Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Etiology, Diagnosis, and Treatment of Coeliac Diseases
edited by Paul J Ciclitira
submission deadline 30 Nov 2025 | Viewed by 119 | Submission Open
Keywords: coeliac disease; blood tests; dietary treatment; etiology
(This special issue belongs to the Section Medical Research)
Investigations of Circular RNAs in Plants submission deadline 1 Dec 2025 | 1 articles | Viewed by 951 | Submission Open
Keywords: plant circRNAs; miRNAs; stress responses; abiotic; biotic; translation; gene regulation; growth; development
(This special issue belongs to the Section Plant Science)
MASLD and Its Comorbidities: From Epidemiology to Future Therapeutic Perspectives
edited by
submission deadline 1 Dec 2025 | Viewed by 387 | Submission Open
Keywords: MASLD and comorbidities/complications; diagnostic techniques and biomarkers; clinical trials; innovative therapies
(This special issue belongs to the Section Medical Research)
MASLD and Its Comorbidities: From Pathophysiology Perspectives
edited by
submission deadline 1 Dec 2025 | Viewed by 298 | Submission Open
Keywords: MASLD; integrative physiology; pathogenesis; biomarkers; translational research
(This special issue belongs to the Section Physiology and Pathology)
Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation
edited by and Gelu Onose
submission deadline 2 Dec 2025 | 6 articles | Viewed by 16193 | Submission Open
Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions
(This special issue belongs to the Section Medical Research)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 349 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology
edited by and Panagiotis Tsiakanikas
submission deadline 12 Dec 2025 | Viewed by 316 | Submission Open
Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes
(This special issue belongs to the Section Genetics and Genomics)
Microvascular Dynamics: Insights and Applications
edited by and Friedrich Jung
submission deadline 15 Dec 2025 | 6 articles | Viewed by 15052 | Submission Open
Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical
(This special issue belongs to the Section Physiology and Pathology)
Unusual Genomic Traits in Their Evolutionary Context
edited by Miguel Naranjo-Ortiz
submission deadline 15 Dec 2025 | Viewed by 166 | Submission Open
Keywords: unusual genomes; genomic traits; comparative genomics; descriptive genomics; evolutionary genomics; non-model organisms; methodological limitations in genomics
(This special issue belongs to the Section Genetics and Genomics)
2nd Edition—Featured Papers on the Origins of Life
edited by James R. Lyons
submission deadline 17 Dec 2025 | 4 articles | Viewed by 6274 | Submission Open
Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems
(This special issue belongs to the Section Origin of Life)
Unravelling the Molecular Mechanisms of Different Stress Responses in Plants
edited by
submission deadline 18 Dec 2025 | 2 articles | Viewed by 2367 | Submission Open
Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Innovative Approaches in Dermatological Therapies and Diagnostics submission deadline 26 Dec 2025 | 6 articles | Viewed by 13204 | Submission Open
Keywords: dermatology; inflammatory diseases; skin cancer; non-invasive diagnosis; dermoscopy; confocal dermoscopy; targeted therapy; JAK inhibitors; biologics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Recent Advances in Shockwave Therapy for Musculoskeletal and Soft-Tissue Disorders
edited by , , Maria Chiara Vulpiani, Maria Cristina D'Agostino, Larisa Ryskalin and Federica Fulceri
submission deadline 26 Dec 2025 | 5 articles | Viewed by 11902 | Submission Open
Keywords: shockwave; tissue regeneration; pain; functional recovery and healing; physical medicine and rehabilitation; clinical applications; imaging
(This special issue belongs to the Section Medical Research)
Advances in Diagnostic Imaging for Systemic Disorders
edited by Christoph Strolz
submission deadline 29 Dec 2025 | Viewed by 148 | Submission Open
Keywords: high-resolution computed tomography (HRCT); diffusion-weighted imaging (DWI); dual-energy CT in musculoskeletal imaging; high-resolution ultrasonography; SPECT/CT; PET/CT modalities
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Current Views on Knee Osteoarthritis: 3rd Edition submission deadline 30 Dec 2025 | 2 articles | Viewed by 4313 | Submission Open
Keywords: knee osteoarthritis; metabolic syndrome; obesity; pathogenesis; adipokines; disease-modifying; treatment; personalized medicine
(This special issue belongs to the Section Medical Research)
Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 618 | Submission Open
Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication
(This special issue belongs to the Section Physiology and Pathology)
Advances in Neural Stem Cell Medicine
edited by Kiminobu Sugaya
submission deadline 30 Dec 2025 | Viewed by 121 | Submission Open
Keywords: neural stem cell; neurodegenerative diseases; cell therapy; exosomes
(This special issue belongs to the Section Physiology and Pathology)
Cystic Fibrosis: A Disease with a New Face
edited by and Patricia A. Walker
submission deadline 31 Dec 2025 | 14 articles | Viewed by 43301 | Submission Open
Keywords: cystic fibrosis; CFTR modulator; CF newborn screening; CF nutrition; lung transplant in CF; CF family planning
(This special issue belongs to the Section Medical Research)
Gastrointestinal Health: Clinical Research and Therapeutic Innovations
edited by
submission deadline 31 Dec 2025 | 21 articles | Viewed by 41621 | Submission Open
Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence
(This special issue belongs to the Section Medical Research)
Plant Biotic and Abiotic Stresses 2024
edited by and
submission deadline 31 Dec 2025 | 23 articles | Viewed by 35217 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
New Trends in Otorhinolaryngology submission deadline 31 Dec 2025 | 9 articles | Viewed by 27821 | Submission Open
Keywords: head and neck; otolaryngology; hearing loss; speech disorders; swallowing disorders; cancer; microRNA; nose; plastic surgery
(This special issue belongs to the Section Medical Research)
Clinical Management and Prevention of Adverse Pregnancy Outcomes submission deadline 31 Dec 2025 | 5 articles | Viewed by 20993 | Submission Open
Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies
(This special issue belongs to the Section Reproductive and Developmental Biology)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 18721 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
New Insights into Breast Cancer: Current Controversies and Future Perspectives
edited by , Angela Bucaro and Flavia de Lauretis
submission deadline 31 Dec 2025 | 10 articles | Viewed by 14290 | Submission Open
Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies
(This special issue belongs to the Section Medical Research)
Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies submission deadline 31 Dec 2025 | 4 articles | Viewed by 13970 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death
(This special issue belongs to the Section Medical Research)
Ecology and Conservation of Small Mammals: Exploring Biodiversity, Climate Resilience, and Ecosystem Dynamics Through Small Mammal Monitoring and Research: 2nd Edition submission deadline 31 Dec 2025 | 8 articles | Viewed by 11001 | Submission Open
Keywords: small mammals; biodiversity; indicators; monitoring; assessment; communities
(This special issue belongs to the Section Diversity and Ecology)
Trends in Clinical Research 2025 submission deadline 31 Dec 2025 | 4 articles | Viewed by 10248 | Submission Open
Keywords: artificial intelligence; biomedical research; digital health; evidence-based medicine; health policy; new therapies; new drugs; patient-centered research; personalized medicine; translational medicine
(This special issue belongs to the Section Medical Research)
Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition submission deadline 31 Dec 2025 | 8 articles | Viewed by 10041 | Submission Open
Keywords: obstetrics; gynecology; translational research; translational medicine
(This special issue belongs to the Section Medical Research)
Effects of Exercise and Functional Interventions on Musculoskeletal Health
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 9845 | Submission Open
Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science
(This special issue belongs to the Section Medical Research)
Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 7805 | Submission Open
Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment
(This special issue belongs to the Section Medical Research)
Advances in Non-Invasive Brain Stimulation submission deadline 31 Dec 2025 | 2 articles | Viewed by 7767 | Submission Open
Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound
(This special issue belongs to the Section Medical Research)
Recent Advances in Functional Genomics
edited by Katerina R. Katsani and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7230 | Submission Open
Keywords: chromatin profiling; CRISPR screens; crop genomics; epigenome editing; epigenomics; interactomes; metagenomics; pharmacogenomics; phenomics
(This special issue belongs to the Section Genetics and Genomics)
Mechanism, Diagnostic and Therapeutic Novelties in Dermatology: 3rd Edition
edited by Jose Carlos Armario Hita, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6037 | Submission Open
Keywords: physiopathology; skin sonography; dermoscopy; innovation; confocal microscopy; biological treatment; psoriasis; atopic dermatitis; inmmunomediated diseases; urticaria; laser CO2
(This special issue belongs to the Section Medical Research)
Plant Physiology: From Omic Analysis Toward Physiological Mechanism Research: 2nd Edition
edited by and Fang He
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5045 | Submission Open
Keywords: plant physiology; transcriptome; proteomics; gene regulatory network; bioinformation; omics; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Molecular Biomarkers in Inflammatory Diseases
edited by Stelvio Tonello
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4449 | Submission Open
Keywords: cytokines; chemokines; and immune mediators as pharmacodynamic biomarkers; genomic and epigenomic contributions to drug response variability; proteomic and metabolomic profiling to guide pharmacotherapy in inflammation; biomarker-driven strategies for drug development and personalized treatment; mechanistic studies on drug– biomarker interactions and their clinical relevance; novel biomarkers for predicting adverse drug reactions in inflammatory diseases
(This special issue belongs to the Section Medical Research)
Molecular Mechanisms of Preeclampsia
edited by Feng Li
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4405 | Submission Open
Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment
edited by and Hans Hultborn
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4018 | Submission Open
Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements
(This special issue belongs to the Section Medical Research)
Bioactive Compounds for Medicine and Health submission deadline 31 Dec 2025 | 3 articles | Viewed by 3617 | Submission Open
Keywords: phytochemistry; bioactive compounds; cancer; immune modulation; heart disease; diabetes; obesity; neurodegenerative diseases; neuroprotection
(This special issue belongs to the Section Pharmaceutical Science)
Antimicrobial Innovations
edited by and Miho Nakamura
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3491 | Submission Open
Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety
(This special issue belongs to the Section Microbiology)
Feature Papers in Animal Science: 4th Edition
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3280 | Submission Open
Keywords: fish; microbial ecology; lipid nutrition; electron microscopy; gut microbiota; proteomics; next-generation sequencing; arthropod parasites; protease inhibitors; disease vectors; cystatin; serpin; Kunitz; tick; insect; vector– host interaction; innate immunity; shellfish immunology; bivalve molluscs; transcriptomics; diseases; hemocytes; microscopy
(This special issue belongs to the Section Animal Science)
Airway Management in Emergency and Intensive Care Medicine
edited by and Tonny V. Veenith
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2990 | Submission Open
Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment
(This special issue belongs to the Section Medical Research)
Pain: New Insights into Mechanisms, Diagnosis, Therapy, and Management
edited by and I-Han Hsiao
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2890 | Submission Open
Keywords: pain; mechanisms; signaling pathways; diagnosis
(This special issue belongs to the Section Physiology and Pathology)
The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache
edited by , , Muneto Tatsumoto and Shingo Shimoda
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2878 | Submission Open
Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences
(This special issue belongs to the Section Medical Research)
Animal Reproduction and Health
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2237 | Submission Open
Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development
(This special issue belongs to the Section Animal Science)
Synthetic Genetic Elements, Devices, and Systems: 2nd Edition
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2192 | Submission Open
Keywords: synthetic biology; synthetic genetic elements/parts; biobricks; artificial gene synthesis; biocomputing; directed evolution; metabolic engineering/cell factory; optogenetics; genetic code expansion; xenobiology
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Diagnosis and Treatment of Erectile Dysfunction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2027 | Submission Open
Keywords: erectile dysfunction; non-invasive methods; surgical strategies
(This special issue belongs to the Section Physiology and Pathology)
From Muscle to Fascia: Current Trends and Future Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 2004 | Submission Open
Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies
(This special issue belongs to the Section Physiology and Pathology)
Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity
edited by Elisa Na
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1937 | Submission Open
Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics
(This special issue belongs to the Section Physiology and Pathology)
Move to Thrive: Pioneering Health and Resilience Through Physical Activity submission deadline 31 Dec 2025 | 1 articles | Viewed by 1786 | Submission Open
Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise
(This special issue belongs to the Section Physiology and Pathology)
Traumatic Brain Injury: Epidemiology, Diagnosis, Treatment and Biomarkers submission deadline 31 Dec 2025 | 1 articles | Viewed by 1321 | Submission Open
Keywords: traumatic brain injury; neurotrauma; epidemiology; rehabilitation; neurological disorders; biomarkers
(This special issue belongs to the Section Physiology and Pathology)
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