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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Vessel to Muscle—an Integrative Approach to Ischemic Heart Disease

edited by

Irina Iuliana Costache Enache

Ciprian Rezus

and

Minerva Codruta Badescu

submission deadline 15 Oct 2026 | 2 articles | Viewed by 3984 | Submission Open

Keywords: ischemic heart disease; atherosclerotic plaque features; microvascular dysfunction; coronary vasospasm; percutaneous transluminal coronary angioplasty; coronary artery bypass grafting; cardiac magnetic resonance imaging; coronary computed tomography angiography

(This special issue belongs to the Section Physiology and Pathology)

Outlook for Cerebrovascular Damage Research

edited by Ane Claudia Fernandes Nunes

submission deadline 15 Oct 2026 | 1 articles | Viewed by 2547 | Submission Open

Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood–brain barrier; small vessel disease

(This special issue belongs to the Section Physiology and Pathology)

Point-of-Care Ultrasound (POCUS) in Nephrology

edited by Abhilash Koratala, Gregorio Romero-González and Aala Jaberi

submission deadline 16 Oct 2026 | Viewed by 306 | Submission Open

Keywords: point-of-care ultrasound; nephrology; doppler ultrasound; venous congestion; cardiorenal syndrome; volume assessment; acute kidney injury; dialysis

(This special issue belongs to the Section Medical Research)

Advances in Vascular Medicine: From Endovascular Innovations to Pathophysiological Insights

edited by

Edit Dósa

submission deadline 17 Oct 2026 | 4 articles | Viewed by 4618 | Submission Open

Keywords: endovascular therapy; vascular pathophysiology; intravascular imaging; atherosclerosis; precision vascular medicine

(This special issue belongs to the Section Medical Research)

2nd Edition—Food Microbiological Contamination

edited by

Sara Primavilla

and

Rossana Roila

submission deadline 18 Oct 2026 | 3 articles | Viewed by 3735 | Submission Open

Keywords: food safety; food microbiology; foodborne pathogens; food spoilage; food quality; food contamination; microbiological hazards; natural antimicrobials

(This special issue belongs to the Section Microbiology)

Antimicrobial Resistance as a Dynamic System: Behavior and Ecology from Pathogens to Populations

edited by

Kwabena O. Duedu

Jean Ralph Zahar

and

Eric Sampane-Donkor

submission deadline 18 Oct 2026 | 1 articles | Viewed by 515 | Submission Open

Keywords: antimicrobial resistance (AMR); environmental microbiology; epidemiology; phenotypic plasticity; microbial ecology; resistance dynamics; pathogen behavior

(This special issue belongs to the Section Microbiology)

Novel Liquid Biopsy Biomarkers and Multi-Omic Integration in Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 20 Oct 2026 | 1 articles | Viewed by 5825 | Submission Open

Keywords: liquid biopsy; metabolic diseases; cell-free DNA; extracellular vesicles; multi-omics; biomarkers; epigenetics; machine learning; NAFLD

(This special issue belongs to the Section Medical Research)

Advanced Interventions in Diabetic Foot Ulcers

edited by

Florin Teodor Bobirca

Octavian Mihalache

and Petronel Mustatea

submission deadline 20 Oct 2026 | 1 articles | Viewed by 698 | Submission Open

Keywords: diabetic foot; gangrene; ulcer; peripheral arterial disease; peripheral neuropathy; Charcot foot; negative pressure

(This special issue belongs to the Section Medical Research)

Animal Reproduction and Health

edited by

Rachel Moxon

and

Ana Faustino

submission deadline 28 Oct 2026 | 4 articles | Viewed by 8678 | Submission Open

Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development

(This special issue belongs to the Section Animal Science)

Research Progress in Kidney Diseases

edited by Ane Claudia Fernandes Nunes

submission deadline 30 Oct 2026 | 10 articles | Viewed by 22976 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; hemodialysis; nephrology; renal failure; hypertension; diabetes; molecular genetics

(This special issue belongs to the Section Physiology and Pathology)

New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease: 2nd Edition

edited by

Laura Patton

and

Guido Gabriele

submission deadline 30 Oct 2026 | 5 articles | Viewed by 18046 | Submission Open

Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain

(This special issue belongs to the Section Medical Research)

Allergies and Allergic Diseases—Perspectives in Diagnosis and Management: 2nd Edition

edited by

Kinga Lis

submission deadline 30 Oct 2026 | 6 articles | Viewed by 10822 | Submission Open

Keywords: allergy; anaphylaxis; cross-allergies; IgE; exercise-induced anaphylaxis; component-resolved diagnosis

(This special issue belongs to the Section Medical Research)

Gut Microbes Associating with the Host

edited by

Jianmin Chai

and

Kun Li

submission deadline 30 Oct 2026 | 3 articles | Viewed by 9075 | Submission Open

Keywords: gut microbes; microbiome; animals; nutrition

(This special issue belongs to the Section Microbiology)

Encephalitis: From Molecular Pathophysiology to Therapy

edited by Anna Tröscher and Judith Wagner

submission deadline 30 Oct 2026 | 5 articles | Viewed by 7572 | Submission Open

Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Physiology and Pathology)

Organ Predilection of Certain Gastrointestinal Diseases—Pathophysiology, Diagnosis and Management

edited by

Monjur Ahmed

submission deadline 30 Oct 2026 | 2 articles | Viewed by 6724 | Submission Open

Keywords: disease predilection in gastrointestinal tract; esophagus with certain diseases; stomach with certain diseases; duodenum with certain diseases; jejunum with certain diseases; ileum with certain diseases; colorectum with certain diseases

(This special issue belongs to the Section Physiology and Pathology)

Extremophiles Breakthrough: Hot Topics and Current Issues in Their Isolation, Identification and Biotechnological Applications—2nd Edition

edited by

Martina Aulitto

Giovanni Gallo

and

Emanuela Maresca

submission deadline 30 Oct 2026 | 1 articles | Viewed by 2918 | Submission Open

Keywords: astrobiology; biochemistry and molecular biology; biodiversity and ecology; biotechnology; extraterrestrial analogs; extreme environments; extremophiles; genetics, genomics, and proteomics; origin of life; phylogeny and evolution; physiology and metabolism

(This special issue belongs to the Section Microbiology)

Artificial Intelligence in Head and Neck Cancer Radiotherapy and Imaging

edited by Elias Liolis and

Admir Mulita

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1732 | Submission Open

Keywords: head and neck cancer; treatment planning; radiotherapy; oral cavity cancer; PET-CT imaging

(This special issue belongs to the Section Medical Research)

New Treatment Options for Metastatic Non-Small Cell Lung Cancer and Gastrointestinal Cancer

edited by Lydia Meder and Anna M. Dmitrieva

submission deadline 30 Oct 2026 | 2 articles | Viewed by 1402 | Submission Open

Keywords: non-small cell lung cancer; gastrointestinal cancer; metastasis; molecular mechanisms; targeted therapy; immunotherapy; chemotherapy; vaccines; cancer treatment

(This special issue belongs to the Section Medical Research)

CKD and Glomerular Diseases

edited by Ina Maria Kacsò

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1250 | Submission Open

Keywords: chronic kidney disease (CKD); end-stage renal disease; glomerular diseases; CKD progression; renal replacement therapies

(This special issue belongs to the Section Medical Research)

Coagulation and Its Disorders: Diagnostics, Therapeutics, and Clinical Management

edited by

Anna Lisa Montemari

submission deadline 30 Oct 2026 | Viewed by 478 | Submission Open

Keywords: coagulation; bleeding disorders; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammation and coagulation disorders; thrombosis; platelet disorders; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

Metabolic Reprogramming in Cancers: Vulnerabilities and Therapeutic Exploitation

edited by Sonja Ludwig, Priyanka Sharma, Subrata Kumar Pore and Anjali Bhat

submission deadline 30 Oct 2026 | Viewed by 205 | Submission Open

Keywords: Cancer metabolism; metabolic reprogramming; tumor microenvironment; glycolysis; glutamine metabolism; mitochondrial metabolism; lipid metabolism; oncometabolites; ferroptosis; immunometabolism; metabolic inhibitors; therapeutic targeting; precision oncology; systems metabolomics

(This special issue belongs to the Section Physiology and Pathology)

Plant Virus-Host Interactions: From Pathogenesis to Integrated Disease Management

edited by

Xuefeng Yuan

and Chengming Yu

submission deadline 30 Oct 2026 | Viewed by 199 | Submission Open

Keywords: plant viruses; viral pathogenesis; host factor; disease management; viral variety; fitness; virus or viroid-induced gene silencing; genome editing; next-generation sequencing; microarray profiling; recombinant DNA technology; transgenic plants; insect vectors; molecularly assisted breeding for resistance

(This special issue belongs to the Section Plant Science)

Innovative Applications of Extracellular Vesicles: From Diagnostics to Drug Delivery

edited by

Alessandra Lo Cicero

submission deadline 31 Oct 2026 | 6 articles | Viewed by 22064 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers; diagnostics; cell-cell communication; drug delivery; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment—4th Edition

edited by

Mariana Floria

Daniela Maria Tanase

and

Anca Trifan

submission deadline 31 Oct 2026 | 10 articles | Viewed by 10639 | Submission Open

Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steatohepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases

(This special issue belongs to the Section Physiology and Pathology)

Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions

edited by

Yung-Li Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 6992 | Submission Open

Keywords: microplastics; nanomaterials; environmental toxicology; oxidative stress; physiological function

(This special issue belongs to the Section Physiology and Pathology)

Recent Trends in Prebiotic Chemistry

edited by Maheen Gull

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5749 | Submission Open

Keywords: early earth; prebiotic chemistry; meteorites; molecules of life; phosphorylation; challenges in prebiotic chemistry; chirality; condensation; wet–dry cycles; RNA world; hydrothermal systems; mineral catalysis

(This special issue belongs to the Section Origins of Life)

The Management and Prognosis of Open-Angle Glaucoma

edited by

Nicoleta Anton

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4901 | Submission Open

Keywords: open-angle glaucoma; cataracts; visual impairment

(This special issue belongs to the Section Medical Research)

The Role of Mitochondrial Function in Cancer and Diseases and Therapeutic Explorations

edited by

Amer Ahmed

and

Barbara Illi

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4701 | Submission Open

Keywords: cancer metabolism; mitochondrial DNA (mtDNA) mutations; oxidative stress; mitophagy and autophagy; mitochondria-targeted therapy; metabolic reprograming; mitochondrial dynamics (fusion and fission); redox biology

(This special issue belongs to the Section Physiology and Pathology)

Advancing Cancer Radiodiagnostics Through Artificial Intelligence: Techniques, Applications, and Challenges

edited by Pei-Ju Chao,

Tsair-Fwu Lee

Peter Elkin

and

Roberto Iezzi

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3466 | Submission Open

Keywords: artificial intelligence; cancer radiodiagnostics; machine learning; tumor detection; radiomics integration

(This special issue belongs to the Section Medical Research)

Thrombosis and Blood Disorders: Mechanisms and Management

edited by

Robert Maitta

and Miriam Andrea Duque

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3411 | Submission Open

Keywords: platelet; hemostasis; anemia; toll-like receptor; immunity; phagocytosis; transfusions; thrombosis; proliferation; coagulopathy; hemorrhage; Von Willebrand factor; thrombocyte

(This special issue belongs to the Section Medical Research)

Insect Taxonomy in the Era of Mitogenomics

edited by

Josip Skejo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2385 | Submission Open

Keywords: mitochondrial genomes; mitogenomes; entomology; phylogenetic; taxonomy; mitogenomic sequencing

(This special issue belongs to the Section Biodiversity, Ecology and Evolution)

Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure

edited by

Chun-Chao Chen

Wen-Rui Hao

and

Ju-Chi Liu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2173 | Submission Open

Keywords: heart failure; biomarkers; molecular mechanisms

(This special issue belongs to the Section Physiology and Pathology)

The Roles and Regulation of RECK in Cell Behavior, Animal Development, and Diseases

edited by

Makoto Noda

and

David B. Alexander

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1674 | Submission Open

Keywords: cancer; metastasis; cell migration; angiogenesis; neurogenesis; extracellular matrix; disease models

(This special issue belongs to the Section Physiology and Pathology)

Mechanisms and Ecology of Migration and Homing

edited by Hynek Burda

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1594 | Submission Open

Keywords: migration; homing; navigation; spatial orientation; magnetoreception; cognitive maps; seasonality; spatial memory

(This special issue belongs to the Section Biodiversity, Ecology and Evolution)

Management of Endocrine Disorders: Current Insights and Future Directions

edited by

Carmine Bruno

and

Emanuela Traini

submission deadline 31 Oct 2026 | 3 articles | Viewed by 1270 | Submission Open

Keywords: precision medicine; thyroid cancer; andrology; metabolism; obesity

(This special issue belongs to the Section Medical Research)

Objective Tools to Aid the Diagnosis and Treatment of Neurodevelopmental Disorders

edited by

Maria Pia Bucci

submission deadline 31 Oct 2026 | 1 articles | Viewed by 1122 | Submission Open

Keywords: intervertion training ; eye tracker ; dyslexia ; postural sways ; reading ; ASD ; ADHD ; attention ; emotion

(This special issue belongs to the Section Medical Research)

Machine Learning for Biomedical and Clinical Informatics: From Data-Driven Methods to Translational Medical Research

edited by

Balu Bhasuran

and Kalpana Raja

submission deadline 31 Oct 2026 | 1 articles | Viewed by 690 | Submission Open

Keywords: biomedical informatics; translational medical research; clinical informatics; causal inference in health data; machine learning in healthcare; electronic health records (EHR); natural language processing; large language models; artificial intelligence in medicine; explainable and trustworthy AI

(This special issue belongs to the Section Medical Research)

Brain Function and Neuroimaging: From Disease to AI

edited by

Ming-Chang Chiang

and

Chiahui Yen

submission deadline 31 Oct 2026 | 1 articles | Viewed by 670 | Submission Open

Keywords: neuroimaging; brain functions; neurological diseases; AI; deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Pharmacotherapy in Critical Care: Clinical Insight and Emerging Strategy

edited by

Caterina Aurilio

submission deadline 31 Oct 2026 | Viewed by 520 | Submission Open

Keywords: sepsis; multidrug resistance; extracorporeal treatments; intracranial hypertension; immunomodulation; organ support; precision medicine; intensive care pharmacology

(This special issue belongs to the Section Medical Research)

Back to Basics in Palaeontology: 2nd Edition

edited by Hua Stephane

submission deadline 31 Oct 2026 | Viewed by 453 | Submission Open

Keywords: fundamentals; natural history; multidisciplinarity; firsthand bibliography; actualism

(This special issue belongs to the Section Paleobiology)

Artificial Intelligence and Deep Learning Models for Human Diseases Diagnosis and Prediction

edited by

Mobarak I. Hoque

Long Bai

and Shilong Yao

submission deadline 31 Oct 2026 | Viewed by 292 | Submission Open

Keywords: artificial intelligence in medicine; clinical decision support; medical imaging; precision medicine; healthcare innovation; trustworthy AI; healthcare analytics; predictive modeling; digital health

(This special issue belongs to the Section Medical Research)

Precision Approaches in Solid Tumor Oncology: From Molecular Pathways to Therapy Response

edited by

Cristina Díaz del Arco

and Luís Ortega-Medina

submission deadline 31 Oct 2026 | Viewed by 270 | Submission Open

Keywords: biomarkers; histology; immunohistochemistry; solid tumors; precision oncology; therapy response

(This special issue belongs to the Section Medical Research)

Poultry Nutrition and Gut Microbiota Health

edited by

Ala Abudabos

submission deadline 31 Oct 2026 | Viewed by 229 | Submission Open

Keywords: gut health; microbiota; necrotic enteritis; coccidiosis; immunity; poultry; natural additives

(This special issue belongs to the Section Animal Science)

Pathological Mechanisms of Heart Failure with Preserved Ejection Fraction

edited by

Mei Methawasin

and Erik Blackwood

submission deadline 31 Oct 2026 | Viewed by 229 | Submission Open

Keywords: diastolic dysfunction; microvascular inflammation; sarcomere dysfunction; cytoskeletal alteration; mitochondrial dysfunction; oxidative stress; immunometabolic remodeling; calcium handling dysregulation; protein quality control; post translational modification; epigenetic regulation; systemic inflammation; inter-organ crosstalk; cardiometabolic–kidney disease; cellular senescence

(This special issue belongs to the Section Physiology and Pathology)

Pathogenesis, Diagnosis and Therapy of Complex Pediatric Sinonasal and Skull Base Lesions

edited by Vijay Patel, Jillian Plonsker and Michael Levy

submission deadline 31 Oct 2026 | Viewed by 207 | Submission Open

Keywords: pediatric; skull base; endoscopy; interventional visualization

(This special issue belongs to the Section Medical Research)

Environmental and Microbial Stressors in Neuronal Dysfunction: Mechanistic Insights

edited by

Ovidiu Dumitru Ilie

and Adriana Petrovici

submission deadline 31 Oct 2026 | Viewed by 180 | Submission Open

Keywords: experimental neurotoxicology; neuropsychiatric disorders; neurotrophin signaling; BDNF–Trk pathway; oxidative stress; gut–brain axis; microbiota–brain interactions; toxicant-induced neuronal dysfunction; zebrafish (Danio rerio) model; rodent models; behavioral phenotyping; brain histopathology

(This special issue belongs to the Section Physiology and Pathology)

Molecular Epidemiology and Evolution of Pathogenic Viruses

edited by

Yoshiyuki Suzuki

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: molecular epidemiology; molecular evolution; pathogenic virus; antigenicity; phylogeny; mutation; recombination; reassortment; natural selection; interspecies transmission

(This special issue belongs to the Section Epidemiology)

Advances in Research on Phytohormones

edited by

Kincső Decsi

submission deadline 1 Nov 2026 | Viewed by 695 | Submission Open

Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses

(This special issue belongs to the Section Plant Science)

Gut Microbiome and Neurodegenerative Disease

edited by Scott A. Jackson and

Leigh A. Frame

submission deadline 15 Nov 2026 | Viewed by 321 | Submission Open

Keywords: gut microbiome; gut–brain axis; neurodegenerative disease; Alzheimer’s disease; Parkinson’s disease; microbiota–host interactions; microbial metabolites; blood–brain barrier; enteric nervous system; vagus nerve signaling; dysbiosis; metagenomics; multi-omics; microbiome biomarkers; translational microbiome research

(This special issue belongs to the Section Physiology and Pathology)

Immunopathology of Oral Mucosal Disease

edited by Dinko Martinovic

submission deadline 15 Nov 2026 | Viewed by 180 | Submission Open

Keywords: immunopathology; immune dysfunction; oral mucosal diseases; oral squamous cell carcinoma; oral potentially malignant disorders; oral lichen planus; recurrent aphthous stomatitis

(This special issue belongs to the Section Physiology and Pathology)

Displaying special issue 151-200 on page 4 of 9.

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