Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Musculoskeletal Medicine in Rheumatic Diseases
edited by and Emilio Filippucci
submission deadline 26 Mar 2025 | 3 articles | Viewed by 3364 | Submission Open
Keywords: rheumatic disease; rheumatoid arthritis; spondylarthritis; microcrystal arthritis; musculoskeletal ultrasonography; biologic treatment; disease-modifying antirheumatic drugs; imagining techniques
(This special issue belongs to the Section Medical Research)
Recent Advances in Physiotherapy for Musculoskeletal
edited by Miguel Ángel Rosety-Rodríguez and
submission deadline 28 Mar 2025 | 1 articles | Viewed by 914 | Submission Open
Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery
(This special issue belongs to the Section Physiology and Pathology)
Innovative Approaches in Dermatological Therapies and Diagnostics submission deadline 28 Mar 2025 | Viewed by 465 | Submission Open
Keywords: dermatology; inflammatory diseases; skin cancer; non-invasive diagnosis; dermoscopy; confocal dermoscopy; targeted therapy; JAK inhibitors; biologics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Sialic Acid and Sialic Acid Derivatives in Biomedicine
edited by and
submission deadline 30 Mar 2025 | Viewed by 266 | Submission Open
Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker
(This special issue belongs to the Section Physiology and Pathology)
Gender Medicine: Current Knowledge and Future Perspectives
edited by
submission deadline 30 Mar 2025 | Viewed by 185 | Submission Open
Keywords: gender; gender medicine; LGBTQ + health; health equity in gender medicine; intersectionality; pharmacology; reproductive health; chronic diseases; transgender healthcare; sex-specific healthcare
(This special issue belongs to the Section Medical Research)
Novel Approaches in Plastic and Reconstructive Surgery to Improve Quality of Life
edited by Silvan Maximilian Klein and Alexandra M. Anker
submission deadline 31 Mar 2025 | 24 articles | Viewed by 28641 | Submission Open
Keywords: reconstructive surgery; peripheral nerve injury; tissue repair; tissue engineering; peripheral nerve gaps; management of bone defects; molecular aspects of tissue repair; cancer therapy; cancer diagnostics; tissue imaging; artificial intelligence; cell-based tissue repair; rehabilitation after reconstructive surgery; facial reconstruction; breast reconstruction; lymphedema surgery
(This special issue belongs to the Section Medical Research)
What Is Life?
edited by and André Brack
submission deadline 31 Mar 2025 | 9 articles | Viewed by 20996 | Submission Open
Keywords: definition of life; origins of life; synthetic biology; theoretical biology; quantum biology; water; time; electrostatic potential; DNA; mutations; molecular interactions
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
Feature Paper in Physiology and Pathology: 2nd Edition
edited by and Eleni Stamellou
submission deadline 31 Mar 2025 | 18 articles | Viewed by 18504 | Submission Open
Keywords: applied physiology; biomechanics; cardiovascular pathobiology; cell physiology; comparative pathology; comparative physiology
(This special issue belongs to the Section Physiology and Pathology)
Recent Advances in Chemosensory-Based Behaviorally, Physiologically, and Molecularly Manipulated Technology of Pest Insects
edited by and Nanji Jiang
submission deadline 31 Mar 2025 | 10 articles | Viewed by 12403 | Submission Open
Keywords: insect pests; chemosensory reception; environmental cues; neural pathways; molecular function; pest management
(This special issue belongs to the Section Animal Science)
Gastrointestinal Health: Clinical Research and Therapeutic Innovations
edited by
submission deadline 31 Mar 2025 | 10 articles | Viewed by 11392 | Submission Open
Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence
(This special issue belongs to the Section Medical Research)
Physical Medicine and Rehabilitation: Trends and Applications—3rd Edition submission deadline 31 Mar 2025 | 10 articles | Viewed by 8787 | Submission Open
Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy
(This special issue belongs to the Section Epidemiology)
Emerging Biomarkers: Recent Findings and Application in Pathological Condition Detection—2nd Edition submission deadline 31 Mar 2025 | 5 articles | Viewed by 7894 | Submission Open
Keywords: biomarkers; biological fluids; early diagnosis; laboratory medicine
(This special issue belongs to the Section Medical Research)
Implications of Bioactive Compounds in Lifelong Disorders submission deadline 31 Mar 2025 | 5 articles | Viewed by 6965 | Submission Open
Keywords: phytochemicals; functional food; oxidative stress; metabolic syndrome; neuroinflammation; antioxidant; polyphenols; diabetes; inflammatory bowel disease; natural products; neurodegenerative disease
(This special issue belongs to the Section Pharmaceutical Science)
Skin Technology and Artificial Intelligence in Dermatology
edited by Mohamad Goldust and Maria M. Tsoukas
submission deadline 31 Mar 2025 | 1 articles | Viewed by 3910 | Submission Open
Keywords: skin technology; artificial intelligence; machine learning
(This special issue belongs to the Section Medical Research)
Clinical Management and Prevention of Adverse Pregnancy Outcomes submission deadline 31 Mar 2025 | 4 articles | Viewed by 3846 | Submission Open
Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies
(This special issue belongs to the Section Reproductive and Developmental Biology)
Evolutionary and Conservation Genetics: 3rd Edition
edited by and Ilenia Azzena
submission deadline 31 Mar 2025 | 3 articles | Viewed by 3468 | Submission Open
Keywords: evolutionary genetics; population genetics; conservation genetics; phylogeography; phylogenetics; phylodynamics; molecular taxonomy
(This special issue belongs to the Section Evolutionary Biology)
Ecotoxicity Effects of Metals and Microplastics on Aquatic Organisms
edited by Chiara Martino
submission deadline 31 Mar 2025 | 3 articles | Viewed by 3045 | Submission Open
Keywords: aquatic organisms; emerging contaminants; metals; microplastics; defense strategies; cell stress; heavy metals; environmental stress; pollution; ecotoxicology
(This special issue belongs to the Section Animal Science)
A Paradigm Shift in Airway and Pain Management—2nd Edition
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1994 | Submission Open
Keywords: airway management; pain management; ultrasonography; motor activity; nerve block; anesthesia; conduction; regenerative medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Medical Research)
Non-coding RNAs: Genomics, Biogenesis, Mechanisms, and Functions
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1849 | Submission Open
Keywords: ncRNA-interacting proteins; ncRNA modification; ncRNA biogenesis; ncRNA degradation; ncRNA decay; function; disease; therapeutic targets
(This special issue belongs to the Section Physiology and Pathology)
Synthesis and Evaluation of Novel Anticancer and Anti-Inflammatory Agents
edited by Po-Jen Chen, and Shun-Hua Chen
submission deadline 31 Mar 2025 | 2 articles | Viewed by 1792 | Submission Open
Keywords: anticancer agents; anti-inflammatory agents; pharmacology; molecular and cell biology; drug design; medicinal chemistry; pharmacodynamics; pharmacokinetics; structure– activity relationship (SAR)
(This special issue belongs to the Section Pharmaceutical Science)
Space Medicine Ophthalmology: Insights from Molecular Observations to the Clinical Management of Ocular Risks in Microgravity
edited by Joshua Ong
submission deadline 31 Mar 2025 | 2 articles | Viewed by 1409 | Submission Open
Keywords: spaceflight; space medicine; ophthalmology; space medicine; microgravity; cornea; retina; ocular surface
(This special issue belongs to the Section Astrobiology)
Sports Medicine: Nutritional Sciences and Nutritional Biochemistry: 2nd Edition
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1281 | Submission Open
Keywords: sport nutrition; sport supplementation; sport biochemistry; metabolomics; miRNA
(This special issue belongs to the Section Physiology and Pathology)
Plant Physiology: From Omic Analysis Toward Physiological Mechanism Research: 2nd Edition
edited by and Fang He
submission deadline 31 Mar 2025 | 1 articles | Viewed by 918 | Submission Open
Keywords: plant physiology; transcriptome; proteomics; gene regulatory network; bioinformation; omics; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Prevention Data Collecting Technology or Methodology to Live a Safe, Secure, Comfortable, Healthy and Sustainable Life submission deadline 31 Mar 2025 | Viewed by 614 | Submission Open
(This special issue belongs to the Section Medical Research)
Molecular and Cellular Biology of Transplantation
edited by Robert Ramm and Sebastian G. Michel
submission deadline 31 Mar 2025 | Viewed by 237 | Submission Open
Keywords: xeno- and allotransplantation; ex vivo perfusion; costimulatory blockade; CAR Treg; accommodation
(This special issue belongs to the Section Physiology and Pathology)
Dialysis submission deadline 31 Mar 2025 | Viewed by 216 | Submission Open
Keywords: hemodialysis; hemodiafiltration; peritoneal dialysis; home hemodialysis; incremental dialysis; dialyzer membrane; vascular access; dialysis adequacy; cardiovascular disease; infection; symptoms in dialysis; mineral bone disease; inflammation; anemia; frailty; quality of life
(This special issue belongs to the Section Medical Research)
Bone and Cartilage Fractures: Types, Diagnosis, Complications, Prevention and Treatment
edited by Massimiliano Leigheb, Gabriele Colò and
submission deadline 31 Mar 2025 | Viewed by 207 | Submission Open
Keywords: fracture; traumatology; diagnosis; surgery; osteosynthesis; reduction; cartilage; chondral; lesion; injury; rehabilitation; complication
(This special issue belongs to the Section Medical Research)
Nephrology in the 21st Century: Native Kidney Diseases and Impact of Artificial Intelligence, and Advances in Renal Transplantation
edited by Marjan Afrouzian, Lukman Cheraghvandi and Jenna Reisler
submission deadline 31 Mar 2025 | Viewed by 195 | Submission Open
Keywords: Artificial Intelligence (AI); nephrology; native kidney diseases; renal transplantation
(This special issue belongs to the Section Medical Research)
Current Updates in Pharmacoepidemiology
edited by
submission deadline 31 Mar 2025 | Viewed by 190 | Submission Open
Keywords: pharmacoepidemiology; real-world data; medication safety; machine learning; big data analytics; personalized medicine; drug efficacy; population health; pharmacovigilance
(This special issue belongs to the Section Pharmaceutical Science)
Innovative Approaches in Breast Reconstruction: From Diagnostics to Treatment of Complications
edited by Eun Young Rha
submission deadline 31 Mar 2025 | Viewed by 189 | Submission Open
Keywords: breast reconstruction; imaging study; autologous tissue; implant; acellular dermal matrix; surgical outcome; scar
(This special issue belongs to the Section Medical Research)
Novel Approaches and Strategies in Nutrition and Feeding of Animals: 2nd Edition
edited by
submission deadline 31 Mar 2025 | Viewed by 179 | Submission Open
Keywords: animal nutrition; animal production efficiency; animal product quality (milk; eggs; meat); bioactive compounds; sustainability feeding management; advanced grazing management; feed aditives; alternative feed ingredients; fish nutrition; nutrition and health; human health
(This special issue belongs to the Section Animal Science)
Advances in Cardiac Arrest: Prognostic Performance and Management
edited by
submission deadline 31 Mar 2025 | Viewed by 170 | Submission Open
Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine
(This special issue belongs to the Section Medical Research)
Molecular and Cellular Biology of Angiogenesis
edited by Roberta Marques Lassance-Soares
submission deadline 31 Mar 2025 | Viewed by 154 | Submission Open
Keywords: neovascularization; endothelial proliferation; vascular growth
(This special issue belongs to the Section Physiology and Pathology)
Vitamin D in Autoimmune and Infectious Diseases submission deadline 31 Mar 2025 | Viewed by 151 | Submission Open
Keywords: vitamin D; autoimmunity; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; infectious agents; COVID-19; SARS-CoV-2
(This special issue belongs to the Section Physiology and Pathology)
Exploring the Interplay between Diet, Microbiota, and Cancer submission deadline 31 Mar 2025 | Viewed by 135 | Submission Open
Keywords: microbiota/microbiome and cancer; dysbiosis; environmental pollutants; xenobiotic; metabolic disorders; diet; health/cancer; microbiota– host symbiosis; age diet; probiotics; prebiotics
(This special issue belongs to the Section Microbiology)
Lipid Metabolism, Regulation and Biosynthesis of Microalgae
edited by Yi Xin and
submission deadline 10 Apr 2025 | 3 articles | Viewed by 7532 | Submission Open
Keywords: microalgae; lipid biosynthesis; lipid metabolism; carbon and nitrogen metabolism; energy metabolism; genetic engineering; genome editing; environmental stress; signaling regulation; tag biosynthesis; biochemical regulation
(This special issue belongs to the Section Plant Science)
Plant Functional Genomics and Breeding
edited by
submission deadline 10 Apr 2025 | 4 articles | Viewed by 3608 | Submission Open
Keywords: functional genomics; biological breeding; gene cloning; molecular network; genetic improvement
(This special issue belongs to the Section Plant Science)
Assessments of Bioactive and Toxic Substances in Cellular and Animal Models
edited by and Tomáš Jambor
submission deadline 15 Apr 2025 | 4 articles | Viewed by 7225 | Submission Open
Keywords: cell biology; animal physiology; natural compounds; xenobiotics; trace elements; reproductive toxicology; oxidative status markers; health status; ecotoxicology
(This special issue belongs to the Section Physiology and Pathology)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 15 Apr 2025 | Viewed by 198 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Current Challenges in Space Neuroscience submission deadline 18 Apr 2025 | 4 articles | Viewed by 9773 | Submission Open
Keywords: cognition; microgravity; sleep  ; stress; Martian and lunar dust; neural stem cells and progenitors
(This special issue belongs to the Section Astrobiology)
Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine
edited by
submission deadline 18 Apr 2025 | 1 articles | Viewed by 1240 | Submission Open
Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Primary Cilia in Cellular Metabolism and Development
edited by
submission deadline 18 Apr 2025 | Viewed by 176 | Submission Open
Keywords: autophagy; cilia; cellular signaling; cancer cell metabolism
(This special issue belongs to the Section Physiology and Pathology)
Current and Future Perspectives of Artificial Intelligence in Medicine
edited by Giuseppe Consorti, Lisa Catarzi and
submission deadline 21 Apr 2025 | 1 articles | Viewed by 939 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; medical practices; artificial neural network; computational health informatics; predictive analytics in healthcare; ethics in AI for medical applications
(This special issue belongs to the Section Medical Research)
Strategies for Controlling Synthetic Cells: Approaches, Models, Applications
edited by and
submission deadline 22 Apr 2025 | 1 articles | Viewed by 2558 | Submission Open
Keywords: artificial cells; bioreactors; biosensor; cell-free systems; coacervates; controlled behavior; DNA signals; drug delivery; gene expression regulation; liposomes; microcompartments; modeling; molecular communication; nanomedicine; nanoparticles; optogenetics; polymersomes; protocells; signaling; stimulus-response; synthetic biology; synthetic cells
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Muscle Wasting, Aging, and Cancer: The Effects of Physical Exercise
edited by
submission deadline 22 Apr 2025 | Viewed by 238 | Submission Open
Keywords: sarcopenia; aging; cancer; muscle wasting; physical exercise; resistance training; satellite cells; inflammation; metabolic health; quality of life
(This special issue belongs to the Section Physiology and Pathology)
Radiological Diagnosis of Cervical Spondylosis and Carotid Artery Disease
edited by Anusha Vaddi
submission deadline 22 Apr 2025 | Viewed by 201 | Submission Open
Keywords: carotid artery disease; atherosclerosis; cervical spondylosis; c-spine; radiological diagnosis; diagnostic accuracy; AI in radiology
(This special issue belongs to the Section Medical Research)
Pathogenic Mechanisms, Diagnosis, and Treatment of Hypertension: Insights and Implications
edited by Shengyu Mu and Sankar Devarajan
submission deadline 25 Apr 2025 | 2 articles | Viewed by 3378 | Submission Open
Keywords: hypertension; cardiovascular disease; blood pressure; pathogenesis
(This special issue belongs to the Section Physiology and Pathology)
Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies submission deadline 26 Apr 2025 | Viewed by 964 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death
(This special issue belongs to the Section Medical Research)
Recent Advances in Functional Genomics
edited by Katerina R. Katsani and
submission deadline 28 Apr 2025 | 2 articles | Viewed by 3666 | Submission Open
Keywords: chromatin profiling; CRISPR screens; crop genomics; epigenome editing; epigenomics; interactomes; metagenomics; pharmacogenomics; phenomics
(This special issue belongs to the Section Genetics and Genomics)
Recent Insights in the Pathogenesis, Diagnosis, Prognosis and Treatment of Glomerular Disorders
edited by Adrian Constantin Covic and
submission deadline 29 Apr 2025 | 2 articles | Viewed by 1276 | Submission Open
Keywords: glomerular disorders; pathology; kidney biopsy; immunology; immunosuppresion; vasculitis
(This special issue belongs to the Section Medical Research)
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