Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unravelling the Molecular Mechanisms of Different Stress Responses in Plants
edited by
submission deadline 9 May 2025 | 1 articles | Viewed by 999 | Submission Open
Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms
(This special issue belongs to the Section Plant Science)
MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 259 | Submission Open
Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies
(This special issue belongs to the Section Medical Research)
MASLD and Its Comorbidities: From Pathophysiology Perspectives
edited by
submission deadline 9 May 2025 | Viewed by 210 | Submission Open
Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research
(This special issue belongs to the Section Physiology and Pathology)
Ruminant Nutrition Strategies to Improve Feed Efficiency and Reduce Methane Emissions: 2nd Edition
edited by , Tongjun Guo and
submission deadline 15 May 2025 | Viewed by 305 | Submission Open
Keywords: ruminant nutrition; roughage utilization; unconventional feed materials; feed efficiency; production performance; methane emissions; feed additive
(This special issue belongs to the Section Animal Science)
Personalized Prevention and Treatment in Endocrinology, Diabetes and Metabolic Diseases
edited by Grigorios Panagiotou
submission deadline 16 May 2025 | 11 articles | Viewed by 23705 | Submission Open
Keywords: personalized medicine; precision prevention; multi-omics; obesity; diabetes and endocrinology
(This special issue belongs to the Section Medical Research)
Advances in Substance Abuse and Addiction
edited by , and Chieh-Liang Huang
submission deadline 16 May 2025 | 4 articles | Viewed by 7148 | Submission Open
Keywords: addiction medicine; opioid pharmacology; substance abuse; addictive disorders intervention
(This special issue belongs to the Section Pharmaceutical Science)
Innovations in Thoracic Surgery and Medicine: Advancements and Challenges
edited by Paolo Scanagatta
submission deadline 18 May 2025 | 4 articles | Viewed by 4583 | Submission Open
Keywords: thoracic medicine; thoracic surgery; lung cancer; artificial intelligence (AI); VATS; thoracic anesthesia; innovations
(This special issue belongs to the Section Medical Research)
Innovative Perspectives in Physical Therapy and Health submission deadline 22 May 2025 | 3 articles | Viewed by 3791 | Submission Open
Keywords: physical therapy; health; pain management; musculoskeletal disorders; ultrasonography; rehabilitation; innovative therapies
(This special issue belongs to the Section Medical Research)
Pain and Therapy: Historical Perspectives and Future Directions submission deadline 22 May 2025 | 3 articles | Viewed by 3070 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Medical Research)
Effects of Exercise Training on Muscle Function
edited by Marco Duca and
submission deadline 26 May 2025 | 7 articles | Viewed by 15043 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Conservative Management of Chronic Disease
edited by
submission deadline 26 May 2025 | 5 articles | Viewed by 14168 | Submission Open
Keywords: chronic disease  ; conservative management; trial protocol; clinical research; interventions
(This special issue belongs to the Section Medical Research)
Feature Papers in Synthetic Biology and Systems Biology 2024
edited by
submission deadline 26 May 2025 | Viewed by 616 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Green Medicine: Unraveling the Medicinal Effects of Plant Extracts and Functional Foods submission deadline 28 May 2025 | 13 articles | Viewed by 19523 | Submission Open
Keywords: plant extracts; phytochemicals; inflammation; obesity; liver disease; oxidative stress; antioxidants; diabetes; skin damage; aging
(This special issue belongs to the Section Pharmaceutical Science)
New Updates in Adipocytes and Adipose Tissue: 2nd Edition submission deadline 30 May 2025 | 5 articles | Viewed by 17365 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges submission deadline 30 May 2025 | 8 articles | Viewed by 15222 | Submission Open
Keywords: cardiovascular disease; hyperlipidemia; neuropathy; nephropathy; retinopathy; skin conditions; impaired wound healing; hearing impairment; psychological effects; epigenetic imprinting; molecular profiling; biomarkers; targeted therapy; glucose control; conventional and complementary approaches; stem cell damage; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
Bioactive Natural Compounds: Therapeutic Insights and Applications
edited by Vaidotas Žvikas
submission deadline 30 May 2025 | 7 articles | Viewed by 10751 | Submission Open
Keywords: medicinal plants; bioactive compounds; plant extracts; phytochemicals; analytical method validation
(This special issue belongs to the Section Pharmaceutical Science)
New Advances in Neuroimaging and Brain Functions: 2nd Edition submission deadline 30 May 2025 | 3 articles | Viewed by 10642 | Submission Open
Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Fish Nutrition, Production, and Welfare
edited by Liviu-Dan Miron, , and
submission deadline 30 May 2025 | 4 articles | Viewed by 9277 | Submission Open
Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management
(This special issue belongs to the Section Animal Science)
Applications of EEG in Neural Rehabilitation: 2nd Edition submission deadline 30 May 2025 | 2 articles | Viewed by 6289 | Submission Open
Keywords: neurorehabilitation; neuroplasticity; EEG; ERPs; qEEG; EEG mediated patient-therapist interaction; BCI; exoskeleton; cognitive rehabilitation; brain rewiring
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Pain Management and Related Complications in the Orthopedics and Neurology
edited by Danilo Donati and
submission deadline 30 May 2025 | 1 articles | Viewed by 3265 | Submission Open
Keywords: pain management of the upper and lower limb; pain management of the spine; orthopaedic rehabilitation; prevention of fall risks prevention and management infections; muscle; tendon; and joint diseases; neurological impacts on musculoskeletal health
(This special issue belongs to the Section Physiology and Pathology)
Human Infertility and Reproductive Endocrinology: 2nd Edition
edited by
submission deadline 30 May 2025 | 2 articles | Viewed by 3075 | Submission Open
Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility
(This special issue belongs to the Section Reproductive and Developmental Biology)
Microbial Diversity and Function in Aquatic Environments
edited by Xianglong Chen and
submission deadline 30 May 2025 | 1 articles | Viewed by 2677 | Submission Open
Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches
(This special issue belongs to the Section Microbiology)
Advancing Nanotechnology in Cancer Theranostics
edited by
submission deadline 30 May 2025 | 1 articles | Viewed by 1706 | Submission Open
Keywords: nanotechnology; cancer; nanoscale materials; nanoparticles; diagnostic accuracy; therapeutic efficacy; metastasis detection and prediction; targeted drug delivery; personalized cancer therapy
(This special issue belongs to the Section Medical Research)
Diagnostic Imaging in Colorectal Cancer
edited by and Chiara Zanon
submission deadline 30 May 2025 | 1 articles | Viewed by 1522 | Submission Open
Keywords: colorectal cancer; artificial intelligence; texture analysis; ultrasound; magnetic resonance imaging; PET/MRI
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Strategies for Enchancing the Production in Plant
edited by , , Jie Huang and Xixi Liu
submission deadline 30 May 2025 | 2 articles | Viewed by 1500 | Submission Open
Keywords: genetic improvement; biostimulants; nutrient management; synthetic biology
(This special issue belongs to the Section Plant Science)
Advances in Vascular Health and Metabolism
edited by Ana Blazquez-Medela
submission deadline 30 May 2025 | 1 articles | Viewed by 720 | Submission Open
Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease
(This special issue belongs to the Section Medical Research)
Molecular Biomarkers in Inflammatory Disease
edited by Stelvio Tonello
submission deadline 30 May 2025 | 1 articles | Viewed by 624 | Submission Open
Keywords: cytokines; chemokines; and immune mediators as pharmacodynamic biomarkers; genomic and epigenomic contributions to drug response variability; proteomic and metabolomic profiling to guide pharmacotherapy in inflammation; biomarker-driven strategies for drug development and personalized treatment; mechanistic studies on drug– biomarker interactions and their clinical relevance; novel biomarkers for predicting adverse drug reactions in inflammatory diseases
(This special issue belongs to the Section Medical Research)
Role of Mitochondria in the Pathophysiology of Cardiovascular Diseases
edited by Yuriana Oropeza-Almazán and Héctor Chapoy-Villanueva
submission deadline 30 May 2025 | Viewed by 474 | Submission Open
Keywords: cardiovascular diseases (CVDs); mitochondria; mitochondrial dysfunction; ATP production; mitochondrial fission; mitochondrial fusion; electron transport chain; oxidative phosphorylation; mitophagy; cardiac hypertrophy; myocardial infarction; IR injury; mitochondrial ROS; ROS signaling; ion homeostasis; cardiac arrhythmias
(This special issue belongs to the Section Physiology and Pathology)
3D Imaging and Facial Reconstruction
edited by Marios Papadakis
submission deadline 30 May 2025 | Viewed by 342 | Submission Open
Keywords: 3D imaging; facial plastic surgery; reconstructive surgery; virtual surgical planning; custom implants; preoperative planning; intraoperative navigation
(This special issue belongs to the Section Medical Research)
Advances in Knee Osteoarthritis and Photobiomodulation Therapy submission deadline 30 May 2025 | Viewed by 284 | Submission Open
Keywords: knee osteoarthritis; light-emitting diode therapy; low-level laser therapy; high-intensity laser therapy; photobiomodulation therapy
(This special issue belongs to the Section Medical Research)
Sustainable Agroforestry: Molecular Strategies for Integrated Pest and Disease Management
edited by Gothandapani Sellamuthu and Kanakachari Mogilicherla
submission deadline 30 May 2025 | Viewed by 203 | Submission Open
Keywords: sustainable agroforestry; integrated pest management; genomics; transcriptomics; CRISPR technology; RNAi; plant– microbe interactions; biopesticides
(This special issue belongs to the Section Plant Science)
Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology
edited by and Panagiotis Tsiakanikas
submission deadline 30 May 2025 | Viewed by 179 | Submission Open
Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes
(This special issue belongs to the Section Genetics and Genomics)
Vision Science and Optometry submission deadline 31 May 2025 | 13 articles | Viewed by 12254 | Submission Open
Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior poles; circadian light
(This special issue belongs to the Section Medical Research)
Pediatric Ophthalmic Pathology—Integrating Clinical and Basic Research
edited by and Brenda L. Bohnsack
submission deadline 31 May 2025 | 2 articles | Viewed by 1113 | Submission Open
Keywords: congenital eye anomalies; anterior segment disorders; genetic eye disorders; pediatric eye conditions; pediatric ophthalmology
(This special issue belongs to the Section Physiology and Pathology)
Atherosclerosis: Pathogenesis, Clinical Advances and Future Perspectives submission deadline 31 May 2025 | 1 articles | Viewed by 1087 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; hypercholesterolemia; hypertension; inflammation; cardiovascular prevention
(This special issue belongs to the Section Medical Research)
Exploring Enteric Glia: Implications for Gastrointestinal and Systemic Disorders
edited by Vladimir Grubišić
submission deadline 31 May 2025 | Viewed by 915 | Submission Open
Keywords: gut– brain axis; gut– liver axis; gut– pancreas axis; intestinal epithelial barrier function; intestinal vascular barrier function; myenteric plexus barrier; neuro– glia– immune interactions; metabolic disorders; neurodegenerative diseases; neurodevelopmental disorders
(This special issue belongs to the Section Physiology and Pathology)
Microvascular and Macrovascular Response in Healthy and Critically Ill
edited by Andrius Pranskunas and
submission deadline 31 May 2025 | 1 articles | Viewed by 760 | Submission Open
Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation
(This special issue belongs to the Section Physiology and Pathology)
Advances in Emergency and Critical Care Medicine
edited by
submission deadline 31 May 2025 | Viewed by 540 | Submission Open
Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly
(This special issue belongs to the Section Medical Research)
Metabolic Research in Animal Nutrition submission deadline 31 May 2025 | Viewed by 337 | Submission Open
Keywords: nutrition; supplementation; microbiota; obesity; metabolic syndrome; metabolic disorders and diseases; hormonal factors; development and metabolism; metabolomics; nutrigenomics
(This special issue belongs to the Section Animal Science)
Topographic and Functional Anatomy of Musculoskeletal System: 2nd Edition submission deadline 31 May 2025 | Viewed by 275 | Submission Open
Keywords: muscle; bone; joint; peripheral nerve; motor innervation; proprioception; anatomical variant; radiologic imaging; development; comparative anatomy
(This special issue belongs to the Section Medical Research)
Targeting Hormonal Regulation in Prostate Cancer
edited by Marília Figueira
submission deadline 31 May 2025 | Viewed by 256 | Submission Open
Keywords: prostate cancer; castrate resistant prostate cancer (CRPC); metastatic prostate cancer; estrogens; estrogen receptors; drug resistance
(This special issue belongs to the Section Medical Research)
Advances in Novel Biomarkers and Emerging Immune/Targeted Therapies in Solid Tumors
edited by and Liang Lu
submission deadline 31 May 2025 | Viewed by 250 | Submission Open
Keywords: solid tumor; biomarker; molecular targets; tyrosine kinase inhibitors (TKIs); immune checkpoint inhibitors (ICIs); oncogenic driver mutation; acquired resistance; precision oncology; cancer; next-generation sequence
(This special issue belongs to the Section Medical Research)
Cell Asymmetry and Polarity: Guiding Cellular Behavior and Development: Second Edition
edited by
submission deadline 31 May 2025 | Viewed by 157 | Submission Open
Keywords: cell asymmetry; cell polarity; tissue morphogenesis; planar cell polarity (PCP) pathway; Wnt pathway; therapeutic implications
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Global Developments in Musculoskeletal Health Research and Practice
edited by Stefanie Krauth, and John A. Hammond
submission deadline 31 May 2025 | Viewed by 150 | Submission Open
Keywords: musculoskeletal diseases; therapeutics; epidemiological studies
(This special issue belongs to the Section Epidemiology)
Therapeutic Approaches of Marine Natural Products in Health and Disease
edited by Thilina U. Jayawardena and D. P. Nagahawatta
submission deadline 31 May 2025 | Viewed by 129 | Submission Open
Keywords: marine natural products; bioactive compounds; drug discovery; therapeutic applications
(This special issue belongs to the Section Pharmaceutical Science)
Gut Microbes Associating with the Host
edited by and
submission deadline 10 Jun 2025 | Viewed by 731 | Submission Open
Keywords: gut microbes; microbiome; animals; nutrition
(This special issue belongs to the Section Microbiology)
Antibiotic Resistance in Biofilm: 2nd Edition
edited by
submission deadline 16 Jun 2025 | 4 articles | Viewed by 7325 | Submission Open
Keywords: biofilm; food industry; antimicrobial resistance; antibiotic resistance gene transfer; antibiofilm activity; control strategies
(This special issue belongs to the Section Microbiology)
Advances in the Treatment of Pulmonary Hypertension and Pulmonary Embolism submission deadline 16 Jun 2025 | 2 articles | Viewed by 2506 | Submission Open
Keywords: pulmonary hypertension; pulmonary embolism; therapy; cardiac imaging; artificial intelligence
(This special issue belongs to the Section Medical Research)
New Restorative Technologies in the Management and Characterization Techniques of the Hard and Soft Tissues of Oral Cavity
edited by , Silvia Pizzi and Careri Maria
submission deadline 20 Jun 2025 | 2 articles | Viewed by 1049 | Submission Open
Keywords: microscopy analysis imaging; jaw bone; oral mucosa; autofluorescence; adhesive dentistry; oral surgery; regenerative medicine; lasers
(This special issue belongs to the Section Medical Research)
Nutrition, Exercise and Stress
edited by Maleah Holland-Winkler
submission deadline 25 Jun 2025 | Viewed by 213 | Submission Open
Keywords: nutrition; exercise; stress
(This special issue belongs to the Section Physiology and Pathology)
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