Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Advances in Diagnosis and Treatment of Sepsis
edited by Chih-Huang Li
submission deadline 29 Sep 2025 | 5 articles | Viewed by 8064 | Submission Open
Keywords: sepsis; biomarkers; prediction; immunotherapy; AI model
(This special issue belongs to the Section Medical Research)
Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health
edited by and Matina Kouvari
submission deadline 29 Sep 2025 | 1 articles | Viewed by 4728 | Submission Open
Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors
(This special issue belongs to the Section Epidemiology)
Advances in Knee Biomechanics
edited by Jason Shearn
submission deadline 30 Sep 2025 | 9 articles | Viewed by 28999 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Advanced Strategies in Fracture Treatments
edited by and Chun-Yu Chen
submission deadline 30 Sep 2025 | 9 articles | Viewed by 18486 | Submission Open
Keywords: state of the art; peri-articular fracture; osteoporotic fracture; fragility fracture; treatment protocols
(This special issue belongs to the Section Medical Research)
Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 14031 | Submission Open
Keywords: plant cell culture; plant tissue culture; medicinal plants; secondary metabolites; bioactive compounds; nutraceuticals; recombinant proteins; biologics
(This special issue belongs to the Section Plant Science)
Ion Channels and Neurological Disease: 2nd Edition
edited by and Marzia Martina
submission deadline 30 Sep 2025 | 6 articles | Viewed by 13789 | Submission Open
Keywords: ion channels; neurological diseases; neurodegeneration; pain; cellular and animal models; neuronal excitability; neuronal activity; synaptic transmission; structural and functional correlates; computational modeling; pathophysiology and pathogenesis; channelopathies; altered currents; neuropharmacology and ethnopharmacology; drug screening; delivery; and targeting; pharmacological treatments; molecular therapeutic options; neuroprotection
(This special issue belongs to the Section Pharmaceutical Science)
Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition submission deadline 30 Sep 2025 | 12 articles | Viewed by 11795 | Submission Open
Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steato-hepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases
(This special issue belongs to the Section Physiology and Pathology)
Etiology, Prediction and Prognosis of Ischemic Stroke
edited by , and Jiang Li
submission deadline 30 Sep 2025 | 3 articles | Viewed by 7029 | Submission Open
Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies
(This special issue belongs to the Section Physiology and Pathology)
A Paradigm Shift in Airway and Pain Management—2nd Edition
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 6867 | Submission Open
Keywords: airway management; pain management; ultrasonography; motor activity; nerve block; anesthesia; conduction; regenerative medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Medical Research)
Veterinary Pathology and Veterinary Anatomy: 3rd Edition submission deadline 30 Sep 2025 | 5 articles | Viewed by 5087 | Submission Open
Keywords: veterinary pathology; veterinary anatomy; SARS-CoV-2 pandemic; climate change; environmental pollution; diagnosis and treatment of animal diseases; computer modelling of pathological processes
(This special issue belongs to the Section Animal Science)
Advancements in Postoperative Management of Patients After Surgery
edited by , , and Alessandro Cappellani
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5053 | Submission Open
Keywords: surgery; ERAS; postoperative management; recovery; pain
(This special issue belongs to the Section Medical Research)
Multi-Omics for Diagnosing Diseases: Bioinformatics Approaches and Integrative Data Analyses submission deadline 30 Sep 2025 | 2 articles | Viewed by 2362 | Submission Open
Keywords: bioinformatics; computer hardware; software; and methods; first-/second-/third-generation sequencing; clinical genomics; mendelian diseases; whole-exome sequencing; evolutionary and comparative genomics; whole-genome sequencing; multi-omics; microbiome diseases
(This special issue belongs to the Section Genetics and Genomics)
Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2139 | Submission Open
Keywords: chronic kidney disease; vascular dysfunction; endothelial cells
(This special issue belongs to the Section Medical Research)
Enhancements in Screening Pathways for Early Detection of Lung Cancer submission deadline 30 Sep 2025 | 2 articles | Viewed by 2056 | Submission Open
Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence
(This special issue belongs to the Section Medical Research)
Advances in Intensive Care Medicine
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 1720 | Submission Open
Keywords: machine learning; critical care; intensive care; ARDS; mechanical ventilation; personalized medicine; advances
(This special issue belongs to the Section Medical Research)
Natural Substances in Nutrition and Health of Animals: 2nd Edition submission deadline 30 Sep 2025 | 2 articles | Viewed by 1686 | Submission Open
Keywords: natural products; organic acids; probiotics; prebiotics; and synbiotics; plant extracts; animal nutrition; animal physiology; animal embryology; animal reproduction; animal models
(This special issue belongs to the Section Animal Science)
Skin Diseases and Dermatologic Comorbidities
edited by Alessia Paganelli, and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1507 | Submission Open
Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers
(This special issue belongs to the Section Physiology and Pathology)
Acari: Biodiversity, Biogeography and Taxonomy Studies
edited by Pavel B. Klimov
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1115 | Submission Open
Keywords: phylogenetics; systematics; evolution and co-evolution; biodiversity; ecology; host associations; role of mites in agriculture and medicine
(This special issue belongs to the Section Animal Science)
New Insights into Athlete Physiology submission deadline 30 Sep 2025 | 1 articles | Viewed by 1087 | Submission Open
Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship
(This special issue belongs to the Section Physiology and Pathology)
Testicular and Penile Disorders: Reproductive, Pathophysiological, Diagnostic and Therapeutic Insights
edited by and Yu-Ching Wen
submission deadline 30 Sep 2025 | 1 articles | Viewed by 786 | Submission Open
Keywords: testicular and Penile Disorders; testicle; physiology; infertility
(This special issue belongs to the Section Physiology and Pathology)
From Pathophysiology to Pathology—an Update on Diabetic Kidney Disease
edited by Sharma Prabhakar
submission deadline 30 Sep 2025 | 1 articles | Viewed by 718 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system; sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Physiology and Pathology)
Cardiorenal Disease: Pathogenesis, Diagnosis, and Treatments
edited by Pedro Caravaca-Pérez and Jose Jesus Broseta
submission deadline 30 Sep 2025 | 1 articles | Viewed by 683 | Submission Open
Keywords: heart failure; kidney disease; cardiorenal syndrome; diagnosis; treatment
(This special issue belongs to the Section Medical Research)
Advances in Livestock Breeding, Nutrition and Metabolism
edited by
submission deadline 30 Sep 2025 | Viewed by 670 | Submission Open
Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability
(This special issue belongs to the Section Animal Science)
Research Progress of Cultivation of Edible Fungi: 2nd Edition
edited by Yajie Zou
submission deadline 30 Sep 2025 | 1 articles | Viewed by 590 | Submission Open
Keywords: edible fungi; cultivation; domesticate; substrate; biological efficiency; nutritional properties; functional compounds; sustainability; commercialization; emerging species
(This special issue belongs to the Section Microbiology)
Precision Therapies in Cancer: Advancements and Future Directions
edited by and Krushna Chandra Hembram
submission deadline 30 Sep 2025 | Viewed by 357 | Submission Open
Keywords: precision oncology; cancer theragnostic; molecular targeting; immunotherapy
(This special issue belongs to the Section Medical Research)
New Developments in Mycology submission deadline 30 Sep 2025 | Viewed by 296 | Submission Open
Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology
(This special issue belongs to the Section Microbiology)
An Update on Diabetic Kidney Disease: Epidemiology, Diagnosis, Treatment
edited by Sharma Prabhakar
submission deadline 30 Sep 2025 | Viewed by 288 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Medical Research)
Space Medicine Advancements: From Human Health to Biomedical System Design
edited by and
submission deadline 30 Sep 2025 | Viewed by 260 | Submission Open
Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations
(This special issue belongs to the Section Medical Research)
Advances in Microvascular Research: 2nd Edition submission deadline 30 Sep 2025 | Viewed by 191 | Submission Open
Keywords: microvascular injury; microvascular dysfunction; microcirculation; vascular inflammation; hypertension; cardiovascular diseases
(This special issue belongs to the Section Physiology and Pathology)
Autoimmune Disorders: From Pathophysiology to Therapeutics
edited by and Chiara Mura
submission deadline 30 Sep 2025 | Viewed by 176 | Submission Open
Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes
(This special issue belongs to the Section Physiology and Pathology)
Computational Approaches in Breast Cancer Diagnosis and Prognosis
edited by Elham Pashaei and
submission deadline 30 Sep 2025 | Viewed by 143 | Submission Open
Keywords: bioinformatics; machine learning; artificial intelligence; breast cancer
(This special issue belongs to the Section Physiology and Pathology)
Advances in Congenital Diaphragmatic Hernia: From Clinical Features to Management
edited by Przemysław Kosinski
submission deadline 30 Sep 2025 | Viewed by 131 | Submission Open
Keywords: congenital diaphragmatic hernia; prenatal diagnosis; fetal interventions; neonatal management; pulmonary hypoplasia; surgical techniques; imaging techniques; genetic testing; FETO; comprehensive care protocols  
(This special issue belongs to the Section Medical Research)
Updates on Cancer Immunology and Immunotherapy
edited by Parnian Jabbari
submission deadline 30 Sep 2025 | Viewed by 121 | Submission Open
Keywords: cancer immunology; immunotherapy; immune checkpoints; tumor microenvironment; chimeric antigen receptor T-cell (CAR-T) therapy; cancer vaccines; immune evasion; tumor immunity; personalized immunotherapy; immune oncology; combination therapy; immune-related adverse events; neoantigens; adoptive cell transfer; oncolytic viruses; targeted immunotherapy; tumor-associated antigens; cancer immunosurveillance; resistance mechanisms; clinical trials in immunotherapy
(This special issue belongs to the Section Medical Research)
New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 3975 | Submission Open
Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs
(This special issue belongs to the Section Medical Research)
Cell-Free DNA as a Biomarker in Metabolic Diseases
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 944 | Submission Open
Keywords: cell-free DNA (cfDNA); liquid biopsy; metabolic diseases; obesity; type 2 diabetes; non-alcoholic fatty liver disease (NAFLD); methylation; mutations
(This special issue belongs to the Section Medical Research)
Developments in the Interrelation of Gut Microbiota and Immune System for Treatment Strategies
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 881 | Submission Open
Keywords: gut microbiota; innate immune system; immunotherapy; dysbiosis;   bifidobacterium; microbiota modulation; probiotics; prebiotics; symbiotics; postbiotics; cancer immunotherapy; autoimmune diseases; vaccine response; immune regulation; therapeutic microbiology; translational medicine
(This special issue belongs to the Section Medical Research)
Sensitization via Skin Exposure
edited by
submission deadline 20 Oct 2025 | Viewed by 87 | Submission Open
Keywords: contact dermatitis; patch test; epidemiology; occupation; prevention
Diversity and Evolution of Pathogenic Viruses
edited by
submission deadline 20 Oct 2025 | Viewed by 58 | Submission Open
Keywords: pathogenic viruses; biologic diversity; evolution
(This special issue belongs to the Section Medical Research)
Cancer Epidemiology
edited by Daniela-Cristina Stefan and Honoré K. Mitonga
submission deadline 24 Oct 2025 | 4 articles | Viewed by 5810 | Submission Open
Keywords: cancer disparities; specific populations; methodological advances; cancer trends; cancer causes; prevention strategies
(This special issue belongs to the Section Epidemiology)
Dive into Myopia
edited by
submission deadline 24 Oct 2025 | Viewed by 222 | Submission Open
Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles
(This special issue belongs to the Section Medical Research)
Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders
edited by Arkadiusz Komorowski
submission deadline 25 Oct 2025 | Viewed by 200 | Submission Open
Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)
(This special issue belongs to the Section Physiology and Pathology)
Laparoscopy and Treatment: An All-Encompassing Solution for Surgeons
edited by Niculae Iordache and Claudiu-Octavian Ungureanu
submission deadline 26 Oct 2025 | 1 articles | Viewed by 1102 | Submission Open
Keywords: oncological; staging laparoscopy; tool; radical surgery; diagnostic
(This special issue belongs to the Section Medical Research)
Therapeutic Effects of Natural Products on Human Diseases: 2nd Edition
edited by
submission deadline 27 Oct 2025 | 10 articles | Viewed by 20687 | Submission Open
Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods
(This special issue belongs to the Section Pharmaceutical Science)
Role of Machine and Deep Learning in Drug Screening
edited by and
submission deadline 29 Oct 2025 | Viewed by 527 | Submission Open
Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine
(This special issue belongs to the Section Pharmaceutical Science)
Soil–Plant–Microbe Interactions: The Role of Biostimulants and Agro-Environmental Implications
edited by Regina Gabilondo and
submission deadline 30 Oct 2025 | 3 articles | Viewed by 6223 | Submission Open
Keywords: soil– plant– microbe system; biostimulants; rhizosphere; fertilizers; availability of mineral nutrients; microfaunal grazing; protozoa; nematode; mycorrhizae; microbial loop
(This special issue belongs to the Section Plant Science)
Advances in Integrative Omics Data Analysis for Cancer Research
edited by , Jianli Dai and Guangyi Niu
submission deadline 30 Oct 2025 | 1 articles | Viewed by 4512 | Submission Open
Keywords: cancer research; omics; bioinformatics; translational medicine
(This special issue belongs to the Section Genetics and Genomics)
Advances in Dryland Agriculture Science
edited by and Hangyu Dong
submission deadline 30 Oct 2025 | 2 articles | Viewed by 2013 | Submission Open
Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation
(This special issue belongs to the Section Plant Science)
Diagnostic Imaging in Colorectal Cancer
edited by and Chiara Zanon
submission deadline 30 Oct 2025 | 1 articles | Viewed by 1990 | Submission Open
Keywords: colorectal cancer; artificial intelligence; texture analysis; ultrasound; magnetic resonance imaging; PET/MRI
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Advances in Anesthesia and Critical Care
edited by
submission deadline 30 Oct 2025 | 2 articles | Viewed by 1495 | Submission Open
Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning
(This special issue belongs to the Section Medical Research)
Optogenetics and Light-Induced Processes in Synthetic Biology
edited by
submission deadline 30 Oct 2025 | Viewed by 692 | Submission Open
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
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