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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Applications of Dermatoscopy in Skin Diseases

edited by

Paweł Pietkiewicz

Enzo Errichetti

and

Cristian Navarrete

submission deadline 29 Aug 2025 | 5 articles | Viewed by 31220 | Submission Open

Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of colour; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy

(This special issue belongs to the Section Medical Research)

Elements Cycling and Plants’ Physiological Characteristics: A Soil–Plant–Atmosphere Continuum Perspective

edited by

Ling Zhang

and

Zhi Li

submission deadline 29 Aug 2025 | 7 articles | Viewed by 13586 | Submission Open

Keywords: element cycling; microbial communities; plant nutrition; plant physiology; plant biochemistry; atmospheric composition; climate change; soil– plant– atmosphere interaction; plant– soil feedback

(This special issue belongs to the Section Plant Science)

Back to Basics in Palaeontology

edited by Hua Stephane

submission deadline 29 Aug 2025 | 8 articles | Viewed by 13047 | Submission Open

Keywords: fundamentals; natural history; multidisciplinarity; first hand bibliography; actualism

(This special issue belongs to the Section Paleobiology)

Nutritional Supplementation, Body Composition and Performance in Athletes

edited by

Bojan Knap

submission deadline 29 Aug 2025 | 2 articles | Viewed by 10588 | Submission Open

Keywords: optimal macro and micronutrients in exercise; plant-based food in sports nutrition; beetroot as ergogenic aid; body mass composition and nutrition practice; phase angle as VO2 max predictor; RED syndrome low and high energetic availability in sports praxis

(This special issue belongs to the Section Physiology and Pathology)

Current Progress in Medical Image Segmentation

edited by

Krishna Chaitanya

submission deadline 29 Aug 2025 | 4 articles | Viewed by 6275 | Submission Open

Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

The Emerging Role of Microbiota in Health and Diseases

edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska

submission deadline 29 Aug 2025 | 3 articles | Viewed by 5619 | Submission Open

Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions

(This special issue belongs to the Section Microbiology)

Clinical and Laboratory Advancements and Challenges in Medically Assisted Reproduction

edited by

Alessandra Alteri

and Valeria Stella Vanni

submission deadline 29 Aug 2025 | 2 articles | Viewed by 5044 | Submission Open

Keywords: medically assisted reproduction; assisted reproduction technologies; clinical embryology; genetic testing; ovarian stimulation; male factor; endometriosis; endometrial receptivity; implantation

(This special issue belongs to the Section Reproductive and Developmental Biology)

Diagnosis and Management of Microbial Infections

edited by

Iulia-Cristina Bagiu

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3928 | Submission Open

Keywords: microbiology; infection; germs; antimicrobial agents; antimicrobial therapy

(This special issue belongs to the Section Microbiology)

Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice

edited by Ralitsa Robeva

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3722 | Submission Open

Keywords: PCOS; hypothalamic amenorrhea; congenital adrenal hyperplasia; hypogonadotropic hypogonadism; premature ovarian insufficiency (POI)

(This special issue belongs to the Section Physiology and Pathology)

Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities

edited by

Camelia Margareta Bogdanici

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3508 | Submission Open

Keywords: vision-related quality of life; personalized medicine; artificial intelligence; ophthalmology and nutrition; optical coherence tomography; ocular surface diseases; retinal vascular diseases

(This special issue belongs to the Section Medical Research)

Bone Cancer: From Molecular Mechanism to Treatment

edited by

Chih-Yang Lin

and Syuan-Ling Lin

submission deadline 29 Aug 2025 | 3 articles | Viewed by 3225 | Submission Open

Keywords: bone cancer; metastasis; angiogenesis; targeted drugs; biomarkers

(This special issue belongs to the Section Medical Research)

Precision Medicine in Cardiovascular Diseases

edited by Brian Xiangzhi Wang

submission deadline 29 Aug 2025 | 1 articles | Viewed by 2238 | Submission Open

Keywords: genomic; cardiovascular disease; congenital; multi-omics studies; precision medicine; personalized medicine; biomarker

(This special issue belongs to the Section Genetics and Genomics)

Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition

edited by

Alin Laurentiu Tatu

submission deadline 29 Aug 2025 | 2 articles | Viewed by 1161 | Submission Open

Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery

(This special issue belongs to the Section Physiology and Pathology)

Kidney Transplantation: What’s Hot and What’s New—2nd Edition

edited by

Giuseppe Ietto

and Caterina Di Bella

submission deadline 29 Aug 2025 | 1 articles | Viewed by 1125 | Submission Open

Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation

(This special issue belongs to the Section Medical Research)

Channel Proteins and Transporters in Human Health and Disease

edited by

Giorgia Scarpellino

Giorgia Chinigò

and

Roberta De Zio

submission deadline 29 Aug 2025 | Viewed by 952 | Submission Open

Keywords: channel proteins; transporters; ion channel

(This special issue belongs to the Section Proteins and Proteomics)

Image Analysis and Postprocessing in Medical Imaging

edited by

Federico Bruno

submission deadline 29 Aug 2025 | Viewed by 202 | Submission Open

Keywords: quantitative imaging biomarkers; image segmentation; artificial intelligence in radiology; image postprocessing

(This special issue belongs to the Section Medical Research)

Microbiota Metabolism and Gut Health in Swine

edited by

Yu Pi

submission deadline 29 Aug 2025 | Viewed by 190 | Submission Open

Keywords: gut microbiota; swine health; microbial metabolites; nutrient absorption; immune response; metagenomics; antibiotic alternatives; swine production

(This special issue belongs to the Section Microbiology)

Disparities in Cancer Treatment

edited by Adam Barsouk

submission deadline 29 Aug 2025 | Viewed by 130 | Submission Open

Keywords: disparities; mortality; survival; race; sex; age; developing nations; public health; prevention

(This special issue belongs to the Section Epidemiology)

Hansen's Disease—Epidemiology, Diagnosis, Treatment and Complications

edited by Karen Olshtain-Pops

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2823 | Submission Open

Keywords: hansen's disease; leprosy; Mycobacterium leprae

(This special issue belongs to the Section Epidemiology)

Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection

edited by Jun Sung Hong

submission deadline 30 Aug 2025 | 1 articles | Viewed by 846 | Submission Open

Keywords: enterobacteriaceae; antimicrobial resistance; infection; health

(This special issue belongs to the Section Microbiology)

Animal Nutritional Physiology: Effects of Feed Additives on Livestock Products

edited by

Anna Arczewska-Włosek

and Katarzyna Poltowicz

submission deadline 30 Aug 2025 | Viewed by 765 | Submission Open

Keywords: feed additives; animal health; animal performance; animal-derived products; animal nutritional physiology

(This special issue belongs to the Section Physiology and Pathology)

Microorganisms Engineering and Gene-Editing Methods

edited by

Jichao Wang

Guang Zhao

and Xia Zhao

submission deadline 30 Aug 2025 | 1 articles | Viewed by 734 | Submission Open

Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination

(This special issue belongs to the Section Genetics and Genomics)

Feature Papers in Medical Research: 3rd Edition

edited by

Christian Lehmann

submission deadline 31 Aug 2025 | 14 articles | Viewed by 17717 | Submission Open

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Recent Advances in Crop Genetics and Breeding

edited by

Tianxiao Chen

Xiangjin Wei

Baohua Feng

and Long Chen

submission deadline 31 Aug 2025 | 4 articles | Viewed by 4110 | Submission Open

Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection

(This special issue belongs to the Section Plant Science)

Migraine and Headache: From Pathophysiological Aspects

edited by

Jacob Genizi

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1640 | Submission Open

Keywords: migraine; headache; pathophysiology; treatment; medication

(This special issue belongs to the Section Physiology and Pathology)

Clinical Manifestations and Treatment of Autoimmune Diseases: 2nd Edition

edited by

Stelvio Tonello

and

Daniele Sola

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1200 | Submission Open

Keywords: autoimmunity; immunobiology; vaccine; leucocytes; immune system

(This special issue belongs to the Section Medical Research)

Encephalitis: From Molecular Pathophysiology to Therapy

edited by Anna Tröscher and Judith Wagner

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1178 | Submission Open

Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Physiology and Pathology)

From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders

edited by

Doina Georgescu

Felix Bratosin

and Ana Lascu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota

(This special issue belongs to the Section Physiology and Pathology)

Recent Advances in Plant Genomics and Genetics

edited by

Tianxiao Chen

Baohua Feng

, Long Chen and

Xiangjin Wei

submission deadline 31 Aug 2025 | Viewed by 680 | Submission Open

Keywords: high-throughput genotyping; plant genetics; plant genomics; genetic markers; genetic improvements; genome editong; CRISPR/Cas9; genomic selection

(This special issue belongs to the Section Genetics and Genomics)

Innovative Drug Development: Balancing Efficacy and Toxicity in Novel Pharmaceuticals

edited by

Iasmina Marcovici

submission deadline 31 Aug 2025 | 1 articles | Viewed by 555 | Submission Open

Keywords: drug development; pharmaceuticals; bioactive compounds; new drug candidates; drug delivery systems; pharmaceutical formulations; efficacy and toxicity screening

(This special issue belongs to the Section Pharmaceutical Science)

New Insights into Pediatric Rheumatic and Autoimmune Diseases

edited by

Lampros Fotis

submission deadline 31 Aug 2025 | 1 articles | Viewed by 433 | Submission Open

Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis

(This special issue belongs to the Section Medical Research)

Integrating Health Informatics and Artificial Intelligence for Advanced Medicine

edited by

Joaquim Carreras

submission deadline 31 Aug 2025 | Viewed by 220 | Submission Open

Keywords: artificial intelligence; machine learning; artificial neural networks; prognosis; treatment; medicine; health care; pathology

(This special issue belongs to the Section Medical Research)

Recent Advances in Bone Biology

edited by Barbara Peruzzi,

Martina Leopizzi

and Giulia Battafarano

submission deadline 31 Aug 2025 | Viewed by 210 | Submission Open

Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism

(This special issue belongs to the Section Physiology and Pathology)

Cutting-Edge Techniques and Innovations in the Management of Aortic Aneurysm

edited by Dimitrios Iliopoulos

submission deadline 31 Aug 2025 | Viewed by 167 | Submission Open

Keywords: aneurysm; aorta; aortic root; biomechanics; aortic dissection; thoracoabdominal aneurysm; valve-sparing aortic root replacement; perfusion

(This special issue belongs to the Section Medical Research)

Body Fluid-Based Biomarkers for Cognitive Impairment

edited by Wei Li

submission deadline 31 Aug 2025 | Viewed by 159 | Submission Open

Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis

(This special issue belongs to the Section Medical Research)

Migraine and Headache: From Clinical and Therapeutic Aspects

edited by

Jacob Genizi

submission deadline 31 Aug 2025 | Viewed by 157 | Submission Open

Keywords: migraine; headache; treatment; medication

(This special issue belongs to the Section Medical Research)

New Insights into Cellular Inflammation and Regeneration

edited by

Jea-Hyun Baek

submission deadline 31 Aug 2025 | Viewed by 154 | Submission Open

Keywords: cellular inflammation; tissue regeneration; immune modulation; regenerative medicine; inflammatory pathways; immune cells and tissue repair; chronic inflammation; biomarkers of regeneration; immune-tissue crosstalk; wound healing; fibrosis and regeneration; inflammation resolution; tissue remodeling; regenerative microenvironment; inflammation-driven pathogenesis; translational immunology

(This special issue belongs to the Section Physiology and Pathology)

Gene Regulation and Expression in Tumors

edited by

Beniamin Grabarek

and Dawid Sobański

submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open

Keywords: gene regulation; tumor biology; transcriptional dysregulation and epigenetics; cancer biomarkers; therapeutic targets; multi-omics approaches

(This special issue belongs to the Section Physiology and Pathology)

The Drug Development for Neurodegenerative Diseases

edited by David R. Elmaleh

submission deadline 31 Aug 2025 | Viewed by 118 | Submission Open

Keywords: neurodegenerative disease; drug treatment approaches; quality of life improvement

(This special issue belongs to the Section Pharmaceutical Science)

Emerging Trends in Tumor Pathology and Precision Oncology

edited by

Valerio Gaetano Vellone

and Gabriele Gaggero

submission deadline 15 Sep 2025 | 2 articles | Viewed by 4246 | Submission Open

Keywords: gynecologic pathology; pediatric pathology; neuropathology; molecular diagnostics; precision oncology

(This special issue belongs to the Section Physiology and Pathology)

New Insights Into Leishmaniasis and Chagas Disease: Focus on Diagnosis and Genetic Characterization of Parasites: 2nd Edition

edited by

Alba Abras

and Cristina Ballart

submission deadline 15 Sep 2025 | 1 articles | Viewed by 2112 | Submission Open

Keywords: leishmania; leishmaniasis; chagas disease; American trypanosomiasis; Trypanosoma cruzi; diagnostics; genetic diversity; characterization; neglected tropical disease

(This special issue belongs to the Section Epidemiology)

Postbiotics—Bioactive Microbial Compounds as Health-Promoting Agents

edited by

Katarzyna Oszajca

and

Janusz Szemraj

submission deadline 15 Sep 2025 | 1 articles | Viewed by 706 | Submission Open

Keywords: gut microbiota; postbiotics; prebiotics; microbiota-derived metabolites; postbiotic supplementation; postbiotics and health benefits; dysbiosis

(This special issue belongs to the Section Microbiology)

Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases

edited by

John Ong

submission deadline 16 Sep 2025 | 1 articles | Viewed by 1323 | Submission Open

Keywords: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease

(This special issue belongs to the Section Medical Research)

Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases

edited by

Lorena Perrone

and Oualid Sbai

submission deadline 25 Sep 2025 | Viewed by 273 | Submission Open

Keywords: mitochondria; neurodegeneration; oxidative stress; calcium homeostasis; mitochondrial fission/fusion; inflammation; gut– brain axis; mitophagy; NLRP3 inflammasome

(This special issue belongs to the Section Physiology and Pathology)

Carbon and Nitrogen Cycles in Terrestrial Ecosystems

edited by

Naiqing Pan

submission deadline 26 Sep 2025 | 3 articles | Viewed by 3843 | Submission Open

Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles

(This special issue belongs to the Section Diversity and Ecology)

Sports Medicine: Nutritional Sciences and Nutritional Biochemistry: 2nd Edition

edited by

Roberto Cannataro

submission deadline 26 Sep 2025 | 1 articles | Viewed by 2084 | Submission Open

Keywords: sport nutrition; sport supplementation; sport biochemistry; metabolomics; miRNA

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease

edited by

Marcin Kosmalski

and Monika Różycka-Kosmalska

submission deadline 29 Sep 2025 | 5 articles | Viewed by 7372 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension

(This special issue belongs to the Section Medical Research)

Current Advances in Diagnosis and Treatment of Sepsis

edited by Chih-Huang Li

submission deadline 29 Sep 2025 | 5 articles | Viewed by 6932 | Submission Open

Keywords: sepsis; biomarkers; prediction; immunotherapy; AI model

(This special issue belongs to the Section Medical Research)

Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health

edited by

Thomas Tsiampalis

and Matina Kouvari

submission deadline 29 Sep 2025 | 1 articles | Viewed by 3770 | Submission Open

Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors

(This special issue belongs to the Section Epidemiology)

Advances in Knee Biomechanics

edited by Jason Shearn

submission deadline 30 Sep 2025 | 9 articles | Viewed by 25130 | Submission Open

Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques

(This special issue belongs to the Section Physiology and Pathology)

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