Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Back to Basics in Palaeontology
edited by Hua Stephane
submission deadline 9 Jul 2025 | 8 articles | Viewed by 13260
Keywords: fundamentals; natural history; multidisciplinarity; first hand bibliography; actualism
(This special issue belongs to the Section Paleobiology)
Update on Microalgae Metabolites submission deadline 10 Jul 2025 | 1 articles | Viewed by 1564 | Submission Open
Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests
(This special issue belongs to the Section Microbiology)
Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans
edited by
submission deadline 11 Jul 2025 | 1 articles | Viewed by 712 | Submission Open
Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; transcranial Doppler measurement; EEG; lifestyle
(This special issue belongs to the Section Physiology and Pathology)
Molecular Mechanisms and Function Impact of Protein Modifications
edited by
submission deadline 15 Jul 2025 | Viewed by 228 | Submission Open
Keywords: protein modifications; enzyme regulation; proteomics and functional; diversity disease mechanisms; diagnostic and therapeutic strategies
(This special issue belongs to the Section Proteins and Proteomics)
Cancer Treatment and Drug Resistance: 2nd Edition
edited by and
submission deadline 20 Jul 2025 | Viewed by 244 | Submission Open
Keywords: cancer treatment; drug resistance; cancer cell signaling; metastasis; apoptosis; cell cycle; novel therapies
(This special issue belongs to the Section Pharmaceutical Science)
Cardioncology: From Molecular Mechanisms to Advanced Imaging and New Treatments
edited by , Giuseppe Pacileo and
submission deadline 21 Jul 2025 | 2 articles | Viewed by 3623 | Submission Open
Keywords: cardiotoxicity; echocardiography; cardiac magnetic resonance; cardiac computed tomography; serum cardiac biomarkers; cancer therapy; arrhythmias; cardiotoxicity treatment
(This special issue belongs to the Section Physiology and Pathology)
Emergency and Trauma Management
edited by Pietro Fransvea and Gabriele Sganga
submission deadline 22 Jul 2025 | 1 articles | Viewed by 1555 | Submission Open
Keywords: acute care surgery; trauma; general surgery; minimally invasive surgery; emergency management
(This special issue belongs to the Section Medical Research)
Spinal Neuromodulation: From Basic and Translational Research to Clinical Practice submission deadline 25 Jul 2025 | 1 articles | Viewed by 1779 | Submission Open
Keywords: spinal neuromodulation; translational neuroscience; spinal cord injury; neural plasticity; multi-disciplinary rehabilitation
(This special issue belongs to the Section Medical Research)
Blood Rheology: Insights & Innovations
edited by Nadia Antonova
submission deadline 28 Jul 2025 | 1 articles | Viewed by 1951 | Submission Open
Keywords: hemorheology  ; microfluidics  ; blood viscosity  ; mechanobiology  ; cellular mechanics
(This special issue belongs to the Section Medical Research)
Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare
edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura
submission deadline 29 Jul 2025 | 2 articles | Viewed by 2133 | Submission Open
Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19
(This special issue belongs to the Section Pharmaceutical Science)
Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies submission deadline 30 Jul 2025 | 5 articles | Viewed by 14910 | Submission Open
Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies
(This special issue belongs to the Section Physiology and Pathology)
Clinical Update for Resuscitation Science
edited by Mitsuaki Nishikimi
submission deadline 30 Jul 2025 | 5 articles | Viewed by 8516 | Submission Open
Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma
(This special issue belongs to the Section Medical Research)
Diagnosis, Treatment, and Prognosis of Neuroendocrine Neoplasms
edited by Pernille Holmager and
submission deadline 30 Jul 2025 | Viewed by 224 | Submission Open
Keywords: diagnosis; medical treatment; radionuclide treatment; prognosis
(This special issue belongs to the Section Medical Research)
Advances in Upper Respiratory Tract Disorders and Head and Neck Cancers: From Pathophysiology to Innovative Approaches submission deadline 30 Jul 2025 | Viewed by 153 | Submission Open
Keywords: inflammation; infection; cancer; respiratory tract; head and neck
(This special issue belongs to the Section Physiology and Pathology)
Cardiovascular Diseases: From Basic Research to Clinical Application—2nd Edition submission deadline 31 Jul 2025 | 14 articles | Viewed by 22492 | Submission Open
Keywords: CVDs; risk factors; prevention; treatment; novelties in research; artificial intelligence
(This special issue belongs to the Section Medical Research)
Focus on Exercise Physiology and Sports Performance: 2nd Edition
edited by
submission deadline 31 Jul 2025 | 10 articles | Viewed by 20945 | Submission Open
Keywords: exercise; physical activity; nutrition; exercise physiology; sports performance
(This special issue belongs to the Section Physiology and Pathology)
The Effects of Neurosteroids on Neurological and Psychiatric Disorders
edited by Irina S. Balan
submission deadline 31 Jul 2025 | 5 articles | Viewed by 13268 | Submission Open
Keywords: pregnane neurosteroids; androstane neurosteroids; sulfated neurosteroids; neuroactive steroids; neurological disorders; psychiatric disorders; therapeutic potential; neuroprotective properties; anti-inflammatory properties
(This special issue belongs to the Section Physiology and Pathology)
Cornea and Anterior Eye Diseases: 2nd Edition
edited by , and Giancarlo Montani
submission deadline 31 Jul 2025 | 5 articles | Viewed by 8510 | Submission Open
Keywords: cornea; anterior eye; corneal dystrophy; dry eye; ocular surface; ocular imaging; contact lenses; myopia control with contact lenses; contact lens complications; primary eye care
(This special issue belongs to the Section Medical Research)
What Is New in Psychiatry and Psychopharmacology—2nd Edition submission deadline 31 Jul 2025 | 4 articles | Viewed by 7342 | Submission Open
Keywords: clinical psychiatry; biomarkers; psychopharmacology; addictions; agitations; pharmacological resistance; transcranial magnetic resonance
(This special issue belongs to the Section Pharmaceutical Science)
Biological and Clinical Research of Germ Cells
edited by
submission deadline 31 Jul 2025 | 3 articles | Viewed by 6922 | Submission Open
Keywords: germ cells; spermatozoa; oocytes; cumulus oocyte complex; sexually transmitted infections; ICSI; IVF; infertility; reproduction
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Advances in the Structure and Function of Microbial Communities
edited by and
submission deadline 31 Jul 2025 | 3 articles | Viewed by 6855 | Submission Open
Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability
(This special issue belongs to the Section Microbiology)
Cardiovascular–Kidney–Metabolic (CKM) Syndrome
edited by Chien Yu Lin and
submission deadline 31 Jul 2025 | 3 articles | Viewed by 6093 | Submission Open
Keywords: cardiovascular-kidney-metabolic (CKM) syndrome; mortality; biomarkers; epidemiology; environmental pollutants; gut microbiome; oxidative stress; metabolic syndrome; coronary heart disease; chronic renal failure; cardiovascular disease; cardiorenal syndrome; metabolic disorders; heart failure; diabetes and CKD; inflammation and CKM syndrome; multi-organ interaction; translational research in CKM
(This special issue belongs to the Section Medical Research)
Prognosis and Management of Dry Eye Disease submission deadline 31 Jul 2025 | 2 articles | Viewed by 4356 | Submission Open
Keywords: dry eye disease; dry eye epidemiology; dry eye management; dry eye natural course; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; artificial tear substitutes; tear film lipid layer; meibomian glands
(This special issue belongs to the Section Medical Research)
Biomarker Analysis for Sports Performance and Health submission deadline 31 Jul 2025 | 1 articles | Viewed by 3624 | Submission Open
Keywords: exercise physiology; bioenergetics; biology; human locomotion; performance analysis; sports sciences; training optimization
(This special issue belongs to the Section Physiology and Pathology)
Novel Therapies for Chronic Inflammatory Diseases and Autoimmune Diseases submission deadline 31 Jul 2025 | 3 articles | Viewed by 2864 | Submission Open
Keywords: chronic inflammatory diseases; autoimmune diseases; biomarker identification; innovative biologics; small-molecule inhibitors; gene editing technologies; cell-based therapeutics
(This special issue belongs to the Section Medical Research)
Skin Cancer: From Molecular Basis to Therapy: 2nd Edition
edited by
submission deadline 31 Jul 2025 | 3 articles | Viewed by 2764 | Submission Open
Keywords: nonmelanoma skin cancer; melanoma; cutaneous lymphoma; Kaposi sarcoma; skin-directed therapy; carcinogenesis; UV radiation; tumor predisposition syndrome
(This special issue belongs to the Section Medical Research)
Updates on Respiratory Pathologies submission deadline 31 Jul 2025 | 4 articles | Viewed by 2735 | Submission Open
Keywords: respiratory disorders; chronic obstructive pulmonary disease; respiratory tract infection; pulmonary clinical treatment
(This special issue belongs to the Section Physiology and Pathology)
Gastrointestinal Diseases: Innovations in Diagnostics, Therapeutics, and Prognosis
edited by Ľudovít Danihel
submission deadline 31 Jul 2025 | 2 articles | Viewed by 1873 | Submission Open
Keywords: diagnostics; therapeutics; gastrointestinal diseases; artificial intelligence; clinical cases
(This special issue belongs to the Section Medical Research)
Inflammation and Natural Products: 2nd Edition
edited by , and Irene García Domínguez
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1477 | Submission Open
Keywords: natural products; inflammation; biological activity; anti-inflammatory activity; antioxidant activity; anticancer potential; terrestrial products; marine products; phytochemistry; pharmacology
(This special issue belongs to the Section Pharmaceutical Science)
Recent Advances in Lymphomas
edited by Magdalena Witkowska
submission deadline 31 Jul 2025 | 1 articles | Viewed by 933 | Submission Open
Keywords: lymphoma; cellular therapy; epigenetics; immunotherapy; targeted therapies
(This special issue belongs to the Section Medical Research)
Pathological and Clinical Updates on Eye Diseases
edited by Pier Luigi Surico and
submission deadline 31 Jul 2025 | 1 articles | Viewed by 686 | Submission Open
Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea
(This special issue belongs to the Section Medical Research)
Advances in Wildlife Behavior and Biodiversity submission deadline 31 Jul 2025 | 1 articles | Viewed by 663 | Submission Open
Keywords: behavioral abnormalities; the ability to exhibit natural behavior; reduced genetic diversity; habitat loss; extinction of species; species rehousing; coexistence
(This special issue belongs to the Section Diversity and Ecology)
Structure, Activity, and Function of Protein Methyltransferases: 2nd Edition submission deadline 31 Jul 2025 | Viewed by 543 | Submission Open
(This special issue belongs to the Section Proteins and Proteomics)
Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies
edited by
submission deadline 31 Jul 2025 | Viewed by 265 | Submission Open
Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology
(This special issue belongs to the Section Medical Research)
Organ Predilection of Certain Gastrointestinal Diseases—Pathophysiology, Diagnosis and Management
edited by
submission deadline 31 Jul 2025 | Viewed by 191 | Submission Open
Keywords: disease predilection in gastrointestinal tract; esophagus with certain diseases; stomach with certain diseases; duodenum with certain diseases; jejunum with certain diseases; ileum with certain diseases; colorectum with certain diseases
(This special issue belongs to the Section Physiology and Pathology)
Gene Editing of Large Mammals: 2nd Edition submission deadline 1 Aug 2025 | Viewed by 129 | Submission Open
Keywords: gene editing; large mammals; molecular breeding; application prospect
(This special issue belongs to the Section Animal Science)
Current Trends in Obstructive Sleep Apnea
edited by Kimberly A. Hardin
submission deadline 15 Aug 2025 | 2 articles | Viewed by 1281 | Submission Open
Keywords: obstructive sleep apnea  ; diagnosis and biomarkers  ; personalized treatment strategies  ; clinical phenotypes  ; innovative therapies
(This special issue belongs to the Section Medical Research)
Natural Bioactives: Exploring Their Therapeutic Potential—2nd Edition submission deadline 20 Aug 2025 | 3 articles | Viewed by 667 | Submission Open
Keywords: bioactive compounds; medicinal plants; bioactive metabolites with antioxidant properties; anti-inflammatory properties; antitumor properties; cytotoxic properties; antipsychotic properties; anxiolytic properties; neuroprotective properties; hypotensive properties; vasorelaxant properties; antimicrobial properties (antiviral; antibacterial; antifungal; and antiparasitic properties)
(This special issue belongs to the Section Pharmaceutical Science)
Environmental Stress and Adaptation: Molecular Mechanisms and Ecosystems Biodiversity submission deadline 21 Aug 2025 | Viewed by 292 | Submission Open
Keywords: abiotic oxidative stress; aquatic biodiversity monitoring; reactive oxygen species; riparian and mangrove vegetation management; environmental DNA (eDNA) metabarcoding
(This special issue belongs to the Section Diversity and Ecology)
New Insights Into Artificial Intelligence in Medical Imaging
edited by , , and Salvatore Lavalle
submission deadline 22 Aug 2025 | 2 articles | Viewed by 7307 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; image analysis; precision medicine; image-guided interventions; decision support systems
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Advances in Endovascular Therapies and Acute Stroke Management
edited by
submission deadline 25 Aug 2025 | 2 articles | Viewed by 1055 | Submission Open
Keywords: mechanical thrombectomy; endovascular reperfusion; stroke intervention technologies; acute ischemic stroke treatment; stroke imaging biomarkers
(This special issue belongs to the Section Medical Research)
Applications of Molecular Dynamics to Biological Systems
edited by
submission deadline 26 Aug 2025 | 3 articles | Viewed by 2147 | Submission Open
Keywords: computer simulation; biophysical modeling; molecular dynamics
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
Hand Soft Tissue Disorders: Mechanisms and Therapeutic Advances
edited by Ishith Seth
submission deadline 26 Aug 2025 | 1 articles | Viewed by 981 | Submission Open
Keywords: dupuytren’ s disease; hand soft tissue disorders; genomics; biomarkers; artificial intelligence
(This special issue belongs to the Section Medical Research)
Pharmacology, Diagnosis and Treatments of Psychiatric Diseases
edited by Giuseppe Marano and
submission deadline 26 Aug 2025 | Viewed by 326 | Submission Open
Keywords: mental health disorders; clinical psychology; psychopharmacology; treatment efficacy; neuroimaging techniques; personalized medicine; diagnosis
(This special issue belongs to the Section Medical Research)
Emerging Applications of Nanobiotechnology in Medicine and Health
edited by Roshanak Khandanlou
submission deadline 28 Aug 2025 | Viewed by 176 | Submission Open
Keywords: nanobiotechnology; targeted drug-delivery; tissue engineering; cancer treatment; regenerative medicine; medical applications
(This special issue belongs to the Section Medical Research)
Cystic Fibrosis: A Disease with a New Face
edited by and Patricia A. Walker
submission deadline 29 Aug 2025 | 11 articles | Viewed by 32454 | Submission Open
Keywords: cystic fibrosis; CFTR modulator; CF newborn screening; CF nutrition; lung transplant in CF; CF family planning
(This special issue belongs to the Section Medical Research)
Applications of Dermatoscopy in Skin Diseases submission deadline 29 Aug 2025 | 5 articles | Viewed by 31917 | Submission Open
Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of colour; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy
(This special issue belongs to the Section Medical Research)
Elements Cycling and Plants’ Physiological Characteristics: A Soil–Plant–Atmosphere Continuum Perspective
edited by and
submission deadline 29 Aug 2025 | 7 articles | Viewed by 13814 | Submission Open
Keywords: element cycling; microbial communities; plant nutrition; plant physiology; plant biochemistry; atmospheric composition; climate change; soil– plant– atmosphere interaction; plant– soil feedback
(This special issue belongs to the Section Plant Science)
Nutritional Supplementation, Body Composition and Performance in Athletes
edited by
submission deadline 29 Aug 2025 | 2 articles | Viewed by 11070 | Submission Open
Keywords: optimal macro and micronutrients in exercise; plant-based food in sports nutrition; beetroot as ergogenic aid; body mass composition and nutrition practice; phase angle as VO2 max predictor; RED syndrome low and high energetic availability in sports praxis
(This special issue belongs to the Section Physiology and Pathology)
Current Progress in Medical Image Segmentation
edited by
submission deadline 29 Aug 2025 | 4 articles | Viewed by 6443 | Submission Open
Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
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