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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease

edited by

Laura Patton

and

Guido Gabriele

submission deadline 30 Jun 2025 | 4 articles | Viewed by 17244 | Submission Open

Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain

(This special issue belongs to the Section Physiology and Pathology)

Retinal Diseases: From Molecular Mechanisms to Therapeutics

edited by

Soo-Young Kim

submission deadline 30 Jun 2025 | 8 articles | Viewed by 17034 | Submission Open

Keywords: retinal disease; inflammatory disease; genetic diseases; ocular drug development

(This special issue belongs to the Section Physiology and Pathology)

Nutritional Supplements and Cardiovascular Function in Athletes and Sedentary People

edited by

Ines Drenjančević

submission deadline 30 Jun 2025 | 5 articles | Viewed by 7784 | Submission Open

Keywords: athletes; sedentary; eating habits; nutrition; endothelium; microcirculation; vascular function; nutritional supplements; oxidative stress; antioxidants; NRF2-signaling pathway; functional food; cardiovascular function; prevention; physical activity

(This special issue belongs to the Section Medical Research)

Recent Advances in Shockwave Therapy for Musculoskeletal and Soft-Tissue Disorders

edited by

Marco Gesi

Mario Vetrano

, Maria Chiara Vulpiani, Maria Cristina D'Agostino, Larisa Ryskalin and Federica Fulceri

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5590 | Submission Open

Keywords: shockwave; tissue regeneration; pain; functional recovery and healing; physical medicine and rehabilitation; clinical applications; imaging

(This special issue belongs to the Section Medical Research)

Epidemiology Studies of Cardiovascular Diseases in Older Adults

edited by Nadya Kagansky

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4542 | Submission Open

Keywords: cardiovascular diseases in older adults; gerontology; hypertension; hyperlipidemia; diabetes; obesity

(This special issue belongs to the Section Epidemiology)

Revolutionizing Neuroregeneration

edited by

Kiminobu Sugaya

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3997 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; neuroregeneration; stroke; regenerative therapy

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Bone Remodeling

edited by

Tada-aki Kudo

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3793 | Submission Open

Keywords: bone remodeling; osteoblast; osteoclast; osteocyte; osteoporosis

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Physiological Responses of Plants Under Abiotic Stresses

edited by Dawei Shi

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3443 | Submission Open

Keywords: crops; woody plants; horticultural plants; physiological responses; abiotic stresses; photosynthesis

(This special issue belongs to the Section Plant Science)

Neuroinflammation in Huntington’s Disease: Detrimental Crosstalk

edited by

Michele D'Angelo

and

Vanessa Castelli

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2773 | Submission Open

Keywords: Huntington’ s disease; mutant huntingtin (mHtt) protein; central nervous system; mutated protein; glial cells

(This special issue belongs to the Section Physiology and Pathology)

Genetics, Breeding and Reproduction of Honeybees: Second Edition

edited by

Xiao Chen

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2603 | Submission Open

Keywords: phenomics; genetics; genomics; functional genomics; metabolomics; functional genes identification; genetics editing; genome selection; genetic evaluation; hybrid breeding; egg-laying; honey production; queen breeding; varroa resistance

(This special issue belongs to the Section Animal Science)

Prevention, Evaluation, and Control of HIV Infection

edited by

Οlga Tsachouridou

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2336 | Submission Open

Keywords: HIV/AIDS; HIV testing; immune activation; HIV pathogenesis; inflammation; HIV transmission and prevention; antiretroviral therapy

(This special issue belongs to the Section Microbiology)

Feature Paper in Genetics and Genomics

edited by

Lluís Ribas de Pouplana

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2288 | Submission Open

Keywords: DNA; RNA; gene discovery and function; gene expression; population genetics; genome projects; comparative and functional genomics; medical genetics; complex traits; chromosome biology; epigenomics and epigenetics; statistical genetics and methodology; genomic assay technology; sequencing technologies; bioinformatics

(This special issue belongs to the Section Genetics and Genomics)

Mechanism, Diagnosis, and Treatment of Aortic Diseases: 2nd Edition

edited by

Edit Dósa

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2223 | Submission Open

Keywords: aorta; aortic disease; aortic aneurysm; aortic dissection; penetrating aortic ulcer; aortic stenosis; arteritis; pathomechanism; diagnosis; pharmacological therapy; invasive therapy; endovascular therapy; open surgery

(This special issue belongs to the Section Medical Research)

Acute Kidney Events in Intensive Care

edited by

Silvia De Rosa

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2197 | Submission Open

Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; biomarkers

(This special issue belongs to the Section Medical Research)

Advanced Heart Failure and Transplant Cardiology

edited by David Dobarro

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2151 | Submission Open

Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices

(This special issue belongs to the Section Medical Research)

Advancements in Veterinary Oncology

edited by

José Pimenta

Mário Pedro Goncalves Cotovio

Justina Prada

and

Isabel Pires

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2145 | Submission Open

Keywords: veterinary and comparative oncology; epidemiology; tumor biology; diagnosis; treatment; biomarkers

(This special issue belongs to the Section Animal Science)

Innovative Technologies in Pain Management

edited by

Hector Beltran-Alacreu

and

José A. Moral-Munoz

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1184 | Submission Open

Keywords: pain management; extended reality (XR) technologies; gamification for pain relief; psychosocial variables; interdisciplinary approaches

(This special issue belongs to the Section Physiology and Pathology)

Advancements in Hematologic Malignancies: Innovations in Diagnosis and Therapy

edited by Chohao Lee

submission deadline 30 Jun 2025 | 1 articles | Viewed by 971 | Submission Open

Keywords: hematologic malignancies; stem cell transplantation; CAR-T cell therapy; immunotherapy; multiple myeloma; leukemia; precision medicine; hematopoietic stem cells; drug resistance; novel therapeutics

(This special issue belongs to the Section Medical Research)

Integrating Bioinformatics and Artificial Intelligence: Transforming Data into Insights for Precision Medicine

edited by Usef Faghihi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 735 | Submission Open

Keywords: bioinformatics; artificial intelligence; precision medicine; machine learning; computational biology; multi-omics data integration; biomarker discovery; predictive modeling; personalized medicine; computational drug discovery

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

The Other Pediatric Primary Headaches: 2nd Edition

edited by

Vincenzo Raieli

Vittorio Sciruicchio

and Giuseppe Santangelo

submission deadline 30 Jun 2025 | 1 articles | Viewed by 666 | Submission Open

Keywords: pediatric TACs; primary pediatric headaches; pediatric tension headaches; preventive treatment; acute treatment; clinical features; children; pediatric headaches in IV 3ICHD

(This special issue belongs to the Section Medical Research)

Diabetes and Microbiome

edited by

Gratiela Pircalabioru

and

Octavian Savu

submission deadline 30 Jun 2025 | Viewed by 464 | Submission Open

Keywords: diabetes mellitus; microbiome; microbiota metabolites; metabolic disease; dysbiosis

(This special issue belongs to the Section Microbiology)

Advanced Neuroimaging Techniques in Stroke Management

edited by Foteini Christidi,

Anna Tsiakiri

and

Efstratios Karavasilis

submission deadline 30 Jun 2025 | Viewed by 328 | Submission Open

Keywords: stroke; neuroimaging; MRI; CT; stroke management; biomarkers; acute stroke; chronic stroke; neuroplasticity; neuromodulation

(This special issue belongs to the Section Medical Research)

Advances in Veterinary Ophthalmology: Innovative Approaches to Ocular Diseases in Animals

edited by

Dagmara Winiarczyk

submission deadline 30 Jun 2025 | Viewed by 224 | Submission Open

Keywords: ocular diseases; dogs; cats; tear film; molecular mechanism

(This special issue belongs to the Section Animal Science)

Advances in CT Angiography and Perfusion

edited by Marcin Sawicki

submission deadline 30 Jun 2025 | Viewed by 204 | Submission Open

Keywords: CT angiography; CT perfusion; artificial intelligence; dynamic CT angiography; 4D CT angiography; acute ischemic stroke

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Role of the Kynurenine System in Neurological Disorders

edited by

Gábor Nagy-Grócz

and Tamás Körtési

submission deadline 30 Jun 2025 | Viewed by 175 | Submission Open

Keywords: kynurenine pathway; neurological disorders; kynurenic acid; quinolinic acid

(This special issue belongs to the Section Physiology and Pathology)

Innovations in Pediatric Immunology and Environmental Health

edited by

Wonsuck Yoon

submission deadline 30 Jun 2025 | Viewed by 139 | Submission Open

Keywords: indoor microbiome; children's health; environmental microorganisms; maternal factors; allergies and asthma; immune development

(This special issue belongs to the Section Physiology and Pathology)

Infection, Inflammation and Rheumatology

edited by

Arvind Nune

submission deadline 4 Jul 2025 | 2 articles | Viewed by 2392 | Submission Open

Keywords: infection; COVID-19; inflammation; vaccination; rheumatic diseases

(This special issue belongs to the Section Physiology and Pathology)

Update on Microalgae Metabolites

edited by

Eduardo Jacob-Lopes

and

Leila Queiroz Zepka

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1516 | Submission Open

Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests

(This special issue belongs to the Section Microbiology)

Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans

edited by

Akos Koller

submission deadline 11 Jul 2025 | 1 articles | Viewed by 647 | Submission Open

Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; transcranial Doppler measurement; EEG; lifestyle

(This special issue belongs to the Section Physiology and Pathology)

Molecular Mechanisms and Function Impact of Protein Modifications

edited by

Yie Hwa Chang

submission deadline 15 Jul 2025 | Viewed by 215 | Submission Open

Keywords: protein modifications; enzyme regulation; proteomics and functional; diversity disease mechanisms; diagnostic and therapeutic strategies

(This special issue belongs to the Section Proteins and Proteomics)

Cancer Treatment and Drug Resistance: 2nd Edition

edited by

Zhixiang Wang

and

Hamid Maadi

submission deadline 20 Jul 2025 | Viewed by 232 | Submission Open

Keywords: cancer treatment; drug resistance; cancer cell signaling; metastasis; apoptosis; cell cycle; novel therapies

(This special issue belongs to the Section Pharmaceutical Science)

Cardioncology: From Molecular Mechanisms to Advanced Imaging and New Treatments

edited by

Carla Contaldi

, Giuseppe Pacileo and

Paolo Calabrò

submission deadline 21 Jul 2025 | 2 articles | Viewed by 3502 | Submission Open

Keywords: cardiotoxicity; echocardiography; cardiac magnetic resonance; cardiac computed tomography; serum cardiac biomarkers; cancer therapy; arrhythmias; cardiotoxicity treatment

(This special issue belongs to the Section Physiology and Pathology)

Emerging Knowledge on Human Immunodeficiency Virus

edited by

Giota Lourida

and

Dimitrios Paraskevis

submission deadline 22 Jul 2025 | 2 articles | Viewed by 7682 | Submission Open

Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis

(This special issue belongs to the Section Medical Research)

Emergency and Trauma Management

edited by Pietro Fransvea and Gabriele Sganga

submission deadline 22 Jul 2025 | 1 articles | Viewed by 1523 | Submission Open

Keywords: acute care surgery; trauma; general surgery; minimally invasive surgery; emergency management

(This special issue belongs to the Section Medical Research)

Spinal Neuromodulation: From Basic and Translational Research to Clinical Practice

edited by

Alexander V. Ovechkin

submission deadline 25 Jul 2025 | 1 articles | Viewed by 1737 | Submission Open

Keywords: spinal neuromodulation; translational neuroscience; spinal cord injury; neural plasticity; multi-disciplinary rehabilitation

(This special issue belongs to the Section Medical Research)

Diagnosis, Treatment and Prognosis of Prostate Cancer

edited by

Juan Gómez Rivas

and Jesús Moreno Sierra

submission deadline 26 Jul 2025 | Viewed by 268 | Submission Open

Keywords: active surveillance; hormonal treatment; personalized medicine; prostate cancer; robotic surgery; targeted therapy

(This special issue belongs to the Section Medical Research)

Blood Rheology: Insights & Innovations

edited by Nadia Antonova

submission deadline 28 Jul 2025 | 1 articles | Viewed by 1792 | Submission Open

Keywords: hemorheology ; microfluidics ; blood viscosity ; mechanobiology ; cellular mechanics

(This special issue belongs to the Section Medical Research)

Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare

edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura

submission deadline 29 Jul 2025 | 2 articles | Viewed by 1922 | Submission Open

Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19

(This special issue belongs to the Section Pharmaceutical Science)

Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies

edited by

Valentin Nicolae Varlas

submission deadline 30 Jul 2025 | 5 articles | Viewed by 14547 | Submission Open

Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies

(This special issue belongs to the Section Physiology and Pathology)

Clinical Update for Resuscitation Science

edited by Mitsuaki Nishikimi

submission deadline 30 Jul 2025 | 5 articles | Viewed by 8345 | Submission Open

Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma

(This special issue belongs to the Section Medical Research)

Transformative Frontiers in Mental Health Treatment: Advances in Neuropsychopharmacology

edited by

Senthil Kumaran Satyanarayanan

and

Luca Steardo

submission deadline 30 Jul 2025 | Viewed by 237 | Submission Open

Keywords: neuropsychopharmacology; mental health; novel drug therapies; biomarkers; personalized medicine; psychiatric conditions; treatment innovation; pharmacogenomics; synaptic plasticity; neuroinflammation; neuroendocrine systems

(This special issue belongs to the Section Pharmaceutical Science)

Diagnosis, Treatment, and Prognosis of Neuroendocrine Neoplasms

edited by Pernille Holmager and

Zhiwei Hu

submission deadline 30 Jul 2025 | Viewed by 223 | Submission Open

Keywords: diagnosis; medical treatment; radionuclide treatment; prognosis

(This special issue belongs to the Section Medical Research)

Advances in Upper Respiratory Tract Disorders and Head and Neck Cancers: From Pathophysiology to Innovative Approaches

edited by

Pei-Rung Yang

and

Geng-He Chang

submission deadline 30 Jul 2025 | Viewed by 146 | Submission Open

Keywords: inflammation; infection; cancer; respiratory tract; head and neck

(This special issue belongs to the Section Physiology and Pathology)

Cardiovascular Diseases: From Basic Research to Clinical Application—2nd Edition

edited by

Cristiana Bustea

and

Delia Mirela Tit

submission deadline 31 Jul 2025 | 14 articles | Viewed by 21739 | Submission Open

Keywords: CVDs; risk factors; prevention; treatment; novelties in research; artificial intelligence

(This special issue belongs to the Section Medical Research)

Focus on Exercise Physiology and Sports Performance: 2nd Edition

edited by

Laikang Yu

submission deadline 31 Jul 2025 | 10 articles | Viewed by 19653 | Submission Open

Keywords: exercise; physical activity; nutrition; exercise physiology; sports performance

(This special issue belongs to the Section Physiology and Pathology)

The Effects of Neurosteroids on Neurological and Psychiatric Disorders

edited by Irina S. Balan

submission deadline 31 Jul 2025 | 5 articles | Viewed by 12914 | Submission Open

Keywords: pregnane neurosteroids; androstane neurosteroids; sulfated neurosteroids; neuroactive steroids; neurological disorders; psychiatric disorders; therapeutic potential; neuroprotective properties; anti-inflammatory properties

(This special issue belongs to the Section Physiology and Pathology)

Cornea and Anterior Eye Diseases: 2nd Edition

edited by

Raúl Martín

Sara Ortiz-Toquero

and Giancarlo Montani

submission deadline 31 Jul 2025 | 5 articles | Viewed by 8368 | Submission Open

Keywords: cornea; anterior eye; corneal dystrophy; dry eye; ocular surface; ocular imaging; contact lenses; myopia control with contact lenses; contact lens complications; primary eye care

(This special issue belongs to the Section Medical Research)

What Is New in Psychiatry and Psychopharmacology—2nd Edition

edited by

Donatella Marazziti

submission deadline 31 Jul 2025 | 4 articles | Viewed by 7026 | Submission Open

Keywords: clinical psychiatry; biomarkers; psychopharmacology; addictions; agitations; pharmacological resistance; transcranial magnetic resonance

(This special issue belongs to the Section Pharmaceutical Science)

Advances in the Structure and Function of Microbial Communities

edited by

Qing Hu

and

Xuliang Zhuang

submission deadline 31 Jul 2025 | 3 articles | Viewed by 6760 | Submission Open

Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability

(This special issue belongs to the Section Microbiology)

Biological and Clinical Research of Germ Cells

edited by

Liana Bosco

submission deadline 31 Jul 2025 | 3 articles | Viewed by 6731 | Submission Open

Keywords: germ cells; spermatozoa; oocytes; cumulus oocyte complex; sexually transmitted infections; ICSI; IVF; infertility; reproduction

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

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