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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications

edited by

Chien-Hung Lin

submission deadline 30 Dec 2025 | Viewed by 108 | Submission Open

Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication

(This special issue belongs to the Section Physiology and Pathology)

Advances in Neural Stem Cell Medicine

edited by Kiminobu Sugaya

submission deadline 30 Dec 2025 | Viewed by 90 | Submission Open

Keywords: neural stem cell; neurodegenerative diseases; cell therapy; exosomes

(This special issue belongs to the Section Physiology and Pathology)

Cystic Fibrosis: A Disease with a New Face

edited by

Janice Wang

and Patricia A. Walker

submission deadline 31 Dec 2025 | 14 articles | Viewed by 38126 | Submission Open

Keywords: cystic fibrosis; CFTR modulator; CF newborn screening; CF nutrition; lung transplant in CF; CF family planning

(This special issue belongs to the Section Medical Research)

Gastrointestinal Health: Clinical Research and Therapeutic Innovations

edited by

Ludovico Abenavoli

submission deadline 31 Dec 2025 | 18 articles | Viewed by 31277 | Submission Open

Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence

(This special issue belongs to the Section Medical Research)

Plant Biotic and Abiotic Stresses 2024

edited by

Gastón Pizzio

and

Jie Luo

submission deadline 31 Dec 2025 | 23 articles | Viewed by 31034 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress

(This special issue belongs to the Section Plant Science)

New Trends in Otorhinolaryngology

edited by

Arianna Di Stadio

Massimo Ralli

and

Pietro De Luca

submission deadline 31 Dec 2025 | 9 articles | Viewed by 20489 | Submission Open

Keywords: head and neck; otolaryngology; hearing loss; speech disorders; swallowing disorders; cancer; microRNA; nose; plastic surgery

(This special issue belongs to the Section Medical Research)

Clinical Management and Prevention of Adverse Pregnancy Outcomes

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 15786 | Submission Open

Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies

(This special issue belongs to the Section Reproductive and Developmental Biology)

New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases

edited by

Zhihong (Jewel) Hu

submission deadline 31 Dec 2025 | 5 articles | Viewed by 13129 | Submission Open

Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA

(This special issue belongs to the Section Medical Research)

Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies

edited by

Ioannis Katsaros

and

Dimitrios Schizas

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9406 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death

(This special issue belongs to the Section Medical Research)

New Insights into Breast Cancer: Current Controversies and Future Perspectives

edited by

Alejandro Martin Sanchez

, Angela Bucaro and Flavia de Lauretis

submission deadline 31 Dec 2025 | 7 articles | Viewed by 9228 | Submission Open

Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies

(This special issue belongs to the Section Medical Research)

Ecology and Conservation of Small Mammals: Exploring Biodiversity, Climate Resilience, and Ecosystem Dynamics Through Small Mammal Monitoring and Research: 2nd Edition

edited by

Vasileios A. Bontzorlos

and

George P. Mitsainas

submission deadline 31 Dec 2025 | 7 articles | Viewed by 8927 | Submission Open

Keywords: small mammals; biodiversity; indicators; monitoring; assessment; communities

(This special issue belongs to the Section Diversity and Ecology)

Trends in Clinical Research 2025

edited by

Pabulo Rampelotto

Anca Oana Docea

and

Katalin Prokai-Tatrai

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7073 | Submission Open

Keywords: artificial intelligence; biomedical research; digital health; evidence-based medicine; health policy; new therapies; new drugs; patient-centered research; personalized medicine; translational medicine

(This special issue belongs to the Section Medical Research)

Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition

edited by

Elżbieta Janina Płuciennik

Żaneta Kałuzińska-Kołat

and

Damian Kołat

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6552 | Submission Open

Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment

(This special issue belongs to the Section Medical Research)

Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition

edited by

Stefano Canosa

and

Anna Maria Nuzzo

submission deadline 31 Dec 2025 | 6 articles | Viewed by 6425 | Submission Open

Keywords: obstetrics; gynecology; translational research; translational medicine

(This special issue belongs to the Section Medical Research)

Recent Advances in Functional Genomics

edited by Katerina R. Katsani and

Cinzia Montemurro

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6048 | Submission Open

Keywords: chromatin profiling; CRISPR screens; crop genomics; epigenome editing; epigenomics; interactomes; metagenomics; pharmacogenomics; phenomics

(This special issue belongs to the Section Genetics and Genomics)

Advances in Non-Invasive Brain Stimulation

edited by

Mariagiovanna Cantone

and

Giuseppe Lanza

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5920 | Submission Open

Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound

(This special issue belongs to the Section Medical Research)

Effects of Exercise and Functional Interventions on Musculoskeletal Health

edited by

Seong-Gil Kim

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5410 | Submission Open

Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science

(This special issue belongs to the Section Medical Research)

Mechanism, Diagnostic and Therapeutic Novelties in Dermatology: 3rd Edition

edited by Jose Carlos Armario Hita,

Jose Juan Pereyra Rodriguez

and

Ricardo Ruiz-Villaverde

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4058 | Submission Open

Keywords: physiopathology; skin sonography; dermoscopy; innovation; confocal microscopy; biological treatment; psoriasis; atopic dermatitis; inmmunomediated diseases; urticaria; laser CO2

(This special issue belongs to the Section Medical Research)

Plant Physiology: From Omic Analysis Toward Physiological Mechanism Research: 2nd Edition

edited by

Sen Meng

and Fang He

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3915 | Submission Open

Keywords: plant physiology; transcriptome; proteomics; gene regulatory network; bioinformation; omics; molecular mechanisms

(This special issue belongs to the Section Plant Science)

Molecular Mechanisms of Preeclampsia

edited by Feng Li

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3514 | Submission Open

Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation

(This special issue belongs to the Section Reproductive and Developmental Biology)

Molecular Biomarkers in Inflammatory Diseases

edited by Stelvio Tonello

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2981 | Submission Open

Keywords: cytokines; chemokines; and immune mediators as pharmacodynamic biomarkers; genomic and epigenomic contributions to drug response variability; proteomic and metabolomic profiling to guide pharmacotherapy in inflammation; biomarker-driven strategies for drug development and personalized treatment; mechanistic studies on drug– biomarker interactions and their clinical relevance; novel biomarkers for predicting adverse drug reactions in inflammatory diseases

(This special issue belongs to the Section Medical Research)

Antimicrobial Innovations

edited by

Pere Puigbò

and Miho Nakamura

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2709 | Submission Open

Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety

(This special issue belongs to the Section Microbiology)

Feature Papers in Animal Science: 4th Edition

edited by

Einar Ringø

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2662 | Submission Open

Keywords: fish; microbial ecology; lipid nutrition; electron microscopy; gut microbiota; proteomics; next-generation sequencing; arthropod parasites; protease inhibitors; disease vectors; cystatin; serpin; Kunitz; tick; insect; vector– host interaction; innate immunity; shellfish immunology; bivalve molluscs; transcriptomics; diseases; hemocytes; microscopy

(This special issue belongs to the Section Animal Science)

Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment

edited by

Mengliang Zhang

and Hans Hultborn

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2438 | Submission Open

Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements

(This special issue belongs to the Section Medical Research)

Bioactive Compounds for Medicine and Health

edited by

Christiana Charalambous

and

Alexandru Vasincu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2419 | Submission Open

Keywords: phytochemistry; bioactive compounds; cancer; immune modulation; heart disease; diabetes; obesity; neurodegenerative diseases; neuroprotection

(This special issue belongs to the Section Pharmaceutical Science)

The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache

edited by

Masahito Katsuki

Tomokazu Shimazu

, Muneto Tatsumoto and Shingo Shimoda

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2262 | Submission Open

Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences

(This special issue belongs to the Section Medical Research)

From Muscle to Fascia: Current Trends and Future Perspectives

edited by

Antonio Stecco

Carla Stecco

and

Carmelo Pirri

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1800 | Submission Open

Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies

(This special issue belongs to the Section Physiology and Pathology)

Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity

edited by Elisa Na

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1552 | Submission Open

Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics

(This special issue belongs to the Section Physiology and Pathology)

Synthetic Genetic Elements, Devices, and Systems: 2nd Edition

edited by

Chunbo Lou

and

Yusuke Kato

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1422 | Submission Open

Keywords: synthetic biology; synthetic genetic elements/parts; biobricks; artificial gene synthesis; biocomputing; directed evolution; metabolic engineering/cell factory; optogenetics; genetic code expansion; xenobiology

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Diagnosis and Treatment of Erectile Dysfunction

edited by

Geng-Long Hsu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1393 | Submission Open

Keywords: erectile dysfunction; non-invasive methods; surgical strategies

(This special issue belongs to the Section Physiology and Pathology)

Airway Management in Emergency and Intensive Care Medicine

edited by

Prashant Nasa

and Tonny V. Veenith

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1341 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1236 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

(This special issue belongs to the Section Physiology and Pathology)

Animal Reproduction and Health

edited by

Rachel Moxon

and

Ana Faustino

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1107 | Submission Open

Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development

(This special issue belongs to the Section Animal Science)

Pain: New Insights into Mechanisms, Diagnosis, Therapy, and Management

edited by

Yiwen Lin

and I-Han Hsiao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1075 | Submission Open

Keywords: pain; mechanisms; signaling pathways; diagnosis

(This special issue belongs to the Section Physiology and Pathology)

Advances in Artificial Intelligence for Medical Image Analysis: 2nd Edition

edited by

Xin Jin

submission deadline 31 Dec 2025 | 1 articles | Viewed by 800 | Submission Open

Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion

(This special issue belongs to the Section Medical Research)

Traumatic Brain Injury: Epidemiology, Diagnosis, Treatment and Biomarkers

edited by

Jeff Victoroff

and

Alfredo Conti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 794 | Submission Open

Keywords: traumatic brain injury; neurotrauma; epidemiology; rehabilitation; neurological disorders; biomarkers

(This special issue belongs to the Section Physiology and Pathology)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 767 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Conservation Ecology and Management of Mammalian Predators

edited by

Sándor Csányi

and

Miklós Gábor Heltai

submission deadline 31 Dec 2025 | Viewed by 716 | Submission Open

Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions

(This special issue belongs to the Section Animal Science)

Advancements in Heart Failure Research: 2nd Edition

edited by Tzu-Hurng Cheng,

Ju-Chi Liu

and

Po-Yuan Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 677 | Submission Open

Keywords: cardiac remodeling; biomarkers; precision medicine; patient-centered care; therapeutic innovations

(This special issue belongs to the Section Physiology and Pathology)

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 572 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Update on Clinical Pharmacology

edited by

Ju-Seop Kang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 571 | Submission Open

Keywords: drug efficacy and drug safety; new drug development; therapeutic drug monitoring; clinical trials; pharmacodynamic and pharmacokinetics; pharmacovigilance; clinical toxicology

(This special issue belongs to the Section Pharmaceutical Science)

Advancing Cancer Radiodiagnostics Through Artificial Intelligence: Techniques, Applications, and Challenges

edited by Pei-Ju Chao,

Tsair-Fwu Lee

Peter Elkin

and

Roberto Iezzi

submission deadline 31 Dec 2025 | Viewed by 560 | Submission Open

Keywords: artificial intelligence; cancer radiodiagnostics; machine learning; tumor detection; radiomics integration

(This special issue belongs to the Section Medical Research)

The Interactions Between Cells and Their Microenvironment

edited by

Ping Yang

and

Haitao Nie

submission deadline 31 Dec 2025 | Viewed by 441 | Submission Open

Keywords: cell microenvironment; extracellular matrix; interstitial cells

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Radiological Diagnosis of Cervical Spondylosis and Carotid Artery Disease

edited by Anusha Vaddi

submission deadline 31 Dec 2025 | Viewed by 350 | Submission Open

Keywords: carotid artery disease; atherosclerosis; cervical spondylosis; c-spine; radiological diagnosis; diagnostic accuracy; AI in radiology

(This special issue belongs to the Section Medical Research)

Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides

edited by

Yanchun Deng

and

Xiushi Yang

submission deadline 31 Dec 2025 | Viewed by 347 | Submission Open

Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging

(This special issue belongs to the Section Pharmaceutical Science)

Early Prebiotic Reaction Networks

edited by Olga Taran and Paul J. Bracher

submission deadline 31 Dec 2025 | Viewed by 314 | Submission Open

Keywords: thioesters; autocatalytic reactions; redox cycling; chemical fossils; TCA cycle analogues

(This special issue belongs to the Section Origin of Life)

Sustainable Agroforestry: Molecular Strategies for Integrated Pest and Disease Management

edited by Gothandapani Sellamuthu and Kanakachari Mogilicherla

submission deadline 31 Dec 2025 | Viewed by 280 | Submission Open

Keywords: sustainable agroforestry; integrated pest management; genomics; transcriptomics; CRISPR technology; RNAi; plant– microbe interactions; biopesticides

(This special issue belongs to the Section Plant Science)

Plant Adaptation Mechanisms to Abiotic Stresses

edited by Sunchung Park and Ezekiel Ahn

submission deadline 31 Dec 2025 | Viewed by 227 | Submission Open

Keywords: abiotic stress; plant adaptation mechanisms; cold; heat; drought; salinity; flooding; waterlogging; transcription factors

(This special issue belongs to the Section Plant Science)

The Biology and Functions of Platelets: Emerging Challenges

edited by

Robert Maitta

and Miriam Andrea Duque

submission deadline 31 Dec 2025 | Viewed by 217 | Submission Open

Keywords: platelet; hemostasis; toll-like receptor; immunity; phagocytosis; transfusions; von Willebrand factor; thrombocyte