Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 13 February 2026 | Viewed by 1213
Special Issue Editor
2. Research Center for Sport Physiology, Hungarian University of Sports Science, Budapest, Hungary
3. Department of Physiology, New York Medical College, Valhalla, NY, USA
Interests: regulation of cerebral blood flow in heath and diseased conditions
Special Issue Information
Dear Colleagues,
Optimal cerebrovascular perfusion is vital for maintaining healthy brain function. This complete task is achieved by different and appropriate mechanisms regulating the resistance of various extracranial and intracranial vessels, such as arteries, arterioles, and even venules.
One of the specific attributes of cerebral circulation is its well-developed autoregulation. This tight control of cerebral blood flow (CBF) is crucial to maintaining a relatively constant blood supply of the brain, as well as intracranial blood volume, and at the same time to comply with the limited space available in the skull.
Thus, small intracranial cerebral arteries have a well-developed constrictor function. On the other hand, this limitation does not affect extracranial arteries, allowing them to dilate freely, thus providing increased blood flow to the brain. Hemodynamic forces play an important role in the autoregulation of CBF, as previous studies have established that it is achieved by pressure- and flow-sensitive vasomotor mechanisms. In addition to these, other cellular, metabolic, and neural factors also play important roles in enabling brain tissues to control cerebrovascular resistance and thus blood supply, mechanisms collectively called neurovascular coupling.
In diseased conditions, such as hypertension, diabetes, pre-eclampsia, traumatic brain injury, aging, etc., these mechanisms can become impaired, leading to stroke, micro-bleeding, edema, Alzheimer-like dementia, and so on.
Many of the underlying molecular and functional pathomechanisms are still unresolved; thus, both basic and clinical research are needed to elucidate them.
We invite the submission of manuscripts to this Special Issue that will contribute to improving our understanding of the mechanisms responsible for the appropriate supply and autoregulation of cerebral blood flow and reveal the pathomechanisms responsible for disease relate conditions fostering the development of appropriate preventions and therapies.
Dr. Akos Koller
Guest Editor
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Keywords
- cerebral blood flow
- hemodynamic forces
- cerebrovascular resistance
- endothelium
- smooth muscle
- arachidonic acid metabolites
- reactive oxygen species
- molecular mediators
- protein and mRNA expressions
- brain disease conditions
- transcranial Doppler measurement
- EEG
- lifestyle
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