Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 151
Special Issue Editors
Interests: hypoxia signaling; metabolic-associated fatty liver diseases; beige adipogenesis mechanisms; hepatic ketogenesis; liver cancer
Interests: hypoxia; autophagy; mitochondria; glutamate signaling; oxidative stress
Interests: metabolism; mitochondria; cell biology; signal transduction; cancer; OxPHOS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxygen is an essential nutrient and plays a key role in processes such as cellular metabolism and bioenergetic homeostasis. However, under certain physiological or pathological conditions, organisms may experience low oxygen levels, a condition referred to as hypoxia. Hypoxia is crucial in normal physiological processes, as it helps regulate cellular oxygen levels and influences key functions such as oxygen consumption, red blood cell production, angiogenesis, and metabolism. On the other hand, hypoxia is also implicated in a variety of pathological conditions, where it triggers cellular signaling pathways that contribute to disease development and progression. The primary regulator of hypoxia is the hypoxia-inducible factor (HIF), a transcription factor complex that includes HIF-1α or HIF-2α, along with the HIF-1β/ARNT subunit. While the HIF-α subunits are mainly regulated by prolyl hydroxylase domain-containing enzymes (PHDs), their activity is also modulated by other factors such as factor-inhibiting HIF1α (FIH1) and various metabolic pathways, including metabolites. Therefore, understanding the relationship between hypoxia and cellular metabolism is crucial for exploring the therapeutic potential of drugs targeting the HIF signaling pathways.
This Special Issue of Metabolites, titled "Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications," aims to publish research exploring the crosstalk between hypoxia and various metabolic processes, including glycolysis, carbohydrate metabolism, fatty acid metabolism, mitochondrial function, and peroxisomal activity. Papers focusing on metabolites that regulate hypoxia at the molecular, cellular, and integrative levels are also welcome.
Dr. Raja Gopal Reddy Mooli
Dr. Hang Cheng
Dr. Nathan Lanning
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxygen
- hypoxia
- metabolism
- Hypoxia Inducible Factors (HIFs)
- prolyl hydroxylase domain-containing enzymes (PHDs)
- metabolic regulation
- glucose metabolism
- fatty acid metabolism
- TCA cycle
- metabolites
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
