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Advances in Murine Models for Metabolic Diseases: Insights into Diabetes,...
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Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 1379

Special Issue Editor

Prof. Dr. Samuel Treviño

E-Mail Website
Guest Editor
Laboratory of Metabolomic and Chronic Degenerative Diseases, Physiology Institute, Meritorious Autonomous University of Puebla, Puebla C.P. 72560, Mexico
Interests: metabolic diseases; chronic degenerative diseases; endocrinology; inflammation; oxidative stress; biochemistry; molecular biology

Special Issue Information

Dear Colleagues,

Advances in murine models are crucial for understanding the complex interplay of metabolic diseases like diabetes, obesity, and cardiovascular conditions. This Special Issue of Metabolites focuses on cutting-edge research utilizing these models to dissect disease mechanisms and identify potential therapeutic targets.

Focus: This Special Issue emphasizes innovative approaches in the murine modeling of metabolic diseases. This includes genetically modified mice (e.g., knockouts, knock-ins, and transgenics), diet-induced models (e.g., high-fat diet and high-fructose diet), and combined approaches that mimic the multifaceted nature of human diseases. We also encourage submissions exploring the impact of gut microbiota, inflammation, and other contributing factors on metabolic dysfunction in these models.

Scope: This Special Issue covers a broad spectrum of research areas, including the following:

  • Mechanistic studies investigating the molecular pathways involved in disease development and progression.
  • Preclinical testing of novel therapeutic interventions, including pharmacological agents, dietary interventions, and gene therapies.
  • Studies exploring the link between metabolic disorders and related complications, such as cardiovascular disease, neuropathy, and nephropathy.
  • Development and validation of new techniques for assessing metabolic phenotypes in mice, including metabolomics, imaging, and physiological measurements.

Purpose: This Special Issue aims at providing a comprehensive overview of the current state of the art in murine models of metabolic diseases. It serves as a valuable resource for researchers in the field, facilitating the exchange of knowledge and fostering collaborations. By highlighting recent advances and identifying knowledge gaps, this Special Issue will guide future research and accelerate the development of effective strategies for preventing and treating human metabolic disorders.

Prof. Dr. Samuel Treviño
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • murine models
  • metabolic diseases
  • molecular mechanisms
  • biochemical pathways
  • pharmacological strategies
  • interactome
  • comorbidities
  • metabolic phenotypes
  • novel techniques

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

9 pages, 1359 KiB  
Article
Clay Attenuates Diarrhea Induced by Fat in a Mouse Model
by Shalom Emmanuel, Nyma Siddiqui, Ting Du, Eric Asare, Yuan Chen, Huan Xie, Dong Liang and Song Gao
Metabolites 2025, 15(7), 483; https://doi.org/10.3390/metabo15070483 - 17 Jul 2025
Abstract
Background: Diarrhea induced by an excessive amount of fat is a prevalent gastrointestinal disorder. Currently, there are limited animal models and treatment options for diarrhea associated with fat. This study aims to develop a mouse model of high-fat-associated diarrhea using glyceryl-trioleate (GTO) and [...] Read more.
Background: Diarrhea induced by an excessive amount of fat is a prevalent gastrointestinal disorder. Currently, there are limited animal models and treatment options for diarrhea associated with fat. This study aims to develop a mouse model of high-fat-associated diarrhea using glyceryl-trioleate (GTO) and evaluate the potential of montmorillonite clay (MMT) in mitigating this condition. Methods: GTO was administered to mice at different doses through oral gavage to induce diarrhea. Clay was treated through oral gavage to evaluate its anti-diarrhea effect. Fecal conditions were monitored. Intestinal tissues were subjected to histological examination to assess structural integrity. The total fecal bile acids were evaluated using a bile acid assay kit to determine the mechanism of action. Results: The results showed that a diarrhea model was established by administering GTO at 2000 mg/kg. When the animals were treated with clay, diarrhea incidence and severity were decreased significantly in a dose-dependent manner. Compared to the untreated group receiving GTO alone, clay co-administration at 2000 mg/kg reduced diarrhea scores by approximately 48%, while the higher dose of 4000 mg/kg achieved an 83% reduction. Fecal bile acid analysis showed that diarrhea is associated with total bile acid levels in the feces. Histological exams showed that diarrhea is associated with tissue inflammation in the colon. Conclusions: This study showed that GTO administration induced diarrhea in mice, and clay effectively alleviates fat-induced diarrhea through modulation of fecal bile acid composition. These findings suggest that this model can be used to evaluate diarrhea associated with excessive amounts of fat and clay that can be further tested for diarrhea attenuation. Full article
(This article belongs to the Special Issue Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions)
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32 pages, 5153 KiB  
Article
Naringenin Decreases Retroperitoneal Adiposity and Improves Metabolic Parameters in a Rat Model of Western Diet-Induced Obesity
by Gabriela López-Almada, J. Abraham Domínguez-Avila, Rosario Maribel Robles-Sánchez, Jonathan Arauz-Cabrera, Gustavo Martínez-Coronilla, Gustavo A. González-Aguilar and Norma Julieta Salazar-López
Metabolites 2025, 15(2), 109; https://doi.org/10.3390/metabo15020109 - 8 Feb 2025
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Abstract
Background: Obesity is a multifactorial disease with detrimental effects on health and quality of life; unregulated satiety plays a crucial role in food intake and obesity development. Naringenin (NAR) has shown beneficial effects on lipid and carbohydrate metabolism, although its impact on adiposity [...] Read more.
Background: Obesity is a multifactorial disease with detrimental effects on health and quality of life; unregulated satiety plays a crucial role in food intake and obesity development. Naringenin (NAR) has shown beneficial effects on lipid and carbohydrate metabolism, although its impact on adiposity and satiety remains unclear. This study reports a Western diet (WD)-induced obesity model in rats, wherein 100 mg/kg of NAR was administered as an anti-obesity agent for 8 weeks; oxidative stress, lipid profile, and satiety biomarkers were then studied, as well as in silico interaction between NAR and cholecystokinin (CCK) and ghrelin receptors. Results: NAR supplementation resulted in a significant decrease in retroperitoneal adipose tissue and liver weight, as compared to the untreated WD group (p < 0.05), potentially associated with a decreased feed efficiency. NAR also inhibited the development of dyslipidemia, particularly by reducing serum triglycerides (p < 0.05). NAR supplementation increased CCK serum levels in the basal diet group, an effect that was abolished by the WD (p < 0.05); likewise, no changes were determined on ghrelin (p > 0.05). In silico data shows that NAR is capable of interacting with the CCK and ghrelin receptors, which suggests a potential for it to modulate hunger/satiety signaling by interacting with them. Conclusions: We conclude that NAR has anti-obesogenic effects and may regulate CCK serum levels, although further research is still needed. Full article
(This article belongs to the Special Issue Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions)
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