Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Progress in Medical Image Segmentation
edited by
submission deadline 29 Aug 2025 | 4 articles | Viewed by 5124 | Submission Open
Keywords: medical image segmentation; deep learning; generative models; algorithm; clinical integration; biological variability; transformer architectures; interactive segmentation; interdisciplinary collaboration
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Clinical and Laboratory Advancements and Challenges in Medically Assisted Reproduction
edited by and Valeria Stella Vanni
submission deadline 29 Aug 2025 | 2 articles | Viewed by 3794 | Submission Open
Keywords: medically assisted reproduction; assisted reproduction technologies; clinical embryology; genetic testing; ovarian stimulation; male factor; endometriosis; endometrial receptivity; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
Personalized Medicine in Ophthalmic Diseases: Updated Challenges and Opportunities submission deadline 29 Aug 2025 | 3 articles | Viewed by 3112 | Submission Open
Keywords: vision-related quality of life; personalized medicine; artificial intelligence; ophthalmology and nutrition; optical coherence tomography; ocular surface diseases; retinal vascular diseases
(This special issue belongs to the Section Medical Research)
Diagnosis and Management of Microbial Infections submission deadline 29 Aug 2025 | 3 articles | Viewed by 2982 | Submission Open
Keywords: microbiology; infection; germs; antimicrobial agents; antimicrobial therapy
(This special issue belongs to the Section Microbiology)
Bone Cancer: From Molecular Mechanism to Treatment
edited by and Syuan-Ling Lin
submission deadline 29 Aug 2025 | 2 articles | Viewed by 2375 | Submission Open
Keywords: bone cancer; metastasis; angiogenesis; targeted drugs; biomarkers
(This special issue belongs to the Section Medical Research)
Precision Medicine in Cardiovascular Diseases
edited by Brian Xiangzhi Wang
submission deadline 29 Aug 2025 | 1 articles | Viewed by 2042 | Submission Open
Keywords: genomic; cardiovascular disease; congenital; multi-omics studies; precision medicine; personalized medicine; biomarker
(This special issue belongs to the Section Genetics and Genomics)
Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice
edited by Ralitsa Robeva
submission deadline 29 Aug 2025 | 2 articles | Viewed by 1458 | Submission Open
Keywords: PCOS; hypothalamic amenorrhea; congenital adrenal hyperplasia; hypogonadotropic hypogonadism; premature ovarian insufficiency (POI)
(This special issue belongs to the Section Physiology and Pathology)
Channel Proteins and Transporters in Human Health and Disease submission deadline 29 Aug 2025 | Viewed by 840 | Submission Open
Keywords: channel proteins; transporters; ion channel
(This special issue belongs to the Section Proteins and Proteomics)
Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition submission deadline 29 Aug 2025 | 1 articles | Viewed by 827 | Submission Open
Keywords: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities keyword; inflammatory diseases; hair; skin cancer; comorbidities; skin surgery
(This special issue belongs to the Section Physiology and Pathology)
Kidney Transplantation: What’s Hot and What’s New—2nd Edition
edited by and Caterina Di Bella
submission deadline 29 Aug 2025 | 1 articles | Viewed by 788 | Submission Open
Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation
(This special issue belongs to the Section Medical Research)
Microbiota Metabolism and Gut Health in Swine
edited by
submission deadline 29 Aug 2025 | Viewed by 160 | Submission Open
Keywords: gut microbiota; swine health; microbial metabolites; nutrient absorption; immune response; metagenomics; antibiotic alternatives; swine production
(This special issue belongs to the Section Microbiology)
Image Analysis and Postprocessing in Medical Imaging
edited by
submission deadline 29 Aug 2025 | Viewed by 149 | Submission Open
Keywords: quantitative imaging biomarkers; image segmentation; artificial intelligence in radiology; image postprocessing
(This special issue belongs to the Section Medical Research)
Disparities in Cancer Treatment
edited by Adam Barsouk
submission deadline 29 Aug 2025 | Viewed by 95 | Submission Open
Keywords: disparities; mortality; survival; race; sex; age; developing nations; public health; prevention
(This special issue belongs to the Section Epidemiology)
Hansen's Disease—Epidemiology, Diagnosis, Treatment and Complications
edited by Karen Olshtain-Pops
submission deadline 30 Aug 2025 | 1 articles | Viewed by 2542 | Submission Open
Keywords: hansen's disease; leprosy; Mycobacterium leprae
(This special issue belongs to the Section Epidemiology)
Animal Nutritional Physiology: Effects of Feed Additives on Livestock Products
edited by and Katarzyna Poltowicz
submission deadline 30 Aug 2025 | Viewed by 677 | Submission Open
Keywords: feed additives; animal health; animal performance; animal-derived products; animal nutritional physiology
(This special issue belongs to the Section Physiology and Pathology)
Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection
edited by Junsung Hong
submission deadline 30 Aug 2025 | 1 articles | Viewed by 653 | Submission Open
Keywords: enterobacteriaceae; antimicrobial resistance; infection; health
(This special issue belongs to the Section Microbiology)
Microorganisms Engineering and Gene-Editing Methods
edited by , and Xia Zhao
submission deadline 30 Aug 2025 | Viewed by 230 | Submission Open
Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination
(This special issue belongs to the Section Genetics and Genomics)
Feature Papers in Medical Research: 3rd Edition
edited by
submission deadline 31 Aug 2025 | 13 articles | Viewed by 13652 | Submission Open
Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research
(This special issue belongs to the Section Medical Research)
Recent Advances in Crop Genetics and Breeding
edited by , , and Long Chen
submission deadline 31 Aug 2025 | 3 articles | Viewed by 3201 | Submission Open
Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection
(This special issue belongs to the Section Plant Science)
Migraine and Headache: From Pathophysiological Aspects
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1328 | Submission Open
Keywords: migraine; headache; pathophysiology; treatment; medication
(This special issue belongs to the Section Physiology and Pathology)
Encephalitis: From Molecular Pathophysiology to Therapy
edited by Anna Tröscher and Judith Wagner
submission deadline 31 Aug 2025 | 1 articles | Viewed by 997 | Submission Open
Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy
(This special issue belongs to the Section Physiology and Pathology)
Recent Advances in Plant Genomics and Genetics
edited by , , Long Chen and
submission deadline 31 Aug 2025 | Viewed by 553 | Submission Open
Keywords: high-throughput genotyping; plant genetics; plant genomics; genetic markers; genetic improvements; genome editong; CRISPR/Cas9; genomic selection
(This special issue belongs to the Section Genetics and Genomics)
Clinical Manifestations and Treatment of Autoimmune Diseases: 2nd Edition submission deadline 31 Aug 2025 | 1 articles | Viewed by 399 | Submission Open
Keywords: autoimmunity; immunobiology; vaccine; leucocytes; immune system
(This special issue belongs to the Section Medical Research)
Recent Advances in Bone Biology
edited by Barbara Peruzzi, and Giulia Battafarano
submission deadline 31 Aug 2025 | Viewed by 176 | Submission Open
Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism
(This special issue belongs to the Section Physiology and Pathology)
Integrating Health Informatics and Artificial Intelligence for Advanced Medicine
edited by
submission deadline 31 Aug 2025 | Viewed by 168 | Submission Open
Keywords: artificial intelligence; machine learning; artificial neural networks; prognosis; treatment; medicine; health care; pathology
(This special issue belongs to the Section Medical Research)
From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders
edited by , and Ana Lascu
submission deadline 31 Aug 2025 | Viewed by 158 | Submission Open
Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota
(This special issue belongs to the Section Physiology and Pathology)
Cutting-Edge Techniques and Innovations in the Management of Aortic Aneurysm
edited by Dimitrios Iliopoulos
submission deadline 31 Aug 2025 | Viewed by 144 | Submission Open
Keywords: aneurysm; aorta; aortic root; biomechanics; aortic dissection; thoracoabdominal aneurysm; valve-sparing aortic root replacement; perfusion
(This special issue belongs to the Section Medical Research)
New Insights into Pediatric Rheumatic and Autoimmune Diseases
edited by Lampros Fotis
submission deadline 31 Aug 2025 | Viewed by 132 | Submission Open
Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis
(This special issue belongs to the Section Medical Research)
Migraine and Headache: From Clinical and Therapeutic Aspects
edited by
submission deadline 31 Aug 2025 | Viewed by 131 | Submission Open
Keywords: migraine; headache; treatment; medication
(This special issue belongs to the Section Medical Research)
Body Fluid-Based Biomarkers for Cognitive Impairment
edited by Wei Li
submission deadline 31 Aug 2025 | Viewed by 128 | Submission Open
Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis
(This special issue belongs to the Section Medical Research)
New Insights into Cellular Inflammation and Regeneration
edited by
submission deadline 31 Aug 2025 | Viewed by 112 | Submission Open
Keywords: cellular inflammation; tissue regeneration; immune modulation; regenerative medicine; inflammatory pathways; immune cells and tissue repair; chronic inflammation; biomarkers of regeneration; immune-tissue crosstalk; wound healing; fibrosis and regeneration; inflammation resolution; tissue remodeling; regenerative microenvironment; inflammation-driven pathogenesis; translational immunology
(This special issue belongs to the Section Physiology and Pathology)
Gene Regulation and Expression in Tumors
edited by and Dawid Sobański
submission deadline 31 Aug 2025 | Viewed by 109 | Submission Open
Keywords: gene regulation; tumor biology; transcriptional dysregulation and epigenetics; cancer biomarkers; therapeutic targets; multi-omics approaches
(This special issue belongs to the Section Physiology and Pathology)
The Drug Development for Neurodegenerative Diseases
edited by David R. Elmaleh
submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open
Keywords: neurodegenerative disease; drug treatment approaches; quality of life improvement
(This special issue belongs to the Section Pharmaceutical Science)
Innovative Drug Development: Balancing Efficacy and Toxicity in Novel Pharmaceuticals
edited by
submission deadline 31 Aug 2025 | Viewed by 81 | Submission Open
Keywords: drug development; pharmaceuticals; bioactive compounds; new drug candidates; drug delivery systems; pharmaceutical formulations; efficacy and toxicity screening
(This special issue belongs to the Section Pharmaceutical Science)
Emerging Trends in Tumor Pathology and Precision Oncology
edited by and Gabriele Gaggero
submission deadline 15 Sep 2025 | 2 articles | Viewed by 3395 | Submission Open
Keywords: gynecologic pathology; pediatric pathology; neuropathology; molecular diagnostics; precision oncology
(This special issue belongs to the Section Physiology and Pathology)
New Insights Into Leishmaniasis and Chagas Disease: Focus on Diagnosis and Genetic Characterization of Parasites: 2nd Edition
edited by and Cristina Ballart
submission deadline 15 Sep 2025 | 1 articles | Viewed by 1981 | Submission Open
Keywords: leishmania; leishmaniasis; chagas disease; American trypanosomiasis; Trypanosoma cruzi; diagnostics; genetic diversity; characterization; neglected tropical disease
(This special issue belongs to the Section Epidemiology)
Postbiotics—Bioactive Microbial Compounds as Health-Promoting Agents submission deadline 15 Sep 2025 | Viewed by 97 | Submission Open
Keywords: gut microbiota; postbiotics; prebiotics; microbiota-derived metabolites; postbiotic supplementation; postbiotics and health benefits; dysbiosis
(This special issue belongs to the Section Microbiology)
Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases
edited by John Ong
submission deadline 16 Sep 2025 | 1 articles | Viewed by 1204 | Submission Open
Keywords: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease
(This special issue belongs to the Section Medical Research)
Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases
edited by and Oualid Sbai
submission deadline 25 Sep 2025 | Viewed by 246 | Submission Open
Keywords: mitochondria; neurodegeneration; oxidative stress; calcium homeostasis; mitochondrial fission/fusion; inflammation; gut– brain axis; mitophagy; NLRP3 inflammasome
(This special issue belongs to the Section Physiology and Pathology)
Carbon and Nitrogen Cycles in Terrestrial Ecosystems
edited by
submission deadline 26 Sep 2025 | 3 articles | Viewed by 3099 | Submission Open
Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles
(This special issue belongs to the Section Diversity and Ecology)
Sports Medicine: Nutritional Sciences and Nutritional Biochemistry: 2nd Edition
edited by
submission deadline 26 Sep 2025 | 1 articles | Viewed by 1808 | Submission Open
Keywords: sport nutrition; sport supplementation; sport biochemistry; metabolomics; miRNA
(This special issue belongs to the Section Physiology and Pathology)
Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease
edited by and Monika Różycka-Kosmalska
submission deadline 29 Sep 2025 | 5 articles | Viewed by 6696 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension
(This special issue belongs to the Section Medical Research)
Current Advances in Diagnosis and Treatment of Sepsis
edited by Chih-Huang Li
submission deadline 29 Sep 2025 | 5 articles | Viewed by 5915 | Submission Open
Keywords: sepsis; biomarkers; prediction; immunotherapy; AI model
(This special issue belongs to the Section Medical Research)
Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health
edited by and Matina Kouvari
submission deadline 29 Sep 2025 | 1 articles | Viewed by 2888 | Submission Open
Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors
(This special issue belongs to the Section Epidemiology)
Advances in Knee Biomechanics
edited by Jason Shearn
submission deadline 30 Sep 2025 | 8 articles | Viewed by 21239 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Advanced Strategies in Fracture Treatments
edited by and Chun-Yu Chen
submission deadline 30 Sep 2025 | 9 articles | Viewed by 12653 | Submission Open
Keywords: state of the art; peri-articular fracture; osteoporotic fracture; fragility fracture; treatment protocols
(This special issue belongs to the Section Medical Research)
Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 10351 | Submission Open
Keywords: plant cell culture; plant tissue culture; medicinal plants; secondary metabolites; bioactive compounds; nutraceuticals; recombinant proteins; biologics
(This special issue belongs to the Section Plant Science)
Etiology, Prediction and Prognosis of Ischemic Stroke
edited by , and Jiang Li
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4880 | Submission Open
Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies
(This special issue belongs to the Section Physiology and Pathology)
A Paradigm Shift in Airway and Pain Management—2nd Edition
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4137 | Submission Open
Keywords: airway management; pain management; ultrasonography; motor activity; nerve block; anesthesia; conduction; regenerative medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Medical Research)
Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition submission deadline 30 Sep 2025 | 5 articles | Viewed by 3419 | Submission Open
Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steato-hepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases
(This special issue belongs to the Section Physiology and Pathology)
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