Connections Between Nutrition, Epidemiology, and Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 774

Special Issue Editor

1. Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
2. Kim Kijoon BOM Clinic, Seoul 05554, Republic of Korea
Interests: nutritional epidemiology; antioxidants; medicinal herbs; functional ingredients; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, the intersection of nutrition, epidemiology, and metabolism has become a focal point for understanding the global rise in chronic diseases. Nutritional epidemiology plays a key role in investigating how dietary patterns and specific bioactive compounds affect metabolic processes and long-term health outcomes. As the burden of metabolic disorders such as obesity, diabetes, and cardiovascular disease continues to grow worldwide, there is an urgent need for multidisciplinary approaches that combine rigorous epidemiological research with insights into molecular metabolism and nutritional science.

This Special Issue aims to bring together cutting-edge research that explores the complex links between diet, metabolic regulation, and disease risk across populations. We welcome original research articles, systematic reviews, and perspectives that advance our understanding of how nutrition influences metabolic pathways, from cellular mechanisms to population-level impacts. Topics of interest include, but are not limited to the following:

  • Nutritional epidemiology and chronic disease risk;
  • The role of antioxidants, phytochemicals, and medicinal herbs in metabolic health;
  • Functional food ingredients and their metabolic effects;
  • Dietary patterns and their associations with metabolic biomarkers;
  • Public health interventions targeting nutrition and metabolism;
  • Integration of omics technologies (e.g., metabolomics, nutrigenomics) in epidemiological studies.

By highlighting the interplay between nutrition, epidemiological evidence, and metabolic outcomes, this Special Issue seeks to foster interdisciplinary dialogue and promote evidence-based strategies for the prevention and management of metabolic disorders. We invite researchers from diverse backgrounds—including nutrition, epidemiology, public health, and clinical research—to contribute their latest findings to this timely collection.

Dr. Kijoon Kim
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional epidemiology
  • metabolism
  • antioxidants
  • medicinal herbs
  • functional ingredients
  • chronic disease
  • public health

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Published Papers (1 paper)

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Research

17 pages, 1246 KB  
Article
Metabolite Genome-Wide Association in Hispanics with Obesity Reveals Genetic Risk and Interactions with Dietary Factors for Type 2 Diabetes
by Chao-Qiang Lai, Laurence D. Parnell, Zhuoheng Li, Sabrina E. Noel, Shilpa N. Bhupathiraju, Katherine L. Tucker and José M. Ordovás
Metabolites 2025, 15(11), 697; https://doi.org/10.3390/metabo15110697 - 28 Oct 2025
Viewed by 576
Abstract
Background: Obesity is a leading cause of type 2 diabetes (T2D), with particularly high prevalence in Hispanic populations residing in the USA. However, how genetic variation influences obesity-related blood metabolite levels which, in turn, contribute to T2D progression, is not well understood. Our [...] Read more.
Background: Obesity is a leading cause of type 2 diabetes (T2D), with particularly high prevalence in Hispanic populations residing in the USA. However, how genetic variation influences obesity-related blood metabolite levels which, in turn, contribute to T2D progression, is not well understood. Our goal was to identify and understand genetic and dietary connections between obesity and T2D in a Hispanic cohort of older adults. Materials and Methods: We conducted a genome-wide association study on 13 specific metabolites previously associated with T2D and characteristic of individuals with abdominal obesity within the Boston Puerto Rican Health Study cohort. We further examined associations of identified metabolite quantitative trait loci (mQTLs) and their interactions with targeted dietary factors on T2D prevalence and related traits. We used gene set and pathway analysis with protein–protein interaction networks to explore the molecular mechanisms underlying the metabolic connections between obesity and T2D. Results: We identified 30 single-nucleotide polymorphisms (SNPs) acting as mQTLs for these 13 metabolites. These mQTLs were located within 19 gene regions, associated with processes such as linoleic acid metabolism, alpha-linolenic acid metabolism, and glycerophospholipid biosynthesis. Although no mQTLs were directly associated with T2D or related traits, 12 demonstrated interactions with certain food groups that affect T2D risk. Moreover, gene set and pathway analysis with protein–protein interaction networks indicated that alpha-linolenic acid metabolism, lipid metabolism, and glycerophospholipid biosynthesis and metabolism among other pathways are potential connections between T2D and obesity. Conclusions: This study identifies biochemical relationships between genetic susceptibility and dietary influences, contributing to our understanding of T2D progression in Hispanic people with obesity. Full article
(This article belongs to the Special Issue Connections Between Nutrition, Epidemiology, and Metabolism)
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