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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Age of Longevity: Unpacking Biogerontology and the Future of Human Life

edited by Paweł Kordowitzki

submission deadline 28 Aug 2026 | 1 articles | Viewed by 1624 | Submission Open

Keywords: biogerontology; biological aging; longevity; healthspan extension; cellular senescence; epigenetic reprogramming; senolytics; gene editing; artificial intelligence in aging research

(This special issue belongs to the Section Physiology and Pathology)

Root–Soil–Microbe Interactions: Mechanisms and Management for Plant Performance and Ecosystem Function

edited by

Yuan Li

submission deadline 28 Aug 2026 | Viewed by 369 | Submission Open

Keywords: Root– soil– microbe interactions; Rhizosphere processes; Plant– microbe networks; Biogeochemical cycling; Microbiome-informed management

(This special issue belongs to the Section Plant Science)

Innovations in Tissue Reconstruction and Wound Repair

edited by Ishith Seth

submission deadline 28 Aug 2026 | 1 articles | Viewed by 365 | Submission Open

Keywords: stem cell therapy; tissue engineering; tissue reconstruction; microsurgery; wound healing; regenerative medicine; biomaterials; perforator flaps; supermicrosurgery

(This special issue belongs to the Section Medical Research)

Omics Approaches in Antipsychotic Pharmacology

edited by

Kyle Burghardt

submission deadline 28 Aug 2026 | Viewed by 318 | Submission Open

Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal

(This special issue belongs to the Section Pharmaceutical Science)

Microbial Diversity and Function in Aquatic Environments

edited by Xianglong Chen and

Liang Guo

submission deadline 30 Aug 2026 | 4 articles | Viewed by 8850 | Submission Open

Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches

(This special issue belongs to the Section Microbiology)

Airway Management in Emergency and Intensive Care Medicine

edited by

Prashant Nasa

and Tonny V. Veenith

submission deadline 30 Aug 2026 | 3 articles | Viewed by 8675 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Skin Diseases and Dermatologic Comorbidities

edited by Alessia Paganelli,

Emanuele Scala

and

Flavia Persechino

submission deadline 30 Aug 2026 | 4 articles | Viewed by 7822 | Submission Open

Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers

(This special issue belongs to the Section Physiology and Pathology)

Molecular Muscle Adaptations Across the Lifespan

edited by S. Kyle Travis and

Sime Versic

submission deadline 30 Aug 2026 | 1 articles | Viewed by 5600 | Submission Open

Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2196 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Global Burden of Chronic Pain: Advances and Challenges in Pain Management and Clinical Practice

edited by Saba Javed and Billy Huh

submission deadline 30 Aug 2026 | 2 articles | Viewed by 2022 | Submission Open

Keywords: chronic pain syndrome; cancer pain syndrome; neuromodulation; intrathecal pump; opioids; nerve blocks; joint injections

(This special issue belongs to the Section Medical Research)

Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications

edited by

Chien-Hung Lin

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1858 | Submission Open

Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Eye Diseases: From Tomography to Clinical Prediction

edited by

Akio Oishi

and

Nilufer Yesilirmak

submission deadline 30 Aug 2026 | Viewed by 492 | Submission Open

Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations

edited by Manuel Gil Lozano and Marina Romaní-Pérez

submission deadline 30 Aug 2026 | Viewed by 415 | Submission Open

Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence and Machine Learning Empower Synthetic and Systems Biology: Theory, Design, Optimization and Application

edited by

Pasquale Stano

and

Jian Xu

submission deadline 30 Aug 2026 | Viewed by 264 | Submission Open

Keywords: AI (artificial intelligence); AI driven drug discovery; automated laboratory platforms; basic and applied science; bioengineering; biological exploration; biological network analysis; complex systems; computational genomics; computational modeling; data driven biology; deep learning; design automation; digital twins in biology; evolutionary design algorithms; gene editing; genetic circuit design; machine learning; metabolic engineering; multi omics integration; predictive biology; protein structure prediction; systems bioinformatics

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition

edited by

Elżbieta Janina Płuciennik

Żaneta Kałuzińska-Kołat

and

Damian Kołat

submission deadline 31 Aug 2026 | 5 articles | Viewed by 11688 | Submission Open

Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment

(This special issue belongs to the Section Medical Research)

Advances in Biomedical Frontier Technologies and Disease Diagnosis

edited by

Alexey Yaremenko

submission deadline 31 Aug 2026 | 2 articles | Viewed by 6014 | Submission Open

Keywords: nanomedicine ; biomaterials ; gene therapy ; drug delivery ; bacteriotherapy ; nanobiotechnology ; hereditary diseases ; bioinformatics ; personalized medicine ; smart biomaterials

(This special issue belongs to the Section Medical Research)

Musculoskeletal Function and Exercise Physiology: Integrative Approaches and Emerging Insights

edited by

Robert Smith

Tyler Neltner

Dimitrije Cabarkapa

and Luke Chowning

submission deadline 31 Aug 2026 | 4 articles | Viewed by 5777 | Submission Open

Keywords: resistance exercise; aerobic exercise; sport performance; neuromuscular; electromyography; muscle function; kinematics; kinetics; biomechanics; motion analysis; imaging techniques; muscle biopsy

(This special issue belongs to the Section Medical Research)

Regulation of Cellular Signaling Pathways in the Metabolic Syndrome

edited by Robert H. Newman and Danielle L. Schmitt

submission deadline 31 Aug 2026 | 4 articles | Viewed by 5447 | Submission Open

Keywords: metabolic syndrome (MetS); cellular signaling pathways; insulin signaling and resistance; nutrient-sensing pathways; inflammation and immune signaling

(This special issue belongs to the Section Physiology and Pathology)

Intensive Care Medicine: Current Concepts and Future Perspectives

edited by Shinichi Watanabe

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3741 | Submission Open

Keywords: intensive care; early mobilization; sepsis; mechanical ventilation; rehabilitation; artificial intelligence; PICS; multidisciplinary collaboration

(This special issue belongs to the Section Medical Research)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3146 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Conservation Ecology and Management of Mammalian Predators

edited by

Sándor Csányi

and

Miklós Gábor Heltai

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2420 | Submission Open

Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions

(This special issue belongs to the Section Animal Science)

Research on Glaucoma Diseases

edited by

Nicoleta Anton

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2249 | Submission Open

Keywords: glaucoma diseases; new technology; artificial intelligence in ophthalmology; gene therapy in glaucoma; new devices; artificial drainage systems

(This special issue belongs to the Section Medical Research)

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1621 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Innovations in Nuclear Medicine and Molecular Imaging

edited by

Christian Kühnel

and

Yiannis Parpottas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 915 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; theranostics; quantitative imaging; artificial intelligence; dosimetry; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition

edited by

Dan Mircea Olinic

and

Agata Stanek

submission deadline 31 Aug 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: vascular diseases; etiology; diagnosis; prognosis; therapy

(This special issue belongs to the Section Medical Research)

Research Advances in Wetland Ecology

edited by

Yuxiang Yuan

and

Yunlong Yao

submission deadline 31 Aug 2026 | Viewed by 265 | Submission Open

Keywords: wetland; restoration; function; plant; algae; lake eutrophication; interspecific relationship; biogeochemical cycling; climate change

(This special issue belongs to the Section Diversity and Ecology)

Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment

edited by

Stefanos Roumeliotis

submission deadline 31 Aug 2026 | Viewed by 250 | Submission Open

Keywords: chronic kidney disease; end stage kidney disease; hemodialysis; peritoneal dialysis; mitochondria; oxidative stress; vascular calcification

(This special issue belongs to the Section Medical Research)

Cellular and Molecular Biology Behind Human Cognition

edited by

Simone Battaglia

and Masaru Tanaka

submission deadline 31 Aug 2026 | Viewed by 231 | Submission Open

Keywords: cognitive biology; synaptic and cellular plasticity; non-invasive brain stimulation techniques; synaptic and circuit plasticity; cognitive resilience; biomarkers of cognitive function; neuroinflammation and neurodegeneration; translational neuroscience; neuroplasticity; precision medicine: biomarkers; neurochemical

(This special issue belongs to the Section Physiology and Pathology)

Molecular Regulation of Fruit Development in Solanaceous Crops: From Genes to Phenotypes

edited by

Han Xiao

, Wencai Yang and Ruohe Yin

submission deadline 31 Aug 2026 | Viewed by 225 | Submission Open

Keywords: Solanaceous crops; fruit development; omics; genetics; phenotype

(This special issue belongs to the Section Plant Science)

Progress in Rehabilitation Interventions for Heart Failure

edited by

João Morais

, Jhonatan Betancourt-Peña, Iago Portela and Mauricio Hernández-Carrillo

submission deadline 31 Aug 2026 | Viewed by 222 | Submission Open

Keywords: heart failure; rehabilitation; exercise; interdisciplinary; telerehabilitation

(This special issue belongs to the Section Medical Research)

Protein Structure and Engineering: From Folding Cages to Functional Assemblies

edited by

Delia Picone

Giarita Ferraro

and

Rosanna Lucignano

submission deadline 31 Aug 2026 | Viewed by 210 | Submission Open

Keywords: protein structure; self-assembly; functional assemblies; protein engineering; protein– protein interaction; biomaterials; building blocks; biotechnological applications

(This special issue belongs to the Section Proteins and Proteomics)

Molecular Pathways Shaping Head and Neck Cancer Care

edited by

Albert Yoon-Kyu Han

submission deadline 31 Aug 2026 | Viewed by 209 | Submission Open

Keywords: head and neck cancer; molecular pathways; tumor microenvironment; precision oncology; translational research

(This special issue belongs to the Section Medical Research)

The Biochemistry of Venoms: Exploring Molecular Diversity, Structural Mechanisms, and Their Biotechnological Uses

edited by

Malson Neilson Lucena

and Ludovico Migliolo

submission deadline 31 Aug 2026 | Viewed by 199 | Submission Open

Keywords: biochemistry of venoms; venomics; diversity of toxins; mechanism of action; bioprospecting

(This special issue belongs to the Section Pharmaceutical Science)

Management of Inflammatory Airway Diseases

edited by

Diego Bagnasco

and

Benedetta Bondi

submission deadline 31 Aug 2026 | Viewed by 197 | Submission Open

Keywords: inflammatory airway diseases; asthma; EGPA; COPD; chronic rhinosinusitis; biomarkers; biologics; treatable traits; precision medicine

(This special issue belongs to the Section Medical Research)

A Paradigm Shift in Airway and Pain Management—3rd Edition

edited by

Jui An Lin

submission deadline 31 Aug 2026 | Viewed by 197 | Submission Open

Keywords: airway management; difficult airway; video intubating stylet; pain management; ultrasonography; motor-sparing strategies; nerve block; regenerative medicine; transarterial embolization for pain management; joint denervation for pain management; rTMS (repetitive transcranial magnetic stimulation); central post-stroke pain; neuromodulation

(This special issue belongs to the Section Medical Research)

Translational Advances in Postoperative Pain: From Mechanisms to Clinical Application

edited by

Sau Ching Stanley Wong

and Boya Liao

submission deadline 31 Aug 2026 | Viewed by 193 | Submission Open

Keywords: postoperative pain; perioperative medicine; chronic postsurgical pain; multimodal analgesia; neu-romodulation; inflammation and pain; opioid sparing strategies; translational pain research; chronic postsurgical pain; persistent opioid use

(This special issue belongs to the Section Medical Research)

Innovations in the Diagnosis and Treatment of Inflammatory Bowel Disease

edited by Aldona Wierzbicka-Rucinska

submission deadline 31 Aug 2026 | Viewed by 186 | Submission Open

Keywords: inflammatory bowel disease (IBD); molecular and imaging diagnostics; personalized treatment approaches; precision medicine; pharmacological and biologic therapies; pathophysiology

(This special issue belongs to the Section Medical Research)

Myeloproliferative Neoplasms: From Biology to Practice

edited by Adrian Duek

submission deadline 31 Aug 2026 | Viewed by 166 | Submission Open

Keywords: polycythemia vera; essential thrombocythemia; primary myelofibrosis; JAK2 V617F; calreticulin; MPL; next-generation sequencing; risk factor scores

(This special issue belongs to the Section Medical Research)

Diagnosis, Treatment and Prognosis of Head and Neck Disorders

edited by

Geng-He Chang

submission deadline 31 Aug 2026 | Viewed by 160 | Submission Open

Keywords: head and neck disorders ; head and neck cancer ; otolaryngology ; diagnostic imaging and endoscopy ; targeted therapy and immunotherapy ; biomarkers and molecular pathology ; precision medicine ; prognostic models and outcomes ; translational research

(This special issue belongs to the Section Medical Research)

Nutritional Value and Stress Tolerance Mechanisms in Legume Crops

edited by Carlos Pimentel

submission deadline 31 Aug 2026 | Viewed by 151 | Submission Open

Keywords: water stress; temperature; salinity; heavy metals; stress adaptation; biological nitrogen fixation; grain quality; yield

(This special issue belongs to the Section Plant Science)

Novel Insights into Stress and Nutritional Regulation in Animals

edited by Hao-Yang Sun,

Qi-Ye Wang

, Zhan-Wei Teng and Xiao Liu

submission deadline 1 Sep 2026 | Viewed by 257 | Submission Open

Keywords: stress; nutrition; resilience; gut– X axis; microbiome; precision nutrition; multi-omics

(This special issue belongs to the Section Animal Science)

New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases: 2nd Edition

edited by

Zhihong (Jewel) Hu

submission deadline 1 Sep 2026 | Viewed by 146 | Submission Open

Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA

(This special issue belongs to the Section Medical Research)

Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition

edited by

Stefano Canosa

and

Anna Maria Nuzzo

submission deadline 15 Sep 2026 | 3 articles | Viewed by 1139 | Submission Open

Keywords: obstetrics; gynecology; translational research; translational medicine

(This special issue belongs to the Section Medical Research)

Plants: Emerging Bio-Manufacturing Chassis for Bioactive Molecules

edited by

Jianfeng Xu

submission deadline 15 Sep 2026 | Viewed by 212 | Submission Open

Keywords: plant biotechnology; metabolic engineering; secondary metabolite; recombinant proteins; synthetic biology; biopharmaceuticals; plant cell culture; molecular farming

(This special issue belongs to the Section Plant Science)

Sleep-Disordered Breathing: Cardiovascular Vulnerability

edited by Ravi S. Aysola

submission deadline 15 Sep 2026 | Viewed by 117 | Submission Open

Keywords: sleep-disordered breathing; obstructive sleep apnea; cardiovascular disease; autonomic nervous system; ventilatory control; intermittent hypoxia; cardiopulmonary coupling; hypertension

(This special issue belongs to the Section Medical Research)

Bioactive Natural Products: From Exploration to Therapeutic Potential

edited by

Shivankar Agrawal

and

Laurent Dufossé

submission deadline 16 Sep 2026 | 1 articles | Viewed by 1435 | Submission Open

Keywords: secondary metabolites; in vivo/in vitro biological activity; structural elucidation; molecular modeling studies; natural pigment

(This special issue belongs to the Section Pharmaceutical Science)

Immune Reset and Renal Recovery: Novel Insights into Kidney Inflammation and Repair

edited by Mohanraj Sadasivam

submission deadline 17 Sep 2026 | Viewed by 537 | Submission Open

Keywords: renal immunopathology; immune reset; CAR-T-cell therapy; B-cell depletion; mRNA therapies; autoimmune kidney disease; lupus nephritis; T-cell tolerance; kidney inflammation; renal regeneration

(This special issue belongs to the Section Medical Research)

Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare

edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura

submission deadline 18 Sep 2026 | 9 articles | Viewed by 17197 | Submission Open

Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19

(This special issue belongs to the Section Pharmaceutical Science)

Gastrointestinal Health: Clinical Research and Therapeutic Innovations—2nd Edition

edited by

Ludovico Abenavoli

and

Giuseppe Guido Maria Scarlata

submission deadline 18 Sep 2026 | 5 articles | Viewed by 3244 | Submission Open

Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence

(This special issue belongs to the Section Medical Research)

Gynecology Update: Modern Diagnostic Approaches and Innovative Therapies

edited by Szabolcs Várbíró,

Keszthelyi Márton

, Richárd Tóth and Balázs Lintner

submission deadline 20 Sep 2026 | 6 articles | Viewed by 6986 | Submission Open

Keywords: gynecologic oncology; endocrinology; reproductive medicine; fertility preservation; prevention; women’ s health innovation; quality of life; personalized therapy

(This special issue belongs to the Section Medical Research)

Displaying special issue 151-200 on page 4 of 9.

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