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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Coronary Artery Disease: Pathophysiological Mechanisms, Imaging Modalities and Therapeutic Implications

edited by

Michele Russo

and Filippo Luca Gurgoglione

submission deadline 31 Oct 2025 | 5 articles | Viewed by 8654 | Submission Open

Keywords: coronary artery disease; coronary atherosclerosis; atherosclerotic plaque progression; coronary imaging; cardiovascular risk factors and coronary atherosclerosis-associated diseases

(This special issue belongs to the Section Medical Research)

Recent Advances in Physiotherapy for Musculoskeletal

edited by

Miguel Ángel Rosety-Rodríguez

and

Jorge Góngora-Rodríguez

submission deadline 31 Oct 2025 | 5 articles | Viewed by 8313 | Submission Open

Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery

(This special issue belongs to the Section Physiology and Pathology)

Ecotoxicity Effects of Metals and Microplastics on Aquatic Organisms

edited by Chiara Martino

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5175 | Submission Open

Keywords: aquatic organisms; emerging contaminants; metals; microplastics; defense strategies; cell stress; heavy metals; environmental stress; pollution; ecotoxicology

(This special issue belongs to the Section Animal Science)

Orthopedic Disease Treatment and Management: Innovations, Challenges, and Future Directions

edited by Mihnea Ioan Gabriel Popa

submission deadline 31 Oct 2025 | 4 articles | Viewed by 4610 | Submission Open

Keywords: orthopedic surgery; musculoskeletal regeneration; biomaterials and implants; minimally invasive techniques; periprosthetic joint infections; regenerative medicine; biomechanics and implant design; orthopedic trauma and reconstruction; rehabilitation and functional recovery; AI and robotics in orthopedics

(This special issue belongs to the Section Medical Research)

Unlocking New Biochemical Pathways: A Bridge for Drug Development in Human and Animal Diseases

edited by

Vincenzo Vestuto

Ignazio Restivo

and

Giuseppe Piegari

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3443 | Submission Open

Keywords: drug discovery; omics sciences; veterinary sciences; oxidative stress; bioactive compounds; inflammation; cancer; neurodegeneration; cell death

(This special issue belongs to the Section Pharmaceutical Science)

Advances and Applications of Sport Physiology: 2nd Edition

edited by

Sime Versic

and

Nikola Foretic

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3324 | Submission Open

Keywords: sports medicine; strength and conditioning; diagnostics; sport injuries; performance analysis

(This special issue belongs to the Section Physiology and Pathology)

Gynecologic Oncology: Recent Advances and Future Perspectives

edited by Theodoros A. Panoskaltsis and

Alkis Matsas

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2623 | Submission Open

Keywords: gynecologic cancer; gynecologic oncology; biomarkers in gynecology

(This special issue belongs to the Section Medical Research)

Health Management of Farm Animals: Physiological and Pathological Aspects

edited by

Vasileios Papatsiros

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2540 | Submission Open

Keywords: cattle; small ruminants; pig; poultry; veterinary medicine; health; disease; welfare

(This special issue belongs to the Section Animal Science)

Molecular Muscle Adaptations Across the Lifespan

edited by S. Kyle Traivs and

Sime Versic

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2400 | Submission Open

Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Bone and Cartilage Fractures: Types, Diagnosis, Complications, Prevention and Treatment

edited by Massimiliano Leigheb, Gabriele Colò and

Giuseppe Basile

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2326 | Submission Open

Keywords: fracture; traumatology; diagnosis; surgery; osteosynthesis; reduction; cartilage; chondral; lesion; injury; rehabilitation; complication

(This special issue belongs to the Section Medical Research)

Advances in Neuroimaging and Functional Brain Analysis

edited by Gianvincenzo Sparacia

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2256 | Submission Open

Keywords: magnetic resonance imaging; resting-state functional magnetic resonance imaging; connectomics; functional connectivity; brain networks; brain diseases assessment

(This special issue belongs to the Section Medical Research)

Microalgae and Their Biotechnological Potential

edited by

Fantao Kong

, Yi Xin and Yuanxue Liang

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2200 | Submission Open

Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering

(This special issue belongs to the Section Microbiology)

Advanced Research in Obstetrics and Gynecology

edited by Vasileios Pergialiotis

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2084 | Submission Open

Keywords: obstetrics; gynecology; gynecologic oncology

(This special issue belongs to the Section Medical Research)

Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment

edited by

Eliza Elena Cintezǎ

and

Ştefana Moisǎ

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1737 | Submission Open

Keywords: congenital heart disease; cardiovascular imaging; minimally invasive interventions; fetal cardiology; transcatheter therapies; artificial intelligence in cardiology; 3D echocardiography; cardiac MRI; personalized medicine; genetic heart disorders; heart failure in children; robotic-assisted surgery; cardiovascular biomarkers; electrophysiology in pediatrics; innovative surgical techniques; early diagnosis of heart disease; emerging therapies in cardiology

(This special issue belongs to the Section Medical Research)

The Management and Prognosis of Open-Angle Glaucoma

edited by

Nicoleta Anton

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1665 | Submission Open

Keywords: open-angle glaucoma; cataracts; visual impairment

(This special issue belongs to the Section Medical Research)

Research on Gastrointestinal Cancer and Nutritional Health

edited by

Irene Lidoriki

, Adam Mylonakis and Dimitrios Tsapralis

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1027 | Submission Open

Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Diagnosis and Treatment of Orthopedic Diseases: Advancing Arthroscopy

edited by

Dimitrios A. Flevas

and

Ioannis Gkiatas

submission deadline 31 Oct 2025 | 1 articles | Viewed by 936 | Submission Open

Keywords: arthroscopy; knee; hip; shoulder; arthroscopic surgery

(This special issue belongs to the Section Medical Research)

Management of Ischemia and Heart Failure—3rd Edition

edited by

Cristian Mornoş

submission deadline 31 Oct 2025 | 1 articles | Viewed by 813 | Submission Open

Keywords: heart failure; myocardial ischemia; left ventricular remodeling; prognosis

(This special issue belongs to the Section Medical Research)

Physiological Responses and Adaptation Mechanisms of Plants to Stress

edited by

Jie Luo

and Bassam T. Yasseen

submission deadline 31 Oct 2025 | 1 articles | Viewed by 783 | Submission Open

Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors

(This special issue belongs to the Section Plant Science)

Opportunistic Infections in the Immunocompromised Patient

edited by

Domenico Benvenuto

and Luca Navarini

submission deadline 31 Oct 2025 | Viewed by 337 | Submission Open

Keywords: immunocompromised patients; opportunistic infections; infectious diseases; HIV; immunological mechanisms; epidemiology

(This special issue belongs to the Section Medical Research)

Skin Care and Innovation from the Perspective of Molecular Dermatology

edited by

Ewa Markiewicz

Olusola Idowu

and

Jacek C. Szepietowski

submission deadline 31 Oct 2025 | Viewed by 329 | Submission Open

Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Eye Diseases: From Tomography to Clinical Prediction

edited by

Akio Oishi

and

Nilufer Yesilirmak

submission deadline 31 Oct 2025 | Viewed by 217 | Submission Open

Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Natural Products for the Management of Acute and Chronic Kidney Disease

edited by Noori S. D. Al-Waili

submission deadline 31 Oct 2025 | Viewed by 188 | Submission Open

Keywords: kidney; diseases; management; natural products; proteinuria; bee products

(This special issue belongs to the Section Pharmaceutical Science)

Therapeutic Approaches of Natural Products in Health and Disease

edited by

Mina Mihaylova Todorova

and

Stoyanka Nikolova

submission deadline 31 Oct 2025 | Viewed by 156 | Submission Open

Keywords: natural products; bioactive compounds; isolation; analysis; metabolism; in vitro and in vivo experiments; pharmacological activity

(This special issue belongs to the Section Pharmaceutical Science)

Cutting-Edge Research and Innovation in Gastrointestinal Oncology

edited by Daniela Cornelia Lazar

submission deadline 31 Oct 2025 | Viewed by 136 | Submission Open

Keywords: gastrointestinal oncology; personalized medicine; immunotherapy and targeted treatment; liquid biopsy and molecular biomarkers; artificial intelligence in GI oncology; drug resistance in GI cancer; gut microbiota and cancer progression; endoscopic techniques in GI oncology; modern surgical procedure in GI oncology; multimodal cancer treatment

(This special issue belongs to the Section Physiology and Pathology)

Research on Viral Infections and Immune Regulation Mechanisms

edited by Moses Turkle Bility

submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open

Keywords: virus infections; virus– host interaction; virome– host interactions; innate immunity; adaptive immunity; host factors in viral infection and immune regulation; acute and chronic infections; restriction factors; viral-vectored strategies; immunotherapeutic strategies against viral infections

(This special issue belongs to the Section Microbiology)

Cross-Species Studies of Cognitive Behaviors: Aspects of Physiological Mechanisms

edited by

Nobuo Masataka

submission deadline 31 Oct 2025 | Viewed by 117 | Submission Open

Keywords: cognitive neuroscience; species-specificity; neural network; brain imaging; communication; social brain; phylogeny

(This special issue belongs to the Section Animal Science)

Urologic Cancer: From Pathophysiology to Therapeutics

edited by

Gianluca Spena

and Roberto Contieri

submission deadline 31 Oct 2025 | Viewed by 90 | Submission Open

Keywords: urologic oncology; robotic surgery; prostate cancer; kidney cancer; bladder cancer; minimally invasive surgery; molecular biomarkers

(This special issue belongs to the Section Medical Research)

Reconstruction of Bone Defects

edited by

Jörg Eschweiler

and

Philipp Kobbe

submission deadline 1 Nov 2025 | 5 articles | Viewed by 5873 | Submission Open

Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings

(This special issue belongs to the Section Medical Research)

Breaking the Code: How Genome Sequencing Is Revolutionizing the Diagnosis of Rare Diseases

edited by

Massimiliano Chetta

and

Nenad Bukvic

submission deadline 6 Nov 2025 | Viewed by 223 | Submission Open

Keywords: genomics; bioinformatics; genetics; cytogenetics

(This special issue belongs to the Section Genetics and Genomics)

Advancing Plant Resilience: Genetics and Agronomy

edited by Meng Jiang, Ruiqing Li and Ning Xu

submission deadline 14 Nov 2025 | Viewed by 110 | Submission Open

Keywords: plant stress; genetic mechanisms; signaling networks; agronomic practices; sustainable agriculture; crop improvement; stress mitigation

(This special issue belongs to the Section Plant Science)

Plant-Derived Natural Products and Their Biomedical Properties: 2nd Edition

edited by

Efstathia Papada

and

Charalampia Amerikanou

submission deadline 15 Nov 2025 | 2 articles | Viewed by 1597 | Submission Open

Keywords: plant-derived natural products; phytochemicals; antioxidants; inflammation; therapeutic agent

(This special issue belongs to the Section Pharmaceutical Science)

Placental Spectrum Disorders and Gynecological Oncology

edited by Gianluca Raffaello Damiani

submission deadline 15 Nov 2025 | Viewed by 109 | Submission Open

Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding

(This special issue belongs to the Section Medical Research)

New Restorative Technologies in the Management and Characterization Techniques of the Hard and Soft Tissues of Oral Cavity

edited by

Ilaria Giovannacci

, Silvia Pizzi and Careri Maria

submission deadline 20 Nov 2025 | 5 articles | Viewed by 6410 | Submission Open

Keywords: microscopy analysis imaging; jaw bone; oral mucosa; autofluorescence; adhesive dentistry; oral surgery; regenerative medicine; lasers

(This special issue belongs to the Section Medical Research)

Telomere Length as a Marker of Biological Age and Age-Related Diseases

edited by Stella Baliou

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3196 | Submission Open

Keywords: telomeres; biological aging; diseases; mechanisms

(This special issue belongs to the Section Medical Research)

Explore Innovative Exercise-Based Interventions for Chronic Diseases

edited by

Hee-Tae Roh

submission deadline 20 Nov 2025 | Viewed by 143 | Submission Open

Keywords: physical activity; acute exercise; exercise training; inflammation; oxidative stress; antioxidant; chronic disease; environmental stress; brain health; aging

(This special issue belongs to the Section Medical Research)

Current and Future Perspectives of Artificial Intelligence in Medicine

edited by Giuseppe Consorti, Lisa Catarzi and

Guido Gabriele

submission deadline 21 Nov 2025 | 4 articles | Viewed by 6470 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; medical practices; artificial neural network; computational health informatics; predictive analytics in healthcare; ethics in AI for medical applications

(This special issue belongs to the Section Medical Research)

Lipid Metabolism Pathways: From Life to Disease

edited by

Anna Eiring

submission deadline 21 Nov 2025 | 1 articles | Viewed by 3871 | Submission Open

Keywords: lipid metabolism; lipid signaling; apoptosis; ferroptosis; autophagy; membrane dynamics; fatty acid oxidation; obesity

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Agri-Food Waste Extracts: Structural and Functional Characterization

edited by

Stefania Lamponi

submission deadline 21 Nov 2025 | Viewed by 286 | Submission Open

Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules

(This special issue belongs to the Section Plant Science)

Advances in Ubiquitous Connective Tissue Architecture: Fascia, Dynamic movements and Perception in Living Structures

edited by

Jean Claude Guimberteau

submission deadline 25 Nov 2025 | 2 articles | Viewed by 5705 | Submission Open

Keywords: fascia; connective tissue; fibrillar network; microvolumes; collagen; cell microenvironment; force absorption system

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Photodynamic Therapy for Medical Applications: From Infections to Tissue Regeneration

edited by Rafał Wiench and

Zhiwei Hu

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1255 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers; reactive oxygen species (ROS); infections and antimicrobial PDT (aPDT); tissue regeneration and wound healing; oral potentially malignant disorders (OPMDs); oncology and cancer treatment; dermatology and skin disorders

(This special issue belongs to the Section Medical Research)

From Prediction to Experimental Assays of More Selective and Cleaner Bioactive Synthetics: A Systemic View

edited by

Gabriela Fiss

and Petrônio Filgueiras de Athayde-Filho

submission deadline 25 Nov 2025 | Viewed by 396 | Submission Open

Keywords: antimicrobial activity; artemia salina; bioinformatics; drug research; green chemistry; lipophilicity; medicinal chemistry

(This special issue belongs to the Section Pharmaceutical Science)

Advances in Geriatric Medicine: Risk Assessment, Biomarkers, and Management Strategies

edited by

Nadya Kagansky

and Yochai Levy

submission deadline 26 Nov 2025 | 2 articles | Viewed by 4249 | Submission Open

Keywords: geriatric risk assessment; biomarkers in aging; personalized geriatric care

(This special issue belongs to the Section Medical Research)

Sialic Acid and Sialic Acid Derivatives in Biomedicine

edited by

Paola Rota

and

Marco Piccoli

submission deadline 26 Nov 2025 | 2 articles | Viewed by 2556 | Submission Open

Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker

(This special issue belongs to the Section Physiology and Pathology)

Advances in Medical Imaging of Animal Models for Human Diseases

edited by

Yihsiu Chung

and Tsai-Hsien Hung

submission deadline 26 Nov 2025 | 1 articles | Viewed by 360 | Submission Open

Keywords: medical imaging; animal models; preclinical research; human disease; oncology

(This special issue belongs to the Section Medical Research)

Advances in Regenerative Medicine in Disease Treatment: Harnessing Potential and Bridging Challenges

edited by Edward H. Ntege and

Adrian Neagu

submission deadline 26 Nov 2025 | Viewed by 145 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; molecular therapy; personalized medicine; targeted delivery; immunomodulation

(This special issue belongs to the Section Physiology and Pathology)

Musculoskeletal Medicine in Rheumatic Diseases

edited by

Florentin Ananu Vreju

and Emilio Filippucci

submission deadline 28 Nov 2025 | 3 articles | Viewed by 8022 | Submission Open

Keywords: rheumatic disease; rheumatoid arthritis; spondylarthritis; microcrystal arthritis; musculoskeletal ultrasonography; biologic treatment; disease-modifying antirheumatic drugs; imagining techniques

(This special issue belongs to the Section Medical Research)

Space Medicine Ophthalmology: Insights from Molecular Observations to the Clinical Management of Ocular Risks in Microgravity

edited by Joshua Ong

submission deadline 28 Nov 2025 | 3 articles | Viewed by 4335 | Submission Open

Keywords: spaceflight; space medicine; ophthalmology; space medicine; microgravity; cornea; retina; ocular surface

(This special issue belongs to the Section Astrobiology)

Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity

edited by

Berit Hippe

submission deadline 28 Nov 2025 | 2 articles | Viewed by 2703 | Submission Open

Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components

(This special issue belongs to the Section Physiology and Pathology)

Muscle Wasting, Aging, and Cancer: The Effects of Physical Exercise

edited by

Paula Tavares

submission deadline 28 Nov 2025 | 1 articles | Viewed by 1576 | Submission Open

Keywords: sarcopenia; aging; cancer; muscle wasting; physical exercise; resistance training; satellite cells; inflammation; metabolic health; quality of life

(This special issue belongs to the Section Physiology and Pathology)

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