Molecular Mechanisms and Function Impact of Protein Modifications
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Proteins and Proteomics".
Deadline for manuscript submissions: 15 July 2025 | Viewed by 185
Special Issue Editor
Interests: angiogenesis; methionine aminopeptidases; protein processing; protein modifications; proteomics; cancer therapy; development of novel diagnostic technologies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over 650 types of protein modifications have been identified, including removal of N-terminal methionine, acetylation, methylation, phosphorylation, ubiquitination, glycosylation, lipidation, and many others. These biological events greatly expand the functional diversity of the proteome and play crucial roles in regulating cellular processes. They can alter protein conformation, localization, activity, stability, and interactions with other biomolecules. Most of these modifications are reversible and dynamically regulated by enzymes that add or remove the modifications. Dysregulation of these modifications can lead to various diseases.
This Special Issue will include research on the molecular mechanisms underlying the biological activities of the enzymes involved in protein modifications, the crosstalk between these modification processes, new approaches for identifying and quantifying modifications, the links between modification processes and human disease outcomes, and innovative strategies for selectively interfering with these processes. We welcome the submission of original research (basic research or clinical research) and review manuscripts that meet this Special Issue's goals.
Dr. Yie Hwa Chang
Guest Editor
Manuscript Submission Information
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Keywords
- protein modifications
- enzyme regulation
- proteomics and functional
- diversity disease mechanisms
- diagnostic and therapeutic strategies
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