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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nutritional and Metabolic Influences on Animal Growth and Reproduction

edited by

Zhipeng Li

and

Baichuan Deng

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2512 | Submission Open

Keywords: metabolites; nutritional and metabolic influences; animal development; meat quality; dairy science; animal reproduction

(This special issue belongs to the Section Animal Metabolism)

Mass Spectrometry Imaging and Spatial Metabolomics

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2436 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Nutrition and Metabolism in Human Diseases 2nd Edition

edited by

Xinhui Wang

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6582 | Submission Open

Keywords: nutrition; metabolism; nutrient; metabolite; disease

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Biotic and Abiotic Stress Responses and Tolerance: Phytohormonal and Metabolic Insights

edited by

Tabibul Islam

and Md. Al Mamun

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5046 | Submission Open

Keywords: biotic and abiotic stress; phytohormones: primary metabolism; secondary metabolites; plant– pathogen interactions; biostimulants; beneficial microbes; plant innate immunity; omics (genomics; transcriptomics; proteomics; metabolomics; etc.)

(This special issue belongs to the Section Plant Metabolism)

Research on Lipid Metabolism in Animals

edited by

Bing Han

Lihong Zhao

and Zhenlong Wang

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2071 | Submission Open

Keywords: lipid metabolism; bile acid; gut microbiota; obesity; meat quality

(This special issue belongs to the Section Animal Metabolism)

Biosynthesis, Metabolism, and Physiological Functions of Gamma-Aminobutyric Acid (2nd Edition)

edited by

Haixing Li

and

Dandan Gao

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1394 | Submission Open

Keywords: gamma-aminobutyric acid; metabolism and metabolomics; biotechnology and bioengineering; biosynthesis; physiological function; gamma-aminobutyric-acid-producing microbes; methodology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Advances in Mass Spectrometry for Plant Metabolite Analysis: Techniques and Applications

edited by

Mila Radan

and

Prakash Babu Adhikari

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1246 | Submission Open

Keywords: mass spectrometry; plant metabolomics; biomarker discovery; metabolic networks: metabolic flux; MS data analysis; metabolic diseases

(This special issue belongs to the Section Plant Metabolism)

Identification of Plant Metabolites: Characterization and Biological Activities, 2nd Edition

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1016 | Submission Open

Keywords: natural compounds; plant metabolites; separation techniques; biological activities

(This special issue belongs to the Section Plant Metabolism)

Advances in LC-MS-Based Metabolomics: From (Un)targeted Screening to Structural Elucidation

edited by Andrea Castellaneta and

Ilario Losito

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1014 | Submission Open

Keywords: liquid chromatography; high-resolution and multi-stage mass spectrometry; lipidomics; structure elucidation; LC-MS methods for metabolite screening; quantitative method development

(This special issue belongs to the Section Metabolomic Profiling Technology)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 31 Oct 2025 | 1 articles | Viewed by 907 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Role of Nutraceuticals in Metabolic Disorders: Mechanisms and Benefits

edited by

Susmita Barman

submission deadline 31 Oct 2025 | Viewed by 345 | Submission Open

Keywords: nutraceuticals; functional foods; metabolic syndrome

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics Approaches to Nutrition, Intestine and Farm Animal

edited by

Shu-cheng Huang

Lihong Zhang

and Aoyun Li

submission deadline 31 Oct 2025 | Viewed by 300 | Submission Open

Keywords: farm animal; nutrition; metabolomics; metabolism; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Evaluation of Metabolic Changes in Mice Under Chronic Toxic Substances Exposure

edited by Yun-Chung Hsiao and

Kun Lu

submission deadline 31 Oct 2025 | Viewed by 194 | Submission Open

Keywords: metabolomics; environmental contaminant; persistent organic pollutant; mass spectrometry; proteomics; toxicant; toxicological assessment; chronic toxicity; xenobiotic metabolism; lipidomic; dose– response relationship; molecular toxicology

(This special issue belongs to the Section Environmental Metabolomics)

Advances in Translational Oncology and Oncometabolism

edited by Graham Pidgeon and

Zivile Useckaite

submission deadline 31 Oct 2025 | Viewed by 135 | Submission Open

Keywords: oncometabolism; obesity; clinical research; clinical trials; oncogenes; translational oncology

(This special issue belongs to the Section Cell Metabolism)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 31 Oct 2025 | Viewed by 120 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

Salivary Biomarkers and Metabolites in Pigs

edited by

Fernando Tecles

submission deadline 31 Oct 2025 | Viewed by 78 | Submission Open

Keywords: saliva; biomarkers; welfare and health; animals

(This special issue belongs to the Section Animal Metabolism)

Metabolism and Reproduction in Animals

edited by

Simona Tafuri

and

Francesca Ciani

submission deadline 31 Oct 2025 | Viewed by 69 | Submission Open

Keywords: metabolism; reproduction; welfare; nutraceuticals; oxidative stress; antioxidants; inflammation; cancer

(This special issue belongs to the Section Animal Metabolism)

The Interaction Between Metabolic Dysfunction and Hypothalamic Inflammation

edited by

Joana M. Gaspar

submission deadline 31 Oct 2025 | Viewed by 52 | Submission Open

Keywords: metabolic disorders; neuroinflammation; hypothalamus; energy homeostasis; feeding behavior; high-fat diets; obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics of Human Nutrition: The Dot of Human Nutrition and the Circle of Soil, Plants, Animals and Microbes in Relation to It, 2nd Edition

edited by

Shoma Berkemeyer

submission deadline 31 Oct 2025 | Viewed by 42 | Submission Open

Keywords: human nutrition; metabolomics; physiology; biochemistry; dietetics; pathophysiology; soil science; crop science; animal husbandry; microbes

(This special issue belongs to the Section Nutrition and Metabolism)

Obesity and Metabolic Syndrome in Children: Insights, Interventions and Emerging Perspectives, 2nd Edition

edited by

Teofana Otilia Bizerea-Moga

and Rade Vukovic

submission deadline 31 Oct 2025 | Viewed by 42 | Submission Open

Keywords: metabolic syndrome in children; childhood obesity; hypertension; glucose tolerance; insulin resistance; nutritional status; metabolomics; oxidative stress; trace elements— selenium

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery: 2nd Edition

edited by

Irene Lidoriki

Dimitrios Schizas

and Maximos Frountzas

submission deadline 31 Oct 2025 | Viewed by 36 | Submission Open

Keywords: biomarkers; nutrition; metabolism; metabolomics; degenerative disease; Parkinson’ s disease; Alzheimer’ s disease; cardiovascular disease; gastrointestinal cancer surgery

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Dysbiosis and Metabolic Disorders of the Microbiota

edited by

Guozhu Ye

submission deadline 1 Nov 2025 | 1 articles | Viewed by 863 | Submission Open

Keywords: metabolomics; metagenomics; metaproteomics; metatranscriptomics; Liquid Chromatograph-Mass Spectrometer; Gas Chromatography-Mass Spectrometer; gut microbiota; environmental microbiota; metabolism; metabolic disorders

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Nutrition and Metabolism in Poultry

edited by Catarina Stefanello

submission deadline 10 Nov 2025 | Viewed by 112 | Submission Open

Keywords: ingredient; feed additive; feed quality; nutrient utilization; intestinal health

(This special issue belongs to the Section Animal Metabolism)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 15 Nov 2025 | 1 articles | Viewed by 1196 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

The Relationship Between Adipose Tissue Insulin Resistance and Metabolic Syndrome

edited by

Atefeh Rabiee

submission deadline 15 Nov 2025 | Viewed by 55 | Submission Open

Keywords: adipose insulin resistance; metabolic syndrome; visceral adiposity; adipocytokines; insulin signaling; lipolysis dysregulation; cardiometabolic risk; lipotoxicity; adipose inflammation; insulin sensitivity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Targeted and Non-Targeted LC- and GC-HRMS Workflows for the Analysis of Emerging Contaminants and the Environmental Exposome

edited by Lapo Renai and

Massimo Del Bubba

submission deadline 16 Nov 2025 | Viewed by 147 | Submission Open

Keywords: chromatography; high-resolution mass spectrometry; non-targeted analysis; exposome; data analysis; environmental analysis; pharmaceuticals; poly- and perfluorinated substances; personal care products; transformation products feature detection and identification

(This special issue belongs to the Section Environmental Metabolomics)

Neurometabolics in a Nutshell

edited by

Justyna Paprocka

submission deadline 20 Nov 2025 | Viewed by 120 | Submission Open

Keywords: neurometabolic disorders; rare diseases; diagnosis; differential diagnosis; treatment options

(This special issue belongs to the Section Cell Metabolism)

Effects of Various Exercise Methods on Metabolic Health

edited by

Hun-Young Park

and Won-Sang Jung

submission deadline 28 Nov 2025 | 1 articles | Viewed by 681 | Submission Open

Keywords: exercise physiology; metabolism; insulin sensitivity; energy expenditure; cardiovascular health; resistance training; high-intensity interval training; hypoxia; mitochondrial function; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Sex Differences in Physical Exercise and Dietary Habits Effects on Metabolic Health

edited by Hannah Cabre and

Adam M. Gonzalez

submission deadline 28 Nov 2025 | Viewed by 339 | Submission Open

Keywords: sex differences; metabolomics; metabolites; menstrual cycle; aging; exercise performance; nutrition intervention; cardiometabolic

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Environmental Metabolites Insights into Health and Disease

edited by

Yu Sun

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3495 | Submission Open

Keywords: environmental metabolites; probiotics; health; disease; toxic metabolites; protective metabolites; metabolomics; environmental exposure; molecular mechanisms; metabolic pathways

(This special issue belongs to the Section Environmental Metabolomics)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3478 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Exploring and Expanding Horizons in Secondary Metabolites: Biosynthesis, Identification, Regulation and Biological Activity

edited by

Alberto Jorge Oliveira Lopes

Antônio Cantanhede Filho

and Claúdia Quintino Da Rocha

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3359 | Submission Open

Keywords: secondary metabolites; biosynthesis; regulation; identification; plants; microorganisms; marine organisms; animals; bioactivity; drug discovery; natural products

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Environmental Exposure and Its Effects on Cardio-Respiratory and Metabolic Health

edited by

Kristine McGrath

and Tatt Jhong Haw

submission deadline 30 Nov 2025 | Viewed by 299 | Submission Open

Keywords: environmental factors; pollution; cardiovascular; cardiometabolic risk factor; biomarkers; mechanisms; cardio-oncology; cardio-respiratory

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Isotope Tracers in Investigating Metabolic Disorders

edited by Nadezda Khodorova

submission deadline 30 Nov 2025 | Viewed by 258 | Submission Open

Keywords: kinetics effect; isotope ratio mass spectrometry; biomarker; fluxomics; metabolomics; stable isotope; tracing experiments; mass spectrometry; breath tests

(This special issue belongs to the Section Metabolomic Profiling Technology)

Investigating the Impact of Teas on Metabolic Disorders: Insights into Underlying Mechanisms and Therapeutic Potential

edited by

Ran Wei

and

Michał Tomczyk

submission deadline 30 Nov 2025 | Viewed by 89 | Submission Open

Keywords: teas; metabolic disorders; mechanism of action; therapeutic potential; diabetes; obesity; cardiovascular diseases; biochemical properties; clinical studies; therapeutic strategies

(This special issue belongs to the Section Nutrition and Metabolism)

The Future Perspective on Screening and Diagnosis of Inborn Errors of Metabolism

edited by Luiz Carlos Santana-Da-Silva, Olga Yaneth Echeverri-Peña and

Angela J. Espejo-Mojica

submission deadline 30 Nov 2025 | Viewed by 84 | Submission Open

Keywords: inborn errors of metabolism (IEM); genetic disorders; diagnostics; biomarkers; omics sciences; imaging techniques (MRS; PET); molecular techniques (NGS; gene editing); personalized medi-cine; early detection

Exposome and Metabolic Effects: Neurological Implications of Environmental Pollutants

edited by

Roberta Zupo

submission deadline 30 Nov 2025 | Viewed by 71 | Submission Open

Keywords: exposome; environmental pollutants; metabolic effects; neurological implications; neurodegenerative diseases; cognitive dysfunction; brain metabolism; toxins; environmental health; developmental disorders; neurobiology; genetic predisposition; preventive strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Phenological Regulation of Secondary Metabolism

edited by

Iván De-la-Cruz-Chacón

, Alma Rosa González-Esquinca and

Xin Fang

submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open

Keywords: phenological fluctuations; metabolites’ phenological fluctuations; secondary metabolites; natural products; specialized metabolites

(This special issue belongs to the Section Plant Metabolism)

Metabolomics in Breath Biomarker Discovery

edited by Waqar Ahmed

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: exhaled breath volatiles; metabolomics; biomarkers; volatile organic compounds

(This special issue belongs to the Section Advances in Metabolomics)

Autophagy and Antioxidant Pathways in Neurodegenerative Diseases

edited by

Federica Armeli

and

Rita Businaro

submission deadline 30 Nov 2025 | Viewed by 46 | Submission Open

Keywords: neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; autophagy; neuroinflammation; oxidative stress; antioxidant pathways; neuroprotection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Imaging and Spectroscopic Based Methods to Understand Cancer Metabolism and Biology 2025

edited by

Madhu Basetti

submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open

Keywords: PET; CT; MRI; NMR; molecular imaging; optical imaging; opto-acoustic imaging; Raman imag-ing and spectroscopy; mass spectroscopy imaging; metabolic pathways; theranostic imaging; machine learning; deep learning; artificial intelligence; image analysis; tumors; cancer; cancer metabolism; cancer biology; tumor microenvironment; tumor heterogeneity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Proteomics and Metabolomics in Human Health and Disease

edited by

Michele Costanzo

and

Margherita Ruoppolo

submission deadline 30 Nov 2025 | Viewed by 40 | Submission Open

Keywords: proteomics; metabolomics; lipidomics; multi-omics; disease mechanisms; machine learning; omics integrations; artificial intelligence

(This special issue belongs to the Section Advances in Metabolomics)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

Metabolomics in Disease Mechanisms and Drug Targets, 2nd Edition

edited by

Kefeng Li

submission deadline 30 Nov 2025 | Viewed by 24 | Submission Open

Keywords: metabolomics; disease mechanism; drug target; biomarker; disease prediction

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics in Personalized Medicine

edited by

Angom Ramcharan Singh

submission deadline 30 Nov 2025 | Viewed by 11 | Submission Open

Keywords: metabolomics; personalized medicine; biomarkers; precision health; disease stratification; metabolic profiling; NMR spectroscopy; mass spectrometry; therapeutic response; systems biology

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics and Plant Defence, 2nd Edition

edited by

Shitou Xia

and

Junxing Lu

submission deadline 5 Dec 2025 | Viewed by 188 | Submission Open

Keywords: metabolomics; plant defence; biotic and abiotic stress; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Metabolite Profiles in Inflammatory Diseases

edited by Rodica Pădureanu and