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Metabolites
Special Issues
Gut Microbiota-Host Metabolic Axis: From Diet to Systemic Health
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Gut Microbiota-Host Metabolic Axis: From Diet to Systemic Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: 10 November 2026 | Viewed by 235

Special Issue Editors

Dr. Ran An

E-Mail Website
Guest Editor
Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: food components; intestinal microbiome
Special Issues, Collections and Topics in MDPI journals
Dr. Jing Zhang

E-Mail Website
Guest Editor
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: gut microbiota; intestinal health; antioxidant; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, Gut Microbiota–Host Metabolic Axis: From Diet to Systemic Health, explores the bidirectional interplay between the gut microbiome and host metabolism in shaping systemic health. The collection examines how dietary components modulate microbial communities, which in turn influence nutrient metabolism, immune function, endocrine signaling and so on. The work elucidates the molecular mechanisms underlying this axis, with implications for metabolic disorders, inflammatory diseases and therapeutic interventions such as probiotics, prebiotics and dietary regimens. Collectively, we are interested in studies investigating the gut microbiota–host metabolic axis as a central hub integrating nutrition, microbial ecology and host physiology. With this, the current issue aims to advance foundational knowledge and translational applications, bridging microbiome science with clinical and public health practice.

Dr. Ran An
Dr. Jing Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiota
  • prebiotic
  • probiotic
  • diet
  • systemic health
  • intervention

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Published Papers (1 paper)

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Research

22 pages, 1861 KB  
Article
Polysaccharide from Gleditsia sinensis Seed Endosperm Ameliorates Type 2 Diabetes and Its Associated Cardiorenal Injuries by Modulating TLR4/MyD88/NF-κB Pathway and Gut Microbiota
by Mei Liu, Wenping Liao, Hongyun Liu, Feng Xu, Yanyan Zhang, Xiangpei Wang and Hongmei Wu
Metabolites 2026, 16(5), 339; https://doi.org/10.3390/metabo16050339 - 18 May 2026
Viewed by 74
Abstract
Background: Type 2 diabetes mellitus (T2DM) represents a pressing global health challenge, underscoring the urgency of developing effective dietary interventions derived from natural resources. Zaojiaomi polysaccharide (ZJMP) from the endosperm of Gleditsia sinensis seeds (zaojiaomi), a traditional edible product, exhibits largely underexplored potential [...] Read more.
Background: Type 2 diabetes mellitus (T2DM) represents a pressing global health challenge, underscoring the urgency of developing effective dietary interventions derived from natural resources. Zaojiaomi polysaccharide (ZJMP) from the endosperm of Gleditsia sinensis seeds (zaojiaomi), a traditional edible product, exhibits largely underexplored potential in T2DM management. Methods: In the present study, the antidiabetic effects and underlying mechanisms of ZJMP were investigated using a rat model of T2DM induced by a high-fat diet (HFD) combined with streptozotocin (STZ). Relevant biochemical indicators were detected, and histopathological examination was performed. The expression levels of key components of the TLR4/MyD88/NF-κB signaling pathway, as well as the inflammatory cytokines IL-6 and IL-1β in renal tissues, were further analyzed. Additionally, gut microbiota composition and the levels of short-chain fatty acids were determined. Results: ZJMP treatment significantly ameliorated hyperglycemia and dyslipidemia, elevated serum insulin levels, reduced intestinal mucosal permeability, and attenuated histopathological lesions in the heart, kidney, and pancreas of T2DM rats. Meanwhile, ZJMP notably alleviated renal inflammation by suppressing the production of IL-1β and IL-6, as well as inhibiting the TLR4/MyD88/NF-κB pathway. Furthermore, ZJMP administration effectively modulated gut microbiota composition and increased fecal concentrations of acetic acid and propionic acid. Conclusions: Collectively, these findings elucidate the novel bioactivity of ZJMP and highlight its potential as a promising functional food ingredient or dietary supplement for T2DM management. Full article
(This article belongs to the Special Issue Gut Microbiota-Host Metabolic Axis: From Diet to Systemic Health)
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