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Life
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Advances in Endovascular Therapies and Acute Stroke Management
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Advances in Endovascular Therapies and Acute Stroke Management

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 451

Special Issue Editor

Dr. Anna Podlasek

E-Mail Website
Guest Editor
Image Guided Therapy and Research Facility (IGTRF), University of Dundee, Dundee DD1 4HN, UK
Interests: stroke
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the latest innovations and clinical advancements in the intersection of endovascular medicine and acute stroke care. Endovascular therapies have revolutionized the management of acute ischemic stroke by providing rapid and minimally invasive interventions that restore blood flow and significantly improve patient outcomes.

This Special Issue’s scope is broad yet focused, aiming to cover cutting-edge research and practical strategies in the following areas:

  • Novel Endovascular Techniques: Development and optimization of mechanical thrombectomy devices, stent retrievers, and aspiration catheters;
  • Advanced Imaging and Biomarkers: Utilization of CT, MRI, and angiography for patient selection, procedural guidance, and treatment evaluation;
  • Emerging Technologies and Reperfusion Strategies: Exploration of innovative tools and therapies to enhance stroke intervention outcomes;
  • Integration of Therapies: Combining endovascular procedures with systemic treatments, such as thrombolytics, to maximize therapeutic effects;
  • Clinical Strategies in Acute Stroke Care: Multidisciplinary approaches to streamline workflows, reduce delays, and improve treatment accessibility;
  • Patient Outcomes and Long-Term Management: Evaluating functional recovery, recurrence prevention, and quality of life after endovascular interventions.

We welcome submissions that contribute to our understanding and refinement of endovascular stroke therapies, including original research and reviews.

This Special Issue offers an opportunity to advance this field by showcasing novel insights, multidisciplinary collaborations, and future directions in acute stroke management.

Dr. Anna Podlasek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanical thrombectomy
  • endovascular reperfusion
  • stroke intervention technologies
  • acute ischemic stroke treatment
  • stroke imaging biomarkers

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

17 pages, 723 KiB  
Article
Outcome Predictor Differences in Infratentorial and Supratentorial Ischemic Stroke
by Manuel Bolognese, Mareike Österreich, Martin Müller, Alexander von Hessling, Grzegorz Marek Karwacki and Lehel-Barna Lakatos
Life 2025, 15(4), 633; https://doi.org/10.3390/life15040633 - 10 Apr 2025
Viewed by 253
Abstract
Acute ischemic stroke outcomes depend on various factors. We investigated whether the outcome-relevant factor (ORF) profiles differ between different vascular territories and different therapeutic strategies. In this retrospective study, we analyzed 410 comprehensive stroke center patients [median age of 70 years (IQR 57–80), [...] Read more.
Acute ischemic stroke outcomes depend on various factors. We investigated whether the outcome-relevant factor (ORF) profiles differ between different vascular territories and different therapeutic strategies. In this retrospective study, we analyzed 410 comprehensive stroke center patients [median age of 70 years (IQR 57–80), 125 women (30%)] by analyzing five groups: all patients, patients with infratentorial infarctions only (n = 80), all patients with supratentorial infarctions (n = 330), patients with supratentorial infarctions without (n = 269), and with mechanical thrombectomy (n = 61). Outcomes were classified with the modified Rankin scale as ≤2 (good) or >2 (poor) after three months. The patient group with infratentorial strokes was compared to the group of patients with supratentorial strokes using the Kruskal–Wallis test or chi-squared statistics. Within each of the five stroke groups, univariate logistic regression analysis was used to identify the ORF of a poor outcome; if more than one ORF was identified, all identified factors were included in one multinomial logistic regression analysis model. Compared to the patients with supratentorial strokes, the patients with infratentorial stroke exhibited a less severe neurological deficit at entry and lower rates of ischemic heart disease, thrombolytic intervention, and cardio-embolism but a higher rate of large vessel disease. After multinomial logistic regression analysis, a poor outcome in the infratentorial group was associated with atrial fibrillation [odds ratio (OR) 13.73 (95% confidence interval 1.05–181.89), p = 0.04], estimated glomerular filtration rate [OR 0.96 (0.91–0.99)], p = 0.02], and marginally with diabetes mellitus [OR 7.69 (0.96–62.63), p = 0.05]. In all three supratentorial stroke groups, the neurological deficit as scored by the National Institute of Health Stroke Scale [OR 1.32 (1.22–1.44), p < 0.0001] was predominantly associated with a poor outcome, accompanied by age only in the group of all supratentorial strokes [OR 1.04 (1.01–1.08), p = 0.01]. In this cohort of mild to moderate stroke patients, the ORFs differed between the supra- and infratentorial stroke populations. Full article
(This article belongs to the Special Issue Advances in Endovascular Therapies and Acute Stroke Management)
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