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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Trends in Tumor Pathology and Precision Oncology

edited by

Valerio Gaetano Vellone

and Gabriele Gaggero

submission deadline 15 Sep 2025 | 2 articles | Viewed by 5969 | Submission Open

Keywords: gynecologic pathology; pediatric pathology; neuropathology; molecular diagnostics; precision oncology

(This special issue belongs to the Section Physiology and Pathology)

New Insights Into Leishmaniasis and Chagas Disease: Focus on Diagnosis and Genetic Characterization of Parasites: 2nd Edition

edited by

Alba Abras

and Cristina Ballart

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2521 | Submission Open

Keywords: leishmania; leishmaniasis; chagas disease; American trypanosomiasis; Trypanosoma cruzi; diagnostics; genetic diversity; characterization; neglected tropical disease

(This special issue belongs to the Section Epidemiology)

Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases

edited by

Lorena Perrone

and Oualid Sbai

submission deadline 25 Sep 2025 | Viewed by 346 | Submission Open

Keywords: mitochondria; neurodegeneration; oxidative stress; calcium homeostasis; mitochondrial fission/fusion; inflammation; gut– brain axis; mitophagy; NLRP3 inflammasome

(This special issue belongs to the Section Physiology and Pathology)

Sports Medicine: Nutritional Sciences and Nutritional Biochemistry: 2nd Edition

edited by

Roberto Cannataro

submission deadline 26 Sep 2025 | 1 articles | Viewed by 2484 | Submission Open

Keywords: sport nutrition; sport supplementation; sport biochemistry; metabolomics; miRNA

(This special issue belongs to the Section Physiology and Pathology)

Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health

edited by

Thomas Tsiampalis

and Matina Kouvari

submission deadline 29 Sep 2025 | 1 articles | Viewed by 5309 | Submission Open

Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors

(This special issue belongs to the Section Epidemiology)

Advances in Knee Biomechanics

edited by Jason Shearn

submission deadline 30 Sep 2025 | 9 articles | Viewed by 31226 | Submission Open

Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques

(This special issue belongs to the Section Physiology and Pathology)

Advanced Strategies in Fracture Treatments

edited by

Kai-Cheng Lin

and Chun-Yu Chen

submission deadline 30 Sep 2025 | 10 articles | Viewed by 20391 | Submission Open

Keywords: state of the art; peri-articular fracture; osteoporotic fracture; fragility fracture; treatment protocols

(This special issue belongs to the Section Medical Research)

Ion Channels and Neurological Disease: 2nd Edition

edited by

Carlo Musio

and Marzia Martina

submission deadline 30 Sep 2025 | 7 articles | Viewed by 16386 | Submission Open

Keywords: ion channels; neurological diseases; neurodegeneration; pain; cellular and animal models; neuronal excitability; neuronal activity; synaptic transmission; structural and functional correlates; computational modeling; pathophysiology and pathogenesis; channelopathies; altered currents; neuropharmacology and ethnopharmacology; drug screening; delivery; and targeting; pharmacological treatments; molecular therapeutic options; neuroprotection

(This special issue belongs to the Section Pharmaceutical Science)

Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition

edited by

Mariana Floria

Anca Trifan

and

Daniela Maria Tanase

submission deadline 30 Sep 2025 | 13 articles | Viewed by 15516 | Submission Open

Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steato-hepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases

(This special issue belongs to the Section Physiology and Pathology)

Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition

edited by

Jianfeng Xu

submission deadline 30 Sep 2025 | 6 articles | Viewed by 15041 | Submission Open

Keywords: plant cell culture; plant tissue culture; medicinal plants; secondary metabolites; bioactive compounds; nutraceuticals; recombinant proteins; biologics

(This special issue belongs to the Section Plant Science)

A Paradigm Shift in Airway and Pain Management—2nd Edition

edited by

Jui An Lin

submission deadline 30 Sep 2025 | 5 articles | Viewed by 8524 | Submission Open

Keywords: airway management; pain management; ultrasonography; motor activity; nerve block; anesthesia; conduction; regenerative medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management

(This special issue belongs to the Section Medical Research)

Etiology, Prediction and Prognosis of Ischemic Stroke

edited by

Vida Abedi

Ramin Zand

and Jiang Li

submission deadline 30 Sep 2025 | 3 articles | Viewed by 7482 | Submission Open

Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies

(This special issue belongs to the Section Physiology and Pathology)

Veterinary Pathology and Veterinary Anatomy: 3rd Edition

edited by

Gheorghe Solcan

and

Carmen Solcan

submission deadline 30 Sep 2025 | 5 articles | Viewed by 6350 | Submission Open

Keywords: veterinary pathology; veterinary anatomy; SARS-CoV-2 pandemic; climate change; environmental pollution; diagnosis and treatment of animal diseases; computer modelling of pathological processes

(This special issue belongs to the Section Animal Science)

Advancements in Postoperative Management of Patients After Surgery

edited by

Antonino Zanghi

Luigi La Via

Antonino Maniaci

and Alessandro Cappellani

submission deadline 30 Sep 2025 | 4 articles | Viewed by 6006 | Submission Open

Keywords: surgery; ERAS; postoperative management; recovery; pain

(This special issue belongs to the Section Medical Research)

Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)

edited by

Yongseek Park

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2859 | Submission Open

Keywords: chronic kidney disease; vascular dysfunction; endothelial cells

(This special issue belongs to the Section Medical Research)

Multi-Omics for Diagnosing Diseases: Bioinformatics Approaches and Integrative Data Analyses

edited by

Emanuel Maldonado

and

Imran Khan

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2534 | Submission Open

Keywords: bioinformatics; computer hardware; software; and methods; first-/second-/third-generation sequencing; clinical genomics; mendelian diseases; whole-exome sequencing; evolutionary and comparative genomics; whole-genome sequencing; multi-omics; microbiome diseases

(This special issue belongs to the Section Genetics and Genomics)

Advances in Intensive Care Medicine

edited by

Denise Battaglini

submission deadline 30 Sep 2025 | 4 articles | Viewed by 2532 | Submission Open

Keywords: machine learning; critical care; intensive care; ARDS; mechanical ventilation; personalized medicine; advances

(This special issue belongs to the Section Medical Research)

Enhancements in Screening Pathways for Early Detection of Lung Cancer

edited by

Paolo Albino Ferrari

and

Antonio Maccio

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2486 | Submission Open

Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence

(This special issue belongs to the Section Medical Research)

Natural Substances in Nutrition and Health of Animals: 2nd Edition

edited by

Karaffová Viera

Zuzana Ševčíková

and

Viera Almášiová

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2015 | Submission Open

Keywords: natural products; organic acids; probiotics; prebiotics; and synbiotics; plant extracts; animal nutrition; animal physiology; animal embryology; animal reproduction; animal models

(This special issue belongs to the Section Animal Science)

Skin Diseases and Dermatologic Comorbidities

edited by Alessia Paganelli,

Emanuele Scala

and

Flavia Persechino

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1829 | Submission Open

Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers

(This special issue belongs to the Section Physiology and Pathology)

New Insights into Athlete Physiology

edited by

Maamer Slimani

and

Nicola Luigi Bragazzi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1485 | Submission Open

Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship

(This special issue belongs to the Section Physiology and Pathology)

Acari: Biodiversity, Biogeography and Taxonomy Studies

edited by Pavel B. Klimov

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1242 | Submission Open

Keywords: phylogenetics; systematics; evolution and co-evolution; biodiversity; ecology; host associations; role of mites in agriculture and medicine

(This special issue belongs to the Section Animal Science)

Space Medicine Advancements: From Human Health to Biomedical System Design

edited by

Jiwoon Park

and

Atul Chander

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1068 | Submission Open

Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations

(This special issue belongs to the Section Medical Research)

Testicular and Penile Disorders: Reproductive, Pathophysiological, Diagnostic and Therapeutic Insights

edited by

Geng-Long Hsu

and Yu-Ching Wen

submission deadline 30 Sep 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: testicular and Penile Disorders; testicle; physiology; infertility

(This special issue belongs to the Section Physiology and Pathology)

Research Progress of Cultivation of Edible Fungi: 2nd Edition

edited by Yajie Zou

submission deadline 30 Sep 2025 | 1 articles | Viewed by 808 | Submission Open

Keywords: edible fungi; cultivation; domesticate; substrate; biological efficiency; nutritional properties; functional compounds; sustainability; commercialization; emerging species

(This special issue belongs to the Section Microbiology)

Advances in Livestock Breeding, Nutrition and Metabolism

edited by

Imran Khan

submission deadline 30 Sep 2025 | Viewed by 741 | Submission Open

Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability

(This special issue belongs to the Section Animal Science)

Precision Therapies in Cancer: Advancements and Future Directions

edited by

Subhajit Chatterjee

and Krushna Chandra Hembram

submission deadline 30 Sep 2025 | Viewed by 386 | Submission Open

Keywords: precision oncology; cancer theragnostic; molecular targeting; immunotherapy

(This special issue belongs to the Section Medical Research)

Advances in Microvascular Research: 2nd Edition

edited by

Panagiota Anyfanti

and

Theodoros Dimitroulas

submission deadline 30 Sep 2025 | Viewed by 230 | Submission Open

Keywords: microvascular injury; microvascular dysfunction; microcirculation; vascular inflammation; hypertension; cardiovascular diseases

(This special issue belongs to the Section Physiology and Pathology)

Autoimmune Disorders: From Pathophysiology to Therapeutics

edited by

Giulia Lanzolla

and Chiara Mura

submission deadline 30 Sep 2025 | Viewed by 206 | Submission Open

Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes

(This special issue belongs to the Section Physiology and Pathology)

Computational Approaches in Breast Cancer Diagnosis and Prognosis

edited by Elham Pashaei and

Jun Wan

submission deadline 30 Sep 2025 | Viewed by 174 | Submission Open

Keywords: bioinformatics; machine learning; artificial intelligence; breast cancer

(This special issue belongs to the Section Physiology and Pathology)

Advances in Congenital Diaphragmatic Hernia: From Clinical Features to Management

edited by Przemysław Kosinski

submission deadline 30 Sep 2025 | Viewed by 171 | Submission Open

Keywords: congenital diaphragmatic hernia; prenatal diagnosis; fetal interventions; neonatal management; pulmonary hypoplasia; surgical techniques; imaging techniques; genetic testing; FETO; comprehensive care protocols

(This special issue belongs to the Section Medical Research)

Updates on Cancer Immunology and Immunotherapy

edited by Parnian Jabbari

submission deadline 30 Sep 2025 | Viewed by 147 | Submission Open

Keywords: cancer immunology; immunotherapy; immune checkpoints; tumor microenvironment; chimeric antigen receptor T-cell (CAR-T) therapy; cancer vaccines; immune evasion; tumor immunity; personalized immunotherapy; immune oncology; combination therapy; immune-related adverse events; neoantigens; adoptive cell transfer; oncolytic viruses; targeted immunotherapy; tumor-associated antigens; cancer immunosurveillance; resistance mechanisms; clinical trials in immunotherapy

(This special issue belongs to the Section Medical Research)

New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases

edited by

Cristina Marginean

submission deadline 20 Oct 2025 | 4 articles | Viewed by 5208 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Cell-Free DNA as a Biomarker in Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1451 | Submission Open

Keywords: cell-free DNA (cfDNA); liquid biopsy; metabolic diseases; obesity; type 2 diabetes; non-alcoholic fatty liver disease (NAFLD); methylation; mutations

(This special issue belongs to the Section Medical Research)

Developments in the Interrelation of Gut Microbiota and Immune System for Treatment Strategies

edited by

Emanuel Vamanu

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1160 | Submission Open

Keywords: gut microbiota; innate immune system; immunotherapy; dysbiosis; bifidobacterium; microbiota modulation; probiotics; prebiotics; symbiotics; postbiotics; cancer immunotherapy; autoimmune diseases; vaccine response; immune regulation; therapeutic microbiology; translational medicine

(This special issue belongs to the Section Medical Research)

Sensitization via Skin Exposure

edited by

Francesca Filon

submission deadline 20 Oct 2025 | Viewed by 124 | Submission Open

Keywords: contact dermatitis; patch test; epidemiology; occupation; prevention

Diversity and Evolution of Pathogenic Viruses

edited by

Yoshiyuki Suzuki

submission deadline 20 Oct 2025 | Viewed by 92 | Submission Open

Keywords: pathogenic viruses; biologic diversity; evolution

(This special issue belongs to the Section Medical Research)

Cancer Epidemiology

edited by Daniela-Cristina Stefan and Honoré K. Mitonga

submission deadline 24 Oct 2025 | 4 articles | Viewed by 6228 | Submission Open

Keywords: cancer disparities; specific populations; methodological advances; cancer trends; cancer causes; prevention strategies

(This special issue belongs to the Section Epidemiology)

Dive into Myopia

edited by

Chun-Fu Liu

submission deadline 24 Oct 2025 | 1 articles | Viewed by 854 | Submission Open

Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles

(This special issue belongs to the Section Medical Research)

Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders

edited by Arkadiusz Komorowski

submission deadline 25 Oct 2025 | Viewed by 238 | Submission Open

Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)

(This special issue belongs to the Section Physiology and Pathology)

Laparoscopy and Treatment: An All-Encompassing Solution for Surgeons

edited by Niculae Iordache and Claudiu-Octavian Ungureanu

submission deadline 26 Oct 2025 | 1 articles | Viewed by 1261 | Submission Open

Keywords: oncological; staging laparoscopy; tool; radical surgery; diagnostic

(This special issue belongs to the Section Medical Research)

Therapeutic Effects of Natural Products on Human Diseases: 2nd Edition

edited by

Seung Ho Lee

submission deadline 27 Oct 2025 | 10 articles | Viewed by 23008 | Submission Open

Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods

(This special issue belongs to the Section Pharmaceutical Science)

Role of Machine and Deep Learning in Drug Screening

edited by

Shahid Ali

and

Teng Zhou

submission deadline 29 Oct 2025 | Viewed by 563 | Submission Open

Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine

(This special issue belongs to the Section Pharmaceutical Science)

Soil–Plant–Microbe Interactions: The Role of Biostimulants and Agro-Environmental Implications

edited by Regina Gabilondo and

Ling Zhang

submission deadline 30 Oct 2025 | 3 articles | Viewed by 6803 | Submission Open

Keywords: soil– plant– microbe system; biostimulants; rhizosphere; fertilizers; availability of mineral nutrients; microfaunal grazing; protozoa; nematode; mycorrhizae; microbial loop

(This special issue belongs to the Section Plant Science)

Advances in Integrative Omics Data Analysis for Cancer Research

edited by

Jian Sang

, Jianli Dai and Guangyi Niu

submission deadline 30 Oct 2025 | 1 articles | Viewed by 4994 | Submission Open

Keywords: cancer research; omics; bioinformatics; translational medicine

(This special issue belongs to the Section Genetics and Genomics)

Advances in Dryland Agriculture Science

edited by

Liangshan Feng

and Hangyu Dong

submission deadline 30 Oct 2025 | 3 articles | Viewed by 2792 | Submission Open

Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation

(This special issue belongs to the Section Plant Science)

Diagnostic Imaging in Colorectal Cancer

edited by

Filippo Crimì

and Chiara Zanon

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2121 | Submission Open

Keywords: colorectal cancer; artificial intelligence; texture analysis; ultrasound; magnetic resonance imaging; PET/MRI

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Advances in Anesthesia and Critical Care

edited by

Gabriele Melegari

submission deadline 30 Oct 2025 | 3 articles | Viewed by 2049 | Submission Open

Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning

(This special issue belongs to the Section Medical Research)

Optogenetics and Light-Induced Processes in Synthetic Biology

edited by

Pasquale Stano

submission deadline 30 Oct 2025 | Viewed by 727 | Submission Open

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Personalized Prevention and Treatment in Endocrinology, Diabetes and Metabolic Diseases

edited by Grigorios Panagiotou

submission deadline 31 Oct 2025 | 11 articles | Viewed by 36747 | Submission Open

Keywords: personalized medicine; precision prevention; multi-omics; obesity; diabetes and endocrinology

(This special issue belongs to the Section Medical Research)

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