

Shuji Ueda

and

Salma Mohamad Yusop

submission deadline 31 Mar 2025 | Viewed by 24 | Submission Open

Keywords: metabolomics; foodomics; blockchain; nutritional genomics; smart farming; sustainable food production; Industry 4.0; precision livestock farming; food safety; genetic modification experiments

(This special issue belongs to the Section Food Metabolomics)

Role of Ceramides in Determining an Increased Cardiovascular and Renal Risk

edited by

Alessandro Mantovani

submission deadline 31 Mar 2025 | Viewed by 23 | Submission Open

Keywords: ceramides; cardiovascular risk; renal disease; biomarkers; sphingolipids; atherosclerosis; chronic kidney disease (CKD); cardiovascular disease (CVD); lipids

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Isotope Tracers in Investigating Metabolic Disorders

edited by Nadezda Khodorova

submission deadline 31 Mar 2025 | Viewed by 5 | Submission Open

Keywords: kinetics effect; isotope ratio mass spectrometry; biomarker; fluxomics; metabolomics; stable isotope; tracing experiments; mass spectrometry; breath tests

(This special issue belongs to the Section Integrative Metabolomics)

New Insights on the Role of Lipid Metabolism in the Development of Cardiac Dysfunction

edited by

Stephen C. Kolwicz

submission deadline 1 Apr 2025 | Viewed by 342 | Submission Open

(This special issue belongs to the Section Lipid Metabolism)

Intestinal Health and Metabolites in Farm Animals

edited by

Qian Jiang

and Junquan Tian

submission deadline 1 Apr 2025 | Viewed by 124 | Submission Open

Keywords: metabolites; intestinal health; oxidative stress; inflammation; epithelial barrier

(This special issue belongs to the Section Animal Metabolism)

Metabolic Changes during Pre- and Post-harvest Fruit and Vegetable Decay, Ripening and Senescence

edited by

Analía Concellón

and

María José Zaro

submission deadline 8 Apr 2025 | 3 articles | Viewed by 3111 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Mechanism of Metabolic Diseases

edited by

Dipsikha Biswas

and Logan Slade

submission deadline 15 Apr 2025 | Viewed by 476 | Submission Open

Keywords: metabolic diseases; nutrient signaling; metabolite profiling; genetic regulation; metabolomics; proteomics; organ crosstalk

(This special issue belongs to the Section Cell Metabolism)

Food Additives in Gut Microbiota and Metabolic Health

edited by Ran An, Jing Zhang and Heng Wang

submission deadline 15 Apr 2025 | Viewed by 51 | Submission Open

Keywords: food additives; emulsifier; carbohydrates; intestine; microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

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