Advances in Cancer Metabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 5 September 2026 | Viewed by 1799
Special Issue Editors
Interests: novel metabolomics methods for studying metabolic dysregulation in diseases, metabolism–immune crosstalk, and small-molecule therapies for metabolic disorders
Interests: molecular mechanisms of tumor metabolism
Special Issue Information
Dear Colleagues,
Metabolic reprogramming is now recognized as a driver of tumor evolution, immune evasion, and therapy response. Recent technologies map metabolism with unprecedented spatiotemporal resolution, revealing metabolic heterogeneity across cancer, stromal, and immune compartments and its consequences for nutrient competition and redox control. Single-cell and spatial metabolomics, as well as in-tissue isotope tracing, are uncovering cell state-specific dependencies. Meanwhile, metabolism-to-epigenome signaling—exemplified by lactate and lactylation—and classic oncometabolites (2-HG, succinate, and fumarate) continue to reshape our view of lineage plasticity and therapeutic resistance.
This Special Issue invites original research, resources, methods, and reviews that (i) define metabolic vulnerabilities and plasticity across tumor ecosystems; (ii) dissect immunometabolic circuits and nutrient competition in the tumor microenvironment; (iii) advance single-cell/spatial metabolomics, in vivo fluxomics, and other cutting-edge approaches toward clinically actionable biomarkers; and (iv) translate mechanisms into therapies (e.g., mitochondria-targeting strategies, lipid and one-carbon metabolism, and rational combinations with immunotherapy or DNA-damage agents). We also welcome clinically oriented studies that benchmark best practices and report translational milestones, such as the emergence of metabolism-targeted drugs (e.g., IDH1/2 inhibitors and HIF-2α inhibition) and their biomarker strategies, to accelerate metabolism-informed diagnostics and treatments.
Dr. Haowen Jiang
Dr. Man Zhao
Dr. Duo Zhang
Guest Editors
Manuscript Submission Information
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Keywords
- cancer metabolism
- metabolic plasticity
- tumor microenvironment
- immunometabolism
- mitochondrial metabolism
- oncometabolites
- metabolic–epigenetic crosstalk
- single-cell metabolomics
- spatial metabolomics
- metabolic flux analysis
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